Details for: PLK1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 27.9526
Cell Significance Index: -7.0900 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 7.5308
Cell Significance Index: -7.1900 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 7.1116
Cell Significance Index: 117.1900 - Cell Name: colon endothelial cell (CL1001572)
Fold Change: 5.8437
Cell Significance Index: 4.4600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 5.4787
Cell Significance Index: -6.7600 - Cell Name: basophilic erythroblast (CL0000549)
Fold Change: 4.8034
Cell Significance Index: 2.1900 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.2538
Cell Significance Index: 13.6300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.0369
Cell Significance Index: 122.2800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.9007
Cell Significance Index: 171.4200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7993
Cell Significance Index: 130.0000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.6554
Cell Significance Index: 20.9900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6180
Cell Significance Index: 67.2200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.5962
Cell Significance Index: 69.4800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5280
Cell Significance Index: 476.7700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3410
Cell Significance Index: 23.5800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3409
Cell Significance Index: 33.7200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3371
Cell Significance Index: 66.9000 - Cell Name: salivary gland cell (CL0009005)
Fold Change: 0.3245
Cell Significance Index: 4.0300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.3244
Cell Significance Index: 6.7900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.3048
Cell Significance Index: 10.5900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2387
Cell Significance Index: 6.6700 - Cell Name: sensory neuron (CL0000101)
Fold Change: 0.2146
Cell Significance Index: 1.2200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.1469
Cell Significance Index: 3.9300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1419
Cell Significance Index: 7.3700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1275
Cell Significance Index: 69.6200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1263
Cell Significance Index: 25.3300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1164
Cell Significance Index: 3.1200 - Cell Name: pro-T cell (CL0000827)
Fold Change: 0.1098
Cell Significance Index: 2.8100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0905
Cell Significance Index: 56.5100 - Cell Name: germ cell (CL0000586)
Fold Change: 0.0894
Cell Significance Index: 0.6800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0816
Cell Significance Index: 2.3500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0739
Cell Significance Index: 1.6000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0536
Cell Significance Index: 2.4300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0436
Cell Significance Index: 1.0900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0388
Cell Significance Index: 13.9100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0324
Cell Significance Index: 0.6900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0309
Cell Significance Index: 21.3900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0169
Cell Significance Index: 7.4800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0142
Cell Significance Index: 0.3800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0117
Cell Significance Index: 0.4100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0109
Cell Significance Index: 0.6100 - Cell Name: epidermal cell (CL0000362)
Fold Change: 0.0000
Cell Significance Index: 0.0000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0006
Cell Significance Index: -0.0100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0015
Cell Significance Index: -2.8000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0028
Cell Significance Index: -2.0900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0043
Cell Significance Index: -7.9100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0045
Cell Significance Index: -6.1800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0046
Cell Significance Index: -7.0400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0057
Cell Significance Index: -3.2300 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0090
Cell Significance Index: -1.1500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0093
Cell Significance Index: -5.8800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0096
Cell Significance Index: -7.3000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0097
Cell Significance Index: -1.3300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0101
Cell Significance Index: -7.4000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0113
Cell Significance Index: -2.0300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0131
Cell Significance Index: -2.2300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0141
Cell Significance Index: -0.7300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0172
Cell Significance Index: -7.8200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0178
Cell Significance Index: -5.1300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0185
Cell Significance Index: -3.8900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0235
Cell Significance Index: -3.4200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0271
Cell Significance Index: -2.7700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0276
Cell Significance Index: -3.1600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0343
Cell Significance Index: -4.2200 - Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: -0.0374
Cell Significance Index: -0.3400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0406
Cell Significance Index: -4.6400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0467
Cell Significance Index: -3.1400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0482
Cell Significance Index: -3.7000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0501
