Details for: PPP1CB
Gene ID: 5500
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PPP1CB
Ensembl ID: ENSG00000213639
Description: protein phosphatase 1 catalytic subunit beta
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 76.71rCSI 67.46%PRS 8.46
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CSI 64.88rCSI 62.46%PRS 12.09
-
CSI 47.91rCSI 68.37%PRS 13.17
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CSI 43.36rCSI 66.23%PRS 11.71
-
CSI 40.57rCSI 46.91%PRS 8.55
-
CSI 33.14rCSI 64.46%PRS 11.91
-
CSI 30.13rCSI 31.49%PRS 12.32
-
CSI 24.91rCSI 72.1%PRS 13.23
-
CSI 24.88rCSI 20.62%PRS 11.02
-
CSI 23.27rCSI 63.95%PRS 19.35
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CSI 22.93rCSI 24.02%PRS 12.46
-
CSI 22.68rCSI 22.31%PRS 12.68
-
CSI 21.66rCSI 55.99%PRS 10.88
-
CSI 21.49rCSI 68.97%PRS 17.15
-
CSI 20.95rCSI 27.84%PRS 12.75
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CSI 19.69rCSI 16.51%PRS 13.99
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CSI 18.87rCSI 25.8%PRS 13.26
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CSI 18.22rCSI 27.49%PRS 11.51
-
CSI 18.07rCSI 43.1%PRS 35.58
-
CSI 17.84rCSI 40.67%PRS 12.24
-
CSI 17.22rCSI 45.34%PRS 22.89
-
CSI 17.12rCSI 23.32%PRS 10.46
-
CSI 16.84rCSI 17.57%PRS 11.98
-
CSI 16.14rCSI 38.31%PRS 14.8
-
CSI 14.94rCSI 26.97%PRS 31.39
-
CSI 14.53rCSI 35.32%PRS 6.65
-
CSI 14.05rCSI 31.11%PRS 10.84
-
CSI 13.96rCSI 55.57%PRS 20.5
-
CSI 12.7rCSI 36.57%PRS 22.78
-
CSI 12.41rCSI 29.51%PRS 17.58
-
CSI 12.35rCSI 11.4%PRS 11.87
-
CSI 11.95rCSI 13.86%PRS 17.27
-
CSI 11.71rCSI 22.17%PRS 32.03
-
CSI 11.33rCSI 52.35%PRS 24.41
-
CSI 11.19rCSI 15.28%PRS 12.94
-
CSI 11.04rCSI 51.46%PRS 28.08
-
CSI 11rCSI 31.46%PRS 21.09
-
CSI 10.9rCSI 51.02%PRS 25.01
-
CSI 10.5rCSI 15.51%PRS 18.38
-
CSI 10.24rCSI 14.98%PRS 12.36
-
CSI 10.2rCSI 27.49%PRS 15.04
-
CSI 9.81rCSI 15.82%PRS 18.72
-
CSI 9.66rCSI 50.72%PRS 21.08
-
CSI 9.53rCSI 13.98%PRS 15.33
-
CSI 9.46rCSI 7.51%PRS 20.51
-
CSI 9.34rCSI 24.78%PRS 19.4
-
CSI 9.16rCSI 23.23%PRS 8.92
-
CSI 9.14rCSI 21.98%PRS 17.58
-
CSI 8.6rCSI 12.46%PRS 17.19
-
CSI 8.46rCSI 11.71%PRS 16.84
-
CSI 8.17rCSI 38.32%PRS 31.35
-
CSI 8.12rCSI 17.87%PRS 17.9
-
CSI 8.1rCSI 22.8%PRS 16.77
-
CSI 7.91rCSI 22.17%PRS 18.04
