Details for: PLCB3

Gene ID: 5331

Symbol: PLCB3

Ensembl ID: ENSG00000149782

Description: phospholipase C beta 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 83.8341
    Cell Significance Index: -13.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.4753
    Cell Significance Index: -13.3100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 27.8106
    Cell Significance Index: -13.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.2888
    Cell Significance Index: -10.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.9412
    Cell Significance Index: -13.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.0619
    Cell Significance Index: -13.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.6789
    Cell Significance Index: 106.0000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.4541
    Cell Significance Index: -13.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.1136
    Cell Significance Index: 126.8900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9510
    Cell Significance Index: -4.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.9301
    Cell Significance Index: 1742.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8039
    Cell Significance Index: 39.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7733
    Cell Significance Index: 192.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1918
    Cell Significance Index: 16.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.1478
    Cell Significance Index: 18.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9689
    Cell Significance Index: 112.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8574
    Cell Significance Index: 18.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7845
    Cell Significance Index: 35.5600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.6920
    Cell Significance Index: 1.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5423
    Cell Significance Index: 28.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4748
    Cell Significance Index: 13.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4220
    Cell Significance Index: 10.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3358
    Cell Significance Index: 54.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2289
    Cell Significance Index: 22.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2239
    Cell Significance Index: 7.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2208
    Cell Significance Index: 7.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2129
    Cell Significance Index: 3.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2048
    Cell Significance Index: 36.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1909
    Cell Significance Index: 23.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1601
    Cell Significance Index: 21.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1523
    Cell Significance Index: 1.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1436
    Cell Significance Index: 3.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1171
    Cell Significance Index: 22.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1168
    Cell Significance Index: 3.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1084
    Cell Significance Index: 2.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1021
    Cell Significance Index: 4.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0846
    Cell Significance Index: 46.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0606
    Cell Significance Index: 26.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0398
    Cell Significance Index: 5.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0382
    Cell Significance Index: 7.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0226
    Cell Significance Index: 8.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0094
    Cell Significance Index: 0.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0008
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0079
    Cell Significance Index: -14.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0092
    Cell Significance Index: -14.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0096
    Cell Significance Index: -7.2500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0109
    Cell Significance Index: -0.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0125
    Cell Significance Index: -7.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0129
    Cell Significance Index: -9.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0136
    Cell Significance Index: -18.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0219
    Cell Significance Index: -9.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0219
    Cell Significance Index: -16.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0220
    Cell Significance Index: -4.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0226
    Cell Significance Index: -14.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0266
    Cell Significance Index: -1.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0277
    Cell Significance Index: -15.6300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0280
    Cell Significance Index: -0.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0311
    Cell Significance Index: -3.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0321
    Cell Significance Index: -9.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0330
    Cell Significance Index: -1.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0365
    Cell Significance Index: -6.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0408
    Cell Significance Index: -1.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0414
