POLR2K | ENSG00000147669 | NCBI 5440

Details for: POLR2K

Gene ID: 5440

Symbol: POLR2K

Ensembl ID: ENSG00000147669

Description: RNA polymerase II, I and III subunit K

Associated with

Abortive elongation of hiv-1 transcript in the absence of tat
(R-HSA-167242)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Chromosome maintenance
(R-HSA-73886)
Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Dna repair
(R-HSA-73894)
Dual incision in tc-ner
(R-HSA-6782135)
Epigenetic regulation of gene expression
(R-HSA-212165)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Fgfr2 alternative splicing
(R-HSA-6803529)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
Formation of the early elongation complex
(R-HSA-113418)
Formation of the hiv-1 early elongation complex
(R-HSA-167158)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hiv elongation arrest and recovery
(R-HSA-167287)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Hiv transcription initiation
(R-HSA-167161)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Innate immune system
(R-HSA-168249)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of rna
(R-HSA-8953854)
Microrna (mirna) biogenesis
(R-HSA-203927)
Mrna capping
(R-HSA-72086)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Mrna splicing - minor pathway
(R-HSA-72165)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleotide excision repair
(R-HSA-5696398)
Pausing and recovery of hiv elongation
(R-HSA-167290)
Pausing and recovery of tat-mediated hiv elongation
(R-HSA-167238)
Piwi-interacting rna (pirna) biogenesis
(R-HSA-5601884)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Rna pol ii ctd phosphorylation and interaction with ce
(R-HSA-77075)
Rna pol ii ctd phosphorylation and interaction with ce during hiv infection
(R-HSA-167160)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase iii abortive and retractive initiation
(R-HSA-749476)
Rna polymerase iii chain elongation
(R-HSA-73780)
Rna polymerase iii transcription
(R-HSA-74158)
Rna polymerase iii transcription initiation
(R-HSA-76046)
Rna polymerase iii transcription initiation from type 1 promoter
(R-HSA-76061)
Rna polymerase iii transcription initiation from type 2 promoter
(R-HSA-76066)
Rna polymerase iii transcription initiation from type 3 promoter
(R-HSA-76071)
Rna polymerase iii transcription termination
(R-HSA-73980)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Rna polymerase i transcription termination
(R-HSA-73863)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 iiia tm
(R-HSA-8851708)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tat-mediated hiv elongation arrest and recovery
(R-HSA-167243)
Telomere maintenance
(R-HSA-157579)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Viral messenger rna synthesis
(R-HSA-168325)
Dna binding
(GO:0003677)
Protein binding
(GO:0005515)
Rna polymerase i activity
(GO:0001054)
Rna polymerase ii activity
(GO:0001055)
Rna polymerase iii activity
(GO:0001056)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 261.3388
Cell Significance Index: -40.6500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 186.8371
Cell Significance Index: -47.3900
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 140.9403
Cell Significance Index: -58.0600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 121.6633
Cell Significance Index: -57.4400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 107.7791
Cell Significance Index: -55.4400
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 86.1969
Cell Significance Index: -57.8400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 44.7218
Cell Significance Index: -55.1400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.8695
Cell Significance Index: -47.8700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 14.9010
Cell Significance Index: -58.8000
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.1501
Cell Significance Index: -40.3900
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.5345
Cell Significance Index: -16.4900
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 2.3293
Cell Significance Index: 14.3400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 2.2107
Cell Significance Index: 359.5500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.8391
Cell Significance Index: 137.0700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.5503
Cell Significance Index: 32.4500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.5488
Cell Significance Index: 212.7000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.5372
Cell Significance Index: 41.8400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.4958
Cell Significance Index: 69.7400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.4503
Cell Significance Index: 178.3300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.4357
Cell Significance Index: 67.4800
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.4142
Cell Significance Index: 772.3500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.3807
Cell Significance Index: 39.5800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.3069
Cell Significance Index: 12.0400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.2875
Cell Significance Index: 67.6000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.2688
Cell Significance Index: 44.0900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.2405
Cell Significance Index: 146.2900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.2253
Cell Significance Index: 220.8800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.2231
Cell Significance Index: 540.7800
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.0150
Cell Significance Index: 26.6900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.9590
Cell Significance Index: 67.8300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.9524
Cell Significance Index: 10.8200
Cell Name: lactocyte (CL0002325)
Fold Change: 0.9090
Cell Significance Index: 117.4400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.9071
Cell Significance Index: 57.1700
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.8683
Cell Significance Index: 9.4400
Cell Name: odontoblast (CL0000060)
Fold Change: 0.7918
Cell Significance Index: 101.5100
Cell Name: kidney cell (CL1000497)
Fold Change: 0.7853
Cell Significance Index: 6.2700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.6667
Cell Significance Index: 19.5800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6591
Cell Significance Index: 34.2400
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.5746
Cell Significance Index: 37.0700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5216
Cell Significance Index: 51.6000
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.3924
Cell Significance Index: 6.9400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3139
Cell Significance Index: 6.8000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2842
Cell Significance Index: 54.0900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.2241
Cell Significance Index: 64.4700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2169
Cell Significance Index: 43.5100
Cell Name: peg cell (CL4033014)
Fold Change: 0.2138
Cell Significance Index: 4.9400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.2127
Cell Significance Index: 5.6800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1954