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CSI 7.72rCSI 11.86%PRS 16.69
-
CSI 7.65rCSI 16.29%PRS 18.88
-
CSI 7.48rCSI 8.78%PRS 13.81
-
CSI 7.4rCSI 26.64%PRS 6.31
-
CSI 7.4rCSI 9.2%PRS 12.34
-
CSI 7.19rCSI 13.72%PRS 27.63
-
CSI 7.08rCSI 38.08%PRS 21.08
-
CSI 7.02rCSI 6.53%PRS 11.74
-
CSI 6.97rCSI 16.25%PRS 25.4
-
CSI 6.91rCSI 7.57%PRS 13.39
-
CSI 6.89rCSI 56%PRS 12.15
-
CSI 6.61rCSI 6.37%PRS 7.94
-
CSI 6.46rCSI 48.49%PRS 21.54
-
CSI 6.41rCSI 4.82%PRS 12.09
-
CSI 6.31rCSI 21.34%PRS 19.7
-
CSI 6.25rCSI 8.84%PRS 16.37
-
CSI 6.23rCSI 36.65%PRS 48.22
-
CSI 6.21rCSI 16.13%PRS 32.24
-
CSI 6.1rCSI 21.4%PRS 21.14
-
CSI 6.05rCSI 26.94%PRS 34.13
-
CSI 5.97rCSI 5.87%PRS 33.45
-
CSI 5.94rCSI 15.43%PRS 15.84
-
CSI 5.88rCSI 4.56%PRS 11.11
-
CSI 5.86rCSI 6.14%PRS 10.87
-
CSI 5.79rCSI 5.31%PRS 13.32
-
CSI 5.77rCSI 34.9%PRS 26.19
-
CSI 5.76rCSI 8.31%PRS 18.83
-
CSI 5.66rCSI 9.98%PRS 15.42
-
CSI 5.62rCSI 3.91%PRS 16.6
-
CSI 5.55rCSI 4.51%PRS 12.37
-
CSI 5.51rCSI 61.65%PRS 38.63
-
CSI 5.45rCSI 13.07%PRS 21.46
-
CSI 5.4rCSI 58.8%PRS 22.6
-
CSI 5.33rCSI 31.03%PRS 17.59
-
CSI 5.23rCSI 8.47%PRS 11.93
-
CSI 5.17rCSI 77.57%PRS 36.65
-
CSI 5.16rCSI 4.3%PRS 34.38
-
CSI 5.15rCSI 11.38%PRS 8.38
-
CSI 5.13rCSI 6.57%PRS 46.99
-
CSI 5.11rCSI 50.28%PRS 34.51
-
CSI 5.07rCSI 43.72%PRS 3.5
-
CSI 5.05rCSI 10.37%PRS 27.45
-
CSI 4.96rCSI 4.69%PRS 12.2
-
CSI 4.95rCSI 3.81%PRS 10.58
-
CSI 4.95rCSI 4.47%PRS 10.3
-
CSI 4.9rCSI 7.47%PRS 10.92
-
CSI -10.7rCSI -13.8%PRS 7.2%
-
CSI -7.7rCSI -6.5%PRS 18.8%
-
CSI -7.3rCSI -7.2%PRS 18.4%
-
CSI -4.2rCSI -5.1%PRS 14.7%
-
CSI -2.4rCSI -1.7%PRS 15.8%
-
CSI -2.0rCSI -2.3%PRS 18.7%
-
CSI -1.8rCSI -2.2%PRS 6.3%
-
CSI -1.5rCSI -8.7%PRS 15.7%
-
CSI -1.4rCSI -2.7%PRS 18.7%
-
CSI -1.2rCSI -6.7%PRS 4.5%
-
CSI -0.8rCSI -3.5%PRS 11.5%
-
CSI -0.7rCSI -2.5%PRS 29.7%
-
CSI -0.5rCSI -2.6%PRS 14.0%
-
CSI -0.5rCSI -2.2%PRS 40.8%
-
CSI -0.4rCSI -0.3%PRS 10.4%
-
CSI -0.4rCSI -0.7%PRS 8.5%
-
CSI -0.3rCSI -0.4%PRS 11.4%
-
CSI -0.1rCSI -0.7%PRS 22.0%
-
CSI -0.1rCSI -0.4%PRS 9.2%
-
CSI 0.0rCSI 0.0%PRS 9.5%
-
CSI 0.1rCSI 0.6%PRS 5.9%
-
CSI 0.1rCSI 0.3%PRS 6.4%
-
CSI 0.1rCSI 0.4%PRS 20.3%
-
CSI 0.2rCSI 1.0%PRS 30.3%
-
CSI 0.2rCSI 0.2%PRS 24.3%
-
CSI 0.2rCSI 0.7%PRS 24.2%
-
CSI 0.2rCSI 2.3%PRS 38.0%
-
CSI 0.2rCSI 3.0%PRS 46.1%
