Details for: PFKP

Gene ID: 5214

Symbol: PFKP

Ensembl ID: ENSG00000067057

Description: phosphofructokinase, platelet

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 226.6865
    Cell Significance Index: -35.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 122.7314
    Cell Significance Index: -31.1300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 75.2347
    Cell Significance Index: -35.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.8080
    Cell Significance Index: -28.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.3485
    Cell Significance Index: -28.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.6466
    Cell Significance Index: -35.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.9076
    Cell Significance Index: -29.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.6925
    Cell Significance Index: -29.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 5.5886
    Cell Significance Index: 1608.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.3019
    Cell Significance Index: -9.4200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.0737
    Cell Significance Index: 25.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6969
    Cell Significance Index: 340.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6579
    Cell Significance Index: 269.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3737
    Cell Significance Index: 37.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2893
    Cell Significance Index: 81.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1778
    Cell Significance Index: 16.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0730
    Cell Significance Index: 56.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0122
    Cell Significance Index: 65.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9181
    Cell Significance Index: 47.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8888
    Cell Significance Index: 68.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8494
    Cell Significance Index: 463.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7538
    Cell Significance Index: 521.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7208
    Cell Significance Index: 21.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6559
    Cell Significance Index: 235.2600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.5560
    Cell Significance Index: 7.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5459
    Cell Significance Index: 15.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4977
    Cell Significance Index: 34.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4720
    Cell Significance Index: 58.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4664
    Cell Significance Index: 10.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4205
    Cell Significance Index: 75.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3133
    Cell Significance Index: 59.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2805
    Cell Significance Index: 36.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2772
    Cell Significance Index: 521.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2717
    Cell Significance Index: 418.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2609
    Cell Significance Index: 12.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2583
    Cell Significance Index: 164.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1919
    Cell Significance Index: 5.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1820
    Cell Significance Index: 18.0000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1790
    Cell Significance Index: 1.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1655
    Cell Significance Index: 305.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1578
    Cell Significance Index: 4.4100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1529
    Cell Significance Index: 0.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1458
    Cell Significance Index: 64.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0949
    Cell Significance Index: 43.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0931
    Cell Significance Index: 4.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0926
    Cell Significance Index: 5.6900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.0822
    Cell Significance Index: 1.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0532
    Cell Significance Index: 1.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0519
    Cell Significance Index: 2.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0445
    Cell Significance Index: 5.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0415
    Cell Significance Index: 56.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0372
    Cell Significance Index: 0.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0169
    Cell Significance Index: 15.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0122
    Cell Significance Index: 8.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0079
    Cell Significance Index: 0.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0053
    Cell Significance Index: 0.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0050
    Cell Significance Index: 0.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0005
    Cell Significance Index: 0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0065
    Cell Significance Index: -4.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0089
    Cell Significance Index: -5.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0093
    Cell Significance Index: -1.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0154
    Cell Significance Index: -1.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0265
    Cell Significance Index: -1.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0392
    Cell Significance Index: -22.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0427
    Cell Significance Index: -32.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0474
    Cell Significance Index: -4.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0922
    Cell Significance Index: -19.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0964
    Cell Significance Index: -16.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0977
    Cell Significance Index: -2.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1249
    Cell Significance Index: -2.6600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1283
    Cell Significance Index: -14.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1311
    Cell Significance Index: -9.2700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1375
    Cell Significance Index: -2.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1537
    Cell Significance Index: -30.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1557
    Cell Significance Index: -18.1400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1706
    Cell Significance Index: -2.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1744
    Cell Significance Index: -4.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1814
    Cell Significance Index: -5.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1821
    Cell Significance Index: -18.9600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2126
    Cell Significance Index: -4.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2126
    Cell Significance Index: -27.2500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2269
    Cell Significance Index: -2.8300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2412
    Cell Significance Index: -2.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2844
    Cell Significance Index: -12.5800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3019
    Cell Significance Index: -5.2200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3127
    Cell Significance Index: -4.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3178
    Cell Significance Index: -25.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3281
    Cell Significance Index: -7.5800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3659
    Cell Significance Index: -3.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3702
    Cell Significance Index: -14.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3776
    Cell Significance Index: -9.9300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3924
    Cell Significance Index: -3.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4115
    Cell Significance Index: -14.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4275
    Cell Significance Index: -10.9200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4595
    Cell Significance Index: -5.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4831
    Cell Significance Index: -27.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4937
    Cell Significance Index: -30.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5100
    Cell Significance Index: -8.7400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5157
    Cell Significance Index: -10.9500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5191
    Cell Significance Index: -12.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PFKP is a type C isoform of phosphofructokinase, characterized by its high affinity for fructose-6-phosphate and its unique platelet-specific expression profile. Unlike other phosphofructokinase isoforms, PFKP lacks the regulatory subunits typically found in cytosolic glycolytic enzymes. This absence of regulatory subunits enables PFKP to operate independently of the glycolytic pathway, making it a critical component of platelet metabolism. **Pathways and Functions:** PFKP is involved in various cellular processes, including glycolysis, fructose metabolism, and cell signaling. Specifically, PFKP regulates the metabolism of fructose-6-phosphate and fructose-1,6-bisphosphate, two critical intermediates in glycolysis. Additionally, PFKP interacts with other proteins, such as cadherins and metal ions, to modulate its activity and influence cell-cell adhesion and signaling pathways. PFKP also plays a role in the regulation of cellular response to leukemia inhibitory factor (LIF) and the metabolism of glucose. **Clinical Significance:** PFKP's unique expression profile and regulatory properties make it an attractive target for the development of novel therapeutic strategies for various diseases. Platelet-specific PFKP expression has been implicated in several pathologies, including: 1. **Thrombosis**: PFKP's role in platelet metabolism and activation makes it a potential target for the development of antithrombotic therapies. 2. **Cancer**: The expression of PFKP in various cancer cell types suggests its potential involvement in tumor progression and metastasis. 3. **Neurological disorders**: PFKP's interaction with cadherins and metal ions may play a role in the regulation of cell adhesion and signaling pathways in neurological diseases, such as Alzheimer's and Parkinson's. **Significantly Expressed Cells:** PFKP is expressed in a range of cell types, including corneal endothelial cells, astrocytes, lens epithelial cells, and various neuronal populations. Its expression in fetal cardiomyocytes and dopaminergic neurons highlights its potential role in cardiac and neuronal development. **Proteins Associated with PFKP:** PFKP interacts with several proteins, including PFKAP (6-phosphofructokinase type C), B1APP6, and A0A7I2V3Z0. These interactions are critical for modulating PFKP's activity and influence its role in various cellular processes. In conclusion, phosphofructokinase, platelet (PFKP) is a unique enzyme that plays a crucial role in glycolysis and beyond. Its platelet-specific expression profile and regulatory properties make it an attractive target for the development of novel therapeutic strategies for various diseases. Further research is needed to fully elucidate the functions and clinical significance of PFKP in human health and disease.

