Details for: PIK3C2A

Gene ID: 5286

Symbol: PIK3C2A

Ensembl ID: ENSG00000011405

Description: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 405.6698
    Cell Significance Index: -63.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 246.2315
    Cell Significance Index: -62.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 138.5021
    Cell Significance Index: -65.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 130.9516
    Cell Significance Index: -53.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 118.0244
    Cell Significance Index: -60.7100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.6904
    Cell Significance Index: -53.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 51.8672
    Cell Significance Index: -63.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.2114
    Cell Significance Index: -62.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.6833
    Cell Significance Index: -40.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.1771
    Cell Significance Index: -55.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.2935
    Cell Significance Index: -64.3000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 4.4304
    Cell Significance Index: 63.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.1616
    Cell Significance Index: 84.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4126
    Cell Significance Index: 478.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8477
    Cell Significance Index: 1668.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.7995
    Cell Significance Index: 100.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6590
    Cell Significance Index: 332.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4963
    Cell Significance Index: 536.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.4109
    Cell Significance Index: 73.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.1564
    Cell Significance Index: 22.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0981
    Cell Significance Index: 178.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0871
    Cell Significance Index: 118.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0447
    Cell Significance Index: 80.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7532
    Cell Significance Index: 520.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7362
    Cell Significance Index: 132.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7270
    Cell Significance Index: 89.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7030
    Cell Significance Index: 20.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6353
    Cell Significance Index: 346.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5984
    Cell Significance Index: 26.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5498
    Cell Significance Index: 20.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5105
    Cell Significance Index: 23.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5076
    Cell Significance Index: 31.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4791
    Cell Significance Index: 902.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4478
    Cell Significance Index: 11.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3994
    Cell Significance Index: 176.5700
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.3959
    Cell Significance Index: 4.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3411
    Cell Significance Index: 33.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3183
    Cell Significance Index: 43.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3078
    Cell Significance Index: 473.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2941
    Cell Significance Index: 186.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2635
    Cell Significance Index: 485.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2399
    Cell Significance Index: 5.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2185
    Cell Significance Index: 41.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1951
    Cell Significance Index: 88.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1617
    Cell Significance Index: 4.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1413
    Cell Significance Index: 192.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1403
    Cell Significance Index: 6.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1255
    Cell Significance Index: 2.1500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0579
    Cell Significance Index: 0.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0371
    Cell Significance Index: 6.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0043
    Cell Significance Index: -3.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0203
    Cell Significance Index: -15.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0427
    Cell Significance Index: -26.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0492
    Cell Significance Index: -27.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0631
    Cell Significance Index: -47.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1060
    Cell Significance Index: -13.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1337
    Cell Significance Index: -13.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1473
    Cell Significance Index: -10.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1474
    Cell Significance Index: -5.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1645
    Cell Significance Index: -34.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1681
    Cell Significance Index: -8.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1718
    Cell Significance Index: -24.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1782
    Cell Significance Index: -4.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1880
    Cell Significance Index: -54.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2344
    Cell Significance Index: -15.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2486
    Cell Significance Index: -11.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2560
    Cell Significance Index: -29.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2971
    Cell Significance Index: -38.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3048
    Cell Significance Index: -35.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3130
    Cell Significance Index: -32.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3420
    Cell Significance Index: -39.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3774
    Cell Significance Index: -9.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3934
    Cell Significance Index: -29.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3989
    Cell Significance Index: -46.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4896
    Cell Significance Index: -30.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4976
    Cell Significance Index: -32.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5041
    Cell Significance Index: -12.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5101
    Cell Significance Index: -13.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5220
    Cell Significance Index: -12.0600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5221
    Cell Significance Index: -11.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5875
    Cell Significance Index: -5.4100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5942
    Cell Significance Index: -10.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6116
    Cell Significance Index: -48.4400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6435
    Cell Significance Index: -9.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6588
    Cell Significance Index: -14.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7156
    Cell Significance Index: -37.5700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7410
    Cell Significance Index: -9.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8426
    Cell Significance Index: -18.4500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.9081
    Cell Significance Index: -13.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9180
    Cell Significance Index: -56.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9269
    Cell Significance Index: -26.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9470
    Cell Significance Index: -20.1000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.9953
    Cell Significance Index: -14.6900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.0213
    Cell Significance Index: -12.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0400
    Cell Significance Index: -14.1900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0485
    Cell Significance Index: -29.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.1013
    Cell Significance Index: -38.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.1604
    Cell Significance Index: -58.6400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1828
    Cell Significance Index: -14.1000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.2410
    Cell Significance Index: -18.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Catalytic Subunit of PI3K:** PIK3C2A is a catalytic subunit of PI3K, which is a family of enzymes involved in the regulation of cellular signaling pathways. 2. **Phosphatidylinositol 3-Kinase Activity:** PIK3C2A possesses phosphatidylinositol 3-kinase activity, which is essential for the phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) to produce phosphatidylinositol 3-phosphate (PIP3). 3. **Cellular Localization:** PIK3C2A is primarily localized to the plasma membrane and cytosol, where it interacts with other proteins to regulate cellular signaling and metabolism. 4. **Expression Pattern:** PIK3C2A is significantly expressed in endothelial cells, astrocytes, and other cell types involved in tissue development and maintenance. **Pathways and Functions:** 1. **PI3K Signaling Pathway:** PIK3C2A is a critical component of the PI3K signaling pathway, which regulates cell survival, proliferation, and migration. 2. **Cell Migration and Proliferation:** PIK3C2A plays a key role in regulating cell migration and proliferation, particularly in endothelial cells and other cell types involved in tissue development. 3. **Autophagy and Metabolism:** PIK3C2A is involved in the regulation of autophagy and metabolism, particularly in the context of energy homeostasis and lipid biosynthesis. 4. **Extracellular Matrix Remodeling:** PIK3C2A is involved in the regulation of extracellular matrix remodeling, particularly in the context of wound healing and tissue development. **Clinical Significance:** 1. **Cancer:** Abnormal expression or activity of PIK3C2A has been implicated in various types of cancer, including breast, lung, and colon cancer. 2. **Cardiovascular Disorders:** PIK3C2A has been implicated in the regulation of cardiovascular function and the development of cardiovascular disorders, such as atherosclerosis and hypertension. 3. **Neurodegenerative Conditions:** PIK3C2A has been implicated in the regulation of neurodegenerative conditions, such as Alzheimer's disease and Parkinson's disease. 4. **Wound Healing:** PIK3C2A plays a critical role in wound healing and tissue development, particularly in the context of skin and cardiovascular biology. In conclusion, PIK3C2A is a critical regulator of cellular signaling and metabolism, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the functional significance of PIK3C2A and its role in human disease.

