Details for: PFN2

Gene ID: 5217

Symbol: PFN2

Ensembl ID: ENSG00000070087

Description: profilin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 213.6356
    Cell Significance Index: -33.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 132.3315
    Cell Significance Index: -33.5700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 79.0877
    Cell Significance Index: -32.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 69.0710
    Cell Significance Index: -32.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 67.6173
    Cell Significance Index: -27.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.9353
    Cell Significance Index: -33.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.5109
    Cell Significance Index: -33.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4743
    Cell Significance Index: -33.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.3277
    Cell Significance Index: 68.7900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.2604
    Cell Significance Index: 42.0000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.6570
    Cell Significance Index: 49.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.4593
    Cell Significance Index: 93.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.8398
    Cell Significance Index: 133.4300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.7293
    Cell Significance Index: 47.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.5906
    Cell Significance Index: 188.5200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.1034
    Cell Significance Index: 19.2000
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.9475
    Cell Significance Index: 15.5100
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 2.9459
    Cell Significance Index: 11.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8913
    Cell Significance Index: 187.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5627
    Cell Significance Index: 81.1800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.5132
    Cell Significance Index: 8.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4168
    Cell Significance Index: 85.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3990
    Cell Significance Index: 280.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3021
    Cell Significance Index: 711.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1567
    Cell Significance Index: 31.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1519
    Cell Significance Index: 30.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0585
    Cell Significance Index: 172.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9563
    Cell Significance Index: 863.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9447
    Cell Significance Index: 129.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8483
    Cell Significance Index: 52.1400
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.8430
    Cell Significance Index: 4.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7967
    Cell Significance Index: 59.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7775
    Cell Significance Index: 36.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7514
    Cell Significance Index: 96.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7479
    Cell Significance Index: 47.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6347
    Cell Significance Index: 43.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6317
    Cell Significance Index: 113.8800
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.6286
    Cell Significance Index: 3.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6238
    Cell Significance Index: 14.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5721
    Cell Significance Index: 70.3400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5136
    Cell Significance Index: 4.7300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5133
    Cell Significance Index: 11.8600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4562
    Cell Significance Index: 12.2300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.4556
    Cell Significance Index: 6.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4466
    Cell Significance Index: 11.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3566
    Cell Significance Index: 157.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2883
    Cell Significance Index: 54.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2687
    Cell Significance Index: 30.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2684
    Cell Significance Index: 4.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2682
    Cell Significance Index: 34.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2458
    Cell Significance Index: 88.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2336
    Cell Significance Index: 16.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2085
    Cell Significance Index: 9.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1250
    Cell Significance Index: 1.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1003
    Cell Significance Index: 17.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0935
    Cell Significance Index: 2.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0567
    Cell Significance Index: 2.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0239
    Cell Significance Index: 17.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0073
    Cell Significance Index: 5.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0010
    Cell Significance Index: 0.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0064
    Cell Significance Index: -3.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0094
    Cell Significance Index: -17.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0120
    Cell Significance Index: -18.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0129
    Cell Significance Index: -24.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0131
    Cell Significance Index: -17.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0208
    Cell Significance Index: -15.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0265
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0295
    Cell Significance Index: -6.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0335
    Cell Significance Index: -1.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0414
    Cell Significance Index: -26.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0455
    Cell Significance Index: -13.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0617
    Cell Significance Index: -28.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0769
    Cell Significance Index: -2.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0806
    Cell Significance Index: -9.2300
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.0836
    Cell Significance Index: -0.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1001
    Cell Significance Index: -10.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1010
    Cell Significance Index: -20.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1400
    Cell Significance Index: -1.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1550
    Cell Significance Index: -18.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1712
    Cell Significance Index: -3.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1893
    Cell Significance Index: -14.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1946
    Cell Significance Index: -15.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1985
    Cell Significance Index: -28.8600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2019
    Cell Significance Index: -2.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2134
    Cell Significance Index: -14.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2170
    Cell Significance Index: -2.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2348
    Cell Significance Index: -8.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2389
    Cell Significance Index: -28.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3040
    Cell Significance Index: -18.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3110
    Cell Significance Index: -32.3800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3127
    Cell Significance Index: -2.4100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3128
    Cell Significance Index: -6.8500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.3712
    Cell Significance Index: -3.1900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3764
    Cell Significance Index: -2.5500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3956
    Cell Significance Index: -8.4600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4311
    Cell Significance Index: -6.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4690
    Cell Significance Index: -19.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4854
    Cell Significance Index: -24.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4955
    Cell Significance Index: -15.7800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.4968
    Cell Significance Index: -1.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Actin-binding protein**: PFN2 interacts with actin monomers, regulating their polymerization and depolymerization. 2. **Regulator of actin cytoskeleton organization**: PFN2 influences actin filament assembly, bundling, and disassembly, affecting cell shape, migration, and adhesion. 3. **Negative regulator of actin polymerization**: PFN2 inhibits the formation of actin filaments, modulating cell migration, epithelial cell migration, and ruffle assembly. 4. **Positive regulator of actin filament bundle assembly**: PFN2 promotes the formation of actin filaments, enhancing stress fiber assembly and synaptic transmission. 5. **Regulator of synaptic transmission**: PFN2 modulates synaptic vesicle exocytosis, chemical synaptic transmission, and presynaptic modulation of neurotransmitter release. **Pathways and Functions** 1. **Actin cytoskeleton organization**: PFN2 regulates actin filament assembly, bundling, and disassembly, influencing cell shape, migration, and adhesion. 2. **Rho GTPase signaling**: PFN2 interacts with Rho GTPases, modulating their activity and influencing actin cytoskeleton organization, cell migration, and synaptic plasticity. 3. **Synaptic transmission**: PFN2 regulates synaptic vesicle exocytosis, chemical synaptic transmission, and presynaptic modulation of neurotransmitter release. 4. **Cell migration**: PFN2 modulates cell migration, epithelial cell migration, and ruffle assembly, influencing tissue development and repair. 5. **Immune cell function**: PFN2 is expressed in immune cells, such as neurons, epithelial cells, and immune cells, and regulates their function and migration. **Clinical Significance** 1. **Neurological disorders**: PFN2 dysregulation has been implicated in neurological disorders, including Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: PFN2 is overexpressed in various cancers, including breast cancer, lung cancer, and colon cancer, and may contribute to tumor progression and metastasis. 3. **Immune system dysfunction**: PFN2 dysregulation may contribute to immune system dysfunction, including autoimmune diseases and immunodeficiency disorders. 4. **Neuropsychiatric disorders**: PFN2 has been implicated in neuropsychiatric disorders, including schizophrenia, bipolar disorder, and major depressive disorder. In conclusion, PFN2 is a multifunctional protein that plays a critical role in regulating actin cytoskeleton dynamics, cell migration, and synaptic transmission. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of PFN2 function and its potential therapeutic applications.