Cell Significance Index: -3.0700 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0502
Cell Significance Index: -0.5200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0561
Cell Significance Index: -2.4800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0598
Cell Significance Index: -3.7700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0599
Cell Significance Index: -7.7500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0632
Cell Significance Index: -4.4700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0639
Cell Significance Index: -0.9200 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.0656
Cell Significance Index: -0.9200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0680
Cell Significance Index: -4.3900 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.0687
Cell Significance Index: -0.5900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0688
Cell Significance Index: -7.1600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0710
Cell Significance Index: -2.6900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0731
Cell Significance Index: -1.8800 - Cell Name: radial glial cell (CL0000681)
Fold Change: -0.0843
Cell Significance Index: -0.5000 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0905
Cell Significance Index: -1.2700 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0974
Cell Significance Index: -2.4300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0992
Cell Significance Index: -6.1000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1000
Cell Significance Index: -7.9200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1002
Cell Significance Index: -5.2600 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.1058
Cell Significance Index: -1.7800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1100
Cell Significance Index: -8.2000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1115
Cell Significance Index: -5.2000 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.1183
Cell Significance Index: -1.8300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1195
Cell Significance Index: -3.5100 - Cell Name: late promyelocyte (CL0002151)
Fold Change: -0.1334
Cell Significance Index: -0.8900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1363
Cell Significance Index: -8.1800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1372
Cell Significance Index: -6.4500 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.1386
Cell Significance Index: -0.9200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1545
Cell Significance Index: -4.5500 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1561
Cell Significance Index: -5.4700 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.1582
Cell Significance Index: -1.1500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1620
Cell Significance Index: -5.1600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3122359881
Symbol: PLK1_HUMAN
Name: Serine/threonine-protein kinase PLK1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8018557
Title: Cloning and characterization of human and murine homologues of the Drosophila polo serine-threonine kinase.
PubMed ID: 8018557
PubMed ID: 7902533
Title: Cell cycle- and terminal differentiation-associated regulation of the mouse mRNA encoding a conserved mitotic protein kinase.
PubMed ID: 7902533
PubMed ID: 7962193
Title: Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5.
PubMed ID: 7962193
PubMed ID: 8127874
Title: Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors.
PubMed ID: 8127874
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7478607
Title: Identification and functional characterization of the human and murine polo-like kinase (Plk) promoter.
PubMed ID: 7478607
PubMed ID: 9083047
Title: Cell cycle regulation of the human polo-like kinase (PLK) promoter.
PubMed ID: 9083047
PubMed ID: 8991084
Title: Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.
PubMed ID: 8991084
PubMed ID: 11202906
Title: The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase.
PubMed ID: 11202906
PubMed ID: 12207013
Title: Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase.
PubMed ID: 12207013
PubMed ID: 12447691
Title: Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1.
PubMed ID: 12447691
PubMed ID: 12442251
Title: Identification of phosphorylation sites in the polo-like kinases Plx1 and Plk1 by a novel strategy based on element and electrospray high resolution mass spectrometry.
PubMed ID: 12442251
DOI: 10.1002/1615-9861(200211)2:11<1516::aid-prot1516>3.0.co;2-y
PubMed ID: 12852856
Title: Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.
PubMed ID: 12852856
PubMed ID: 12639966
Title: Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue.
PubMed ID: 12639966
PubMed ID: 12738781
Title: Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate.
PubMed ID: 12738781
PubMed ID: 12939256
Title: Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis.
PubMed ID: 12939256
PubMed ID: 12524548
Title: Active cyclin B1-Cdk1 first appears on centrosomes in prophase.
PubMed ID: 12524548
DOI: 10.1038/ncb918
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 14734534
Title: Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells.
PubMed ID: 14734534
PubMed ID: 15469984
Title: Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC inhibitor Emi1.
PubMed ID: 15469984
PubMed ID: 15070733
Title: M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.
PubMed ID: 15070733
PubMed ID: 15148369
Title: Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome.
PubMed ID: 15148369
PubMed ID: 16198290
Title: Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis.
PubMed ID: 16198290
PubMed ID: 15661742
Title: Polo-like kinase 1 phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress.
PubMed ID: 15661742
PubMed ID: 15616186
Title: The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles.
PubMed ID: 15616186
PubMed ID: 16439210
Title: The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1.
PubMed ID: 16439210
PubMed ID: 16760428
Title: Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1.
PubMed ID: 16760428
PubMed ID: 16980960
Title: The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity.