Genular Protein ID: 3775694936

Symbol: P3C2A_HUMAN

Name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

UniProtKB Accession Codes:

O00443 B0LPH2 B4E2G4 Q14CQ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 5 CORUM 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EC 3 ELM 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRO 1 PROSITE 8 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 6 RefSeq 3 Rhea 6 SABIO-RK 1 SASBDB 1 SIGNOR 1 SMART 6 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9337861

Title: Cloning of a human phosphoinositide 3-kinase with a C2 domain which displays reduced sensitivity to the inhibitor wortmannin.

PubMed ID: 9337861

DOI: 10.1042/bj3260139

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10766823

Title: The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles.

PubMed ID: 10766823

DOI: 10.1074/jbc.275.16.11943

PubMed ID: 10805725

Title: Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.

PubMed ID: 10805725

DOI: 10.1128/mcb.20.11.3817-3830.2000

PubMed ID: 11606566

Title: Phosphatidylinositol 3-kinase c2alpha contains a nuclear localization sequence and associates with nuclear speckles.

PubMed ID: 11606566

DOI: 10.1074/jbc.m104610200

PubMed ID: 11239472

Title: The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking.

PubMed ID: 11239472

DOI: 10.1016/s1097-2765(01)00191-5

PubMed ID: 14563213

Title: Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation.

PubMed ID: 14563213

DOI: 10.1186/1472-6890-3-4

PubMed ID: 12719431

Title: Mitotic and stress-induced phosphorylation of HsPI3K-C2alpha targets the protein for degradation.

PubMed ID: 12719431

DOI: 10.1074/jbc.m301657200

PubMed ID: 16215232

Title: Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function.

PubMed ID: 16215232

DOI: 10.1074/jbc.m507731200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21081650

Title: PI3KC2alpha, a class II PI3K, is required for dynamin-independent internalization pathways.

PubMed ID: 21081650

DOI: 10.1242/jcs.071712

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21127054

Title: Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells.

