Details for: SERPINB6

Gene ID: 5269

Symbol: SERPINB6

Ensembl ID: ENSG00000124570

Description: serpin family B member 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 354.6235
    Cell Significance Index: -55.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 148.9887
    Cell Significance Index: -37.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 121.7904
    Cell Significance Index: -57.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 119.4564
    Cell Significance Index: -48.5300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 118.9957
    Cell Significance Index: -49.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 105.0477
    Cell Significance Index: -54.0400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 86.0031
    Cell Significance Index: -57.7100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.0661
    Cell Significance Index: -48.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.8191
    Cell Significance Index: -55.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.7576
    Cell Significance Index: -47.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.1513
    Cell Significance Index: -33.1600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.7031
    Cell Significance Index: -45.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.0964
    Cell Significance Index: -55.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.9304
    Cell Significance Index: 204.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.5025
    Cell Significance Index: 75.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.8151
    Cell Significance Index: 249.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.7629
    Cell Significance Index: 40.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.6619
    Cell Significance Index: 44.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4588
    Cell Significance Index: 42.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3935
    Cell Significance Index: 64.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3234
    Cell Significance Index: 169.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2623
    Cell Significance Index: 34.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2124
    Cell Significance Index: 62.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.1659
    Cell Significance Index: 199.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1456
    Cell Significance Index: 30.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9746
    Cell Significance Index: 106.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9664
    Cell Significance Index: 14.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9662
    Cell Significance Index: 45.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9428
    Cell Significance Index: 514.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7498
    Cell Significance Index: 57.5400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6925
    Cell Significance Index: 12.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6292
    Cell Significance Index: 77.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5936
    Cell Significance Index: 107.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5440
    Cell Significance Index: 6.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5339
    Cell Significance Index: 39.7900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.5182
    Cell Significance Index: 3.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4948
    Cell Significance Index: 48.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4925
    Cell Significance Index: 444.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4850
    Cell Significance Index: 97.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4780
    Cell Significance Index: 12.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4518
    Cell Significance Index: 58.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3618
    Cell Significance Index: 129.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3428
    Cell Significance Index: 65.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3283
    Cell Significance Index: 20.6900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1700
    Cell Significance Index: 3.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1621
    Cell Significance Index: 32.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1502
    Cell Significance Index: 204.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1311
    Cell Significance Index: 201.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1266
    Cell Significance Index: 238.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1170
    Cell Significance Index: 215.7400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0977
    Cell Significance Index: 0.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0840
    Cell Significance Index: 53.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0112
    Cell Significance Index: 0.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0048
    Cell Significance Index: 2.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0013
    Cell Significance Index: -0.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0043
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0118
    Cell Significance Index: -8.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0203
    Cell Significance Index: -14.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0278
    Cell Significance Index: -0.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0335
    Cell Significance Index: -3.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0491
    Cell Significance Index: -30.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0640
    Cell Significance Index: -36.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1148
    Cell Significance Index: -33.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1372
    Cell Significance Index: -28.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1617
    Cell Significance Index: -18.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1685
    Cell Significance Index: -19.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1807
    Cell Significance Index: -26.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1957
    Cell Significance Index: -8.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2353
    Cell Significance Index: -13.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2552
    Cell Significance Index: -6.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2746
    Cell Significance Index: -13.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2861
    Cell Significance Index: -18.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3452
    Cell Significance Index: -23.8700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3545
    Cell Significance Index: -4.5400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3580
    Cell Significance Index: -40.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4174
    Cell Significance Index: -29.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4369
    Cell Significance Index: -6.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4431
    Cell Significance Index: -52.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4457
    Cell Significance Index: -9.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4568
    Cell Significance Index: -28.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4621
    Cell Significance Index: -48.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4683
    Cell Significance Index: -24.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4732
    Cell Significance Index: -13.5700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5100
    Cell Significance Index: -13.0300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5413
    Cell Significance Index: -4.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5430
    Cell Significance Index: -18.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5444
    Cell Significance Index: -43.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7287
    Cell Significance Index: -49.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7951
    Cell Significance Index: -22.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8066
    Cell Significance Index: -49.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8249
    Cell Significance Index: -22.0700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.9498
    Cell Significance Index: -13.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.9525
    Cell Significance Index: -33.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0323
    Cell Significance Index: -45.6600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -1.0479
    Cell Significance Index: -10.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0555
    Cell Significance Index: -31.0900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -1.0939
    Cell Significance Index: -11.3200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.0970
    Cell Significance Index: -26.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.1033
    Cell Significance Index: -28.3600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -1.1043
    Cell Significance Index: -11.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SERPINB6 exhibits several key characteristics that define its function as a protease inhibitor: 1. **Serine protease inhibitor activity**: SERPINB6 belongs to the serpin family, which is known for its ability to inhibit serine proteases, such as trypsin, elastase, and plasmin. 2. **Serine-type endopeptidase inhibitor activity**: This activity is specific to serine proteases, which are involved in various cellular processes, including proteolysis, cell signaling, and immune responses. 3. **Negative regulation of endopeptidase activity**: SERPINB6 inhibits the activity of endopeptidases, which are enzymes that break down proteins into smaller peptides or amino acids. 4. **Protease binding**: SERPINB6 can bind to various proteases, including serine proteases, cysteine proteases, and aspartic proteases, thereby inhibiting their activity. **Pathways and Functions** SERPINB6 is involved in various cellular processes, including: 1. **Cellular response to osmotic stress**: SERPINB6 helps regulate the activity of proteases involved in osmotic stress responses, such as the dissolution of fibrin clots and the regulation of fluid balance. 2. **Hemostasis**: SERPINB6 inhibits the activity of proteases involved in blood coagulation and fibrinolysis, thereby regulating the formation and dissolution of blood clots. 3. **Immune system**: SERPINB6 modulates the activity of proteases involved in immune responses, such as the regulation of neutrophil degranulation and the dissolution of fibrin clots. 4. **Neutrophil degranulation**: SERPINB6 inhibits the activity of proteases involved in neutrophil degranulation, which is a critical process in the innate immune response. 5. **Cytoskeletal regulation**: SERPINB6 regulates the activity of proteases involved in cytoskeletal dynamics, which is essential for cell migration, adhesion, and signaling. **Clinical Significance** Dysregulation of SERPINB6 has been implicated in various diseases, including: 1. **Thrombotic disorders**: SERPINB6 deficiency or dysfunction has been linked to an increased risk of thrombotic events, such as deep vein thrombosis and pulmonary embolism. 2. **Inflammatory disorders**: SERPINB6 dysregulation has been implicated in inflammatory disorders, such as rheumatoid arthritis and atherosclerosis. 3. **Neurological disorders**: SERPINB6 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cancer**: SERPINB6 dysregulation has been implicated in cancer progression and metastasis. In conclusion, SERPINB6 plays a critical role in regulating proteolytic activity, which is essential for maintaining cellular homeostasis and preventing excessive tissue damage. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 3981567235

