Details for: PEX14

Gene ID: 5195

Symbol: PEX14

Ensembl ID: ENSG00000142655

Description: peroxisomal biogenesis factor 14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 184.7694
    Cell Significance Index: -28.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 112.6385
    Cell Significance Index: -28.5700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 71.1984
    Cell Significance Index: -29.3300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 61.9189
    Cell Significance Index: -25.1600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.4260
    Cell Significance Index: -25.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.0317
    Cell Significance Index: -29.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.6015
    Cell Significance Index: -28.4000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.6279
    Cell Significance Index: -30.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.3053
    Cell Significance Index: 27.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1070
    Cell Significance Index: 56.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7057
    Cell Significance Index: 338.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.6690
    Cell Significance Index: 105.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6591
    Cell Significance Index: 332.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5454
    Cell Significance Index: 43.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3715
    Cell Significance Index: 105.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0403
    Cell Significance Index: 102.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.9333
    Cell Significance Index: 23.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8989
    Cell Significance Index: 811.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8966
    Cell Significance Index: 50.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.8699
    Cell Significance Index: 22.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8392
    Cell Significance Index: 301.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7365
    Cell Significance Index: 19.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5759
    Cell Significance Index: 93.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5668
    Cell Significance Index: 16.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5649
    Cell Significance Index: 61.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5419
    Cell Significance Index: 374.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4999
    Cell Significance Index: 6.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4958
    Cell Significance Index: 21.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4787
    Cell Significance Index: 24.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4786
    Cell Significance Index: 55.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4641
    Cell Significance Index: 27.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4561
    Cell Significance Index: 17.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3527
    Cell Significance Index: 23.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3265
    Cell Significance Index: 14.8000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.3143
    Cell Significance Index: 2.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2943
    Cell Significance Index: 18.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2853
    Cell Significance Index: 6.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2290
    Cell Significance Index: 4.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1494
    Cell Significance Index: 26.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1387
    Cell Significance Index: 17.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1268
    Cell Significance Index: 238.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1260
    Cell Significance Index: 193.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1256
    Cell Significance Index: 231.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1250
    Cell Significance Index: 55.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1148
    Cell Significance Index: 62.7100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0947
    Cell Significance Index: 1.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0858
    Cell Significance Index: 54.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0836
    Cell Significance Index: 3.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0823
    Cell Significance Index: 1.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0705
    Cell Significance Index: 13.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0645
    Cell Significance Index: 87.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0549
    Cell Significance Index: 24.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0398
    Cell Significance Index: 0.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0266
    Cell Significance Index: 1.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0228
    Cell Significance Index: 0.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0184
    Cell Significance Index: 2.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0142
    Cell Significance Index: 0.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0143
    Cell Significance Index: -1.8300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0191
    Cell Significance Index: -0.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0213
    Cell Significance Index: -3.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0219
    Cell Significance Index: -2.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0294
    Cell Significance Index: -21.7700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0295
    Cell Significance Index: -22.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0316
    Cell Significance Index: -23.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0430
    Cell Significance Index: -2.0200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0440
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0463
    Cell Significance Index: -7.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0464
    Cell Significance Index: -26.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0519
    Cell Significance Index: -32.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0559
    Cell Significance Index: -2.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0772
    Cell Significance Index: -5.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0860
    Cell Significance Index: -10.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0912
    Cell Significance Index: -26.2300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0927
    Cell Significance Index: -2.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0933
    Cell Significance Index: -3.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1014
    Cell Significance Index: -7.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1063
    Cell Significance Index: -10.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1068
    Cell Significance Index: -5.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1350
    Cell Significance Index: -2.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1500
    Cell Significance Index: -31.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1542
    Cell Significance Index: -17.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1922
    Cell Significance Index: -20.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2095
    Cell Significance Index: -6.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2144
    Cell Significance Index: -5.8400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2239
    Cell Significance Index: -2.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2252
    Cell Significance Index: -4.7800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2256
    Cell Significance Index: -1.8400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2487
    Cell Significance Index: -3.0900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2656
    Cell Significance Index: -3.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2889
    Cell Significance Index: -18.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3059
    Cell Significance Index: -18.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3105
    Cell Significance Index: -10.7900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3128
    Cell Significance Index: -1.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3378
    Cell Significance Index: -26.7600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3443
    Cell Significance Index: -4.9300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3591
    Cell Significance Index: -5.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4021
    Cell Significance Index: -6.7300
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.4319
    Cell Significance Index: -1.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4383
    Cell Significance Index: -13.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4433
    Cell Significance Index: -9.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PEX14 is a protein that belongs to the PTS1 receptor-docking protein family. It is highly expressed in various cell types, including neurons, lens epithelial cells, and cardiac myocytes. PEX14 is characterized by its ability to interact with the PTS1 receptor, facilitating the docking of peroxisomal importers and the subsequent import of peroxisomal proteins into the peroxisomal matrix. This interaction is essential for the biogenesis and function of peroxisomes, which are critical for maintaining cellular homeostasis and preventing oxidative stress. **Pathways and Functions:** PEX14 is involved in several key pathways, including: 1. **Peroxisomal biogenesis:** PEX14 plays a crucial role in the biogenesis of peroxisomes by interacting with the PTS1 receptor and facilitating the import of peroxisomal proteins into the peroxisomal matrix. 2. **Protein import:** PEX14 is involved in the import of peroxisomal proteins into the peroxisomal matrix, which is essential for maintaining the function and integrity of peroxisomes. 3. **Metabolism of fatty acids and amino acids:** PEX14 is involved in the metabolism of fatty acids and amino acids, which are critical for maintaining cellular energy homeostasis and preventing oxidative stress. 4. **Detoxification:** PEX14 is involved in the detoxification of reactive oxygen species (ROS), which are generated during the metabolism of fatty acids and amino acids. **Clinical Significance:** Dysregulation of PEX14 has been implicated in various human diseases, including: 1. **Peroxisomal biogenesis disorders:** Mutations in PEX14 can lead to peroxisomal biogenesis disorders, which are characterized by impaired peroxisomal function and accumulation of toxic substances. 2. **Neurodegenerative diseases:** PEX14 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where impaired peroxisomal function can lead to accumulation of toxic substances and oxidative stress. 3. **Cancer:** PEX14 has been implicated in cancer, where impaired peroxisomal function can lead to accumulation of toxic substances and oxidative stress, promoting tumor growth and progression. In conclusion, PEX14 is a critical gene involved in the biogenesis and function of peroxisomes, and dysregulation of PEX14 has been implicated in various human diseases. Further research is needed to fully understand the role of PEX14 in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 2396530028

