Details for: CHIC1

Gene ID: 53344

Symbol: CHIC1

Ensembl ID: ENSG00000204116

Description: cysteine rich hydrophobic domain 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 172.7954
    Cell Significance Index: -26.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 105.1871
    Cell Significance Index: -26.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.8945
    Cell Significance Index: -27.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.0092
    Cell Significance Index: -24.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.8600
    Cell Significance Index: -27.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.7691
    Cell Significance Index: 336.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7603
    Cell Significance Index: 353.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.6829
    Cell Significance Index: 1163.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1270
    Cell Significance Index: 404.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0768
    Cell Significance Index: 47.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0693
    Cell Significance Index: 40.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9387
    Cell Significance Index: 847.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8457
    Cell Significance Index: 18.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8296
    Cell Significance Index: 50.9900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7946
    Cell Significance Index: 9.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7776
    Cell Significance Index: 18.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7347
    Cell Significance Index: 49.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6114
    Cell Significance Index: 34.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5920
    Cell Significance Index: 96.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5505
    Cell Significance Index: 59.8800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4944
    Cell Significance Index: 14.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4148
    Cell Significance Index: 10.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4023
    Cell Significance Index: 30.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3969
    Cell Significance Index: 78.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3804
    Cell Significance Index: 241.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3366
    Cell Significance Index: 7.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2625
    Cell Significance Index: 18.1600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.2104
    Cell Significance Index: 3.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1937
    Cell Significance Index: 364.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1816
    Cell Significance Index: 21.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1811
    Cell Significance Index: 5.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1762
    Cell Significance Index: 4.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0934
    Cell Significance Index: 1.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0911
    Cell Significance Index: 41.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0672
    Cell Significance Index: 103.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0642
    Cell Significance Index: 118.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0630
    Cell Significance Index: 34.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0600
    Cell Significance Index: 1.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0463
    Cell Significance Index: 8.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0449
    Cell Significance Index: 2.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0378
    Cell Significance Index: 51.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0359
    Cell Significance Index: 3.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0323
    Cell Significance Index: 0.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0213
    Cell Significance Index: 0.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0154
    Cell Significance Index: 6.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0094
    Cell Significance Index: -0.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0132
    Cell Significance Index: -1.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0195
    Cell Significance Index: -14.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0211
    Cell Significance Index: -15.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0218
    Cell Significance Index: -0.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0227
    Cell Significance Index: -0.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0246
    Cell Significance Index: -0.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0347
    Cell Significance Index: -26.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0450
    Cell Significance Index: -25.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0464
    Cell Significance Index: -28.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0512
    Cell Significance Index: -7.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0771
    Cell Significance Index: -22.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1116
    Cell Significance Index: -19.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1139
    Cell Significance Index: -6.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1209
    Cell Significance Index: -12.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1275
    Cell Significance Index: -13.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1309
    Cell Significance Index: -27.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1333
    Cell Significance Index: -17.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1425
    Cell Significance Index: -8.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1502
    Cell Significance Index: -17.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1555
    Cell Significance Index: -7.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1611
    Cell Significance Index: -18.4600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1816
    Cell Significance Index: -3.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1855
    Cell Significance Index: -23.9700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2451
