Details for: POLR2A

Gene ID: 5430

Symbol: POLR2A

Ensembl ID: ENSG00000181222

Description: RNA polymerase II subunit A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 309.6848
    Cell Significance Index: -48.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 192.6721
    Cell Significance Index: -48.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 118.2955
    Cell Significance Index: -55.8500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 112.9826
    Cell Significance Index: -45.9000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 104.2993
    Cell Significance Index: -53.6500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 83.2312
    Cell Significance Index: -55.8500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.2957
    Cell Significance Index: -46.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.4914
    Cell Significance Index: -52.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.7024
    Cell Significance Index: -52.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.5655
    Cell Significance Index: -53.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.7762
    Cell Significance Index: -36.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.1142
    Cell Significance Index: -15.5700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.4293
    Cell Significance Index: 18.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.2877
    Cell Significance Index: 293.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.0061
    Cell Significance Index: 90.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4362
    Cell Significance Index: 41.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1406
    Cell Significance Index: 205.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1131
    Cell Significance Index: 57.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1094
    Cell Significance Index: 180.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0903
    Cell Significance Index: 118.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0336
    Cell Significance Index: 66.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9763
    Cell Significance Index: 26.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9739
    Cell Significance Index: 119.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9722
    Cell Significance Index: 195.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9285
    Cell Significance Index: 55.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8863
    Cell Significance Index: 175.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8615
    Cell Significance Index: 23.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8048
    Cell Significance Index: 41.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7386
    Cell Significance Index: 20.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7206
    Cell Significance Index: 393.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6164
    Cell Significance Index: 72.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5598
    Cell Significance Index: 76.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5393
    Cell Significance Index: 238.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4955
    Cell Significance Index: 177.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4406
    Cell Significance Index: 27.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4128
    Cell Significance Index: 14.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3966
    Cell Significance Index: 18.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3153
    Cell Significance Index: 284.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2870
    Cell Significance Index: 540.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2809
    Cell Significance Index: 14.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2677
    Cell Significance Index: 50.9500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2563
    Cell Significance Index: 2.3600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2076
    Cell Significance Index: 2.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1958
    Cell Significance Index: 9.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1455
    Cell Significance Index: 10.2900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1435
    Cell Significance Index: 1.1700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1345
    Cell Significance Index: 1.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1222
    Cell Significance Index: 12.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1221
    Cell Significance Index: 84.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1128
    Cell Significance Index: 71.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1056
    Cell Significance Index: 18.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1023
    Cell Significance Index: 5.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0737
    Cell Significance Index: 5.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0164
    Cell Significance Index: 30.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0096
    Cell Significance Index: 14.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0063
    Cell Significance Index: -0.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0115
    Cell Significance Index: -0.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0135
    Cell Significance Index: -18.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0161
    Cell Significance Index: -11.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0175
    Cell Significance Index: -7.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0201
    Cell Significance Index: -1.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0221
    Cell Significance Index: -16.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0353
    Cell Significance Index: -22.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0501
    Cell Significance Index: -37.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0550
    Cell Significance Index: -5.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0579
    Cell Significance Index: -1.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0719
    Cell Significance Index: -40.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1180
