Gene POLR2K - ENSG00000147669 | NCBI Gene ID: 5440

Details for: POLR2K

Gene ID: 5440

Symbol: POLR2K

Ensembl ID: ENSG00000147669

Description: RNA polymerase II, I and III subunit K

Associated with

Abortive elongation of hiv-1 transcript in the absence of tat
(R-HSA-167242)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Chromosome maintenance
(R-HSA-73886)
Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Dna repair
(R-HSA-73894)
Dual incision in tc-ner
(R-HSA-6782135)
Epigenetic regulation of gene expression
(R-HSA-212165)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Fgfr2 alternative splicing
(R-HSA-6803529)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
Formation of the early elongation complex
(R-HSA-113418)
Formation of the hiv-1 early elongation complex
(R-HSA-167158)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hiv elongation arrest and recovery
(R-HSA-167287)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Hiv transcription initiation
(R-HSA-167161)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Innate immune system
(R-HSA-168249)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of rna
(R-HSA-8953854)
Microrna (mirna) biogenesis
(R-HSA-203927)
Mrna capping
(R-HSA-72086)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Mrna splicing - minor pathway
(R-HSA-72165)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleotide excision repair
(R-HSA-5696398)
Pausing and recovery of hiv elongation
(R-HSA-167290)
Pausing and recovery of tat-mediated hiv elongation
(R-HSA-167238)
Piwi-interacting rna (pirna) biogenesis
(R-HSA-5601884)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Rna pol ii ctd phosphorylation and interaction with ce
(R-HSA-77075)
Rna pol ii ctd phosphorylation and interaction with ce during hiv infection
(R-HSA-167160)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase iii abortive and retractive initiation
(R-HSA-749476)
Rna polymerase iii chain elongation
(R-HSA-73780)
Rna polymerase iii transcription
(R-HSA-74158)
Rna polymerase iii transcription initiation
(R-HSA-76046)
Rna polymerase iii transcription initiation from type 1 promoter
(R-HSA-76061)
Rna polymerase iii transcription initiation from type 2 promoter
(R-HSA-76066)
Rna polymerase iii transcription initiation from type 3 promoter
(R-HSA-76071)
Rna polymerase iii transcription termination
(R-HSA-73980)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Rna polymerase i transcription termination
(R-HSA-73863)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 iiia tm
(R-HSA-8851708)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tat-mediated hiv elongation arrest and recovery
(R-HSA-167243)
Telomere maintenance
(R-HSA-157579)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Viral messenger rna synthesis
(R-HSA-168325)
Dna binding
(GO:0003677)
Protein binding
(GO:0005515)
Rna polymerase i activity
(GO:0001054)
Rna polymerase ii activity
(GO:0001055)
Rna polymerase iii activity
(GO:0001056)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 2.63
Marker Score: 2746
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.33
Marker Score: 1838
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.25
Marker Score: 3726
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.24
Marker Score: 76142
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.16
Marker Score: 8324
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.11
Marker Score: 3385
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.1
Marker Score: 2356
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.06
Marker Score: 52652
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.05
Marker Score: 5658
Cell Name: decidual cell (CL2000002)
Fold Change: 2.05
Marker Score: 8820
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.04
Marker Score: 4992
Cell Name: supporting cell (CL0000630)
Fold Change: 2
Marker Score: 3758
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.98
Marker Score: 68421.5
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.95
Marker Score: 4072
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.92
Marker Score: 3051
Cell Name: mature T cell (CL0002419)
Fold Change: 1.89
Marker Score: 18715
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.89
Marker Score: 9921
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.87
Marker Score: 4711
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.87
Marker Score: 24617
Cell Name: lung secretory cell (CL1000272)
Fold Change: 1.84
Marker Score: 1641
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.83
Marker Score: 1861
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.83
Marker Score: 3723
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.82
Marker Score: 6751
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.82
Marker Score: 1922
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.82
Marker Score: 7138
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.8
Marker Score: 2769
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.79
Marker Score: 2579
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.79
Marker Score: 2942
Cell Name: secretory cell (CL0000151)
Fold Change: 1.78
Marker Score: 3252
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.78
Marker Score: 3026.5