-
CSI 0.2rCSI 1.3%PRS 23.0%
-
CSI 0.2rCSI 1.1%PRS 18.1%
-
CSI 0.2rCSI 1.2%PRS 17.0%
-
CSI 0.2rCSI 0.6%PRS 16.9%
-
CSI 0.2rCSI 3.5%PRS 63.0%
-
CSI 0.2rCSI 0.3%PRS 24.1%
-
CSI 0.2rCSI 1.2%PRS 15.2%
-
CSI 0.2rCSI 0.3%PRS 15.7%
-
CSI 0.3rCSI 1.1%PRS 17.0%
-
CSI 0.3rCSI 0.7%PRS 7.2%
-
CSI 0.3rCSI 1.7%PRS 22.0%
-
CSI 0.3rCSI 3.3%PRS 66.8%
-
CSI 0.3rCSI 2.6%PRS 25.7%
-
CSI 0.3rCSI 2.6%PRS 44.0%
-
CSI 0.4rCSI 0.3%PRS 14.4%
-
CSI 0.4rCSI 1.3%PRS 36.5%
-
CSI 0.4rCSI 0.6%PRS 10.9%
-
CSI 0.4rCSI 1.9%PRS 15.4%
-
CSI 0.4rCSI 3.2%PRS 47.2%
-
CSI 0.4rCSI 1.4%PRS 5.9%
-
CSI 0.4rCSI 4.7%PRS 30.5%
-
CSI 0.4rCSI 1.1%PRS 17.1%
-
CSI 0.5rCSI 2.8%PRS 37.8%
-
CSI 0.5rCSI 1.5%PRS 12.7%
-
CSI 0.5rCSI 1.0%PRS 17.9%
-
CSI 0.5rCSI 1.1%PRS 15.6%
-
CSI 0.5rCSI 0.6%PRS 20.1%
-
CSI 0.5rCSI 0.3%PRS 16.1%
-
CSI 0.5rCSI 1.7%PRS 18.7%
-
CSI 0.5rCSI 1.1%PRS 12.5%
-
CSI 0.6rCSI 1.0%PRS 25.5%
-
CSI 0.6rCSI 2.8%PRS 47.1%
-
CSI 0.6rCSI 2.0%PRS 44.9%
-
CSI 0.6rCSI 2.5%PRS 21.0%
-
CSI 0.6rCSI 6.2%PRS 58.4%
-
CSI 0.6rCSI 0.6%PRS 13.7%
-
CSI 0.6rCSI 1.7%PRS 29.2%
-
CSI 0.6rCSI 2.1%PRS 10.6%
-
CSI 0.6rCSI 4.1%PRS 62.6%
-
CSI 0.6rCSI 1.2%PRS 14.5%
-
CSI 0.7rCSI 4.0%PRS 46.8%
-
CSI 0.7rCSI 15.6%PRS 40.2%
-
CSI 0.7rCSI 1.2%PRS 10.9%
-
CSI 0.7rCSI 1.1%PRS 19.0%
-
CSI 0.7rCSI 1.2%PRS 6.8%
-
CSI 0.7rCSI 1.9%PRS 47.1%
-
CSI 0.7rCSI 2.8%PRS 12.1%
-
CSI 0.8rCSI 1.0%PRS 28.2%
-
CSI 0.8rCSI 0.7%PRS 13.1%
-
CSI 0.8rCSI 4.4%PRS 44.5%
-
CSI 0.8rCSI 2.2%PRS 11.1%
-
CSI 0.8rCSI 1.2%PRS 10.9%
-
CSI 0.9rCSI 1.1%PRS 14.9%
-
CSI 0.9rCSI 1.1%PRS 10.3%
-
CSI 0.9rCSI 1.3%PRS 20.4%
-
CSI 0.9rCSI 2.5%PRS 9.2%
-
CSI 0.9rCSI 2.0%PRS 23.6%
-
CSI 0.9rCSI 1.5%PRS 9.0%
-
CSI 1.0rCSI 11.0%PRS 44.3%
-
CSI 1.0rCSI 1.2%PRS 20.2%
-
CSI 1.0rCSI 2.5%PRS 14.5%
-
CSI 1.0rCSI 3.3%PRS 33.1%
-
CSI 1.0rCSI 1.5%PRS 9.2%
-
CSI 1.0rCSI 3.7%PRS 20.0%
-
CSI 1.0rCSI 1.5%PRS 16.0%
-
CSI 1.1rCSI 1.4%PRS 22.3%
-
CSI 1.1rCSI 15.7%PRS 29.9%
-
CSI 1.1rCSI 2.2%PRS 35.4%
-
CSI 1.1rCSI 6.1%PRS 36.2%
-
CSI 1.1rCSI 0.9%PRS 11.5%
-
CSI 1.1rCSI 0.8%PRS 19.6%
-
CSI 1.1rCSI 3.3%PRS 38.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3568748242
Symbol: PP1B_HUMAN
Name: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8312365
Title: Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB).
