Details for: PIGC

Gene ID: 5279

Symbol: PIGC

Ensembl ID: ENSG00000135845

Description: phosphatidylinositol glycan anchor biosynthesis class C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 154.9389
    Cell Significance Index: -24.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.4811
    Cell Significance Index: -25.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.5672
    Cell Significance Index: -31.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.0635
    Cell Significance Index: -25.6200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.0207
    Cell Significance Index: -29.8500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.9497
    Cell Significance Index: -25.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.0956
    Cell Significance Index: -26.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.0860
    Cell Significance Index: -24.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.0359
    Cell Significance Index: -31.7100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.2734
    Cell Significance Index: -22.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3767
    Cell Significance Index: 160.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0342
    Cell Significance Index: 62.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9899
    Cell Significance Index: 20.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9727
    Cell Significance Index: 105.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8559
    Cell Significance Index: 52.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8097
    Cell Significance Index: 131.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5920
    Cell Significance Index: 81.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5022
    Cell Significance Index: 49.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4887
    Cell Significance Index: 33.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4698
    Cell Significance Index: 29.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4606
    Cell Significance Index: 92.3900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4549
    Cell Significance Index: 10.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4000
    Cell Significance Index: 176.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3895
    Cell Significance Index: 49.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3402
    Cell Significance Index: 235.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3250
    Cell Significance Index: 64.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3018
    Cell Significance Index: 164.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2868
    Cell Significance Index: 48.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2395
    Cell Significance Index: 85.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2255
    Cell Significance Index: 15.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2128
    Cell Significance Index: 9.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2117
    Cell Significance Index: 11.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2046
    Cell Significance Index: 36.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1763
    Cell Significance Index: 9.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1579
    Cell Significance Index: 10.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1577
    Cell Significance Index: 19.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1393
    Cell Significance Index: 4.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1286
    Cell Significance Index: 9.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1249
    Cell Significance Index: 23.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1229
    Cell Significance Index: 14.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0666
    Cell Significance Index: 1.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0656
    Cell Significance Index: 3.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0461
    Cell Significance Index: 0.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0237
    Cell Significance Index: 1.7700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0202
    Cell Significance Index: 0.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0151
    Cell Significance Index: 0.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0143
    Cell Significance Index: 0.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0128
    Cell Significance Index: 0.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0124
    Cell Significance Index: 1.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0121
    Cell Significance Index: 18.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0090
    Cell Significance Index: 16.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0083
    Cell Significance Index: 15.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0051
    Cell Significance Index: 3.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0041
    Cell Significance Index: -3.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0152
    Cell Significance Index: -11.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0173
    Cell Significance Index: -12.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0204
    Cell Significance Index: -12.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0215
    Cell Significance Index: -3.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0240
    Cell Significance Index: -0.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0240
    Cell Significance Index: -1.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0243
    Cell Significance Index: -2.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0261
    Cell Significance Index: -14.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0361
    Cell Significance Index: -16.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0538
    Cell Significance Index: -2.3800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0665
    Cell Significance Index: -1.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0696
    Cell Significance Index: -20.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0736
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0740
    Cell Significance Index: -15.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0775
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0898
    Cell Significance Index: -10.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0900
    Cell Significance Index: -2.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1283
    Cell Significance Index: -4.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1333
    Cell Significance Index: -4.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1455
    Cell Significance Index: -5.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1776
    Cell Significance Index: -11.9500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1842
    Cell Significance Index: -5.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1882
    Cell Significance Index: -5.2600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1937
    Cell Significance Index: -3.7800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2137
    Cell Significance Index: -2.6500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2243
    Cell Significance Index: -25.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2396
    Cell Significance Index: -12.4800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2819
    Cell Significance Index: -3.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2919
    Cell Significance Index: -30.3900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3077
    Cell Significance Index: -4.6100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3277
    Cell Significance Index: -7.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3356
    Cell Significance Index: -26.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3904
    Cell Significance Index: -10.4600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4424
    Cell Significance Index: -4.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4779
    Cell Significance Index: -6.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4903
    Cell Significance Index: -14.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5243
    Cell Significance Index: -32.1500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5514
    Cell Significance Index: -8.1400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5786
    Cell Significance Index: -4.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5840
    Cell Significance Index: -8.8000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5893
    Cell Significance Index: -10.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6576
    Cell Significance Index: -18.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6758
    Cell Significance Index: -17.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6823
    Cell Significance Index: -14.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme function:** PIGC is a glycosylphosphatidylinositol-n-acetylglucosaminyltransferase (GPI-GNT) enzyme that catalyzes the addition of a GPI anchor to proteins. 2. **Cellular localization:** PIGC is primarily found in the endoplasmic reticulum (ER) membrane, where it regulates the GPI anchor biosynthetic process. 3. **Expression pattern:** PIGC is widely expressed in various cell types, including pulmonary interstitial fibroblasts, germ cells, mural cells, and blood cells. 4. **Protein interaction:** PIGC interacts with other proteins involved in the GPI anchor biosynthetic pathway, including GPI-GNT and GPI-anchored proteins. **Pathways and Functions:** 1. **GPI anchor biosynthetic process:** PIGC is a key component of the GPI anchor biosynthetic pathway, which involves the sequential addition of glycosylphosphatidylinositol (GPI) and n-acetylglucosamine (GlcNAc) moieties to proteins. 2. **Glycosylphosphatidylinositol-n-acetylglucosaminyltransferase (GPI-GNT) complex:** PIGC is a component of the GPI-GNT complex, which regulates the addition of GlcNAc moieties to GPI anchors. 3. **Protein binding:** PIGC interacts with other proteins involved in the GPI anchor biosynthetic pathway, including GPI-GNT and GPI-anchored proteins. 4. **Metabolism of proteins:** PIGC plays a crucial role in the metabolism of proteins, enabling their attachment to the cell membrane and regulating their cellular localization and function. **Clinical Significance:** 1. **Immunological disorders:** Abnormalities in the GPI anchor biosynthetic pathway, including PIGC, have been implicated in various immunological disorders, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). 2. **Neurological disorders:** PIGC has been linked to neurological disorders, including multiple sclerosis and Guillain-Barré syndrome. 3. **Cancer:** Aberrant expression of PIGC has been observed in various types of cancer, including lung, breast, and colon cancer. 4. **Infectious diseases:** PIGC has been implicated in the pathogenesis of infectious diseases, such as tuberculosis and malaria. In conclusion, PIGC is a critical enzyme involved in the GPI anchor biosynthetic pathway, regulating the attachment of GPI-anchored proteins to the cell membrane. Abnormalities in PIGC have been implicated in various diseases and disorders, highlighting its importance in immunological, neurological, and oncological processes. Further research is needed to elucidate the exact mechanisms of PIGC in disease pathogenesis and to develop novel therapeutic strategies targeting this enzyme.

