Details for: PGD
Gene ID: 5226
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PGD
Ensembl ID: ENSG00000142657
Description: phosphogluconate dehydrogenase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 34.61rCSI 31.77%PRS 71.13
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CSI 32.26rCSI 37.41%PRS 69.76
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CSI 29.92rCSI 51.26%PRS 71.07
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CSI 29.34rCSI 19.5%PRS 65.33
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CSI 27.29rCSI 51.53%PRS 72.68
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CSI 23.45rCSI 34.31%PRS 66.92
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CSI 23.15rCSI 50.55%PRS 75.58
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CSI 23.07rCSI 20.83%PRS 59.06
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CSI 18.59rCSI 15.03%PRS 63.6
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CSI 15.43rCSI 13.7%PRS 60.14
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CSI 15.06rCSI 11.6%PRS 62.68
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CSI 14.03rCSI 16.84%PRS 60.25
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CSI 13.96rCSI 23%PRS 67.4
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CSI 13.82rCSI 21.35%PRS 60.41
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CSI 13.63rCSI 18.62%PRS 63.87
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CSI 12.37rCSI 40.13%PRS 62.46
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CSI 11.74rCSI 10.17%PRS 67.21
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CSI 10.71rCSI 15.71%PRS 73.84
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CSI 10.37rCSI 14.96%PRS 71.75
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CSI 9.99rCSI 25.36%PRS 56.38
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CSI 9.54rCSI 13.21%PRS 63.22
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CSI 9.17rCSI 6.4%PRS 64.96
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CSI 9.1rCSI 19.25%PRS 79.69
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CSI 8.76rCSI 10.91%PRS 73.14
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CSI 8.23rCSI 5.72%PRS 73.42
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CSI 8.21rCSI 13.24%PRS 65.83
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CSI 8.15rCSI 49.34%PRS 80.62
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CSI 8.03rCSI 11.77%PRS 58.18
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CSI 7.76rCSI 6.81%PRS 67.75
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CSI 7.48rCSI 6.2%PRS 61.53
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CSI 7.39rCSI 6.88%PRS 62.74
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CSI 7.26rCSI 7.78%PRS 61.7
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CSI 7.1rCSI 14.74%PRS 59.36
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CSI 6.62rCSI 43.45%PRS 87.74
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CSI 6.42rCSI 14.58%PRS 66.08
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CSI 6.33rCSI 8.09%PRS 82.56
-
CSI 6.25rCSI 6.14%PRS 77.91
-
CSI 6.23rCSI 7.2%PRS 55.3
-
CSI 6.23rCSI 15.8%PRS 51.64
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CSI 5.87rCSI 13.94%PRS 65.89
