POLR2G | ENSG00000168002 | NCBI 5436

Details for: POLR2G

Gene ID: 5436

Symbol: POLR2G

Ensembl ID: ENSG00000168002

Description: RNA polymerase II subunit G

Associated with

Abortive elongation of hiv-1 transcript in the absence of tat
(R-HSA-167242)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Cell cycle
(R-HSA-1640170)
Chromosome maintenance
(R-HSA-73886)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Dna repair
(R-HSA-73894)
Dual incision in tc-ner
(R-HSA-6782135)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Fgfr2 alternative splicing
(R-HSA-6803529)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
Formation of the early elongation complex
(R-HSA-113418)
Formation of the hiv-1 early elongation complex
(R-HSA-167158)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hiv elongation arrest and recovery
(R-HSA-167287)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Hiv transcription initiation
(R-HSA-167161)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of rna
(R-HSA-8953854)
Microrna (mirna) biogenesis
(R-HSA-203927)
Mrna capping
(R-HSA-72086)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Mrna splicing - minor pathway
(R-HSA-72165)
Nucleotide excision repair
(R-HSA-5696398)
Pausing and recovery of hiv elongation
(R-HSA-167290)
Pausing and recovery of tat-mediated hiv elongation
(R-HSA-167238)
Piwi-interacting rna (pirna) biogenesis
(R-HSA-5601884)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Rna pol ii ctd phosphorylation and interaction with ce
(R-HSA-77075)
Rna pol ii ctd phosphorylation and interaction with ce during hiv infection
(R-HSA-167160)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 iiia tm
(R-HSA-8851708)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tat-mediated hiv elongation arrest and recovery
(R-HSA-167243)
Telomere maintenance
(R-HSA-157579)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Viral messenger rna synthesis
(R-HSA-168325)
Nuclear-transcribed mrna catabolic process
(GO:0000956)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
P-body
(GO:0000932)
Positive regulation of nuclear-transcribed mrna poly(a) tail shortening
(GO:0060213)
Positive regulation of translational initiation
(GO:0045948)
Protein binding
(GO:0005515)
Rna polymerase ii, core complex
(GO:0005665)
Single-stranded dna binding
(GO:0003697)
Single-stranded rna binding
(GO:0003727)
Transcription by rna polymerase ii
(GO:0006366)
Transcription initiation at rna polymerase ii promoter
(GO:0006367)
Translation initiation factor binding
(GO:0031369)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 228.8723
Cell Significance Index: -35.6000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 119.1831
Cell Significance Index: -30.2300
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 105.2076
Cell Significance Index: -43.3400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 93.5861
Cell Significance Index: -38.0200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 91.5864
Cell Significance Index: -43.2400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 81.8258
Cell Significance Index: -42.0900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 64.8414
Cell Significance Index: -43.5100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 40.2621
Cell Significance Index: -38.4400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 34.0766
Cell Significance Index: -42.0200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.1707
Cell Significance Index: -44.0800
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 11.1185
Cell Significance Index: -34.1500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.8084
Cell Significance Index: -15.5600
Cell Name: kidney cell (CL1000497)
Fold Change: 5.5647
Cell Significance Index: 44.4300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.9987
Cell Significance Index: -10.9400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.9316
Cell Significance Index: 31.8700
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 2.8329
Cell Significance Index: 330.1400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 2.8201
Cell Significance Index: 59.0300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.5380
Cell Significance Index: 175.5200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 2.3508
Cell Significance Index: 81.6900
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.9690
Cell Significance Index: 51.7800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.8792
Cell Significance Index: 55.1900
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.8572
Cell Significance Index: 119.8200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.7831
Cell Significance Index: 210.2800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.7800
Cell Significance Index: 289.5000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.5211
Cell Significance Index: 91.3200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.3020
Cell Significance Index: 178.8000
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.1262
Cell Significance Index: 615.0500
Cell Name: odontoblast (CL0000060)
Fold Change: 1.0613
Cell Significance Index: 136.0500
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.0038
Cell Significance Index: 12.8600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.0008
Cell Significance Index: 11.3700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9716
Cell Significance Index: 119.4700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.8985
Cell Significance Index: 397.2400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8921
Cell Significance Index: 160.8200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.7367
Cell Significance Index: 52.1000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.7260
Cell Significance Index: 38.1200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4713
Cell Significance Index: 46.6200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4390
Cell Significance Index: 20.4700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3987
Cell Significance Index: 25.1300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3943
Cell Significance Index: 29.3900
Cell Name: lactocyte (CL0002325)
Fold Change: 0.3210
Cell Significance Index: 41.4800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3209
Cell Significance Index: 16.6700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2111
Cell Significance Index: 6.7600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.1888
Cell Significance Index: 5.0400
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.1740
Cell Significance Index: 3.0800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.1227
Cell Significance Index: 1.1300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1016
Cell Significance Index: 1.7000
Cell Name: peg cell (CL4033014)
Fold Change: 0.0848
Cell Significance Index: 1.9600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0788
Cell Significance Index: 15.0000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0761
Cell Significance Index: 12.9900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0557
Cell Significance Index: 42.1400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0491
Cell Significance Index: 2.3100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0442