    Cell Significance Index: -2.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1219
    Cell Significance Index: -25.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1539
    Cell Significance Index: -44.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1809
    Cell Significance Index: -21.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1820
    Cell Significance Index: -23.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2016
    Cell Significance Index: -2.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2050
    Cell Significance Index: -4.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2139
    Cell Significance Index: -5.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2246
    Cell Significance Index: -25.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3264
    Cell Significance Index: -24.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3395
    Cell Significance Index: -6.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3958
    Cell Significance Index: -11.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4050
    Cell Significance Index: -46.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4666
    Cell Significance Index: -12.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4834
    Cell Significance Index: -8.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4860
    Cell Significance Index: -50.6000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4967
    Cell Significance Index: -14.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4990
    Cell Significance Index: -22.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5047
    Cell Significance Index: -9.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5306
    Cell Significance Index: -13.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5842
    Cell Significance Index: -18.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5977
    Cell Significance Index: -47.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6653
    Cell Significance Index: -25.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6943
    Cell Significance Index: -42.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7016
    Cell Significance Index: -24.3800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7951
    Cell Significance Index: -11.7400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8663
    Cell Significance Index: -22.1300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.8792
    Cell Significance Index: -36.0200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.8820
    Cell Significance Index: -10.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9321
    Cell Significance Index: -23.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.9364
    Cell Significance Index: -21.6400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.9525
    Cell Significance Index: -13.3600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9683
    Cell Significance Index: -5.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** POLR2A is a 130-kDa subunit of the RNAPII complex, composed of five subunits (α, β, β', β'' , and δ). It is highly conserved across eukaryotes, suggesting its essential role in transcription. POLR2A possesses a unique structure, with a C-terminal domain that interacts with the RNAPII holoenzyme and a N-terminal domain that recognizes specific DNA sequences. **Pathways and Functions:** POLR2A is involved in numerous cellular pathways, including: 1. **Gene expression:** POLR2A transcribes genes involved in development, cell cycle regulation, and immune response. 2. **Transcription elongation:** POLR2A regulates transcription elongation, including the arrest and recovery of HIV-1 transcription. 3. **Cell cycle regulation:** POLR2A is required for cell cycle progression and cell division. 4. **Immune response:** POLR2A is involved in the transcription of genes involved in immune response, including those related to T-cell development and activation. 5. **Chromatin remodeling:** POLR2A interacts with chromatin remodeling complexes to regulate gene expression. **Clinical Significance:** Dysregulation of POLR2A has been implicated in various human diseases, including: 1. **Cancer:** Mutations in POLR2A have been associated with certain types of cancer, such as breast and lung cancer. 2. **Neurological disorders:** POLR2A mutations have been linked to neurodevelopmental disorders, such as autism and schizophrenia. 3. **Immunological disorders:** Dysregulation of POLR2A has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Infectious diseases:** POLR2A is involved in the transcription of HIV-1 genes, making it a potential target for antiviral therapies. **Proteins and Significantly Expressed Cells:** POLR2A interacts with various proteins, including RPB1, RPB5, and RPB7, which are essential for RNAPII function. Significantly expressed cells include neural progenitor cells, skeletal muscle satellite stem cells, and CD8-positive T cells. **Conclusion:** POLR2A is a multifunctional protein that plays a central role in gene expression, cell cycle regulation, and immune response. Its dysregulation has been implicated in various human diseases, highlighting the importance of understanding its mechanisms of action and regulation. Further research is needed to elucidate the complex interactions between POLR2A and other cellular components, ultimately leading to the development of novel therapeutic strategies for human diseases. **Recommendations for Further Research:** 1. **Investigate POLR2A interactions with other proteins:** Elucidate the interactions between POLR2A and other proteins involved in RNAPII function and cellular processes. 2. **Examine POLR2A regulation in disease models:** Investigate the role of POLR2A in disease models, including cancer, neurodevelopmental disorders, and immunological disorders. 3. **Develop therapeutic strategies:** Explore the potential of targeting POLR2A for the treatment of human diseases, including cancer and infectious diseases. By continuing to unravel the mysteries of POLR2A, researchers can gain a deeper understanding of its role in human disease and develop novel therapeutic strategies to improve patient outcomes.