PubMed ID: 8312365
PubMed ID: 7796987
Title: Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians.
PubMed ID: 7796987
DOI: 10.1007/bf00410284
PubMed ID: 10906760
Title: Characterization of the protein phosphatase 1 catalytic subunit in endothelium: involvement in contractile responses.
PubMed ID: 10906760
DOI: 10.1002/1097-4644(2000)79:1<113::aid-jcb110>3.3.co;2-0
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 11399775
Title: Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton.
PubMed ID: 11399775
PubMed ID: 11739654
Title: Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.
PubMed ID: 11739654
PubMed ID: 11564868
Title: Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.
PubMed ID: 11564868
PubMed ID: 12226088
Title: Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.
PubMed ID: 12226088
PubMed ID: 15705855
Title: A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
PubMed ID: 15705855
PubMed ID: 18586956
Title: TIMAP is a positive regulator of pulmonary endothelial barrier function.
PubMed ID: 18586956
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19377461
Title: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.
PubMed ID: 19377461
DOI: 10.1038/nature07954
PubMed ID: 24336203
Title: Retraction: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.
PubMed ID: 24336203
DOI: 10.1038/nature12896
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 20516061
Title: Identification and characterization of a novel human PP1 phosphatase complex.
PubMed ID: 20516061
PubMed ID: 20926688
Title: RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre-60S ribosomal subunits.
PubMed ID: 20926688
PubMed ID: 20354225
Title: New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion.
PubMed ID: 20354225
PubMed ID: 20424263
Title: SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1.
PubMed ID: 20424263
PubMed ID: 21712997
Title: Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.
PubMed ID: 21712997
PubMed ID: 23396208
Title: Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis.
PubMed ID: 23396208
DOI: 10.1038/nm.3085
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27264673
Title: A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hair.
PubMed ID: 27264673
DOI: 10.1002/ajmg.a.37781
PubMed ID: 27681385
Title: De novo missense variants in PPP1CB are associated with intellectual disability and congenital heart disease.
PubMed ID: 27681385
PubMed ID: 27868344
Title: Further evidence that variants in PPP1CB cause a rasopathy similar to Noonan syndrome with loose anagen hair.
PubMed ID: 27868344
DOI: 10.1002/ajmg.a.38056
PubMed ID: 28211982
Title: The recurrent PPP1CB mutation p.Pro49Arg in an additional Noonan-like syndrome individual: Broadening the clinical phenotype.
PubMed ID: 28211982
DOI: 10.1002/ajmg.a.38070
PubMed ID: 28296156
Title: PAI1: a novel PP1-interacting protein that mediates human plasma's anti-apoptotic effect in endothelial cells.
PubMed ID: 28296156
DOI: 10.1111/jcmm.13127
PubMed ID: 30368668
Title: Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1-PPP1CB complexes.
PubMed ID: 30368668
Sequence Information:
- Length: 327
- Mass: 37187
- Checksum: E8356022E9B94ECD
- Sequence:
MADGELNVDS LITRLLEVRG CRPGKIVQMT EAEVRGLCIK SREIFLSQPI LLELEAPLKI CGDIHGQYTD LLRLFEYGGF PPEANYLFLG DYVDRGKQSL ETICLLLAYK IKYPENFFLL RGNHECASIN RIYGFYDECK RRFNIKLWKT FTDCFNCLPI AAIVDEKIFC CHGGLSPDLQ SMEQIRRIMR PTDVPDTGLL CDLLWSDPDK DVQGWGENDR GVSFTFGADV VSKFLNRHDL DLICRAHQVV EDGYEFFAKR QLVTLFSAPN YCGEFDNAGG MMSVDETLMC SFQILKPSEK KAKYQYGGLN SGRPVTPPRT ANPPKKR