    Cell Significance Index: -4.9200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2488
    Cell Significance Index: -5.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2604
    Cell Significance Index: -13.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2672
    Cell Significance Index: -17.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2691
    Cell Significance Index: -8.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2717
    Cell Significance Index: -12.7700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2820
    Cell Significance Index: -4.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2829
    Cell Significance Index: -9.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2855
    Cell Significance Index: -22.6100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2863
    Cell Significance Index: -5.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2882
    Cell Significance Index: -21.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3107
    Cell Significance Index: -9.9500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3150
    Cell Significance Index: -4.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3183
    Cell Significance Index: -22.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3457
    Cell Significance Index: -18.0100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3583
    Cell Significance Index: -5.0100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3717
    Cell Significance Index: -8.0300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3801
    Cell Significance Index: -4.7400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4129
    Cell Significance Index: -7.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4660
    Cell Significance Index: -12.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4705
    Cell Significance Index: -10.8700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4921
    Cell Significance Index: -7.2700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4999
    Cell Significance Index: -12.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5058
    Cell Significance Index: -17.7200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5079
    Cell Significance Index: -6.4100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5551
    Cell Significance Index: -11.8700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5608
    Cell Significance Index: -6.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5701
    Cell Significance Index: -24.7900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.6099
    Cell Significance Index: -7.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6286
    Cell Significance Index: -18.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CHIC1 is a member of the CHIC family of proteins, which are characterized by their cysteine-rich hydrophobic domains. These domains are essential for protein-protein interactions and are involved in regulating various cellular processes. CHIC1 is specifically expressed in hematopoietic cells, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, and CD8-positive, alpha-beta regulatory T cells. Its expression is also observed in non-hematopoietic cells, such as enteroendocrine cells of the colon and GABAergic interneurons in the brain. **Pathways and Functions:** CHIC1 is involved in several signaling pathways that regulate cell growth, differentiation, and survival. One of its primary functions is to interact with the JAK/STAT pathway, which is crucial for the regulation of hematopoiesis. CHIC1 also interacts with the PI3K/AKT pathway, which is involved in cell survival and proliferation. Additionally, CHIC1 has been shown to regulate the activity of the NF-κB transcription factor, which plays a key role in immune responses and inflammation. **Clinical Significance:** Chronic myelomonocytic leukemia (CMML) is a type of leukemia characterized by the accumulation of immature white blood cells. Research has shown that CHIC1 is frequently mutated or deleted in CMML, suggesting its potential role as a tumor suppressor gene. Furthermore, CHIC1 has been implicated in the pathogenesis of other diseases, including T-cell acute lymphoblastic leukemia (T-ALL) and multiple myeloma. In the context of immunology, CHIC1 has been shown to regulate the activity of regulatory T cells, which play a crucial role in maintaining immune tolerance. Dysregulation of CHIC1 expression has been linked to immune disorders, such as autoimmune diseases and transplant rejection. In conclusion, CHIC1 is a multifunctional protein that plays a critical role in regulating various cellular processes, including hematopoiesis, cell growth, and immune responses. Its dysregulation has been implicated in several diseases, including leukemia, autoimmune disorders, and transplant rejection. Further research is needed to fully elucidate the functions and significance of CHIC1 in human health and disease. **Recommendations for Future Research:** 1. Investigate the role of CHIC1 in other disease contexts, including cancer and autoimmune disorders. 2. Elucidate the mechanisms by which CHIC1 regulates the JAK/STAT and PI3K/AKT pathways. 3. Explore the therapeutic potential of CHIC1 as a tumor suppressor gene in leukemia and other diseases. 4. Investigate the role of CHIC1 in regulating the activity of regulatory T cells and its implications for immune tolerance. By continuing to explore the functions and significance of CHIC1, researchers can gain a deeper understanding of the molecular mechanisms underlying human disease and develop novel therapeutic strategies to combat these conditions.

Genular Protein ID: 1061626493

Symbol: CHIC1_HUMAN

Name: Cysteine-rich hydrophobic domain-containing protein 1

UniProtKB Accession Codes:

Q5VXU3 A0PJZ2 B0QZ87 B9EGS5 Q5CZ84

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9321471

Title: Localization and expression analysis of a novel conserved brain expressed transcript, Brx/BRX, lying within the Xic/XIC candidate region.

PubMed ID: 9321471

DOI: 10.1007/s003359900561

Sequence Information:

  • Length: 224
  • Mass: 25616
  • Checksum: ED6438E3B379F7E6
  • Sequence:
    • MSILLPNMAE FDTISELEEE EEEEAATSSS SPSSSSSVSG PDDDEEDEEE EEEEEEEEEE 
EEEEEEEEAP PPPRVVSEEH LRRYAPDPVL VRGAGHITVF GLSNKFDTEF PSVLTGKVAP 
EEFKTSIGRV NACLKKALPV NVKWLLCGCL CCCCTLGCSL WPVICLNKRT RRSIQKLIEW 
ENNRLYHKLA LHWKLTKRKC ETSNMMEYVI LIEFLPKYPI FRPD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.