Genular Protein ID: 3878296146

Symbol: RPB1_HUMAN

Name: 3'-5' exoribonuclease

UniProtKB Accession Codes:

P24928 A6NN93 B9EH88 Q6NX41

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 2 CORUM 1 CTD 1 ChEBI 33 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 2 EMBL 10 EMDB 15 EvolutionaryTrace 1 GO 21 Gene3D 9 GeneCards 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 40 PDBsum 40 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 8 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 41 RefSeq 1 Rhea 13 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1542581

Title: Complete sequence of the human RNA polymerase II largest subunit.

PubMed ID: 1542581

DOI: 10.1093/nar/20.4.910

PubMed ID: 7622068

Title: The human gene encoding the largest subunit of RNA polymerase II.

PubMed ID: 7622068

DOI: 10.1016/0378-1119(95)00081-g

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8381534

Title: Identification of a 3'-->5' exonuclease activity associated with human RNA polymerase II.

PubMed ID: 8381534

DOI: 10.1073/pnas.90.3.843

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 9671816

Title: SAF-B couples transcription and pre-mRNA splicing to SAR/MAR elements.

PubMed ID: 9671816

DOI: 10.1093/nar/26.15.3542

PubMed ID: 10393184

Title: A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription.

PubMed ID: 10393184

DOI: 10.1093/emboj/18.13.3688

PubMed ID: 10454543

Title: Tat-SF1 protein associates with RAP30 and human SPT5 proteins.

PubMed ID: 10454543

DOI: 10.1128/mcb.19.9.5960

PubMed ID: 12381297

Title: The structure of an FF domain from human HYPA/FBP11.

PubMed ID: 12381297

DOI: 10.1016/s0022-2836(02)00968-3

PubMed ID: 12376575

Title: Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing.

PubMed ID: 12376575

DOI: 10.1074/mcp.m200029-mcp200

PubMed ID: 12527917

Title: Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300.

PubMed ID: 12527917

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PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

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PubMed ID: 15563843

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PubMed ID: 15563843

DOI: 10.1016/j.gene.2004.08.027

PubMed ID: 14684736

Title: Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells.

PubMed ID: 14684736

DOI: 10.1074/jbc.m312895200

PubMed ID: 14992727

Title: Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.

PubMed ID: 14992727

DOI: 10.1016/s1097-2765(04)00081-4

PubMed ID: 15992770

Title: Expression of the C-terminal domain of novel human SR-A1 protein: interaction with the CTD domain of RNA polymerase II.

PubMed ID: 15992770

DOI: 10.1016/j.bbrc.2005.06.053

PubMed ID: 16118227

Title: Identification and characterization of a novel human histone H3 lysine 36 specific methyltransferase.

PubMed ID: 16118227

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PubMed ID: 16314571

Title: Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1.

PubMed ID: 16314571

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PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16491129

Title: The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis.

PubMed ID: 16491129

DOI: 10.1038/sj.onc.1209353

PubMed ID: 17234882

Title: The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export.

PubMed ID: 17234882

DOI: 10.1101/gad.1503107

PubMed ID: 18533109

Title: The human interferon-regulated ISG95 protein interacts with RNA polymerase II and shows methyltransferase activity.

PubMed ID: 18533109

DOI: 10.1016/j.bbrc.2008.05.137

PubMed ID: 18550522

Title: Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the carboxyl-terminal domain of RNA polymerase II.

PubMed ID: 18550522

DOI: 10.1074/jbc.m803540200

PubMed ID: 18032511

Title: Transcription of hepatitis delta virus RNA by RNA polymerase II.

PubMed ID: 18032511

DOI: 10.1128/jvi.01758-07

PubMed ID: 17998332

Title: Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.

PubMed ID: 17998332

DOI: 10.1128/mcb.01356-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19106100

Title: MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity.

PubMed ID: 19106100

DOI: 10.1074/jbc.m807098200

PubMed ID: 19450536

Title: TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II.

PubMed ID: 19450536

DOI: 10.1016/j.molcel.2009.04.016

PubMed ID: 19667075

Title: TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II.

PubMed ID: 19667075

DOI: 10.1128/mcb.00637-09

PubMed ID: 19136461

Title: Binding to DNA of the RNA-polymerase II C-terminal domain allows discrimination between Cdk7 and Cdk9 phosphorylation.

PubMed ID: 19136461

DOI: 10.1093/nar/gkn1061

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20231364

Title: RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase.

PubMed ID: 20231364

DOI: 10.1128/mcb.01583-09

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21536736

Title: The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex.

PubMed ID: 21536736

DOI: 10.1101/gad.2038011

PubMed ID: 21127351

Title: Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B.

PubMed ID: 21127351

DOI: 10.1074/jbc.m110.176628

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21454787

Title: The C-terminal domain of RNA polymerase II is modified by site-specific methylation.

PubMed ID: 21454787

DOI: 10.1126/science.1202663

PubMed ID: 22137580

Title: Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes.

PubMed ID: 22137580

DOI: 10.1016/j.molcel.2011.11.006

PubMed ID: 22466610

Title: Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair.

PubMed ID: 22466610

DOI: 10.1038/ng.2229

PubMed ID: 23029222

Title: Herpes simplex virus 1 ICP22 inhibits the transcription of viral gene promoters by binding to and blocking the recruitment of P-TEFb.