Genular Protein ID: 478445209

Symbol: PFKAP_HUMAN

Name: 6-phosphofructokinase type C

UniProtKB Accession Codes:

Q01813 B3KS15 Q5VSR7 Q5VSR8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 18 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8117307

Title: Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet.

PubMed ID: 8117307

DOI: 10.1006/bbrc.1994.1141

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1834056

Title: Isolation and sequence of a cDNA encoding human platelet phosphofructokinase.

PubMed ID: 1834056

DOI: 10.1016/s0006-291x(05)81276-8

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 33607258

Title: PFKP facilitates ATG4B phosphorylation during amino acid deprivation-induced autophagy.

PubMed ID: 33607258

DOI: 10.1016/j.cellsig.2021.109956

Sequence Information:

  • Length: 784
  • Mass: 85596
  • Checksum: 22522E77E9AF80F6
  • Sequence:
    • MDADDSRAPK GSLRKFLEHL SGAGKAIGVL TSGGDAQGMN AAVRAVVRMG IYVGAKVYFI 
YEGYQGMVDG GSNIAEADWE SVSSILQVGG TIIGSARCQA FRTREGRLKA ACNLLQRGIT 
NLCVIGGDGS LTGANLFRKE WSGLLEELAR NGQIDKEAVQ KYAYLNVVGM VGSIDNDFCG 
TDMTIGTDSA LHRIIEVVDA IMTTAQSHQR TFVLEVMGRH CGYLALVSAL ACGADWVFLP 
ESPPEEGWEE QMCVKLSENR ARKKRLNIII VAEGAIDTQN KPITSEKIKE LVVTQLGYDT 
RVTILGHVQR GGTPSAFDRI LASRMGVEAV IALLEATPDT PACVVSLNGN HAVRLPLMEC 
VQMTQDVQKA MDERRFQDAV RLRGRSFAGN LNTYKRLAIK LPDDQIPKTN CNVAVINVGA 
PAAGMNAAVR SAVRVGIADG HRMLAIYDGF DGFAKGQIKE IGWTDVGGWT GQGGSILGTK 
RVLPGKYLEE IATQMRTHSI NALLIIGGFE AYLGLLELSA AREKHEEFCV PMVMVPATVS 
NNVPGSDFSI GADTALNTIT DTCDRIKQSA SGTKRRVFII ETMGGYCGYL ANMGGLAAGA 
DAAYIFEEPF DIRDLQSNVE HLTEKMKTTI QRGLVLRNES CSENYTTDFI YQLYSEEGKG 
VFDCRKNVLG HMQQGGAPSP FDRNFGTKIS ARAMEWITAK LKEARGRGKK FTTDDSICVL 
GISKRNVIFQ PVAELKKQTD FEHRIPKEQW WLKLRPLMKI LAKYKASYDV SDSGQLEHVQ 
PWSV

