Details for: PFKM

Gene ID: 5213

Symbol: PFKM

Ensembl ID: ENSG00000152556

Description: phosphofructokinase, muscle

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 117.7150
    Cell Significance Index: -18.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 80.8616
    Cell Significance Index: -20.5100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 46.6686
    Cell Significance Index: -19.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 41.5500
    Cell Significance Index: -16.8800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.6906
    Cell Significance Index: -16.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.6811
    Cell Significance Index: -21.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.6618
    Cell Significance Index: -20.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7146
    Cell Significance Index: -22.5500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 5.0467
    Cell Significance Index: 81.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.9600
    Cell Significance Index: 101.7900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.0115
    Cell Significance Index: 49.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.8022
    Cell Significance Index: 94.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1877
    Cell Significance Index: 74.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0949
    Cell Significance Index: 84.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8755
    Cell Significance Index: 102.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8649
    Cell Significance Index: 51.9300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8567
    Cell Significance Index: 6.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8228
    Cell Significance Index: 742.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7571
    Cell Significance Index: 151.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7527
    Cell Significance Index: 20.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7235
    Cell Significance Index: 78.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5618
    Cell Significance Index: 77.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5477
    Cell Significance Index: 89.0800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5143
    Cell Significance Index: 4.3200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.5086
    Cell Significance Index: 3.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4476
    Cell Significance Index: 9.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4464
    Cell Significance Index: 12.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4324
    Cell Significance Index: 5.9000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4248
    Cell Significance Index: 5.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4156
    Cell Significance Index: 149.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4067
    Cell Significance Index: 22.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3687
    Cell Significance Index: 47.2600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3495
    Cell Significance Index: 5.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3488
    Cell Significance Index: 24.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3072
    Cell Significance Index: 3.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3027
    Cell Significance Index: 13.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2879
    Cell Significance Index: 57.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2800
    Cell Significance Index: 9.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2244
    Cell Significance Index: 5.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2113
    Cell Significance Index: 40.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2013
    Cell Significance Index: 109.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1992
    Cell Significance Index: 12.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1962
    Cell Significance Index: 4.2500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1846
    Cell Significance Index: 2.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1726
    Cell Significance Index: 21.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1583
    Cell Significance Index: 4.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1551
    Cell Significance Index: 68.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1317
    Cell Significance Index: 23.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1008
    Cell Significance Index: 2.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0822
    Cell Significance Index: 9.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0820
    Cell Significance Index: 10.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0720
    Cell Significance Index: 7.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0700
    Cell Significance Index: 1.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0654
    Cell Significance Index: 2.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0445
    Cell Significance Index: 3.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0349
    Cell Significance Index: 65.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0337
    Cell Significance Index: 1.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0306
    Cell Significance Index: 1.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0287
    Cell Significance Index: 1.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0187
    Cell Significance Index: 13.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0164
    Cell Significance Index: 10.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0144
    Cell Significance Index: 0.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0046
    Cell Significance Index: 8.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0034
    Cell Significance Index: 5.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0076
    Cell Significance Index: -3.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0114
    Cell Significance Index: -15.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0133
    Cell Significance Index: -10.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0141
    Cell Significance Index: -0.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0150
    Cell Significance Index: -0.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0168
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0233
    Cell Significance Index: -17.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0316
    Cell Significance Index: -17.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0376
    Cell Significance Index: -23.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0466
    Cell Significance Index: -0.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0493
    Cell Significance Index: -5.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0530
    Cell Significance Index: -1.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0565
    Cell Significance Index: -1.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0592
    Cell Significance Index: -17.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0632
    Cell Significance Index: -9.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0708
    Cell Significance Index: -5.2800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0845
    Cell Significance Index: -1.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0856
    Cell Significance Index: -4.4600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0981
    Cell Significance Index: -1.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1068
    Cell Significance Index: -22.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1126
    Cell Significance Index: -19.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1169
    Cell Significance Index: -13.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1208
    Cell Significance Index: -5.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1395
    Cell Significance Index: -11.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1414
    Cell Significance Index: -8.6700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1571
    Cell Significance Index: -1.3400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1620
    Cell Significance Index: -2.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1847
    Cell Significance Index: -19.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1865
    Cell Significance Index: -12.0400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1926
    Cell Significance Index: -2.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2097
    Cell Significance Index: -9.8600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2253
    Cell Significance Index: -1.8600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2310
    Cell Significance Index: -3.2400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2414
    Cell Significance Index: -2.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2468
    Cell Significance Index: -7.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2582
    Cell Significance Index: -5.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme Function:** PFKM catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate, a rate-limiting step in glycolysis. 2. **Subcellular Localization:** PFKM is primarily found in the cytosol of muscle cells, where it regulates energy metabolism and glucose homeostasis. 3. **Regulatory Mechanisms:** PFKM is subject to allosteric regulation by ATP, ADP, and citrate, as well as transcriptional regulation by insulin and glucagon. 4. **Protein Structure:** PFKM consists of two subunits (A and B) with distinct structural features, which contribute to its regulatory properties. **Pathways and Functions:** 1. **Glycolysis:** PFKM is a critical component of the glycolytic pathway, regulating the conversion of glucose to pyruvate. 2. **Glucose Homeostasis:** PFKM plays a key role in maintaining glucose homeostasis by regulating glucose uptake and storage in muscle cells. 3. **Energy Metabolism:** PFKM is essential for energy metabolism in muscle cells, where it regulates ATP production and energy storage. 4. **Cell Signaling:** PFKM is involved in cell signaling pathways, including the regulation of insulin secretion and glucose metabolism. **Clinical Significance:** 1. **Cancer:** Altered PFKM expression has been linked to various cancers, including colorectal, breast, and lung cancer, where it contributes to tumor growth and metastasis. 2. **Diabetes:** Dysregulation of PFKM has been implicated in the development of type 2 diabetes, where it contributes to insulin resistance and glucose metabolism disorders. 3. **Cardiovascular Disorders:** PFKM has been linked to cardiovascular disorders, including hypertension and atherosclerosis, where it regulates energy metabolism and glucose homeostasis. 4. **Muscle Diseases:** PFKM mutations have been associated with muscle diseases, including myopathies and muscular dystrophy, where it contributes to muscle energy metabolism and function. In conclusion, PFKM is a critical enzyme in cellular metabolism, regulating energy metabolism, glucose homeostasis, and muscle cell function. Its dysregulation has been implicated in various diseases, highlighting the importance of PFKM in maintaining cellular homeostasis and overall health. Further research is needed to elucidate the mechanisms underlying PFKM dysregulation and its implications for human disease.