Genular Protein ID: 4085879646

Symbol: PIGC_HUMAN

Name: Phosphatidylinositol-glycan biosynthesis class C protein

UniProtKB Accession Codes:

Q92535 O14491

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 GO 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8806613

Title: PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2.

PubMed ID: 8806613

DOI: 10.1006/bbrc.1996.1332

PubMed ID: 9325057

Title: Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1.

PubMed ID: 9325057

DOI: 10.1006/geno.1997.4893

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9463366

Title: The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1.

PubMed ID: 9463366

DOI: 10.1093/emboj/17.4.877

PubMed ID: 16162815

Title: The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component.

PubMed ID: 16162815

DOI: 10.1091/mbc.e05-08-0743

PubMed ID: 27694521

Title: Mutations in the phosphatidylinositol glycan C (PIGC) gene are associated with epilepsy and intellectual disability.

PubMed ID: 27694521

DOI: 10.1136/jmedgenet-2016-104202

Sequence Information:

  • Length: 297
  • Mass: 33583
  • Checksum: BD9584C5D5203A4B
  • Sequence:
    • MYAQPVTNTK EVKWQKVLYE RQPFPDNYVD RRFLEELRKN IHARKYQYWA VVFESSVVIQ 
QLCSVCVFVV IWWYMDEGLL APHWLLGTGL ASSLIGYVLF DLIDGGEGRK KSGQTRWADL 
KSALVFITFT YGFSPVLKTL TESVSTDTIY AMSVFMLLGH LIFFDYGANA AIVSSTLSLN 
MAIFASVCLA SRLPRSLHAF IMVTFAIQIF ALWPMLQKKL KACTPRSYVG VTLLFAFSAV 
GGLLSISAVG AVLFALLLMS ISCLCPFYLI RLQLFKENIH GPWDEAEIKE DLSRFLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.