Genular Protein ID: 3979617050

Symbol: PROF2_HUMAN

Name: Profilin-2

UniProtKB Accession Codes:

P35080 B2R4C8 D3DNI4 Q4VBQ4 Q8WVF9 Q9HBK2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8365484

Title: Cloning and expression of a novel human profilin variant, profilin II.

PubMed ID: 8365484

DOI: 10.1016/0014-5793(93)80262-s

PubMed ID: 11027290

Title: Profilin II is alternatively spliced, resulting in profilin isoforms that are differentially expressed and have distinct biochemical properties.

PubMed ID: 11027290

DOI: 10.1128/mcb.20.21.8209-8219.2000

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7758455

Title: Distinct biochemical characteristics of the two human profilin isoforms.

PubMed ID: 7758455

DOI: 10.1111/j.1432-1033.1995.tb20506.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 36173861

Title: Actin maturation requires the ACTMAP/C19orf54 protease.

PubMed ID: 36173861

DOI: 10.1126/science.abq5082

PubMed ID: 10600384

Title: X-ray structure determination of human profilin II: a comparative structural analysis of human profilins.

PubMed ID: 10600384

DOI: 10.1006/jmbi.1999.3318

Sequence Information:

  • Length: 140
  • Mass: 15046
  • Checksum: F43884E1427C9A99
  • Sequence:
    • MAGWQSYVDN LMCDGCCQEA AIVGYCDAKY VWAATAGGVF QSITPIEIDM IVGKDREGFF 
TNGLTLGAKK CSVIRDSLYV DGDCTMDIRT KSQGGEPTYN VAVGRAGRVL VFVMGKEGVH 
GGGLNKKAYS MAKYLRDSGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.