Details for: PPAT

Gene ID: 5471

Symbol: PPAT

Ensembl ID: ENSG00000128059

Description: phosphoribosyl pyrophosphate amidotransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 95.7278
    Cell Significance Index: -14.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 57.2457
    Cell Significance Index: -14.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 36.5040
    Cell Significance Index: -14.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.5366
    Cell Significance Index: -16.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.3348
    Cell Significance Index: -16.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3157
    Cell Significance Index: -17.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.9297
    Cell Significance Index: -12.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1095
    Cell Significance Index: 109.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9441
    Cell Significance Index: 25.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8867
    Cell Significance Index: 177.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7767
    Cell Significance Index: 46.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7201
    Cell Significance Index: 142.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6676
    Cell Significance Index: 72.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6516
    Cell Significance Index: 75.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5700
    Cell Significance Index: 92.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5520
    Cell Significance Index: 498.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5448
    Cell Significance Index: 14.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4169
    Cell Significance Index: 149.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3925
    Cell Significance Index: 10.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3746
    Cell Significance Index: 21.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3657
    Cell Significance Index: 10.7700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3505
    Cell Significance Index: 3.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3452
    Cell Significance Index: 4.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3222
    Cell Significance Index: 8.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2648
    Cell Significance Index: 18.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2586
    Cell Significance Index: 6.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2574
    Cell Significance Index: 140.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2238
    Cell Significance Index: 30.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2159
    Cell Significance Index: 149.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2006
    Cell Significance Index: 13.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1999
    Cell Significance Index: 5.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1838
    Cell Significance Index: 81.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1741
    Cell Significance Index: 7.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1705
    Cell Significance Index: 20.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1615
    Cell Significance Index: 3.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1537
    Cell Significance Index: 9.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1532
    Cell Significance Index: 3.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1511
    Cell Significance Index: 5.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1504
    Cell Significance Index: 27.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1418
    Cell Significance Index: 10.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1387
    Cell Significance Index: 6.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1206
    Cell Significance Index: 4.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0990
    Cell Significance Index: 11.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0882
    Cell Significance Index: 4.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0853
    Cell Significance Index: 5.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0634
    Cell Significance Index: 12.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0592
    Cell Significance Index: 0.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0497
    Cell Significance Index: 2.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0482
    Cell Significance Index: 6.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0311
    Cell Significance Index: 1.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0294
    Cell Significance Index: 3.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0217
    Cell Significance Index: 0.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0202
    Cell Significance Index: 1.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0127
    Cell Significance Index: 0.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0106
    Cell Significance Index: 20.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0071
    Cell Significance Index: 0.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0062
    Cell Significance Index: 9.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0035
    Cell Significance Index: 6.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0016
    Cell Significance Index: 2.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0056
    Cell Significance Index: -0.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0064
    Cell Significance Index: -4.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0113
    Cell Significance Index: -8.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0116
    Cell Significance Index: -1.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0152
    Cell Significance Index: -11.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0180
    Cell Significance Index: -13.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0198
    Cell Significance Index: -8.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0243
    Cell Significance Index: -13.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0307
    Cell Significance Index: -19.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0354
    Cell Significance Index: -5.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0479
    Cell Significance Index: -13.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0527
    Cell Significance Index: -4.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0561
    Cell Significance Index: -5.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0571
    Cell Significance Index: -1.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0640
    Cell Significance Index: -4.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0648
    Cell Significance Index: -2.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0763
    Cell Significance Index: -1.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0770
    Cell Significance Index: -1.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0828
    Cell Significance Index: -17.4500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0828
    Cell Significance Index: -1.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0925
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1277
    Cell Significance Index: -14.6300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1466
    Cell Significance Index: -0.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1573
    Cell Significance Index: -16.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1661
    Cell Significance Index: -8.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1844
    Cell Significance Index: -14.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1901
    Cell Significance Index: -5.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1965
    Cell Significance Index: -12.0500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2069
    Cell Significance Index: -1.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2138
    Cell Significance Index: -6.2800
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2159
    Cell Significance Index: -1.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2211
    Cell Significance Index: -4.7900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2214
    Cell Significance Index: -3.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2862
    Cell Significance Index: -7.6600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2879
    Cell Significance Index: -2.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2993
    Cell Significance Index: -9.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3036
    Cell Significance Index: -9.6700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3205
    Cell Significance Index: -4.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3293
    Cell Significance Index: -7.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3315
    Cell Significance Index: -8.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3316
    Cell Significance Index: -7.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PPAT is a cytosolic enzyme that exhibits Amidophosphoribosyltransferase activity, which involves the transfer of an amidino group from glutamine to phosphoribosyl pyrophosphate (PRPP). This reaction is a critical step in the de novo biosynthesis of purine and pyrimidine nucleotides. PPAT is also bound to four iron and four sulfur clusters, which are essential for its enzymatic activity. The enzyme is significantly expressed in various cell types, including germ cells, gut endothelial cells, and neural progenitor cells, suggesting its widespread involvement in cellular processes. **Pathways and Functions:** PPAT is integral to several metabolic pathways, including: 1. **De novo purine biosynthesis:** PPAT catalyzes the transfer of an amidino group from glutamine to PRPP, generating carbamoyl phosphate and glutamine. This reaction is a crucial step in the de novo synthesis of purine nucleotides. 2. **De novo pyrimidine biosynthesis:** Although less well-characterized, PPAT may also participate in the de novo biosynthesis of pyrimidine nucleotides. 3. **Glutamine metabolic process:** PPAT is involved in the regulation of glutamine metabolism, which is essential for maintaining cellular homeostasis. 4. **Metal ion binding:** The four iron and four sulfur clusters bound to PPAT are involved in metal ion binding, which is critical for the enzyme's enzymatic activity. **Clinical Significance:** The dysregulation of PPAT has been implicated in various diseases, including: 1. **Cancer:** Altered expression of PPAT has been observed in certain types of cancer, suggesting its potential role in tumorigenesis. 2. **Neurological disorders:** PPAT has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation may contribute to disease pathology. 3. **Immunological disorders:** PPAT may play a role in immunological disorders, such as autoimmune diseases, where its dysregulation can lead to immune system dysfunction. In conclusion, PPAT is a complex enzyme that plays a crucial role in nucleotide biosynthesis, metabolism, and metal ion binding. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms and potential therapeutic applications. As an expert immunologist, it is essential to continue exploring the intricacies of PPAT to unravel its full potential in the field of immunology.

