Details for: POU3F3

Gene ID: 5455

Symbol: POU3F3

Ensembl ID: ENSG00000198914

Description: POU class 3 homeobox 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 17.9895
    Cell Significance Index: 489.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1530
    Cell Significance Index: 70.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4196
    Cell Significance Index: 150.4900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.4173
    Cell Significance Index: 5.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2268
    Cell Significance Index: 65.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0673
    Cell Significance Index: 49.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0630
    Cell Significance Index: 1.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0005
    Cell Significance Index: 0.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0224
    Cell Significance Index: -15.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0308
    Cell Significance Index: -13.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0402
    Cell Significance Index: -4.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0765
    Cell Significance Index: -56.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0990
    Cell Significance Index: -54.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1003
    Cell Significance Index: -56.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1065
    Cell Significance Index: -21.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1071
    Cell Significance Index: -13.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1868
    Cell Significance Index: -8.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3706
    Cell Significance Index: -23.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3746
    Cell Significance Index: -29.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3756
    Cell Significance Index: -48.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4072
    Cell Significance Index: -48.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4462
    Cell Significance Index: -9.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4511
    Cell Significance Index: -51.6900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4877
    Cell Significance Index: -12.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5215
    Cell Significance Index: -27.0900
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.5271
    Cell Significance Index: -5.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6533
    Cell Significance Index: -48.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6794
    Cell Significance Index: -98.7600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.7107
    Cell Significance Index: -9.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7142
    Cell Significance Index: -48.0200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.7161
    Cell Significance Index: -8.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7342
    Cell Significance Index: -47.3700
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.7804
    Cell Significance Index: -9.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8147
    Cell Significance Index: -62.5200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.8433
    Cell Significance Index: -13.5300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.8608
    Cell Significance Index: -8.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8919
    Cell Significance Index: -54.6800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.9510
    Cell Significance Index: -6.8300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.9559
    Cell Significance Index: -8.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9808
    Cell Significance Index: -28.8900
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.9842
    Cell Significance Index: -8.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9862
    Cell Significance Index: -16.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.0276
    Cell Significance Index: -48.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.0681
    Cell Significance Index: -48.4200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -1.1069
    Cell Significance Index: -11.4800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.1333
    Cell Significance Index: -12.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.1377
    Cell Significance Index: -63.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.2055
    Cell Significance Index: -41.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.2481
    Cell Significance Index: -65.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.2953
    Cell Significance Index: -25.2800
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -1.4199
    Cell Significance Index: -13.8800
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -1.4929
    Cell Significance Index: -20.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.5186
    Cell Significance Index: -53.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.5402
    Cell Significance Index: -39.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.5650
    Cell Significance Index: -44.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.5673
    Cell Significance Index: -41.8500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.5953
    Cell Significance Index: -38.6400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -1.5966
    Cell Significance Index: -13.5700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -1.5974
    Cell Significance Index: -14.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.6136
    Cell Significance Index: -18.3300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.6398
    Cell Significance Index: -19.1300
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -1.6807
    Cell Significance Index: -13.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.6926
    Cell Significance Index: -48.5200
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -1.7294
    Cell Significance Index: -13.7600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.7316
    Cell Significance Index: -29.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.7423
    Cell Significance Index: -55.4900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -1.7547
    Cell Significance Index: -10.3000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.7813
    Cell Significance Index: -13.7300
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -1.8060
    Cell Significance Index: -13.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.8363
    Cell Significance Index: -60.1200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.9600
    Cell Significance Index: -39.3500
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: -1.9770
    Cell Significance Index: -10.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -2.0267
    Cell Significance Index: -40.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -2.0451
    Cell Significance Index: -44.7800
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -2.0556
    Cell Significance Index: -12.8200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -2.0847
    Cell Significance Index: -12.7700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -2.0958
    Cell Significance Index: -45.2800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.0992
    Cell Significance Index: -77.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.1355
    Cell Significance Index: -57.2200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -2.1538
    Cell Significance Index: -24.6500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -2.1656
    Cell Significance Index: -46.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.1793
    Cell Significance Index: -58.3000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -2.2137
    Cell Significance Index: -43.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -2.2173
    Cell Significance Index: -58.3100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -2.2416
    Cell Significance Index: -9.7600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -2.2549
    Cell Significance Index: -25.9700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -2.2580
    Cell Significance Index: -56.3300
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -2.3672
    Cell Significance Index: -12.8300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -2.3822
    Cell Significance Index: -19.0200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -2.4780
    Cell Significance Index: -48.4500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -2.4804
    Cell Significance Index: -42.4000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -2.4921
    Cell Significance Index: -25.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -2.4924
    Cell Significance Index: -87.5800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -2.4975
    Cell Significance Index: -28.9700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -2.5505
    Cell Significance Index: -47.1400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -2.5605
    Cell Significance Index: -53.4400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -2.5634
    Cell Significance Index: -30.6600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -2.5765
    Cell Significance Index: -43.7600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -2.6703
    Cell Significance Index: -56.6800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -2.7339
    Cell Significance Index: -55.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** POU3F3 is a transcription factor that belongs to the POU domain-containing family, which is composed of homeobox-containing proteins that regulate development and differentiation. Key characteristics of POU3F3 include: 1. **POU domain**: The POU domain is a conserved structural motif that is characteristic of POU domain-containing proteins. This domain is essential for the DNA-binding activity of POU3F3. 2. **Sequence-specific DNA binding**: POU3F3 binds to specific DNA sequences, which are typically located in the promoter regions of target genes. 3. **Transcriptional regulation**: POU3F3 regulates gene expression by influencing the transcriptional activity of target genes. **Pathways and Functions:** POU3F3 is involved in various cellular processes, including: 1. **Central nervous system development**: POU3F3 is essential for the development of the central nervous system, particularly in the formation of the cerebral cortex and the radial orientation of cell migration. 2. **Kidney development**: POU3F3 plays a crucial role in the development of the kidney, including the formation of the metanephric kidney and the differentiation of renal cells. 3. **Chemical homeostasis**: POU3F3 is involved in the regulation of chemical homeostasis, particularly in the kidneys, where it regulates the expression of genes involved in urea transport and excretion. 4. **Cell proliferation and differentiation**: POU3F3 regulates cell proliferation and differentiation in various cell types, including erythrocytes, blood vessel endothelial cells, and kidney epithelial cells. **Clinical Significance:** Dysregulation of POU3F3 has been implicated in various diseases, including: 1. **Kidney disorders**: Mutations in POU3F3 have been associated with kidney disorders, such as renal agenesis and renal dysplasia. 2. **Neurological disorders**: POU3F3 has been implicated in neurological disorders, including cerebral cortex disorders and autism spectrum disorder. 3. **Cancer**: POU3F3 has been shown to be involved in the regulation of cell proliferation and differentiation in cancer cells, suggesting its potential role as a tumor suppressor gene. In conclusion, POU3F3 is a crucial transcription factor that plays a pivotal role in various cellular processes, including development, differentiation, and function. Its dysregulation has been implicated in various diseases, highlighting the importance of further research on this gene.

