Gene PPP1CB - ENSG00000213639 | NCBI Gene ID: 5500

Details for: PPP1CB

Gene ID: 5500

Symbol: PPP1CB

Ensembl ID: ENSG00000213639

Description: protein phosphatase 1 catalytic subunit beta

Associated with

Cell cycle, mitotic
(R-HSA-69278)
Circadian clock
(R-HSA-400253)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of tgf-beta receptor signaling
(R-HSA-2173788)
G2/m transition
(R-HSA-69275)
Gain-of-function mras complexes activate raf signaling
(R-HSA-9726842)
Infectious disease
(R-HSA-5663205)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Maturation of hrsv a proteins
(R-HSA-9828806)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Mitotic g2-g2/m phases
(R-HSA-453274)
Oncogenic mapk signaling
(R-HSA-6802957)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Respiratory syncytial virus (rsv) genome replication, transcription and translation
(R-HSA-9820965)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate cit
(R-HSA-5625900)
Rho gtpases activate paks
(R-HSA-5627123)
Rho gtpases activate pkns
(R-HSA-5625740)
Rho gtpases activate rocks
(R-HSA-5627117)
Shoc2 m1731 mutant abolishes mras complex function
(R-HSA-9726840)
Signaling by mras-complex mutants
(R-HSA-9660537)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Tgf-beta receptor signaling activates smads
(R-HSA-2173789)
Triglyceride catabolism
(R-HSA-163560)
Triglyceride metabolism
(R-HSA-8979227)
Viral infection pathways
(R-HSA-9824446)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Chromosome, telomeric region
(GO:0000781)
Circadian regulation of gene expression
(GO:0032922)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Entrainment of circadian clock by photoperiod
(GO:0043153)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Glycogen metabolic process
(GO:0005977)
Mapk cascade
(GO:0000165)
Metal ion binding
(GO:0046872)
Myosin-light-chain-phosphatase activity
(GO:0050115)
Myosin phosphatase activity
(GO:0017018)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphatase activity
(GO:0016791)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein kinase binding
(GO:0019901)
Protein serine/threonine phosphatase activity
(GO:0004722)
Ptw/pp1 phosphatase complex
(GO:0072357)
Regulation of cell adhesion
(GO:0030155)
Regulation of circadian rhythm
(GO:0042752)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 4.2
Marker Score: 5473
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.67
Marker Score: 3924
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 2.85
Marker Score: 2029
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.76
Marker Score: 2630
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.75
Marker Score: 6942
Cell Name: supporting cell (CL0000630)
Fold Change: 2.71
Marker Score: 5088
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.7
Marker Score: 1841
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.66
Marker Score: 90336
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.62
Marker Score: 7030.5
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.59
Marker Score: 22346
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.58
Marker Score: 2034
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 2.54
Marker Score: 12473.5
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.53
Marker Score: 958
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.53
Marker Score: 4196
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.52
Marker Score: 5533
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.48
Marker Score: 838.5
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.41
Marker Score: 1401
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.39
Marker Score: 3383
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.37
Marker Score: 6548
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.36
Marker Score: 4190
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.36
Marker Score: 814
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.35
Marker Score: 2473
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.33
Marker Score: 5300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.32
Marker Score: 554
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.32
Marker Score: 26111
Cell Name: basal cell (CL0000646)
Fold Change: 2.31
Marker Score: 2988
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.31
Marker Score: 5429.5
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 2.3
Marker Score: 1280
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.29
Marker Score: 1955
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.29
Marker Score: 2319
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.26
Marker Score: 2394
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 2.25
Marker Score: 714
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.25
Marker Score: 78014
Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.25
Marker Score: 1945
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 2.24
Marker Score: 1700
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 2.23
Marker Score: 1470
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.23
Marker Score: 7921.5
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.21
Marker Score: 5333
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.2
Marker Score: 1098
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.19
Marker Score: 691
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.13
Marker Score: 13565
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 2.12
Marker Score: 18423.5
Cell Name: pericyte (CL0000669)
Fold Change: 2.12
Marker Score: 1236
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.12
Marker Score: 16521
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.11
Marker Score: 609
Cell Name: fibroblast (CL0000057)
Fold Change: 2.1
Marker Score: 2028
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.09
Marker Score: 3074
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.08
Marker Score: 5090.5
Cell Name: elicited macrophage (CL0000861)
Fold Change: 2.07
Marker Score: 12601
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.07
Marker Score: 664
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.07
Marker Score: 5413
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.06
Marker Score: 1059
Cell Name: reticular cell (CL0000432)
Fold Change: 2.05
Marker Score: 749
Cell Name: leukocyte (CL0000738)
Fold Change: 2.05
Marker Score: 1177
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 2.04
Marker Score: 455
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 2.03
Marker Score: 538
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 2.02
Marker Score: 815
Cell Name: glomerular endothelial cell (CL0002188)
Fold Change: 2.02
Marker Score: 513
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.02
Marker Score: 4210
Cell Name: adventitial cell (CL0002503)
Fold Change: 2.01
Marker Score: 496
Cell Name: lymphocyte (CL0000542)
Fold Change: 1.99
Marker Score: 1007
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.99
Marker Score: 2278
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.97
Marker Score: 612
Cell Name: ependymal cell (CL0000065)
Fold Change: 1.97
Marker Score: 687
Cell Name: erythroblast (CL0000765)
Fold Change: 1.97
Marker Score: 1229
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.96
Marker Score: 574
Cell Name: epidermal cell (CL0000362)
Fold Change: 1.96
Marker Score: 551.5
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.96
Marker Score: 2202.5
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.96
Marker Score: 74357
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 1.95
Marker Score: 486
Cell Name: decidual cell (CL2000002)
Fold Change: 1.95
Marker Score: 8411
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 1.95
Marker Score: 498
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.95
Marker Score: 2405
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 1.94
Marker Score: 997
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.94
Marker Score: 424.5
Cell Name: ciliated cell (CL0000064)
Fold Change: 1.94
Marker Score: 6660
Cell Name: theca cell (CL0000503)
Fold Change: 1.94
Marker Score: 1388
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.94
Marker Score: 2814
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.93
Marker Score: 34330
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.93
Marker Score: 804
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.92
Marker Score: 3271
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.92
Marker Score: 4359
Cell Name: endocrine cell (CL0000163)
Fold Change: 1.92
Marker Score: 993.5
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.92
Marker Score: 1123
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 1.91
Marker Score: 507
Cell Name: follicular B cell (CL0000843)
Fold Change: 1.91
Marker Score: 2073
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.91
Marker Score: 2079
Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.9
Marker Score: 438
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.9
Marker Score: 3615.5
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 1.9
Marker Score: 983
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.9
Marker Score: 3790
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 1.89
Marker Score: 622
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.89
Marker Score: 1996
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.89
Marker Score: 538
Cell Name: stromal cell (CL0000499)
Fold Change: 1.89
Marker Score: 2209
Cell Name: secretory cell (CL0000151)
Fold Change: 1.88
Marker Score: 3435
Cell Name: B-1a B cell (CL0000820)
Fold Change: 1.88
Marker Score: 449
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.87
Marker Score: 1874.5
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.87
Marker Score: 888
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.86
Marker Score: 668