Genular Protein ID: 3726849728

Symbol: PUR1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q06203

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 2 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8380692

Title: Molecular cloning of human amidophosphoribosyltransferase.

PubMed ID: 8380692

DOI: 10.1006/bbrc.1993.1030

PubMed ID: 8106516

Title: Two genes for de novo purine nucleotide synthesis on human chromosome 4 are closely linked and divergently transcribed.

PubMed ID: 8106516

DOI: 10.1016/s0021-9258(17)37689-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 517
  • Mass: 57399
  • Checksum: D3F2A354C36B29D9
  • Sequence:
    • MELEELGIRE ECGVFGCIAS GEWPTQLDVP HVITLGLVGL QHRGQESAGI VTSDGSSVPT 
FKSHKGMGLV NHVFTEDNLK KLYVSNLGIG HTRYATTGKC ELENCQPFVV ETLHGKIAVA 
HNGELVNAAR LRKKLLRHGI GLSTSSDSEM ITQLLAYTPP QEQDDTPDWV ARIKNLMKEA 
PTAYSLLIMH RDVIYAVRDP YGNRPLCIGR LIPVSDINDK EKKTSETEGW VVSSESCSFL 
SIGARYYREV LPGEIVEISR HNVQTLDIIS RSEGNPVAFC IFEYVYFARP DSMFEDQMVY 
TVRYRCGQQL AIEAPVDADL VSTVPESATP AALAYAGKCG LPYVEVLCKN RYVGRTFIQP 
NMRLRQLGVA KKFGVLSDNF KGKRIVLVDD SIVRGNTISP IIKLLKESGA KEVHIRVASP 
PIKYPCFMGI NIPTKEELIA NKPEFDHLAE YLGANSVVYL SVEGLVSSVQ EGIKFKKQKE 
KKHDIMIQEN GNGLECFEKS GHCTACLTGK YPVELEW

Genular Protein ID: 2820009632

Symbol: Q59G63_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59G63

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 2 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 217
  • Mass: 24561
  • Checksum: E673189EE34734B1
  • Sequence:
    • RKIILKFYLN IVAATQPREN ICLFCILLLI ILSFLLYQCG LPYVEVLCKN RYVGRTFIQP 
NMRLRQLGVA KKFGVLSDNF KGKRIVLVDD SIVRGNTISP IIKLLKESGA KEVHIRVASP 
PIKYPCFMGI NIPTKEELIA NKPEFDHLAE YLGANSVVYL SVEGLVSSVQ EGIKFKKQKE 
KKHDIMIQEN GNGLECFEKS GHCTACLTGK YPVELEW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.