Cell Significance Index: 1.1900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0425
Cell Significance Index: 8.4300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.0417
Cell Significance Index: 0.7700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0023
Cell Significance Index: -0.0600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0055
Cell Significance Index: -4.0800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0071
Cell Significance Index: -5.2000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0118
Cell Significance Index: -1.2100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0171
Cell Significance Index: -32.1200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0250
Cell Significance Index: -15.6300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0289
Cell Significance Index: -53.2600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0340
Cell Significance Index: -52.4000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0410
Cell Significance Index: -55.7100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0420
Cell Significance Index: -23.6900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0496
Cell Significance Index: -9.9600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0529
Cell Significance Index: -18.9700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0552
Cell Significance Index: -35.0300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0686
Cell Significance Index: -1.4600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0699
Cell Significance Index: -3.1700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0877
Cell Significance Index: -3.0800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0895
Cell Significance Index: -40.6000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1005
Cell Significance Index: -21.1700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1063
Cell Significance Index: -12.1800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1102
Cell Significance Index: -3.0800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1107
Cell Significance Index: -31.8400
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1123
Cell Significance Index: -2.8700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1876
Cell Significance Index: -9.7700
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1977
Cell Significance Index: -22.5700
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.1996
Cell Significance Index: -2.8000
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.2328
Cell Significance Index: -3.5400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2344
Cell Significance Index: -34.0700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3270
Cell Significance Index: -8.9000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3315
Cell Significance Index: -18.6000
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: -0.3378
Cell Significance Index: -2.0900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3856
Cell Significance Index: -23.7000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3865
Cell Significance Index: -30.6100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4280
Cell Significance Index: -44.5600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5514
Cell Significance Index: -16.2400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.5566
Cell Significance Index: -42.7100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.5697
Cell Significance Index: -15.2400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5886
Cell Significance Index: -36.0900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.5937
Cell Significance Index: -8.1000
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.6011
Cell Significance Index: -7.1700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.6165
Cell Significance Index: -41.4600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.6256
Cell Significance Index: -3.7800
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.6863
Cell Significance Index: -9.6200
Cell Name: glioblast (CL0000030)
Fold Change: -0.7055
Cell Significance Index: -4.4300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.7701
Cell Significance Index: -19.2500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.8342
Cell Significance Index: -12.5000
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -0.8831
Cell Significance Index: -5.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** POLR2G is a conserved subunit of the RNAP II complex, which is a multi-subunit enzyme responsible for transcribing DNA into RNA. The POLR2G subunit is encoded by the POLR2G gene and is highly similar to the RPB7 subunit found in other species. The POLR2G subunit is characterized by its ability to interact with other RNAP II subunits and facilitate the assembly of the transcriptional machinery. The gene is also known for its involvement in the regulation of gene expression, particularly in the context of viral infections, such as HIV-1. **Pathways and Functions** POLR2G is involved in several key pathways, including: 1. **Transcriptional regulation**: POLR2G is a critical component of the RNAP II complex, which is responsible for transcribing DNA into RNA. The gene is involved in the regulation of gene expression, particularly in the context of viral infections, such as HIV-1. 2. **Cell cycle regulation**: POLR2G has been implicated in the regulation of cell cycle progression, particularly in the context of DNA repair and replication. 3. **DNA repair**: The POLR2G subunit is involved in the repair of DNA damage, particularly in the context of nucleotide excision repair (NER) and base excision repair (BER). 4. **Signal transduction**: POLR2G has been implicated in several signal transduction pathways, including those involved in cell growth, differentiation, and survival. 5. **Viral infection**: The POLR2G subunit is involved in the regulation of viral transcription, particularly in the context of HIV-1. **Clinical Significance** The POLR2G gene has been implicated in several diseases and disorders, including: 1. **Cancer**: POLR2G has been implicated in the regulation of gene expression in cancer cells, particularly in the context of viral infections. 2. **Neurological disorders**: The POLR2G subunit has been implicated in the regulation of gene expression in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Infectious diseases**: POLR2G has been implicated in the regulation of viral transcription, particularly in the context of HIV-1 and other retroviruses. 4. **Developmental disorders**: The POLR2G subunit has been implicated in the regulation of gene expression in developmental disorders, such as Down syndrome. In summary, the POLR2G gene plays a critical role in the regulation of gene expression and transcription in eukaryotic cells. The gene is involved in several key pathways, including transcriptional regulation, cell cycle regulation, DNA repair, and signal transduction. The clinical significance of the POLR2G gene has been implicated in several diseases and disorders, including cancer, neurological disorders, infectious diseases, and developmental disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