Cell Name: retinal rod cell (CL0000604)
Fold Change: 1.78
Marker Score: 5075
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.78
Marker Score: 4766
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.78
Marker Score: 1897
Cell Name: kidney cell (CL1000497)
Fold Change: 1.77
Marker Score: 1183
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.77
Marker Score: 15245
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.76
Marker Score: 624
Cell Name: club cell (CL0000158)
Fold Change: 1.75
Marker Score: 2043
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.74
Marker Score: 3470
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 1.73
Marker Score: 925
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.73
Marker Score: 1233
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 1.73
Marker Score: 597
Cell Name: serous secreting cell (CL0000313)
Fold Change: 1.72
Marker Score: 688
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.72
Marker Score: 1839
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.72
Marker Score: 1618
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.72
Marker Score: 947
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.72
Marker Score: 6103
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.71
Marker Score: 4653
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.71
Marker Score: 881
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.71
Marker Score: 19262
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.7
Marker Score: 11098
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.69
Marker Score: 1703
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.69
Marker Score: 2486
Cell Name: chondrocyte (CL0000138)
Fold Change: 1.69
Marker Score: 759
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.68
Marker Score: 6863
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1.67
Marker Score: 622
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.67
Marker Score: 3781
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.66
Marker Score: 4924
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 1.66
Marker Score: 782
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.64
Marker Score: 2321
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.63
Marker Score: 389
Cell Name: peptic cell (CL0000155)
Fold Change: 1.63
Marker Score: 681
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 1.63
Marker Score: 1019
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 1.63
Marker Score: 2117
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.62
Marker Score: 468
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.62
Marker Score: 1015
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.61
Marker Score: 1019
Cell Name: radial glial cell (CL0000681)
Fold Change: 1.61
Marker Score: 594.5
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.61
Marker Score: 541
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.61
Marker Score: 1938.5
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.6
Marker Score: 1251
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.59
Marker Score: 3752
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.58
Marker Score: 1680
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 1.58
Marker Score: 1491
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.58
Marker Score: 7742.5
Cell Name: granulocyte (CL0000094)
Fold Change: 1.57
Marker Score: 706
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.57
Marker Score: 392
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.57
Marker Score: 469
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.57
Marker Score: 1232
Cell Name: plasmablast (CL0000980)
Fold Change: 1.57
Marker Score: 2087
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.57
Marker Score: 368
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.56
Marker Score: 392
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.56
Marker Score: 528
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.56
Marker Score: 1310
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.55
Marker Score: 645
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.54
Marker Score: 888
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.54
Marker Score: 1051
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.54
Marker Score: 2184
Cell Name: malignant cell (CL0001064)
Fold Change: 1.54
Marker Score: 20669
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.54
Marker Score: 1448
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 1.54
Marker Score: 795
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.53
Marker Score: 9773
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.53
Marker Score: 1649
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 1.52
Marker Score: 402.5
Cell Name: enteric neuron (CL0007011)
Fold Change: 1.52
Marker Score: 808
Cell Name: stem cell (CL0000034)
Fold Change: 1.51
Marker Score: 3598
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.51
Marker Score: 715
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.5
Marker Score: 2173
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.5
Marker Score: 395
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 1.5
Marker Score: 4370
Cell Name: motor neuron (CL0000100)
Fold Change: 1.5
Marker Score: 888