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CSI 5.45rCSI 31.22%PRS 71.51
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CSI 5.06rCSI 33.21%PRS 86.81
-
CSI 4.97rCSI 4.12%PRS 64.43
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CSI 4.96rCSI 4.77%PRS 62.27
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CSI 4.8rCSI 3.78%PRS 68.94
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CSI 4.77rCSI 4.86%PRS 74.93
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CSI 4.73rCSI 4.37%PRS 63.62
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CSI 4.54rCSI 6.31%PRS 60.7
-
CSI 4.51rCSI 4.72%PRS 60.19
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CSI 4.5rCSI 3.55%PRS 49
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CSI 4.45rCSI 6.8%PRS 71.59
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CSI 4.28rCSI 6.2%PRS 78.19
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CSI 4.17rCSI 6.37%PRS 77.7
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CSI 4.13rCSI 6.62%PRS 82.55
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CSI 4.12rCSI 9.68%PRS 66.82
-
CSI 4.1rCSI 18.21%PRS 61.77
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CSI 4.03rCSI 4.96%PRS 75.58
-
CSI 4.01rCSI 3.37%PRS 79.18
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CSI 3.98rCSI 39.35%PRS 79.04
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CSI 3.96rCSI 5.19%PRS 75.76
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CSI 3.95rCSI 19.49%PRS 73.24
-
CSI 3.92rCSI 21.17%PRS 74.39
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CSI 3.86rCSI 20.62%PRS 90.56
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CSI 3.86rCSI 5.92%PRS 71.31
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CSI 3.76rCSI 3.93%PRS 62.54
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CSI 3.74rCSI 6.06%PRS 58.84
-
CSI 3.69rCSI 5.26%PRS 64.44
-
CSI 3.65rCSI 5.51%PRS 66.49
-
CSI 3.65rCSI 6.43%PRS 59.03
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CSI 3.63rCSI 4.85%PRS 62.5
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CSI 3.59rCSI 5.52%PRS 58
-
CSI 3.59rCSI 9.67%PRS 69.33
-
CSI 3.53rCSI 7.92%PRS 44.59
-
CSI 3.43rCSI 5.87%PRS 84.59
-
CSI 3.42rCSI 4.66%PRS 54
-
CSI 3.37rCSI 9.94%PRS 65.21
-
CSI 3.28rCSI 35.63%PRS 82.12
-
CSI 3.27rCSI 3.98%PRS 69.7
-
CSI 3.26rCSI 4.19%PRS 59.33
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CSI 3.24rCSI 3.12%PRS 52.84
-
CSI 3.18rCSI 6.38%PRS 51.22
-
CSI 3.17rCSI 9.09%PRS 81.94
-
CSI 3.11rCSI 5.49%PRS 42.98
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CSI 3.11rCSI 6.97%PRS 79.4
-
CSI 3.1rCSI 2.36%PRS 75.29
-
CSI 3.03rCSI 15.21%PRS 74.81
-
CSI 2.96rCSI 2.47%PRS 72.62
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CSI 2.96rCSI 2.8%PRS 61.75
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CSI 2.95rCSI 5.33%PRS 75.84
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CSI 2.94rCSI 6.57%PRS 69.98
-
CSI 2.94rCSI 3.12%PRS 72.45
-
CSI 2.88rCSI 5.84%PRS 41.54
-
CSI 2.85rCSI 4.54%PRS 54.67
-
CSI 2.8rCSI 6.4%PRS 62.11
-
CSI 2.79rCSI 7.97%PRS 73.39
-
CSI 2.76rCSI 3.47%PRS 74.06
-
CSI 2.72rCSI 5.99%PRS 66.56
-
CSI 2.65rCSI 5.01%PRS 80.31
-
CSI 2.64rCSI 3.29%PRS 41.98
-
CSI 2.62rCSI 6.26%PRS 70.69