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**Key Characteristics** 1. **Catalytic Subunit of PP1**: PPP1CB is a catalytic subunit of protein phosphatase 1 (PP1), a serine/threonine phosphatase that plays a crucial role in regulating various cellular processes. 2. **High Expression in Specific Cell Types**: PPP1CB is highly expressed in uterine smooth muscle cells, skeletal muscle satellite stem cells, kidney interstitial cells, and other cell types involved in cell cycle regulation, metabolism, and signal transduction. 3. **Regulation of Cell Cycle and Metabolism**: PPP1CB regulates cell cycle progression, particularly at the G2/M transition, and is involved in metabolic processes such as glycogen metabolism and lipid metabolism. 4. **Involvement in Signal Transduction**: PPP1CB is involved in signal transduction pathways, including those mediated by growth factor receptors, second messengers, and MAPK cascades. **Pathways and Functions** 1. **Cell Cycle Regulation**: PPP1CB regulates cell cycle progression by dephosphorylating and activating or inhibiting key regulators of the cell cycle, such as cyclin-dependent kinases (CDKs) and cyclins. 2. **Signal Transduction**: PPP1CB is involved in signal transduction pathways, including those mediated by growth factor receptors, second messengers, and MAPK cascades. 3. **Metabolism**: PPP1CB regulates metabolic processes, including glycogen metabolism, lipid metabolism, and triglyceride metabolism. 4. **Regulation of Cell Adhesion**: PPP1CB regulates cell adhesion by dephosphorylating and activating or inhibiting key regulators of cell adhesion, such as integrins and E-cadherin. **Clinical Significance** 1. **Cancer**: Abnormal expression or function of PPP1CB has been implicated in various cancers, including breast cancer, lung cancer, and colon cancer. 2. **Cardiovascular Disease**: PPP1CB is involved in regulating cell cycle progression and metabolism, which are critical processes in cardiovascular disease. 3. **Infectious Diseases**: PPP1CB is involved in regulating signal transduction pathways, which are critical for the immune response to infectious diseases. 4. **Neurological Disorders**: PPP1CB has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. In conclusion, PPP1CB is a critical gene that plays a multifaceted role in regulating various cellular processes, including cell cycle regulation, signal transduction, and metabolism. Abnormal expression or function of PPP1CB has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Genular Protein ID: 3568748242