Genular Protein ID: 3394175688

Symbol: PFKAM_HUMAN

Name: 6-phosphofructokinase type A

UniProtKB Accession Codes:

P08237 J3KNX3 Q16814 Q16815 Q6ZTT1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CPTAC 2 CTD 1 ChEBI 18 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 33 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 9 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1833270

Title: Structure of the entire human muscle phosphofructokinase-encoding gene: a two-promoter system.

PubMed ID: 1833270

DOI: 10.1016/0378-1119(91)90262-a

PubMed ID: 2526045

Title: Cloning and expression of a human muscle phosphofructokinase cDNA.

PubMed ID: 2526045

DOI: 10.1016/0378-1119(89)90372-7

PubMed ID: 2822475

Title: Cloning of human muscle phosphofructokinase cDNA.

PubMed ID: 2822475

DOI: 10.1016/0014-5793(87)80519-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2140567

Title: Alternative splicing of the transcript encoding the human muscle isoenzyme of phosphofructokinase.

PubMed ID: 2140567

DOI: 10.1016/s0021-9258(19)38803-9

PubMed ID: 2526044

Title: Human 6-phosphofructo-1-kinase gene has an additional intron upstream of start codon.

PubMed ID: 2526044

DOI: 10.1016/0378-1119(89)90019-x

PubMed ID: 7550225

Title: Mutations in muscle phosphofructokinase gene.

PubMed ID: 7550225

DOI: 10.1002/humu.1380060102

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29775581

Title: p300-mediated lysine 2-hydroxyisobutyrylation regulates glycolysis.

PubMed ID: 29775581

DOI: 10.1016/j.molcel.2018.04.011

PubMed ID: 7513946

Title: Identification of three novel mutations in non-Ashkenazi Italian patients with muscle phosphofructokinase deficiency.

PubMed ID: 7513946

PubMed ID: 7825568

Title: Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency.

PubMed ID: 7825568

PubMed ID: 8889589

Title: Novel missense mutation (W686C) of the phosphofructokinase-M gene in a Japanese patient with a mild form of glycogenosis VII.

PubMed ID: 8889589

DOI: 10.1002/(sici)1098-1004(1996)8:3<273::aid-humu13>3.0.co;2-#

PubMed ID: 22133655

Title: Clinical features and new molecular findings in muscle phosphofructokinase deficiency (GSD type VII).

PubMed ID: 22133655

DOI: 10.1016/j.nmd.2011.10.022

PubMed ID: 24427140

Title: First description of phosphofructokinase deficiency in spain: identification of a novel homozygous missense mutation in the PFKM gene.