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CSI 0.4rCSI 4.3%PRS 76.9%
-
CSI 0.4rCSI 6.1%PRS 76.6%
-
CSI 0.5rCSI 1.9%PRS 74.7%
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CSI 0.5rCSI 5.2%PRS 74.5%
-
CSI 0.5rCSI 8.8%PRS 89.7%
-
CSI 0.5rCSI 5.9%PRS 82.3%
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CSI 0.5rCSI 7.0%PRS 88.0%
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CSI 0.5rCSI 1.7%PRS 48.1%
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CSI 0.6rCSI 8.4%PRS 79.1%
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CSI 0.6rCSI 2.1%PRS 44.6%
-
CSI 0.6rCSI 2.5%PRS 76.6%
-
CSI 0.6rCSI 3.3%PRS 84.6%
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CSI 0.6rCSI 1.4%PRS 58.6%
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CSI 0.7rCSI 2.2%PRS 67.1%
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CSI 0.7rCSI 1.7%PRS 66.4%
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CSI 0.7rCSI 1.0%PRS 67.4%
-
CSI 0.7rCSI 4.3%PRS 71.1%
-
CSI 0.8rCSI 2.7%PRS 70.8%
-
CSI 0.8rCSI 5.0%PRS 79.5%
-
CSI 0.8rCSI 3.6%PRS 80.7%
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CSI 0.9rCSI 2.2%PRS 42.5%
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CSI 0.9rCSI 1.5%PRS 51.7%
-
CSI 1.0rCSI 3.8%PRS 77.8%
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CSI 1.0rCSI 2.1%PRS 48.4%
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CSI 1.0rCSI 5.9%PRS 80.6%
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CSI 1.0rCSI 3.4%PRS 66.1%
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CSI 1.0rCSI 1.5%PRS 75.4%
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CSI 1.0rCSI 2.0%PRS 59.9%
-
CSI 1.1rCSI 1.8%PRS 45.9%
-
CSI 1.1rCSI 1.4%PRS 71.2%
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CSI 1.2rCSI 4.1%PRS 90.6%
-
CSI 1.2rCSI 1.8%PRS 58.4%
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CSI 1.2rCSI 8.4%PRS 76.5%
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CSI 1.2rCSI 4.3%PRS 74.7%
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CSI 1.3rCSI 2.7%PRS 73.3%
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CSI 1.3rCSI 1.7%PRS 45.2%
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CSI 1.3rCSI 4.6%PRS 42.3%
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CSI 1.3rCSI 4.5%PRS 84.3%
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CSI 1.3rCSI 2.3%PRS 75.6%
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CSI 1.3rCSI 1.7%PRS 63.9%
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CSI 1.4rCSI 4.2%PRS 45.5%
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CSI 1.4rCSI 2.0%PRS 77.9%
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CSI 1.4rCSI 1.6%PRS 80.5%
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CSI 1.4rCSI 4.6%PRS 62.3%
-
CSI 1.4rCSI 2.0%PRS 65.7%
-
CSI 1.4rCSI 2.7%PRS 81.7%
-
CSI 1.5rCSI 3.5%PRS 63.1%
-
CSI 1.5rCSI 11.3%PRS 73.5%
-
CSI 1.5rCSI 2.9%PRS 65.2%
-
CSI 1.5rCSI 5.6%PRS 48.6%
-
CSI 1.5rCSI 4.4%PRS 74.4%
-
CSI 1.6rCSI 3.3%PRS 80.1%
-
CSI 1.6rCSI 1.7%PRS 58.6%
-
CSI 1.6rCSI 12.2%PRS 78.1%
-
CSI 1.6rCSI 49.3%PRS 81.5%
-
CSI 1.7rCSI 1.9%PRS 52.3%
-
CSI 1.7rCSI 2.8%PRS 51.4%
-
CSI 1.7rCSI 7.1%PRS 65.4%
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CSI 1.7rCSI 2.7%PRS 64.5%
-
CSI 1.8rCSI 1.6%PRS 50.1%
-
CSI 1.8rCSI 2.6%PRS 72.8%
