Details for: PPP1CB
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 548.0400
Cell Significance Index: -85.2500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 336.4172
Cell Significance Index: -85.3300 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 222.4555
Cell Significance Index: -91.6400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 201.1130
Cell Significance Index: -94.9500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 194.1135
Cell Significance Index: -78.8600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 172.6138
Cell Significance Index: -88.7900 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 142.5139
Cell Significance Index: -95.6300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 82.7029
Cell Significance Index: -78.9600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 73.0399
Cell Significance Index: -90.0600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 32.8311
Cell Significance Index: -87.9500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 24.2394
Cell Significance Index: -95.6500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 21.5110
Cell Significance Index: -66.0700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 13.3145
Cell Significance Index: -29.1400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.4401
Cell Significance Index: 161.6800 - Cell Name: peg cell (CL4033014)
Fold Change: 3.2400
Cell Significance Index: 74.8600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.9566
Cell Significance Index: 406.0300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.6928
Cell Significance Index: 125.5500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.2787
Cell Significance Index: 31.0900 - Cell Name: odontoblast (CL0000060)
Fold Change: 2.0770
Cell Significance Index: 266.2600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.0151
Cell Significance Index: 404.2300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.9971
Cell Significance Index: 54.3600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.9026
Cell Significance Index: 841.2000 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.8772
Cell Significance Index: 242.5300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.8274
Cell Significance Index: 329.4300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.7332
Cell Significance Index: 213.1100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.6615
Cell Significance Index: 907.3700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.3640
Cell Significance Index: 47.4000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.3570
Cell Significance Index: 38.9000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.3551
Cell Significance Index: 1223.5600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.0943
Cell Significance Index: 77.4000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.0726
Cell Significance Index: 79.9400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.8725
Cell Significance Index: 312.9400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.7407
Cell Significance Index: 38.8900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7159
Cell Significance Index: 142.0800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.6596
Cell Significance Index: 456.1800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.5987
Cell Significance Index: 38.6300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5711
Cell Significance Index: 92.8900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.5180
Cell Significance Index: 39.7500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5071
Cell Significance Index: 31.1700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4988
Cell Significance Index: 25.9100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.4087
Cell Significance Index: 259.5800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3951
Cell Significance Index: 67.4600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3525
Cell Significance Index: 67.0900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3367
Cell Significance Index: 36.6200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3075
Cell Significance Index: 579.0700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2981
Cell Significance Index: 35.1600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2899
Cell Significance Index: 6.2800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.2628
Cell Significance Index: 119.2800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2345
Cell Significance Index: 13.1600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0823
Cell Significance Index: 2.3700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0661
Cell Significance Index: 89.8100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0161
Cell Significance Index: 24.7400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0043
Cell Significance Index: 3.1500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0041
Cell Significance Index: -0.1100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0051
Cell Significance Index: -9.3900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0192
Cell Significance Index: -14.5300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0211
Cell Significance Index: -0.3500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0211
Cell Significance Index: -1.3300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0371
Cell Significance Index: -27.5000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0741
Cell Significance Index: -46.2500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1134
Cell Significance Index: -63.9600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1196
Cell Significance Index: -12.2200 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1204
Cell Significance Index: -3.1700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1909
Cell Significance Index: -40.2100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.2664
Cell Significance Index: -26.3500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2821
Cell Significance Index: -81.1800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3047
Cell Significance Index: -34.7800 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3186
Cell Significance Index: -3.6200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3317
Cell Significance Index: -9.2700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.3517
Cell Significance Index: -12.3600 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3906
Cell Significance Index: -7.2200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3938
Cell Significance Index: -17.4200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3982
Cell Significance Index: -57.8900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4492
Cell Significance Index: -52.3500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4773
Cell Significance Index: -54.6800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.4888
Cell Significance Index: -24.7000 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.4907
Cell Significance Index: -3.0200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5234
Cell Significance Index: -54.5000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5334
Cell Significance Index: -35.8700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.5413
Cell Significance Index: -11.3300 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.5890
Cell Significance Index: -12.5900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5944
Cell Significance Index: -22.5100 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.6100
Cell Significance Index: -10.7800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7360
Cell Significance Index: -58.2900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.8335
Cell Significance Index: -57.6400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.8961
Cell Significance Index: -19.0900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.9287
Cell Significance Index: -24.8900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.9706
Cell Significance Index: -24.9500 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -1.0003
Cell Significance Index: -23.9900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.0096
Cell Significance Index: -52.5900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -1.0398
Cell Significance Index: -21.5700 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.1587
Cell Significance Index: -10.6700 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.2482
Cell Significance Index: -10.4900 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -1.2649
Cell Significance Index: -37.1500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.4338
Cell Significance Index: -38.3500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.5435
Cell Significance Index: -94.6300 - Cell Name: pro-T cell (CL0000827)
Fold Change: -1.6119
Cell Significance Index: -41.1800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.6122
Cell Significance Index: -51.6400 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -1.6174
Cell Significance Index: -66.2700 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.7118
Cell Significance Index: -29.5100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3568748242
Symbol: PP1B_HUMAN
Name: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8312365
Title: Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB).