Cell Significance Index: 33.3700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1628
Cell Significance Index: 7.3800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1614
Cell Significance Index: 32.0300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1034
Cell Significance Index: 78.2800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0322
Cell Significance Index: 23.6000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0239
Cell Significance Index: 0.4000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0028
Cell Significance Index: -2.0500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0043
Cell Significance Index: -1.5500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0101
Cell Significance Index: -6.3300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0217
Cell Significance Index: -40.8300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0374
Cell Significance Index: -69.0400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0379
Cell Significance Index: -3.8700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0443
Cell Significance Index: -68.1300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0481
Cell Significance Index: -27.1300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0515
Cell Significance Index: -70.0000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0709
Cell Significance Index: -45.0000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0972
Cell Significance Index: -20.4800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1135
Cell Significance Index: -51.5100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1406
Cell Significance Index: -16.3900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2162
Cell Significance Index: -24.7700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.2176
Cell Significance Index: -6.2700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2282
Cell Significance Index: -4.8600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2889
Cell Significance Index: -7.3800
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2943
Cell Significance Index: -2.4000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3518
Cell Significance Index: -51.1400
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3727
Cell Significance Index: -42.5500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3922
Cell Significance Index: -31.0600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4028
Cell Significance Index: -12.9000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4123
Cell Significance Index: -11.0300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4958
Cell Significance Index: -13.8600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.5270
Cell Significance Index: -31.6400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5550
Cell Significance Index: -34.1100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5689
Cell Significance Index: -59.2400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.5805
Cell Significance Index: -7.9200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.6734
Cell Significance Index: -18.0500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.7026
Cell Significance Index: -53.9200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.7140
Cell Significance Index: -48.0100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.7692
Cell Significance Index: -27.0300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.7787
Cell Significance Index: -4.7100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.7854
Cell Significance Index: -44.0700
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.8213
Cell Significance Index: -9.7900
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.8345
Cell Significance Index: -7.0100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.8838
Cell Significance Index: -16.3400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9388
Cell Significance Index: -57.5600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.9744
Cell Significance Index: -28.7000
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -1.0651
Cell Significance Index: -8.2100
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.1345
Cell Significance Index: -17.0000
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -1.2495
Cell Significance Index: -12.9400
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.2517
Cell Significance Index: -45.9500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.2717
Cell Significance Index: -56.2500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.2764
Cell Significance Index: -32.8100
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.4280
Cell Significance Index: -50.0300
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -1.4774
Cell Significance Index: -18.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** POLR2K is a subunit of RNA polymerase II, which is a multi-subunit enzyme composed of five polypeptides (RPA1, RPB1, RPB2, RPB3, and RPB5). POLR2K is specifically involved in the transcriptional regulation of HIV-1 and has been shown to interact with other proteins, such as the HIV-1 transactivator protein (Tat), to facilitate viral transcription. POLR2K is also involved in the regulation of cellular gene expression, particularly in the context of gene silencing and the processing of pre-mRNA. **Pathways and Functions** POLR2K is involved in various cellular pathways, including: 1. **Transcriptional regulation**: POLR2K plays a key role in the regulation of gene expression, particularly in the context of HIV-1 transcription. It interacts with other proteins, such as Tat, to facilitate viral transcription. 2. **Cell cycle regulation**: POLR2K is involved in the regulation of the cell cycle, particularly in the context of DNA repair and chromatin maintenance. 3. **DNA repair**: POLR2K is involved in the repair of DNA damage, particularly in the context of nucleotide excision repair (NER) and mismatch repair. 4. **Chromatin maintenance**: POLR2K is involved in the maintenance of chromatin structure and function, particularly in the context of histone modification and epigenetic regulation. 5. **HIV-1 life cycle**: POLR2K is specifically involved in the regulation of HIV-1 transcription and has been implicated in the development of HIV-1 resistance to antiretroviral therapy. **Clinical Significance** POLR2K has significant clinical implications, particularly in the context of HIV-1 infection and cancer. Studies have shown that POLR2K is involved in the regulation of HIV-1 transcription and that alterations in POLR2K expression or function can impact viral replication and disease progression. Additionally, POLR2K has been implicated in the development of certain cancers, including breast and lung cancer, where it may play a role in the regulation of gene expression and chromatin maintenance. In conclusion, POLR2K is a critical component of the RNA polymerase II complex, which plays a central role in the regulation of gene expression and the transcription of protein-coding genes in eukaryotic cells. Its involvement in the regulation of HIV-1 transcription and its role in various cellular pathways make it a significant target for the development of novel therapeutic strategies for HIV-1 infection and cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