DNA-directed RNA polymerase II subunit RPB7

Genular Protein ID: 3791887378

Symbol: RPB7_HUMAN

Name: DNA-directed RNA polymerase II subunit RPB7

UniProtKB Accession Codes:

P62487 B2R5C0 P52433 Q2M1Z4

Database IDs:

Citations:

PubMed ID: 7579693

Title: Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology.

PubMed ID: 7579693

DOI: 10.1091/mbc.6.7.759

PubMed ID: 9256063

Title: Human gene for the RNA polymerase II seventh subunit (hsRPB7): structure, expression and chromosomal localization.

PubMed ID: 9256063

DOI: 10.1016/s0167-4781(97)00041-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 16282592

Title: Crystal structure and RNA binding of the Rpb4/Rpb7 subunits of human RNA polymerase II.

PubMed ID: 16282592

DOI: 10.1093/nar/gki945

PubMed ID: 27193682

Title: Near-atomic resolution visualization of human transcription promoter opening.

PubMed ID: 27193682

DOI: 10.1038/nature17970

PubMed ID: 30190596

Title: Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.

PubMed ID: 30190596

DOI: 10.1038/s41594-018-0118-5

Sequence Information:

Length: 172
Mass: 19294
Checksum: AF3CE655F658CD5C
Sequence:

MFYHISLEHE ILLHPRYFGP NLLNTVKQKL FTEVEGTCTG KYGFVIAVTT IDNIGAGVIQ 
PGRGFVLYPV KYKAIVFRPF KGEVVDAVVT QVNKVGLFTE IGPMSCFISR HSIPSEMEFD 
PNSNPPCYKT MDEDIVIQQD DEIRLKIVGT RVDKNDIFAI GSLMDDYLGL VS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: POLR2G

Associated with

Cells (max top 100)

Other Information

Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology. PubMed ID: 7579693

Human gene for the RNA polymerase II seventh subunit (hsRPB7): structure, expression and chromosomal localization. PubMed ID: 9256063

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. PubMed ID: 9852112

Initial characterization of the human central proteome. PubMed ID: 21269460

Crystal structure and RNA binding of the Rpb4/Rpb7 subunits of human RNA polymerase II. PubMed ID: 16282592

Near-atomic resolution visualization of human transcription promoter opening. PubMed ID: 27193682

Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1. PubMed ID: 30190596