PubMed ID: 16980960
DOI: 10.1038/ncb1474
PubMed ID: 16247472
Title: Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA.
PubMed ID: 16247472
PubMed ID: 17081991
Title: Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation.
PubMed ID: 17081991
PubMed ID: 16645325
Title: Expression of polo-like kinase 1 (PLK1) protein predicts the survival of patients with gastric carcinoma.
PubMed ID: 16645325
DOI: 10.1159/000093003
PubMed ID: 17981789
Title: A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma.
PubMed ID: 17981789
PubMed ID: 17218258
Title: PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint.
PubMed ID: 17218258
PubMed ID: 17617734
Title: Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1.
PubMed ID: 17617734
DOI: 10.4161/cc.6.13.4442
PubMed ID: 17310276
Title: TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity.
PubMed ID: 17310276
PubMed ID: 17376779
Title: Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1.
PubMed ID: 17376779
PubMed ID: 17943598
Title: Expression of PLK1 and survivin in diffuse large B-cell lymphoma.
PubMed ID: 17943598
PubMed ID: 17351640
Title: Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1.
PubMed ID: 17351640
DOI: 10.1038/ncb1557
PubMed ID: 17495026
Title: The tumor suppressor CYLD regulates entry into mitosis.
PubMed ID: 17495026
PubMed ID: 18794143
Title: HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression.
PubMed ID: 18794143
PubMed ID: 18662541
Title: The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.
PubMed ID: 18662541
PubMed ID: 18329369
Title: Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.
PubMed ID: 18329369
PubMed ID: 18418051
Title: p73-mediated transcriptional activity is negatively regulated by polo-like kinase 1.
PubMed ID: 18418051
DOI: 10.4161/cc.7.9.5777
PubMed ID: 18521620
Title: Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora.
PubMed ID: 18521620
PubMed ID: 18331714
Title: sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1.
PubMed ID: 18331714
PubMed ID: 18477460
Title: Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1.
PubMed ID: 18477460
PubMed ID: 18174154
Title: Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation.
PubMed ID: 18174154
PubMed ID: 19029337
Title: FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle.
PubMed ID: 19029337
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19160488
Title: Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression.
PubMed ID: 19160488
DOI: 10.1038/ncb1767
PubMed ID: 18615013
Title: Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
PubMed ID: 18615013
DOI: 10.1038/nature07185
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19596235
Title: Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
PubMed ID: 19596235
PubMed ID: 19473992
Title: Plk1-mediated phosphorylation of Topors regulates p53 stability.
PubMed ID: 19473992
PubMed ID: 19509060
Title: Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome.
PubMed ID: 19509060
DOI: 10.1242/jcs.042747
PubMed ID: 19351716
Title: Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a.
PubMed ID: 19351716
DOI: 10.1242/jcs.044321
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19468300
Title: Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.
PubMed ID: 19468300
PubMed ID: 19468302
Title: Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.
PubMed ID: 19468302
PubMed ID: 20671765
Title: Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy.
PubMed ID: 20671765
DOI: 10.1038/nrd3184
PubMed ID: 20679239
Title: Polo-like kinase 1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase.
PubMed ID: 20679239
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21857149
Title: Phosphorylation of Ataxin-10 by polo-like kinase 1 is required for cytokinesis.
PubMed ID: 21857149
PubMed ID: 21880710
Title: Phosphorylation of right open reading frame 2 (Rio2) protein kinase by polo-like kinase 1 regulates mitotic progression.
PubMed ID: 21880710
PubMed ID: 21402792
Title: The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment.
PubMed ID: 21402792
PubMed ID: 22753416
Title: Furry protein promotes Aurora A-mediated polo-like kinase 1 activation.
PubMed ID: 22753416
PubMed ID: 22325354
Title: Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
PubMed ID: 22325354
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24067371
Title: CUL3 and protein kinases: insights from PLK1/KLHL22 interaction.
PubMed ID: 24067371
DOI: 10.4161/cc.25369
PubMed ID: 24018379
Title: Centrosomal protein FOR20 is essential for S-phase progression by recruiting Plk1 to centrosomes.
PubMed ID: 24018379
DOI: 10.1038/cr.2013.127
PubMed ID: 23455152
Title: Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit.