    Cell Significance Index: -5.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0522
    Cell Significance Index: -7.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0533
    Cell Significance Index: -3.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0668
    Cell Significance Index: -7.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0750
    Cell Significance Index: -8.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0809
    Cell Significance Index: -17.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0992
    Cell Significance Index: -1.6600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1083
    Cell Significance Index: -1.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1150
    Cell Significance Index: -7.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1170
    Cell Significance Index: -2.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1242
    Cell Significance Index: -8.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1252
    Cell Significance Index: -13.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1297
    Cell Significance Index: -7.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1414
    Cell Significance Index: -10.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1446
    Cell Significance Index: -11.4500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1594
    Cell Significance Index: -1.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1695
    Cell Significance Index: -6.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1735
    Cell Significance Index: -6.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1737
    Cell Significance Index: -11.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1972
    Cell Significance Index: -5.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2084
    Cell Significance Index: -12.8100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2238
    Cell Significance Index: -3.1800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2240
    Cell Significance Index: -2.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2315
    Cell Significance Index: -12.9900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2790
    Cell Significance Index: -4.0000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2807
    Cell Significance Index: -4.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2826
    Cell Significance Index: -7.5600
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.2913
    Cell Significance Index: -1.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2920
    Cell Significance Index: -8.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2938
    Cell Significance Index: -5.4300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3029
    Cell Significance Index: -6.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3032
    Cell Significance Index: -10.6200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3071
    Cell Significance Index: -13.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3083
    Cell Significance Index: -9.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3086
    Cell Significance Index: -11.3300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3118
    Cell Significance Index: -3.3900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3315
    Cell Significance Index: -6.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLCB3 is a calcium-dependent phospholipase C enzyme that exhibits distinct characteristics, including: 1. **Specificity**: PLCB3 is highly specific for PIP2, hydrolyzing it into IP3 and DAG. 2. **Regulation**: PLCB3 activity is regulated by calcium ions, which bind to the enzyme and facilitate its activity. 3. **Cellular localization**: PLCB3 is found in various cellular compartments, including the cytosol, Golgi apparatus, and plasma membrane. 4. **Expression**: PLCB3 is expressed in multiple cell types, including enterocytes, immune cells, and neuronal cells. **Pathways and Functions:** PLCB3 plays a pivotal role in several signaling pathways, including: 1. **Calcium signaling**: PLCB3 hydrolyzes PIP2 to produce IP3 and DAG, which activate calcium-dependent kinases and regulate calcium homeostasis. 2. **G-protein coupled receptor (GPCR) signaling**: PLCB3 mediates GPCR downstream signaling, influencing various cellular processes, such as insulin secretion and blood pressure regulation. 3. **Wnt signaling**: PLCB3 is involved in Wnt-independent signaling, modulating cellular proliferation and differentiation. 4. **Neurotransmission**: PLCB3 is expressed in neuronal cells and plays a role in neurotransmitter release and postsynaptic signaling. **Clinical Significance:** PLCB3 has significant clinical implications, including: 1. **Insulin secretion**: PLCB3 regulates insulin secretion in response to glucose and fatty acid binding to GPR40 (FFAR1). 2. **Blood pressure regulation**: PLCB3 influences systemic arterial blood pressure through its involvement in calcium signaling and GPCR-mediated events. 3. **Immune regulation**: PLCB3 modulates immune responses, including the activation of innate lymphoid cells and the regulation of systemic inflammation. 4. **Neurological disorders**: PLCB3 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, where it may play a role in neurotransmitter release and synaptic plasticity. In conclusion, PLCB3 is a multifaceted enzyme that plays a critical role in various cellular processes, including immune response, metabolic regulation, and neurotransmission. Its specific characteristics, pathways, and functions highlight its importance in maintaining cellular homeostasis and overall health. Further research is necessary to fully elucidate the clinical significance of PLCB3 and its potential as a therapeutic target for various diseases.