PubMed ID: 21127054

DOI: 10.1074/jbc.m110.200295

PubMed ID: 17371240

Title: Role of class II phosphoinositide 3-kinase in cell signalling.

PubMed ID: 17371240

DOI: 10.1042/bst0350211

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31034465

Title: Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction.

PubMed ID: 31034465

DOI: 10.1371/journal.pgen.1008088

PubMed ID: 17038310

Title: Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha.

PubMed ID: 17038310

DOI: 10.1074/jbc.m607079200

Sequence Information:

  • Length: 1686
  • Mass: 190680
  • Checksum: 904AA5470F80DAC6
  • Sequence:
    • MAQISSNSGF KECPSSHPEP TRAKDVDKEE ALQMEAEALA KLQKDRQVTD NQRGFELSSS 
TRKKAQVYNK QDYDLMVFPE SDSQKRALDI DVEKLTQAEL EKLLLDDSFE TKKTPVLPVT 
PILSPSFSAQ LYFRPTIQRG QWPPGLPGPS TYALPSIYPS TYSKQAAFQN GFNPRMPTFP 
STEPIYLSLP GQSPYFSYPL TPATPFHPQG SLPIYRPVVS TDMAKLFDKI ASTSEFLKNG 
KARTDLEITD SKVSNLQVSP KSEDISKFDW LDLDPLSKPK VDNVEVLDHE EEKNVSSLLA 
KDPWDAVLLE ERSTANCHLE RKVNGKSLSV ATVTRSQSLN IRTTQLAKAQ GHISQKDPNG 
TSSLPTGSSL LQEVEVQNEE MAAFCRSITK LKTKFPYTNH RTNPGYLLSP VTAQRNICGE 
NASVKVSIDI EGFQLPVTFT CDVSSTVEII IMQALCWVHD DLNQVDVGSY VLKVCGQEEV 
LQNNHCLGSH EHIQNCRKWD TEIRLQLLTF SAMCQNLART AEDDETPVDL NKHLYQIEKP 
CKEAMTRHPV EELLDSYHNQ VELALQIENQ HRAVDQVIKA VRKICSALDG VETLAITESV 
KKLKRAVNLP RSKTADVTSL FGGEDTSRSS TRGSLNPENP VQVSINQLTA AIYDLLRLHA 
NSGRSPTDCA QSSKSVKEAW TTTEQLQFTI FAAHGISSNW VSNYEKYYLI CSLSHNGKDL 
FKPIQSKKVG TYKNFFYLIK WDELIIFPIQ ISQLPLESVL HLTLFGILNQ SSGSSPDSNK 
QRKGPEALGK VSLPLFDFKR FLTCGTKLLY LWTSSHTNSV PGTVTKKGYV MERIVLQVDF 
PSPAFDIIYT TPQVDRSIIQ QHNLETLEND IKGKLLDILH KDSSLGLSKE DKAFLWEKRY 
YCFKHPNCLP KILASAPNWK WVNLAKTYSL LHQWPALYPL IALELLDSKF ADQEVRSLAV 
TWIEAISDDE LTDLLPQFVQ ALKYEIYLNS SLVQFLLSRA LGNIQIAHNL YWLLKDALHD 
VQFSTRYEHV LGALLSVGGK RLREELLKQT KLVQLLGGVA EKVRQASGSA RQVVLQRSME 
RVQSFFQKNK CRLPLKPSLV AKELNIKSCS FFSSNAVPLK VTMVNADPMG EEINVMFKVG 
EDLRQDMLAL QMIKIMDKIW LKEGLDLRMV IFKCLSTGRD RGMVELVPAS DTLRKIQVEY 
GVTGSFKDKP LAEWLRKYNP SEEEYEKASE NFIYSCAGCC VATYVLGICD RHNDNIMLRS 
TGHMFHIDFG KFLGHAQMFG SFKRDRAPFV LTSDMAYVIN GGEKPTIRFQ LFVDLCCQAY 
NLIRKQTNLF LNLLSLMIPS GLPELTSIQD LKYVRDALQP QTTDAEATIF FTRLIESSLG 
SIATKFNFFI HNLAQLRFSG LPSNDEPILS FSPKTYSFRQ DGRIKEVSVF TYHKKYNPDK 
HYIYVVRILR EGQIEPSFVF RTFDEFQELH NKLSIIFPLW KLPGFPNRMV LGRTHIKDVA 
AKRKIELNSY LQSLMNASTD VAECDLVCTF FHPLLRDEKA EGIARSADAG SFSPTPGQIG 
GAVKLSISYR NGTLFIMVMH IKDLVTEDGA DPNPYVKTYL LPDNHKTSKR KTKISRKTRN 
PTFNEMLVYS GYSKETLRQR ELQLSVLSAE SLRENFFLGG VTLPLKDFNL SKETVKWYQL 
TAATYL