PubMed ID: 23029222

DOI: 10.1371/journal.pone.0045749

PubMed ID: 23395899

Title: RNA polymerase II acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA.

PubMed ID: 23395899

DOI: 10.1038/emboj.2013.18

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24207025

Title: Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells.

PubMed ID: 24207025

DOI: 10.1016/j.molcel.2013.10.009

PubMed ID: 23149945

Title: Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.

PubMed ID: 23149945

DOI: 10.1128/mcb.01195-12

PubMed ID: 23652018

Title: GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.

PubMed ID: 23652018

DOI: 10.1038/ncomms2823

PubMed ID: 24656813

Title: Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex.

PubMed ID: 24656813

DOI: 10.1016/j.celrep.2014.03.013

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26687004

Title: Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells.

PubMed ID: 26687004

DOI: 10.7554/elife.11215

PubMed ID: 26566685

Title: Site-specific methylation and acetylation of lysine residues in the C-terminal domain (CTD) of RNA polymerase II.

PubMed ID: 26566685

DOI: 10.1080/21541264.2015.1114983

PubMed ID: 26124092

Title: FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP.

PubMed ID: 26124092

DOI: 10.1073/pnas.1506282112

PubMed ID: 26655721

Title: Selective Recognition of H3.1K36 Dimethylation/H4K16 Acetylation Facilitates the Regulation of All-trans-retinoic Acid (ATRA)-responsive Genes by Putative Chromatin Reader ZMYND8.

PubMed ID: 26655721

DOI: 10.1074/jbc.m115.679985

PubMed ID: 26700805

Title: SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination.

PubMed ID: 26700805

DOI: 10.1038/nature16469

PubMed ID: 28076779

Title: Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation.

PubMed ID: 28076779

DOI: 10.1016/j.celrep.2016.12.050

PubMed ID: 28108474

Title: The human initiator is a distinct and abundant element that is precisely positioned in focused core promoters.

PubMed ID: 28108474

DOI: 10.1101/gad.293837.116

PubMed ID: 30538201

Title: Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.

PubMed ID: 30538201

DOI: 10.1073/pnas.1818012115

PubMed ID: 32142649

Title: Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.

PubMed ID: 32142649

DOI: 10.1016/j.cell.2020.02.010

PubMed ID: 32142654

Title: Regulation of the RNAPII Pool Is Integral to the DNA Damage Response.

PubMed ID: 32142654

DOI: 10.1016/j.cell.2020.02.009

PubMed ID: 35633597

Title: UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1.

PubMed ID: 35633597

DOI: 10.1016/j.dnarep.2022.103343

PubMed ID: 17157258

Title: Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1.

PubMed ID: 17157258

DOI: 10.1016/j.molcel.2006.10.027

PubMed ID: 23748380

Title: Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5.

PubMed ID: 23748380

DOI: 10.1038/nsmb.2596

PubMed ID: 27193682

Title: Near-atomic resolution visualization of human transcription promoter opening.

PubMed ID: 27193682

DOI: 10.1038/nature17970

PubMed ID: 30190596

Title: Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.

PubMed ID: 30190596

DOI: 10.1038/s41594-018-0118-5

PubMed ID: 31353023

Title: De Novo Heterozygous POLR2A Variants Cause a Neurodevelopmental Syndrome with Profound Infantile-Onset Hypotonia.

PubMed ID: 31353023

DOI: 10.1016/j.ajhg.2019.06.016

Sequence Information:

  • Length: 1970
  • Mass: 217176
  • Checksum: 28D6FD25693A6472
  • Sequence:
    • MHGGGPPSGD SACPLRTIKR VQFGVLSPDE LKRMSVTEGG IKYPETTEGG RPKLGGLMDP 
RQGVIERTGR CQTCAGNMTE CPGHFGHIEL AKPVFHVGFL VKTMKVLRCV CFFCSKLLVD 
SNNPKIKDIL AKSKGQPKKR LTHVYDLCKG KNICEGGEEM DNKFGVEQPE GDEDLTKEKG 
HGGCGRYQPR IRRSGLELYA EWKHVNEDSQ EKKILLSPER VHEIFKRISD EECFVLGMEP 
RYARPEWMIV TVLPVPPLSV RPAVVMQGSA RNQDDLTHKL ADIVKINNQL RRNEQNGAAA 
HVIAEDVKLL QFHVATMVDN ELPGLPRAMQ KSGRPLKSLK QRLKGKEGRV RGNLMGKRVD 
FSARTVITPD PNLSIDQVGV PRSIAANMTF AEIVTPFNID RLQELVRRGN SQYPGAKYII 
RDNGDRIDLR FHPKPSDLHL QTGYKVERHM CDGDIVIFNR QPTLHKMSMM GHRVRILPWS 
TFRLNLSVTT PYNADFDGDE MNLHLPQSLE TRAEIQELAM VPRMIVTPQS NRPVMGIVQD 
TLTAVRKFTK RDVFLERGEV MNLLMFLSTW DGKVPQPAIL KPRPLWTGKQ IFSLIIPGHI 
NCIRTHSTHP DDEDSGPYKH ISPGDTKVVV ENGELIMGIL CKKSLGTSAG SLVHISYLEM 
GHDITRLFYS NIQTVINNWL LIEGHTIGIG DSIADSKTYQ DIQNTIKKAK QDVIEVIEKA 
HNNELEPTPG NTLRQTFENQ VNRILNDARD KTGSSAQKSL SEYNNFKSMV VSGAKGSKIN 
ISQVIAVVGQ QNVEGKRIPF GFKHRTLPHF IKDDYGPESR GFVENSYLAG LTPTEFFFHA 
MGGREGLIDT AVKTAETGYI QRRLIKSMES VMVKYDATVR NSINQVVQLR YGEDGLAGES 
VEFQNLATLK PSNKAFEKKF RFDYTNERAL RRTLQEDLVK DVLSNAHIQN ELEREFERMR 
EDREVLRVIF PTGDSKVVLP CNLLRMIWNA QKIFHINPRL PSDLHPIKVV EGVKELSKKL 
VIVNGDDPLS RQAQENATLL FNIHLRSTLC SRRMAEEFRL SGEAFDWLLG EIESKFNQAI 
AHPGEMVGAL AAQSLGEPAT QMTLNTFHYA GVSAKNVTLG VPRLKELINI SKKPKTPSLT 
VFLLGQSARD AERAKDILCR LEHTTLRKVT ANTAIYYDPN PQSTVVAEDQ EWVNVYYEMP 
DFDVARISPW LLRVELDRKH MTDRKLTMEQ IAEKINAGFG DDLNCIFNDD NAEKLVLRIR 
IMNSDENKMQ EEEEVVDKMD DDVFLRCIES NMLTDMTLQG IEQISKVYMH LPQTDNKKKI 
IITEDGEFKA LQEWILETDG VSLMRVLSEK DVDPVRTTSN DIVEIFTVLG IEAVRKALER 
ELYHVISFDG SYVNYRHLAL LCDTMTCRGH LMAITRHGVN RQDTGPLMKC SFEETVDVLM 
EAAAHGESDP MKGVSENIML GQLAPAGTGC FDLLLDAEKC KYGMEIPTNI PGLGAAGPTG 
MFFGSAPSPM GGISPAMTPW NQGATPAYGA WSPSVGSGMT PGAAGFSPSA ASDASGFSPG 
YSPAWSPTPG SPGSPGPSSP YIPSPGGAMS PSYSPTSPAY EPRSPGGYTP QSPSYSPTSP 
SYSPTSPSYS PTSPNYSPTS PSYSPTSPSY SPTSPSYSPT SPSYSPTSPS YSPTSPSYSP 
TSPSYSPTSP SYSPTSPSYS PTSPSYSPTS PSYSPTSPSY SPTSPSYSPT SPSYSPTSPS 
YSPTSPNYSP TSPNYTPTSP SYSPTSPSYS PTSPNYTPTS PNYSPTSPSY SPTSPSYSPT 
SPSYSPSSPR YTPQSPTYTP SSPSYSPSSP SYSPASPKYT PTSPSYSPSS PEYTPTSPKY 
SPTSPKYSPT SPKYSPTSPT YSPTTPKYSP TSPTYSPTSP VYTPTSPKYS PTSPTYSPTS 
PKYSPTSPTY SPTSPKGSTY SPTSPGYSPT SPTYSLTSPA ISPDDSDEEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.