DNA-directed RNA polymerases I, II, and III subunit RPABC4

Genular Protein ID: 2049522235

Symbol: RPAB4_HUMAN

Name: DNA-directed RNA polymerases I, II, and III subunit RPABC4

UniProtKB Accession Codes:

P53803 Q6IBD4

Database IDs:

Citations:

PubMed ID: 7651387

Title: Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae.

PubMed ID: 7651387

DOI: 10.1128/mcb.15.9.4702

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20413673

Title: Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells.

PubMed ID: 20413673

DOI: 10.1101/gr.101337.109

PubMed ID: 27193682

Title: Near-atomic resolution visualization of human transcription promoter opening.

PubMed ID: 27193682

DOI: 10.1038/nature17970

PubMed ID: 30190596

Title: Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.

PubMed ID: 30190596

DOI: 10.1038/s41594-018-0118-5

PubMed ID: 33335104

Title: Structure of human RNA polymerase III.

PubMed ID: 33335104

DOI: 10.1038/s41467-020-20262-5

PubMed ID: 34671025

Title: Structure of the human RNA polymerase I elongation complex.

PubMed ID: 34671025

DOI: 10.1038/s41421-021-00335-5

PubMed ID: 33674783

Title: Structure of human RNA polymerase III elongation complex.

PubMed ID: 33674783

DOI: 10.1038/s41422-021-00472-2

PubMed ID: 34675218

Title: Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine.

PubMed ID: 34675218

DOI: 10.1038/s41467-021-26402-9

PubMed ID: 33558764

Title: Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.

PubMed ID: 33558764

DOI: 10.1038/s41594-020-00555-5

PubMed ID: 34887565

Title: Cryo-EM structures of human RNA polymerase I.

PubMed ID: 34887565

DOI: 10.1038/s41594-021-00693-4

PubMed ID: 33558766

Title: Structural insights into transcriptional regulation of human RNA polymerase III.

PubMed ID: 33558766

DOI: 10.1038/s41594-021-00557-x

PubMed ID: 36271492

Title: The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans.

PubMed ID: 36271492

DOI: 10.26508/lsa.202201568

Sequence Information:

Length: 58
Mass: 7004
Checksum: 239BA3A67416F02C
Sequence:

MDTQKDVQPP KQQPMIYICG ECHTENEIKS RDPIRCRECG YRIMYKKRTK RLVVFDAR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: POLR2K

Associated with

Cells (max top 100)

Other Information

Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. PubMed ID: 7651387

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells. PubMed ID: 20413673

Near-atomic resolution visualization of human transcription promoter opening. PubMed ID: 27193682

Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1. PubMed ID: 30190596

Structure of human RNA polymerase III. PubMed ID: 33335104

Structure of the human RNA polymerase I elongation complex. PubMed ID: 34671025

Structure of human RNA polymerase III elongation complex. PubMed ID: 33674783

Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine. PubMed ID: 34675218

Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. PubMed ID: 33558764

Cryo-EM structures of human RNA polymerase I. PubMed ID: 34887565

Structural insights into transcriptional regulation of human RNA polymerase III. PubMed ID: 33558766

The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans. PubMed ID: 36271492