PubMed ID: 8312365
PubMed ID: 7796987
Title: Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians.
PubMed ID: 7796987
DOI: 10.1007/bf00410284
PubMed ID: 10906760
Title: Characterization of the protein phosphatase 1 catalytic subunit in endothelium: involvement in contractile responses.
PubMed ID: 10906760
DOI: 10.1002/1097-4644(2000)79:1<113::aid-jcb110>3.3.co;2-0
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 11399775
Title: Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton.
PubMed ID: 11399775
PubMed ID: 11739654
Title: Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.
PubMed ID: 11739654
PubMed ID: 11564868
Title: Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.
PubMed ID: 11564868
PubMed ID: 12226088
Title: Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.
PubMed ID: 12226088
PubMed ID: 15705855
Title: A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
PubMed ID: 15705855
PubMed ID: 18586956
Title: TIMAP is a positive regulator of pulmonary endothelial barrier function.
PubMed ID: 18586956
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19377461
Title: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.
PubMed ID: 19377461
DOI: 10.1038/nature07954
PubMed ID: 24336203
Title: Retraction: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.
PubMed ID: 24336203
DOI: 10.1038/nature12896
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 20516061
Title: Identification and characterization of a novel human PP1 phosphatase complex.
PubMed ID: 20516061
PubMed ID: 20926688
Title: RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre-60S ribosomal subunits.
PubMed ID: 20926688
PubMed ID: 20354225
Title: New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion.
PubMed ID: 20354225
PubMed ID: 20424263
Title: SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1.
PubMed ID: 20424263
PubMed ID: 21712997
Title: Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.
PubMed ID: 21712997
PubMed ID: 23396208
Title: Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis.
PubMed ID: 23396208
DOI: 10.1038/nm.3085
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27264673
Title: A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hair.
PubMed ID: 27264673
DOI: 10.1002/ajmg.a.37781
PubMed ID: 27681385
Title: De novo missense variants in PPP1CB are associated with intellectual disability and congenital heart disease.
PubMed ID: 27681385
PubMed ID: 27868344
Title: Further evidence that variants in PPP1CB cause a rasopathy similar to Noonan syndrome with loose anagen hair.
PubMed ID: 27868344
DOI: 10.1002/ajmg.a.38056
PubMed ID: 28211982
Title: The recurrent PPP1CB mutation p.Pro49Arg in an additional Noonan-like syndrome individual: Broadening the clinical phenotype.
PubMed ID: 28211982
DOI: 10.1002/ajmg.a.38070
PubMed ID: 28296156
Title: PAI1: a novel PP1-interacting protein that mediates human plasma's anti-apoptotic effect in endothelial cells.
PubMed ID: 28296156
DOI: 10.1111/jcmm.13127
PubMed ID: 30368668
Title: Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1-PPP1CB complexes.
PubMed ID: 30368668
Sequence Information:
- Length: 327
- Mass: 37187
- Checksum: E8356022E9B94ECD
- Sequence:
MADGELNVDS LITRLLEVRG CRPGKIVQMT EAEVRGLCIK SREIFLSQPI LLELEAPLKI CGDIHGQYTD LLRLFEYGGF PPEANYLFLG DYVDRGKQSL ETICLLLAYK IKYPENFFLL RGNHECASIN RIYGFYDECK RRFNIKLWKT FTDCFNCLPI AAIVDEKIFC CHGGLSPDLQ SMEQIRRIMR PTDVPDTGLL CDLLWSDPDK DVQGWGENDR GVSFTFGADV VSKFLNRHDL DLICRAHQVV EDGYEFFAKR QLVTLFSAPN YCGEFDNAGG MMSVDETLMC SFQILKPSEK KAKYQYGGLN SGRPVTPPRT ANPPKKR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.