Symbol: SPB6_HUMAN

Name: Serpin B6

UniProtKB Accession Codes:

P35237 B2RBA8 Q59F97 Q5TD06 Q7Z2Y7 Q96J44 Q9UDI7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 Ensembl 8 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 10 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8415716

Title: Cloning and molecular characterization of a human intracellular serine proteinase inhibitor.

PubMed ID: 8415716

DOI: 10.1073/pnas.90.20.9417

PubMed ID: 8136380

Title: Complementary DNA cloning and kinetic characterization of a novel intracellular serine proteinase inhibitor: mechanism of action with trypsin and factor Xa as model proteinases.

PubMed ID: 8136380

DOI: 10.1021/bi00177a037

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8486644

Title: Identification and purification of a novel serine proteinase inhibitor.

PubMed ID: 8486644

DOI: 10.1016/s0021-9258(18)98385-7

PubMed ID: 10068683

Title: The intracellular serpin proteinase inhibitor 6 is expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilic granule protease, cathepsin G.

PubMed ID: 10068683

PubMed ID: 14670919

Title: Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers.

PubMed ID: 14670919

DOI: 10.1182/blood-2003-08-2981

PubMed ID: 17761692

Title: SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes.

PubMed ID: 17761692

DOI: 10.1093/jb/mvm156

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20451170

Title: A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss.