Hover over a box to see details here...

**Key Characteristics** POLR2K is a subunit of RNA polymerase II, which is a multi-subunit enzyme composed of five polypeptides (RPA1, RPB1, RPB2, RPB3, and RPB5). POLR2K is specifically involved in the transcriptional regulation of HIV-1 and has been shown to interact with other proteins, such as the HIV-1 transactivator protein (Tat), to facilitate viral transcription. POLR2K is also involved in the regulation of cellular gene expression, particularly in the context of gene silencing and the processing of pre-mRNA. **Pathways and Functions** POLR2K is involved in various cellular pathways, including: 1. **Transcriptional regulation**: POLR2K plays a key role in the regulation of gene expression, particularly in the context of HIV-1 transcription. It interacts with other proteins, such as Tat, to facilitate viral transcription. 2. **Cell cycle regulation**: POLR2K is involved in the regulation of the cell cycle, particularly in the context of DNA repair and chromatin maintenance. 3. **DNA repair**: POLR2K is involved in the repair of DNA damage, particularly in the context of nucleotide excision repair (NER) and mismatch repair. 4. **Chromatin maintenance**: POLR2K is involved in the maintenance of chromatin structure and function, particularly in the context of histone modification and epigenetic regulation. 5. **HIV-1 life cycle**: POLR2K is specifically involved in the regulation of HIV-1 transcription and has been implicated in the development of HIV-1 resistance to antiretroviral therapy. **Clinical Significance** POLR2K has significant clinical implications, particularly in the context of HIV-1 infection and cancer. Studies have shown that POLR2K is involved in the regulation of HIV-1 transcription and that alterations in POLR2K expression or function can impact viral replication and disease progression. Additionally, POLR2K has been implicated in the development of certain cancers, including breast and lung cancer, where it may play a role in the regulation of gene expression and chromatin maintenance. In conclusion, POLR2K is a critical component of the RNA polymerase II complex, which plays a central role in the regulation of gene expression and the transcription of protein-coding genes in eukaryotic cells. Its involvement in the regulation of HIV-1 transcription and its role in various cellular pathways make it a significant target for the development of novel therapeutic strategies for HIV-1 infection and cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

DNA-directed RNA polymerases I, II, and III subunit RPABC4

Genular Protein ID: 2049522235

Symbol: RPAB4_HUMAN

Name: DNA-directed RNA polymerases I, II, and III subunit RPABC4

UniProtKB Accession Codes:

P53803 Q6IBD4

Database IDs:

Citations:

PubMed ID: 7651387

Title: Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae.

PubMed ID: 7651387

DOI: 10.1128/mcb.15.9.4702

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20413673

Title: Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells.

PubMed ID: 20413673

DOI: 10.1101/gr.101337.109

PubMed ID: 33335104

Title: Structure of human RNA polymerase III.

PubMed ID: 33335104

DOI: 10.1038/s41467-020-20262-5

PubMed ID: 33674783

Title: Structure of human RNA polymerase III elongation complex.

PubMed ID: 33674783

DOI: 10.1038/s41422-021-00472-2

PubMed ID: 34675218

Title: Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine.

PubMed ID: 34675218

DOI: 10.1038/s41467-021-26402-9

PubMed ID: 33558764

Title: Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.

PubMed ID: 33558764

DOI: 10.1038/s41594-020-00555-5

PubMed ID: 33558766

Title: Structural insights into transcriptional regulation of human RNA polymerase III.

PubMed ID: 33558766

DOI: 10.1038/s41594-021-00557-x

Sequence Information:

Length: 58
Mass: 7004
Checksum: 239BA3A67416F02C
Sequence:

MDTQKDVQPP KQQPMIYICG ECHTENEIKS RDPIRCRECG YRIMYKKRTK RLVVFDAR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: POLR2K

Associated with

Cells (max top 100)

Other Information

Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. PubMed ID: 7651387

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells. PubMed ID: 20413673

Structure of human RNA polymerase III. PubMed ID: 33335104

Structure of human RNA polymerase III elongation complex. PubMed ID: 33674783

Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine. PubMed ID: 34675218

Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. PubMed ID: 33558764

Structural insights into transcriptional regulation of human RNA polymerase III. PubMed ID: 33558766