PubMed ID: 23455152
PubMed ID: 23509069
Title: MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.
PubMed ID: 23509069
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23455478
Title: Ubiquitylation-dependent localization of PLK1 in mitosis.
PubMed ID: 23455478
DOI: 10.1038/ncb2695
PubMed ID: 25986610
Title: Phosphorylation of SAF-A/hnRNP-U serine 59 by polo-like kinase 1 is required for mitosis.
PubMed ID: 25986610
DOI: 10.1128/mcb.01312-14
PubMed ID: 25659891
Title: Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.
PubMed ID: 25659891
PubMed ID: 25503564
Title: Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.
PubMed ID: 25503564
DOI: 10.1038/ncb3076
PubMed ID: 26811421
Title: TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.
PubMed ID: 26811421
PubMed ID: 28512243
Title: Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response.
PubMed ID: 28512243
PubMed ID: 27979967
Title: DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle.
PubMed ID: 27979967
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 29191835
Title: Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions.
PubMed ID: 29191835
PubMed ID: 30715179
Title: Mutations in the microtubule-associated protein MAP11 (C7orf43) cause microcephaly in humans and zebrafish.
PubMed ID: 30715179
DOI: 10.1093/brain/awz004
PubMed ID: 32799774
Title: SKA3 Promotes Cell Growth in Breast Cancer by Inhibiting PLK-1 Protein Degradation.
PubMed ID: 32799774
PubMed ID: 34260926
Title: Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation.
PubMed ID: 34260926
PubMed ID: 37674080
Title: Poltheta is phosphorylated by PLK1 to repair double-strand breaks in mitosis.
PubMed ID: 37674080
PubMed ID: 37440612
Title: RHINO directs MMEJ to repair DNA breaks in mitosis.
PubMed ID: 37440612
PubMed ID: 14532005
Title: The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.
PubMed ID: 14532005
PubMed ID: 14592974
Title: The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex.
PubMed ID: 14592974
DOI: 10.1093/emboj/cdg558
PubMed ID: 17461553
Title: Structure of the catalytic domain of human polo-like kinase 1.
PubMed ID: 17461553
DOI: 10.1021/bi602474j
PubMed ID: 18005335
Title: Selectivity-determining residues in Plk1.
PubMed ID: 18005335
PubMed ID: 17307877
Title: Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization.
PubMed ID: 17307877
PubMed ID: 18391401
Title: Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin.
PubMed ID: 18391401
PubMed ID: 19597481
Title: Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
PubMed ID: 19597481
DOI: 10.1038/nsmb.1628
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 603
- Mass: 68255
- Checksum: 178C2F13C10E8206
- Sequence:
MSAAVTAGKL ARAPADPGKA GVPGVAAPGA PAAAPPAKEI PEVLVDPRSR RRYVRGRFLG KGGFAKCFEI SDADTKEVFA GKIVPKSLLL KPHQREKMSM EISIHRSLAH QHVVGFHGFF EDNDFVFVVL ELCRRRSLLE LHKRRKALTE PEARYYLRQI VLGCQYLHRN RVIHRDLKLG NLFLNEDLEV KIGDFGLATK VEYDGERKKT LCGTPNYIAP EVLSKKGHSF EVDVWSIGCI MYTLLVGKPP FETSCLKETY LRIKKNEYSI PKHINPVAAS LIQKMLQTDP TARPTINELL NDEFFTSGYI PARLPITCLT IPPRFSIAPS SLDPSNRKPL TVLNKGLENP LPERPREKEE PVVRETGEVV DCHLSDMLQQ LHSVNASKPS ERGLVRQEEA EDPACIPIFW VSKWVDYSDK YGLGYQLCDN SVGVLFNDST RLILYNDGDS LQYIERDGTE SYLTVSSHPN SLMKKITLLK YFRNYMSEHL LKAGANITPR EGDELARLPY LRTWFRTRSA IILHLSNGSV QINFFQDHTK LILCPLMAAV TYIDEKRDFR TYRLSLLEEY GCCKELASRL RYARTMVDKL LSSRSASNRL KAS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.