Genular Protein ID: 3117301410

Symbol: PLCB3_HUMAN

Name: Phosphoinositide phospholipase C-beta-3

UniProtKB Accession Codes:

Q01970 A5PKZ6 G5E960 Q8N1A4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CORUM 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 1 EMBL 37 EMDB 5 Ensembl 3 EvolutionaryTrace 1 GO 20 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 3 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 3 Rhea 4 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7612006

Title: Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene.

PubMed ID: 7612006

DOI: 10.1006/bbrc.1995.1955

PubMed ID: 7607669

Title: Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3).

PubMed ID: 7607669

DOI: 10.1016/0888-7543(95)80164-h

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1333955

Title: Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily.

PubMed ID: 1333955

DOI: 10.1111/j.1432-1033.1992.tb17450.x

PubMed ID: 9188725

Title: Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs.

PubMed ID: 9188725

DOI: 10.1021/bi9702288

PubMed ID: 15143197

Title: NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation.

PubMed ID: 15143197

DOI: 10.1128/mcb.24.11.5069-5079.2004

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29122926

Title: Defect in phosphoinositide signalling through a homozygous variant in PLCB3 causes a new form of spondylometaphyseal dysplasia with corneal dystrophy.

PubMed ID: 29122926

DOI: 10.1136/jmedgenet-2017-104827

PubMed ID: 20966218

Title: Kinetic scaffolding mediated by a phospholipase C-beta and Gq signaling complex.

PubMed ID: 20966218

DOI: 10.1126/science.1193438

PubMed ID: 37991948

Title: The mechanism of Galphaq regulation of PLCbeta3-catalyzed PIP2 hydrolysis.

PubMed ID: 37991948

DOI: 10.1073/pnas.2315011120

Sequence Information:

  • Length: 1234
  • Mass: 138799
  • Checksum: C5106EFBA8037788
  • Sequence:
    • MAGAQPGVHA LQLEPPTVVE TLRRGSKFIK WDEETSSRNL VTLRVDPNGF FLYWTGPNME 
VDTLDISSIR DTRTGRYARL PKDPKIREVL GFGGPDARLE EKLMTVVSGP DPVNTVFLNF 
MAVQDDTAKV WSEELFKLAM NILAQNASRN TFLRKAYTKL KLQVNQDGRI PVKNILKMFS 
ADKKRVETAL ESCGLKFNRS ESIRPDEFSL EIFERFLNKL CLRPDIDKIL LEIGAKGKPY 
LTLEQLMDFI NQKQRDPRLN EVLYPPLRPS QARLLIEKYE PNQQFLERDQ MSMEGFSRYL 
GGEENGILPL EALDLSTDMT QPLSAYFINS SHNTYLTAGQ LAGTSSVEMY RQALLWGCRC 
VELDVWKGRP PEEEPFITHG FTMTTEVPLR DVLEAIAETA FKTSPYPVIL SFENHVDSAK 
QQAKMAEYCR SIFGDALLIE PLDKYPLAPG VPLPSPQDLM GRILVKNKKR HRPSAGGPDS 
AGRKRPLEQS NSALSESSAA TEPSSPQLGS PSSDSCPGLS NGEEVGLEKP SLEPQKSLGD 
EGLNRGPYVL GPADREDEEE DEEEEEQTDP KKPTTDEGTA SSEVNATEEM STLVNYIEPV 
KFKSFEAARK RNKCFEMSSF VETKAMEQLT KSPMEFVEYN KQQLSRIYPK GTRVDSSNYM 
PQLFWNVGCQ LVALNFQTLD VAMQLNAGVF EYNGRSGYLL KPEFMRRPDK SFDPFTEVIV 
DGIVANALRV KVISGQFLSD RKVGIYVEVD MFGLPVDTRR KYRTRTSQGN SFNPVWDEEP 
FDFPKVVLPT LASLRIAAFE EGGKFVGHRI LPVSAIRSGY HYVCLRNEAN QPLCLPALLI 
YTEASDYIPD DHQDYAEALI NPIKHVSLMD QRARQLAALI GESEAQAGQE TCQDTQSQQL 
GSQPSSNPTP SPLDASPRRP PGPTTSPAST SLSSPGQRDD LIASILSEVA PTPLDELRGH 
KALVKLRSRQ ERDLRELRKK HQRKAVTLTR RLLDGLAQAQ AEGRCRLRPG ALGGAADVED 
TKEGEDEAKR YQEFQNRQVQ SLLELREAQV DAEAQRRLEH LRQALQRLRE VVLDANTTQF 
KRLKEMNERE KKELQKILDR KRHNSISEAK MRDKHKKEAE LTEINRRHIT ESVNSIRRLE 
EAQKQRHDRL VAGQQQVLQQ LAEEEPKLLA QLAQECQEQR ARLPQEIRRS LLGEMPEGLG 
DGPLVACASN GHAPGSSGHL SGADSESQEE NTQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.