PubMed ID: 20451170

DOI: 10.1016/j.ajhg.2010.04.004

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 376
  • Mass: 42622
  • Checksum: 3A06BC26A7510E1A
  • Sequence:
    • MDVLAEANGT FALNLLKTLG KDNSKNVFFS PMSMSCALAM VYMGAKGNTA AQMAQILSFN 
KSGGGGDIHQ GFQSLLTEVN KTGTQYLLRM ANRLFGEKSC DFLSSFRDSC QKFYQAEMEE 
LDFISAVEKS RKHINTWVAE KTEGKIAELL SPGSVDPLTR LVLVNAVYFR GNWDEQFDKE 
NTEERLFKVS KNEEKPVQMM FKQSTFKKTY IGEIFTQILV LPYVGKELNM IIMLPDETTD 
LRTVEKELTY EKFVEWTRLD MMDEEEVEVS LPRFKLEESY DMESVLRNLG MTDAFELGKA 
DFSGMSQTDL SLSKVVHKSF VEVNEEGTEA AAATAAIMMM RCARFVPRFC ADHPFLFFIQ 
HSKTNGILFC GRFSSP

Genular Protein ID: 3841443823

Symbol: A0A024QZX5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A024QZX5

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 GO 2 Gene3D 2 GeneTree 1 HGNC 1 InterPro 6 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 RuleBase 1 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 380
  • Mass: 43024
  • Checksum: CC74C679CAA6D4F7
  • Sequence:
    • MSAIMDVLAE ANGTFALNLL KTLGKDNSKN VFFSPMSMSC ALAMVYMGAK GNTAAQMAQI 
LSFNKSGGGG DIHQGFQSLL TEVNKTGTQY LLRMANRLFG EKSCDFLSSF RDSCQKFYQA 
EMEELDFISA VEKSRKHINT WVAEKTEGKI AELLSPGSVD PLTRLVLVNA VYFRGNWDEQ 
FDKENTEERL FKVSKNEEKP VQMMFKQSTF KKTYIGEIFT QILVLPYVGK ELNMIIMLPD 
ETTDLRTVEK ELTYEKFVEW TRLDMMDEEE VEVSLPRFKL EESYDMESVL RNLGMTDAFE 
LGKADFSGMS QTDLSLSKVV HKSFVEVNEE GTEAAAATAA IMMMRCARFV PRFCADHPFL 
FFIQHSKTNG ILFCGRFSSP

Genular Protein ID: 171147446

Symbol: A0A2R8YD12_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2R8YD12

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 2 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 RuleBase 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 332
  • Mass: 38125
  • Checksum: 975F45F8063AA5E9
  • Sequence:
    • MSCPCKQNFL HILSFNKSGG GGDIHQGFQS LLTEVNKTGT QYLLRMANRL FGEKSCDFLS 
SFRDSCQKFY QAEMEELDFI SAVEKSRKHI NTWVAEKTEG KIAELLSPGS VDPLTRLVLV 
NAVYFRGNWD EQFDKENTEE RLFKVSKNEE KPVQMMFKQS TFKKTYIGEI FTQILVLPYV 
GKELNMIIML PDETTDLRTV EKELTYEKFV EWTRLDMMDE EEVEVSLPRF KLEESYDMES 
VLRNLGMTDA FELGKADFSG MSQTDLSLSK VVHKSFVEVN EEGTEAAAAT AAIMMMRCAR 
FVPRFCADHP FLFFIQHSKT NGILFCGRFS SP

Genular Protein ID: 1818578606

Symbol: A0A087X1N8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X1N8

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 2 Gene3D 2 GeneTree 1 HGNC 1 IntAct 1 InterPro 6 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 395
  • Mass: 44822
  • Checksum: 90C02D1F1FEFAA19
  • Sequence:
    • MSSRQRGNFN YKLAFKSAIM DVLAEANGTF ALNLLKTLGK DNSKNVFFSP MSMSCALAMV 
YMGAKGNTAA QMAQILSFNK SGGGGDIHQG FQSLLTEVNK TGTQYLLRMA NRLFGEKSCD 
FLSSFRDSCQ KFYQAEMEEL DFISAVEKSR KHINTWVAEK TEGKIAELLS PGSVDPLTRL 
VLVNAVYFRG NWDEQFDKEN TEERLFKVSK NEEKPVQMMF KQSTFKKTYI GEIFTQILVL 
PYVGKELNMI IMLPDETTDL RTVEKELTYE KFVEWTRLDM MDEEEVEVSL PRFKLEESYD 
MESVLRNLGM TDAFELGKAD FSGMSQTDLS LSKVVHKSFV EVNEEGTEAA AATAAIMMMR 
CARFVPRFCA DHPFLFFIQH SKTNGILFCG RFSSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.