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CSI 1.8rCSI 3.6%PRS 79.4%
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CSI 1.8rCSI 9.3%PRS 83.6%
-
CSI 1.8rCSI 2.1%PRS 64.5%
-
CSI 1.8rCSI 2.3%PRS 68.6%
-
CSI 1.8rCSI 2.3%PRS 58.8%
-
CSI 1.8rCSI 11.4%PRS 88.4%
-
CSI 1.8rCSI 1.9%PRS 68.0%
-
CSI 1.9rCSI 2.4%PRS 72.6%
-
CSI 1.9rCSI 2.5%PRS 82.5%
-
CSI 1.9rCSI 1.9%PRS 83.1%
-
CSI 2.0rCSI 3.0%PRS 62.9%
-
CSI 2.0rCSI 2.4%PRS 43.7%
-
CSI 2.0rCSI 2.7%PRS 68.8%
-
CSI 2.0rCSI 2.7%PRS 71.0%
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CSI 2.0rCSI 3.3%PRS 73.3%
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CSI 2.1rCSI 5.1%PRS 60.6%
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CSI 2.1rCSI 1.6%PRS 67.8%
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CSI 2.2rCSI 3.6%PRS 43.9%
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CSI 2.2rCSI 2.2%PRS 55.5%
-
CSI 2.2rCSI 4.0%PRS 61.2%
-
CSI 2.3rCSI 3.0%PRS 67.0%
-
CSI 2.3rCSI 1.8%PRS 64.1%
-
CSI 2.3rCSI 13.0%PRS 68.9%
-
CSI 2.3rCSI 6.6%PRS 73.4%
-
CSI 2.3rCSI 1.6%PRS 75.4%
-
CSI 2.3rCSI 2.8%PRS 49.3%
-
CSI 2.4rCSI 2.0%PRS 67.5%
-
CSI 2.4rCSI 3.0%PRS 54.7%
-
CSI 2.4rCSI 1.8%PRS 78.6%
-
CSI 2.5rCSI 10.9%PRS 74.4%
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CSI 2.6rCSI 15.0%PRS 71.4%
-
CSI 2.6rCSI 6.3%PRS 70.7%
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CSI 2.6rCSI 3.3%PRS 42.0%
-
CSI 2.7rCSI 5.0%PRS 80.3%
-
CSI 2.7rCSI 6.0%PRS 66.6%
-
CSI 2.8rCSI 3.5%PRS 74.1%
-
CSI 2.8rCSI 8.0%PRS 73.4%
-
CSI 2.8rCSI 6.4%PRS 62.1%
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CSI 2.9rCSI 4.5%PRS 54.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 20646162
Symbol: 6PGD_HUMAN
Name: 6-phosphogluconate dehydrogenase, decarboxylating
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8978909
Title: Identification of a cDNA encoding 6-phosphogluconate dehydrogenase from a human heart cDNA library.
PubMed ID: 8978909
DOI: 10.1007/bf00554412
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 483
- Mass: 53140
- Checksum: 6CEFC0077D1283E3
- Sequence:
MAQADIALIG LAVMGQNLIL NMNDHGFVVC AFNRTVSKVD DFLANEAKGT KVVGAQSLKE MVSKLKKPRR IILLVKAGQA VDDFIEKLVP LLDTGDIIID GGNSEYRDTT RRCRDLKAKG ILFVGSGVSG GEEGARYGPS LMPGGNKEAW PHIKTIFQGI AAKVGTGEPC CDWVGDEGAG HFVKMVHNGI EYGDMQLICE AYHLMKDVLG MAQDEMAQAF EDWNKTELDS FLIEITANIL KFQDTDGKHL LPKIRDSAGQ KGTGKWTAIS ALEYGVPVTL IGEAVFARCL SSLKDERIQA SKKLKGPQKF QFDGDKKSFL EDIRKALYAS KIISYAQGFM LLRQAATEFG WTLNYGGIAL MWRGGCIIRS VFLGKIKDAF DRNPELQNLL LDDFFKSAVE NCQDSWRRAV STGVQAGIPM PCFTTALSFY DGYRHEMLPA SLIQAQRDYF GAHTYELLAK PGQFIHTNWT GHGGTVSSSS YNA
Genular Protein ID: 2229603535
Symbol: B4E2U0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 461
- Mass: 50792
- Checksum: 05CBAD6DF9B986F9
- Sequence:
MAQADIALIG LAVMGQNLIL NMNDHGFVVC AFNRTVSKVD DFLANEAKGT KVVGAQSLKE MVSKLKKPRR IILLVKAGQA VDDFIEKLRR CRDLKAKGIL FVGSGVSGGE EGARYGPSLM PGGNKEAWPH IKTIFQGIAA KVGTGEPCCD WVGDEGAGHF VKMVHNGIEY GDMQLICEAY HLMKDVLGMA QDEMAQAFED WNKTELDSFL IEITANILKF QDTNGKHLLP KIRDSAGQKG TGKWTAISAL EYGVPVTLIG EAVFARCLSS LKDERIQASK KLKGPQKFQF DGDKKSFLED IRKALYASKI ISYAQGFMLL RQAATEFGWT LNYGGIALMW RGGCIIRSVF LGKIKDAFDR NPELQNLLLD DFFKSAVENC QDSWRRAVST GVQAGIPMPC FTTALSFYDG YRHEMLPASL IQAQRDYFGA HTYELLAKPG QFIHTNWTGH GGTVSSSSYN A