Details for: PEX14

Gene ID: 5195

Symbol: PEX14

Ensembl ID: ENSG00000142655

Description: peroxisomal biogenesis factor 14

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.64
    Marker Score: 60590
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.62
    Marker Score: 6605
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.6
    Marker Score: 2148
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.55
    Marker Score: 95242
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.54
    Marker Score: 34443
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.53
    Marker Score: 14430
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.53
    Marker Score: 14507
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.51
    Marker Score: 1826
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.51
    Marker Score: 1666
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.5
    Marker Score: 5343
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.5
    Marker Score: 15503
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.48
    Marker Score: 12722
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.47
    Marker Score: 3467
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168043
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.46
    Marker Score: 29025
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.45
    Marker Score: 850
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.44
    Marker Score: 21466
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.42
    Marker Score: 30242
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.39
    Marker Score: 2139
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.38
    Marker Score: 5336
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.38
    Marker Score: 10548.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.35
    Marker Score: 51328
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.34
    Marker Score: 704
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.33
    Marker Score: 1503
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.32
    Marker Score: 739
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.32
    Marker Score: 1137
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.31
    Marker Score: 5413
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.29
    Marker Score: 994
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.27
    Marker Score: 531
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.26
    Marker Score: 8082
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19621
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.22
    Marker Score: 4003
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.2
    Marker Score: 3427
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.2
    Marker Score: 699
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.19
    Marker Score: 2077
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.19
    Marker Score: 950.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.18
    Marker Score: 4924.5
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.17
    Marker Score: 958
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.15
    Marker Score: 4535
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.13
    Marker Score: 2296
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.12
    Marker Score: 1211
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.12
    Marker Score: 4844
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.1
    Marker Score: 403
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.1
    Marker Score: 973
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.06
    Marker Score: 736
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.03
    Marker Score: 5557
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.02
    Marker Score: 299
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.01
    Marker Score: 4668.5
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.01
    Marker Score: 300
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.01
    Marker Score: 275
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71728
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47953
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.99
    Marker Score: 597
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.99
    Marker Score: 2168.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.98
    Marker Score: 1878.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.97
    Marker Score: 17264
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.97
    Marker Score: 2421
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.96
    Marker Score: 1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 487
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.94
    Marker Score: 247
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.92
    Marker Score: 1497
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.91
    Marker Score: 444
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.91
    Marker Score: 331
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2716
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.9
    Marker Score: 3734
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.89
    Marker Score: 279.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4961
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 311.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.86
    Marker Score: 1223
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.86
    Marker Score: 515
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.86
    Marker Score: 3573.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.84
    Marker Score: 213
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.82
    Marker Score: 165
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.82
    Marker Score: 13098
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.81
    Marker Score: 261
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.81
    Marker Score: 852
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.8
    Marker Score: 254
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8
    Marker Score: 396
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.8
    Marker Score: 960
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 606.5
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.79
    Marker Score: 296
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 311
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.77
    Marker Score: 261
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.77
    Marker Score: 2635
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.76
    Marker Score: 502
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3189.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.75
    Marker Score: 2679
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.75
    Marker Score: 4482
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.74
    Marker Score: 274
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.74
    Marker Score: 213
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.73
    Marker Score: 1222
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.73
    Marker Score: 379.5
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.72
    Marker Score: 768.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.71
    Marker Score: 2029
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.71
    Marker Score: 885