Symbol: PP1B_HUMAN

Name: Serine/threonine-protein phosphatase PP1-beta catalytic subunit

UniProtKB Accession Codes:

P62140 B2R5V4 D6W565 P37140 Q5U087 Q6FG45

Database IDs:

Citations:

PubMed ID: 8312365

Title: Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB).

PubMed ID: 8312365

DOI: 10.1016/0167-4889(94)90138-4

PubMed ID: 7796987

Title: Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians.

PubMed ID: 7796987

DOI: 10.1007/bf00410284

PubMed ID: 10906760

Title: Characterization of the protein phosphatase 1 catalytic subunit in endothelium: involvement in contractile responses.

PubMed ID: 10906760

DOI: 10.1002/1097-4644(2000)79:1<113::aid-jcb110>3.3.co;2-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 11399775

Title: Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton.

PubMed ID: 11399775

DOI: 10.1074/jbc.m102615200

PubMed ID: 11739654

Title: Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.

PubMed ID: 11739654

DOI: 10.1242/jcs.114.23.4219

PubMed ID: 11564868

Title: Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

PubMed ID: 11564868

DOI: 10.1128/mcb.21.20.6841-6850.2001

PubMed ID: 12226088

Title: Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.

PubMed ID: 12226088

DOI: 10.1074/jbc.m206838200

PubMed ID: 15705855

Title: A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.

PubMed ID: 15705855

DOI: 10.1126/science.1101902

PubMed ID: 18586956

Title: TIMAP is a positive regulator of pulmonary endothelial barrier function.

PubMed ID: 18586956

DOI: 10.1152/ajplung.00325.2007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19377461

Title: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 19377461

DOI: 10.1038/nature07954

PubMed ID: 24336203

Title: Retraction: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 24336203

DOI: 10.1038/nature12896

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 20516061

Title: Identification and characterization of a novel human PP1 phosphatase complex.

PubMed ID: 20516061

DOI: 10.1074/jbc.m110.109801

PubMed ID: 20926688

Title: RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre-60S ribosomal subunits.

PubMed ID: 20926688

DOI: 10.1091/mbc.e10-04-0287

PubMed ID: 20354225

Title: New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion.

PubMed ID: 20354225

DOI: 10.1126/scisignal.2000616

PubMed ID: 20424263

Title: SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1.