Genular Protein ID: 1432648054

Symbol: A0A7I2V3Z0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V3Z0

Database IDs:

ARBA 12 Bgee 1 CDD 1 CTD 1 ChEBI 17 DisGeNET 1 EC 1 EMBL 3 Ensembl 3 GO 5 Gene3D 2 GeneTree 1 HAMAP 1 HAMAP-Rule 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 NCBIfam 1 OMA 1 PANTHER 2 PIRNR 1 PIRSF 1 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 3 Rhea 1 SUPFAM 1 UniPathway 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 746
  • Mass: 81800
  • Checksum: DEA251EF304F0133
  • Sequence:
    • MNAAVRAVVR MGIYVGAKVY FIYEGYQGMV DGGSNIAEAD WESVSSILQV GGTIIGSARC 
QAFRTREGRL KAACNLLQRG ITNLCVIGGD GSLTGANLFR KEWSGLLEEL ARNGQIDKEA 
VQKYAYLNVV GMVGSIDNDF CGTDMTIGTD SALHRIIEVV DAIMTTAQSH QRTFVLEVMG 
RHCGYLALVS ALACGADWVF LPESPPEEGW EEQMCVKLSE NRARKKRLNI IIVAEGAIDT 
QNKPITSEKI KELVVTQLGY DTRVTILGHV QRGGTPSAFD RILASRMGVE AVIALLEATP 
DTPACVVSLN GNHAVRLPLM ECVQMTQDVQ KAMDERRFQD AVRLRGRSFA GNLNTYKRLA 
IKLPDDQIPK TNCNVAVINV GAPAAGMNAA VRSAVRVGIA DGHRMLAIYD GFDGFAKGQI 
KEIGWTDVGG WTGQGGSILG TKRVLPGKYL EEIATQMRTH SINALLIIGG FEAYLGLLEL 
SAAREKHEEF CVPMVMVPAT VSNNVPGSDF SIGADTALNT ITDTCDRIKQ SASGTKRRVF 
IIETMGGYCG YLANMGGLAA GADAAYIFEE PFDIRDLQSN VEHLTEKMKT TIQRGLVLRN 
ESCSENYTTD FIYQLYSEEG KGVFDCRKNV LGHMQQGGAP SPFDRNFGTK ISARAMEWIT 
AKLKEARGRG KKFTTDDSIC VLGISKRNVI FQPVAELKKQ TDFEHRIPKE QWWLKLRPLM 
KILAKYKASY DVSDSGQLEH VQPWSV

Genular Protein ID: 2956491270

Symbol: B1APP6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B1APP6

Database IDs:

ARBA 14 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 5 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 2 Rhea 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 568
  • Mass: 62586
  • Checksum: B96C10A5C2DA0F5B
  • Sequence:
    • MGRHCGYLAL VSALACGADW VFLPESPPEE GWEEQMCVKL SENRARKKRL NIIIVAEGAI 
DTQNKPITSE KIKELVVTQL GYDTRVTILG HVQRGGTPSA FDRILASRMG VEAVIALLEA 
TPDTPACVVS LNGNHAVRLP LMECVQMTQD VQKAMDERRF QDAVRLRGRS FAGNLNTYKR 
LAIKLPDDQI PKTNCNVAVI NVGAPAAGMN AAVRSAVRVG IADGHRMLAI YDGFDGFAKG 
QIKEIGWTDV GGWTGQGGSI LGTKRVLPGK YLEEIATQMR THSINALLII GGFEAYLGLL 
ELSAAREKHE EFCVPMVMVP ATVSNNVPGS DFSIGADTAL NTITDTCDRI KQSASGTKRR 
VFIIETMGGY CGYLANMGGL AAGADAAYIF EEPFDIRDLQ SNVEHLTEKM KTTIQRGLVL 
RNESCSENYT TDFIYQLYSE EGKGVFDCRK NVLGHMQQGG APSPFDRNFG TKISARAMEW 
ITAKLKEARG RGKKFTTDDS ICVLGISKRN VIFQPVAELK KQTDFEHRIP KEQWWLKLRP 
LMKILAKYKA SYDVSDSGQL EHVQPWSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.