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Other Information

**Key Characteristics:** PEX14 is a protein that belongs to the PTS1 receptor-docking protein family. It is highly expressed in various cell types, including neurons, lens epithelial cells, and cardiac myocytes. PEX14 is characterized by its ability to interact with the PTS1 receptor, facilitating the docking of peroxisomal importers and the subsequent import of peroxisomal proteins into the peroxisomal matrix. This interaction is essential for the biogenesis and function of peroxisomes, which are critical for maintaining cellular homeostasis and preventing oxidative stress. **Pathways and Functions:** PEX14 is involved in several key pathways, including: 1. **Peroxisomal biogenesis:** PEX14 plays a crucial role in the biogenesis of peroxisomes by interacting with the PTS1 receptor and facilitating the import of peroxisomal proteins into the peroxisomal matrix. 2. **Protein import:** PEX14 is involved in the import of peroxisomal proteins into the peroxisomal matrix, which is essential for maintaining the function and integrity of peroxisomes. 3. **Metabolism of fatty acids and amino acids:** PEX14 is involved in the metabolism of fatty acids and amino acids, which are critical for maintaining cellular energy homeostasis and preventing oxidative stress. 4. **Detoxification:** PEX14 is involved in the detoxification of reactive oxygen species (ROS), which are generated during the metabolism of fatty acids and amino acids. **Clinical Significance:** Dysregulation of PEX14 has been implicated in various human diseases, including: 1. **Peroxisomal biogenesis disorders:** Mutations in PEX14 can lead to peroxisomal biogenesis disorders, which are characterized by impaired peroxisomal function and accumulation of toxic substances. 2. **Neurodegenerative diseases:** PEX14 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where impaired peroxisomal function can lead to accumulation of toxic substances and oxidative stress. 3. **Cancer:** PEX14 has been implicated in cancer, where impaired peroxisomal function can lead to accumulation of toxic substances and oxidative stress, promoting tumor growth and progression. In conclusion, PEX14 is a critical gene involved in the biogenesis and function of peroxisomes, and dysregulation of PEX14 has been implicated in various human diseases. Further research is needed to fully understand the role of PEX14 in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 2396530028

Symbol: PEX14_HUMAN

Name: PTS1 receptor-docking protein

UniProtKB Accession Codes:

O75381 B2R7N1 B3KML6 B7Z1N2 Q8WX51

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 12 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9653144

Title: Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import.

PubMed ID: 9653144

DOI: 10.1073/pnas.95.14.8087

PubMed ID: 10212238

Title: The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis.

PubMed ID: 10212238

DOI: 10.1074/jbc.274.18.12593

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10704444

Title: PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.

PubMed ID: 10704444

DOI: 10.1083/jcb.148.5.931

PubMed ID: 11438541

Title: The di-aromatic pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14.

PubMed ID: 11438541

DOI: 10.1074/jbc.m104647200

PubMed ID: 12488033

Title: Mammalian Pex14p: membrane topology and characterisation of the Pex14p-Pex14p interaction.

PubMed ID: 12488033

DOI: 10.1016/s0005-2736(02)00635-1

PubMed ID: 15146459

Title: Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene.

PubMed ID: 15146459

DOI: 10.1002/humu.20032

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21976670

Title: PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14.

PubMed ID: 21976670

DOI: 10.1074/jbc.m111.287201

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28765278

Title: The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo.

PubMed ID: 28765278

DOI: 10.1074/jbc.m117.805044

PubMed ID: 19197237

Title: Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.

PubMed ID: 19197237

DOI: 10.1038/emboj.2009.7

PubMed ID: 24235149

Title: A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes.

PubMed ID: 24235149

DOI: 10.1074/jbc.m113.499707

PubMed ID: 21525035

Title: PEX14 is required for microtubule-based peroxisome motility in human cells.

PubMed ID: 21525035

DOI: 10.1242/jcs.079368

Sequence Information:

  • Length: 377
  • Mass: 41237
  • Checksum: FED28F62A0B94E7F
  • Sequence:
    • MASSEQAEQP SQPSSTPGSE NVLPREPLIA TAVKFLQNSR VRQSPLATRR AFLKKKGLTD 
EEIDMAFQQS GTAADEPSSL GPATQVVPVQ PPHLISQPYS PAGSRWRDYG ALAIIMAGIA 
FGFHQLYKKY LLPLILGGRE DRKQLERMEA GLSELSGSVA QTVTQLQTTL ASVQELLIQQ 
QQKIQELAHE LAAAKATTST NWILESQNIN ELKSEINSLK GLLLNRRQFP PSPSAPKIPS 
WQIPVKSPSP SSPAAVNHHS SSDISPVSNE STSSSPGKEG HSPEGSTVTY HLLGPQEEGE 
GVVDVKGQVR MEVQGEEEKR EDKEDEEDEE DDDVSHVDEE DCLGVQREDR RGGDGQINEQ 
VEKLRRPEGA SNESERD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.