Details for: PEX14
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 184.7694
Cell Significance Index: -28.7400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 112.6385
Cell Significance Index: -28.5700 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 71.1984
Cell Significance Index: -29.3300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 61.9189
Cell Significance Index: -25.1600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 26.4260
Cell Significance Index: -25.2300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 24.0317
Cell Significance Index: -29.6300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.6015
Cell Significance Index: -28.4000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.6279
Cell Significance Index: -30.1000 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.3053
Cell Significance Index: 27.4800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.1070
Cell Significance Index: 56.2600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.7057
Cell Significance Index: 338.5000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.6690
Cell Significance Index: 105.1900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.6591
Cell Significance Index: 332.8100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.5454
Cell Significance Index: 43.1900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.3715
Cell Significance Index: 105.2500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.0403
Cell Significance Index: 102.9100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.9333
Cell Significance Index: 23.3300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8989
Cell Significance Index: 811.6700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.8966
Cell Significance Index: 50.3100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.8699
Cell Significance Index: 22.3600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.8392
Cell Significance Index: 301.0000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.7365
Cell Significance Index: 19.7400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5759
Cell Significance Index: 93.6700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5668
Cell Significance Index: 16.3300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5649
Cell Significance Index: 61.4400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5419
Cell Significance Index: 374.8000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.4999
Cell Significance Index: 6.8200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.4958
Cell Significance Index: 21.9300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4787
Cell Significance Index: 24.8700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.4786
Cell Significance Index: 55.7800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4641
Cell Significance Index: 27.8600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.4561
Cell Significance Index: 17.2700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.3527
Cell Significance Index: 23.7200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3265
Cell Significance Index: 14.8000 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.3143
Cell Significance Index: 2.7900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2943
Cell Significance Index: 18.0900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2853
Cell Significance Index: 6.1800 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.2290
Cell Significance Index: 4.4700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1494
Cell Significance Index: 26.9300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1387
Cell Significance Index: 17.0600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1268
Cell Significance Index: 238.7300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1260
Cell Significance Index: 193.9400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1256
Cell Significance Index: 231.5600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1250
Cell Significance Index: 55.2500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1148
Cell Significance Index: 62.7100 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.0947
Cell Significance Index: 1.6000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0858
Cell Significance Index: 54.5200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0836
Cell Significance Index: 3.9000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0823
Cell Significance Index: 1.4100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0705
Cell Significance Index: 13.4200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0645
Cell Significance Index: 87.6600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0549
Cell Significance Index: 24.9200 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.0398
Cell Significance Index: 0.9500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0266
Cell Significance Index: 1.8400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.0228
Cell Significance Index: 0.6500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0184
Cell Significance Index: 2.5200 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.0142
Cell Significance Index: 0.2100 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0143
Cell Significance Index: -1.8300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0191
Cell Significance Index: -0.4700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0213
Cell Significance Index: -3.1000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0219
Cell Significance Index: -2.8300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0294
Cell Significance Index: -21.7700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0295
Cell Significance Index: -22.3500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0316
Cell Significance Index: -23.1400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0430
Cell Significance Index: -2.0200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0440
Cell Significance Index: -0.9400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0463
Cell Significance Index: -7.9000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0464
Cell Significance Index: -26.1400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0519
Cell Significance Index: -32.4100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0559
Cell Significance Index: -2.9100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0772
Cell Significance Index: -5.4600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0860
Cell Significance Index: -10.1400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0912
Cell Significance Index: -26.2300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0927
Cell Significance Index: -2.0300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0933
Cell Significance Index: -3.2800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1014
Cell Significance Index: -7.5600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1063
Cell Significance Index: -10.8600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1068
Cell Significance Index: -5.6100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1350
Cell Significance Index: -2.8800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1500
Cell Significance Index: -31.5900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1542
Cell Significance Index: -17.6700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1922
Cell Significance Index: -20.0200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2095
Cell Significance Index: -6.7100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2144
Cell Significance Index: -5.8400 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.2239
Cell Significance Index: -2.8200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2252
Cell Significance Index: -4.7800 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2256
Cell Significance Index: -1.8400 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.2487
Cell Significance Index: -3.0900 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.2656
Cell Significance Index: -3.8200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2889
Cell Significance Index: -18.6400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3059
Cell Significance Index: -18.7600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3105
Cell Significance Index: -10.7900 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.3128
Cell Significance Index: -1.8900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3378
Cell Significance Index: -26.7600 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3443
Cell Significance Index: -4.9300 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3591
Cell Significance Index: -5.3000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4021
Cell Significance Index: -6.7300 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.4319
Cell Significance Index: -1.8800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4383
Cell Significance Index: -13.9600 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4433
Cell Significance Index: -9.2800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2396530028
Symbol: PEX14_HUMAN
Name: PTS1 receptor-docking protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9653144
Title: Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import.
PubMed ID: 9653144
PubMed ID: 10212238
Title: The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis.
PubMed ID: 10212238
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10704444
Title: PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.
PubMed ID: 10704444
PubMed ID: 11438541
Title: The di-aromatic pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14.
PubMed ID: 11438541
PubMed ID: 12488033
Title: Mammalian Pex14p: membrane topology and characterisation of the Pex14p-Pex14p interaction.
PubMed ID: 12488033
PubMed ID: 15146459
Title: Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene.
PubMed ID: 15146459
DOI: 10.1002/humu.20032
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21976670
Title: PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14.
PubMed ID: 21976670
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28765278
Title: The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo.
PubMed ID: 28765278
PubMed ID: 19197237
Title: Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.
PubMed ID: 19197237
DOI: 10.1038/emboj.2009.7
PubMed ID: 24235149
Title: A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes.
PubMed ID: 24235149
PubMed ID: 21525035
Title: PEX14 is required for microtubule-based peroxisome motility in human cells.
PubMed ID: 21525035
DOI: 10.1242/jcs.079368
Sequence Information:
- Length: 377
- Mass: 41237
- Checksum: FED28F62A0B94E7F
- Sequence:
MASSEQAEQP SQPSSTPGSE NVLPREPLIA TAVKFLQNSR VRQSPLATRR AFLKKKGLTD EEIDMAFQQS GTAADEPSSL GPATQVVPVQ PPHLISQPYS PAGSRWRDYG ALAIIMAGIA FGFHQLYKKY LLPLILGGRE DRKQLERMEA GLSELSGSVA QTVTQLQTTL ASVQELLIQQ QQKIQELAHE LAAAKATTST NWILESQNIN ELKSEINSLK GLLLNRRQFP PSPSAPKIPS WQIPVKSPSP SSPAAVNHHS SSDISPVSNE STSSSPGKEG HSPEGSTVTY HLLGPQEEGE GVVDVKGQVR MEVQGEEEKR EDKEDEEDEE DDDVSHVDEE DCLGVQREDR RGGDGQINEQ VEKLRRPEGA SNESERD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.