PubMed ID: 24427140

DOI: 10.3389/fphys.2013.00393

Sequence Information:

  • Length: 780
  • Mass: 85183
  • Checksum: 769A2C01F97D1122
  • Sequence:
    • MTHEEHHAAK TLGIGKAIAV LTSGGDAQGM NAAVRAVVRV GIFTGARVFF VHEGYQGLVD 
GGDHIKEATW ESVSMMLQLG GTVIGSARCK DFREREGRLR AAYNLVKRGI TNLCVIGGDG 
SLTGADTFRS EWSDLLSDLQ KAGKITDEEA TKSSYLNIVG LVGSIDNDFC GTDMTIGTDS 
ALHRIMEIVD AITTTAQSHQ RTFVLEVMGR HCGYLALVTS LSCGADWVFI PECPPDDDWE 
EHLCRRLSET RTRGSRLNII IVAEGAIDKN GKPITSEDIK NLVVKRLGYD TRVTVLGHVQ 
RGGTPSAFDR ILGSRMGVEA VMALLEGTPD TPACVVSLSG NQAVRLPLME CVQVTKDVTK 
AMDEKKFDEA LKLRGRSFMN NWEVYKLLAH VRPPVSKSGS HTVAVMNVGA PAAGMNAAVR 
STVRIGLIQG NRVLVVHDGF EGLAKGQIEE AGWSYVGGWT GQGGSKLGTK RTLPKKSFEQ 
ISANITKFNI QGLVIIGGFE AYTGGLELME GRKQFDELCI PFVVIPATVS NNVPGSDFSV 
GADTALNTIC TTCDRIKQSA AGTKRRVFII ETMGGYCGYL ATMAGLAAGA DAAYIFEEPF 
TIRDLQANVE HLVQKMKTTV KRGLVLRNEK CNENYTTDFI FNLYSEEGKG IFDSRKNVLG 
HMQQGGSPTP FDRNFATKMG AKAMNWMSGK IKESYRNGRI FANTPDSGCV LGMRKRALVF 
QPVAELKDQT DFEHRIPKEQ WWLKLRPILK ILAKYEIDLD TSDHAHLEHI TRKRSGEAAV

Genular Protein ID: 3070405689

Symbol: A0A2R8Y891_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2R8Y891

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChEBI 18 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneTree 1 HAMAP 1 HAMAP-Rule 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PRINTS 1 PROSITE 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 4 Rhea 1 SAM 1 SMR 1 SUPFAM 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 883
  • Mass: 96908
  • Checksum: 97E1FE04E6C16EE8
  • Sequence:
    • MHKDEFHLKF FMCVIQSRQL VRTPQRTAGE ASTSSMLIPK PPPKTDILKS LDTMDDPDTV 
GSIPVFKTEC AEVEIQVSKR KRAVVKARGD PTVETMKQRE EWIMTHEEHH AAKTLGIGKA 
IAVLTSGGDA QGMNAAVRAV VRVGIFTGAR VFFVHEGYQG LVDGGDHIKE ATWESVSMML 
QLGGTVIGSA RCKDFREREG RLRAAYNLVK RGITNLCVIG GDGSLTGADT FRSEWSDLLS 
DLQKAGKITD EEATKSSYLN IVGLVGSIDN DFCGTDMTIG TDSALHRIME IVDAITTTAQ 
SHQRTFVLEV MGRHCGYLAL VTSLSCGADW VFIPECPPDD DWEEHLCRRL SETRTRGSRL 
NIIIVAEGAI DKNGKPITSE DIKNLVVKRL GYDTRVTVLG HVQRGGTPSA FDRILGSRMG 
VEAVMALLEG TPDTPACVVS LSGNQAVRLP LMECVQVTKD VTKAMDEKKF DEALKLRGRS 
FMNNWEVYKL LAHVRPPVSK SGSHTVAVMN VGAPAAGMNA AVRSTVRIGL IQGNRVLVVH 
DGFEGLAKGQ IEEAGWSYVG GWTGQGGSKL GTKRTLPKKS FEQISANITK FNIQGLVIIG 
GFEAYTGGLE LMEGRKQFDE LCIPFVVIPA TVSNNVPGSD FSVGADTALN TICTTCDRIK 
QSAAGTKRRV FIIETMGGYC GYLATMAGLA AGADAAYIFE EPFTIRDLQA NVEHLVQKMK 
TTVKRGLVLR NEKCNENYTT DFIFNLYSEE GKGIFDSRKN VLGHMQQGGS PTPFDRNFAT 
KMGAKAMNWM SGKIKESYRN GRIFANTPDS GCVLGMRKRA LVFQPVAELK DQTDFEHRIP 
KEQWWLKLRP ILKILAKYEI DLDTSDHAHL EHITRKRSGE AAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.