Symbol: PEX14_HUMAN

Name: PTS1 receptor-docking protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9653144

Title: Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import.

PubMed ID: 9653144

DOI: 10.1073/pnas.95.14.8087

PubMed ID: 10212238

Title: The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis.

PubMed ID: 10212238

DOI: 10.1074/jbc.274.18.12593

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10704444

Title: PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.

PubMed ID: 10704444

DOI: 10.1083/jcb.148.5.931

PubMed ID: 11438541

Title: The di-aromatic pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14.

PubMed ID: 11438541

DOI: 10.1074/jbc.m104647200

PubMed ID: 12488033

Title: Mammalian Pex14p: membrane topology and characterisation of the Pex14p-Pex14p interaction.

PubMed ID: 12488033

DOI: 10.1016/s0005-2736(02)00635-1

PubMed ID: 15146459

Title: Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene.

PubMed ID: 15146459

DOI: 10.1002/humu.20032

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21976670

Title: PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14.

PubMed ID: 21976670

DOI: 10.1074/jbc.m111.287201

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28765278

Title: The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo.

PubMed ID: 28765278

DOI: 10.1074/jbc.m117.805044

PubMed ID: 19197237

Title: Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.

PubMed ID: 19197237

DOI: 10.1038/emboj.2009.7

PubMed ID: 24235149

Title: A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes.

PubMed ID: 24235149

DOI: 10.1074/jbc.m113.499707

PubMed ID: 21525035

Title: PEX14 is required for microtubule-based peroxisome motility in human cells.

PubMed ID: 21525035

DOI: 10.1242/jcs.079368

Sequence Information:

  • Length: 377
  • Mass: 41237
  • Checksum: FED28F62A0B94E7F
  • Sequence:
  • MASSEQAEQP SQPSSTPGSE NVLPREPLIA TAVKFLQNSR VRQSPLATRR AFLKKKGLTD 
    EEIDMAFQQS GTAADEPSSL GPATQVVPVQ PPHLISQPYS PAGSRWRDYG ALAIIMAGIA 
    FGFHQLYKKY LLPLILGGRE DRKQLERMEA GLSELSGSVA QTVTQLQTTL ASVQELLIQQ 
    QQKIQELAHE LAAAKATTST NWILESQNIN ELKSEINSLK GLLLNRRQFP PSPSAPKIPS 
    WQIPVKSPSP SSPAAVNHHS SSDISPVSNE STSSSPGKEG HSPEGSTVTY HLLGPQEEGE 
    GVVDVKGQVR MEVQGEEEKR EDKEDEEDEE DDDVSHVDEE DCLGVQREDR RGGDGQINEQ 
    VEKLRRPEGA SNESERD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.