Genular Protein ID: 2984107597

Symbol: PO3F3_HUMAN

Name: Brain-specific homeobox/POU domain protein 1

UniProtKB Accession Codes:

P20264 P78379 Q4ZG25

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 GO 26 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8703082

Title: Class III POU genes: generation of homopolymeric amino acid repeats under GC pressure in mammals.

PubMed ID: 8703082

DOI: 10.1007/bf02338824

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 2739723

Title: Expression of a large family of POU-domain regulatory genes in mammalian brain development.

PubMed ID: 2739723

DOI: 10.1038/340035a0

PubMed ID: 31303265

Title: De Novo Variants Disturbing the Transactivation Capacity of POU3F3 Cause a Characteristic Neurodevelopmental Disorder.

PubMed ID: 31303265

DOI: 10.1016/j.ajhg.2019.06.007

Sequence Information:

  • Length: 500
  • Mass: 50327
  • Checksum: E536EFFFA5212319
  • Sequence:
    • MATAASNPYL PGNSLLAAGS IVHSDAAGAG GGGGGGGGGG GGGAGGGGGG MQPGSAAVTS 
GAYRGDPSSV KMVQSDFMQG AMAASNGGHM LSHAHQWVTA LPHAAAAAAA AAAAAVEASS 
PWSGSAVGMA GSPQQPPQPP PPPPQGPDVK GGAGRDDLHA GTALHHRGPP HLGPPPPPPH 
QGHPGGWGAA AAAAAAAAAA AAAAHLPSMA GGQQPPPQSL LYSQPGGFTV NGMLSAPPGP 
GGGGGGAGGG AQSLVHPGLV RGDTPELAEH HHHHHHHAHP HPPHPHHAQG PPHHGGGGGG 
AGPGLNSHDP HSDEDTPTSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL YGNVFSQTTI 
CRFEALQLSF KNMCKLKPLL NKWLEEADSS TGSPTSIDKI AAQGRKRKKR TSIEVSVKGA 
LESHFLKCPK PSAQEITNLA DSLQLEKEVV RVWFCNRRQK EKRMTPPGIQ QQTPDDVYSQ 
VGTVSADTPP PHHGLQTSVQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.