Genular Protein ID: 2457523059

Symbol: B4DG55_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DG55

Database IDs:

ARBA 6 BioGRID-ORCS 1 CDD 5 CTD 1 ChEBI 10 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 4 Gene3D 4 InterPro 17 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 14 PeptideAtlas 1 Pfam 6 RefSeq 1 Rhea 4 SAM 1 SMART 6 SUPFAM 5

Sequence Information:

  • Length: 1306
  • Mass: 148375
  • Checksum: C52FECFB0957796C
  • Sequence:
    • MAAFCRSITK LKTKFPYTNH RTNPGYLLSP VTAQRNICGE NASVKVSIDI EGFQLPVTFT 
CDVSSTVEII IMQALCWVHD DLNQVDVGSY VLKVCGQEEV LQNNHCLGSH EHIQNCRKWD 
TEIRLQLLTF SAMCQNLART AEDDETPVDL NKHLYQIEKP CKEAMTRHPV EELLDSYHNQ 
VELALQIENQ HRAVDQVIKA VRKICSALDG VETLAITESV KKLKRAVNLP RSKTADVTSL 
FGGEDTSRSS TRGSLNPENP VQVSINQLTA AIYDLLRLHA NSGRSPTDCA QSSKSVKEAW 
TTTEQLQFTI FAAHGISSNW VSNYEKYYLI CSLSHNGKDL FKPIQSKKVG TYKNFFYLIK 
WDELIIFPIQ ISQLPLESVL HLTLFGILNQ SSGSSPDSNK QRKGPEALGK VSLPLFDFKR 
FLTCGTKLLY LWTSSHTNSV PGTVTKKGYV MERIVLQVDF PSPAFDIIYT TPQVDRSIIQ 
QHNLETLEND IKGKLLDILH KDSSLGLSKE DKAFLWEKRY YCFKHPNCLP KILASAPNWK 
WVNLAKTYSL LHQWPALYPL IALELLDSKF ADQEVRSLAV TWIEAISDDE LTDLLPQFVQ 
ALKYEIYLNS SLVQFLLSRA LGNIQIAHNL YWLLKDALHD VQFSTRYEHV LGALLSVGGK 
RLREELLKQT KLVQLLGGVA EKVRQASGSA RQVVLQRSME RVQSFFQKNK CRLPLKPSLV 
AKELNIKSCS FFSSNAVPLK VTMVNADPMG EEINVMFKVG EDLRQDMLAL QMIKIMDKIW 
LKEGLDLRMV IFKCLSTGRD RGMVELVPAS DTLRKIQVEY GVTGSFKDKP LAEWLRKYNP 
SEEEYEKASE NFIYSCAGCC VATYVLGICD RHNDNIMLRS TGHMFHIDFG KFLGHAQMFG 
SFKRDRAPFV LTSDMAYVIN GGEKPTIRFQ LFVDLCCQAY NLIRKQTNLF LNLLSLMIPS 
GLPELTSIQD LKYVRDALQP QTTDAEATIF FTRLIESSLG SIATKFNFFI HNLAQLRFSG 
LPSNDEPILS FSPKTYSFRQ DGRIKEVSVF TYHKKYNPDK HYIYVVRILR EGQIEPSFVF 
RTFDEFQELH NKLSIIFPLW KLPGFPNRMV LGRTHIKDVA AKRKIELNSY LQSLMNASTD 
VAECDLVCTF FHPLLRDEKA EGIARSADAG SFSPTPGQIG GAVKLSISYR NGTLFIMVMH 
IKDLVTEDGA DPNPYVKTYL PPDNHKTSKR KTKISRKTRN PTFNEMLVYS GYSKETLRQR 
ELQLSVLSAE SLRENFFLGG VTLPLKDFNL SKETVKWYQL TAATYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.