PubMed ID: 20424263

DOI: 10.1126/scisignal.2000781

PubMed ID: 21712997

Title: Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.

PubMed ID: 21712997

DOI: 10.1371/journal.pone.0021325

PubMed ID: 23396208

Title: Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis.

PubMed ID: 23396208

DOI: 10.1038/nm.3085

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27264673

Title: A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hair.

PubMed ID: 27264673

DOI: 10.1002/ajmg.a.37781

PubMed ID: 27681385

Title: De novo missense variants in PPP1CB are associated with intellectual disability and congenital heart disease.

PubMed ID: 27681385

DOI: 10.1007/s00439-016-1731-1

PubMed ID: 27868344

Title: Further evidence that variants in PPP1CB cause a rasopathy similar to Noonan syndrome with loose anagen hair.

PubMed ID: 27868344

DOI: 10.1002/ajmg.a.38056

PubMed ID: 28211982

Title: The recurrent PPP1CB mutation p.Pro49Arg in an additional Noonan-like syndrome individual: Broadening the clinical phenotype.

PubMed ID: 28211982

DOI: 10.1002/ajmg.a.38070

PubMed ID: 28296156

Title: PAI1: a novel PP1-interacting protein that mediates human plasma's anti-apoptotic effect in endothelial cells.

PubMed ID: 28296156

DOI: 10.1111/jcmm.13127

PubMed ID: 30368668

Title: Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1-PPP1CB complexes.

PubMed ID: 30368668

DOI: 10.1007/s00439-018-1951-7

Sequence Information:

Length: 327
Mass: 37187
Checksum: E8356022E9B94ECD
Sequence:

MADGELNVDS LITRLLEVRG CRPGKIVQMT EAEVRGLCIK SREIFLSQPI LLELEAPLKI 
CGDIHGQYTD LLRLFEYGGF PPEANYLFLG DYVDRGKQSL ETICLLLAYK IKYPENFFLL 
RGNHECASIN RIYGFYDECK RRFNIKLWKT FTDCFNCLPI AAIVDEKIFC CHGGLSPDLQ 
SMEQIRRIMR PTDVPDTGLL CDLLWSDPDK DVQGWGENDR GVSFTFGADV VSKFLNRHDL 
DLICRAHQVV EDGYEFFAKR QLVTLFSAPN YCGEFDNAGG MMSVDETLMC SFQILKPSEK 
KAKYQYGGLN SGRPVTPPRT ANPPKKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: PPP1CB

Associated with

Cells (max top 100)

Other Information

Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB). PubMed ID: 8312365

Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians. PubMed ID: 7796987

Characterization of the protein phosphatase 1 catalytic subunit in endothelium: involvement in contractile responses. PubMed ID: 10906760

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. PubMed ID: 11399775

Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells. PubMed ID: 11739654

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. PubMed ID: 11564868

Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. PubMed ID: 12226088

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. PubMed ID: 15705855

TIMAP is a positive regulator of pulmonary endothelial barrier function. PubMed ID: 18586956

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. PubMed ID: 19377461

Retraction: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. PubMed ID: 24336203

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Identification and characterization of a novel human PP1 phosphatase complex. PubMed ID: 20516061

RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre-60S ribosomal subunits. PubMed ID: 20926688

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. PubMed ID: 20354225

SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1. PubMed ID: 20424263

Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock. PubMed ID: 21712997

Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis. PubMed ID: 23396208

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hair. PubMed ID: 27264673

De novo missense variants in PPP1CB are associated with intellectual disability and congenital heart disease. PubMed ID: 27681385

Further evidence that variants in PPP1CB cause a rasopathy similar to Noonan syndrome with loose anagen hair. PubMed ID: 27868344

The recurrent PPP1CB mutation p.Pro49Arg in an additional Noonan-like syndrome individual: Broadening the clinical phenotype. PubMed ID: 28211982

PAI1: a novel PP1-interacting protein that mediates human plasma's anti-apoptotic effect in endothelial cells. PubMed ID: 28296156

Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1-PPP1CB complexes. PubMed ID: 30368668