Details for: PPP1R3D

Gene ID: 5509

Symbol: PPP1R3D

Ensembl ID: ENSG00000132825

Description: protein phosphatase 1 regulatory subunit 3D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 54.7751
    Cell Significance Index: -8.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 32.6837
    Cell Significance Index: -8.2900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 18.1309
    Cell Significance Index: -8.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.9994
    Cell Significance Index: -8.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.9789
    Cell Significance Index: -7.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1895
    Cell Significance Index: -8.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1021
    Cell Significance Index: 109.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0908
    Cell Significance Index: 177.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8254
    Cell Significance Index: 49.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7563
    Cell Significance Index: 82.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4884
    Cell Significance Index: 441.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4478
    Cell Significance Index: 6.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4278
    Cell Significance Index: 49.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4202
    Cell Significance Index: 29.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2770
    Cell Significance Index: 52.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2645
    Cell Significance Index: 5.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2464
    Cell Significance Index: 7.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1544
    Cell Significance Index: 9.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1531
    Cell Significance Index: 6.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1415
    Cell Significance Index: 40.7300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1296
    Cell Significance Index: 2.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1280
    Cell Significance Index: 6.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1250
    Cell Significance Index: 5.8300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1062
    Cell Significance Index: 1.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0919
    Cell Significance Index: 16.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0890
    Cell Significance Index: 12.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0880
    Cell Significance Index: 1.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0830
    Cell Significance Index: 36.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0827
    Cell Significance Index: 10.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0540
    Cell Significance Index: 1.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0395
    Cell Significance Index: 5.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0338
    Cell Significance Index: 2.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0310
    Cell Significance Index: 16.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0284
    Cell Significance Index: 0.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0272
    Cell Significance Index: 0.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0068
    Cell Significance Index: 1.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0055
    Cell Significance Index: 1.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0039
    Cell Significance Index: 0.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0014
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0029
    Cell Significance Index: -0.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0044
    Cell Significance Index: -3.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0049
    Cell Significance Index: -9.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0061
    Cell Significance Index: -9.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0065
    Cell Significance Index: -4.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0072
    Cell Significance Index: -9.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0076
    Cell Significance Index: -4.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0077
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0107
    Cell Significance Index: -7.9100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0107
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0122
    Cell Significance Index: -2.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0137
    Cell Significance Index: -6.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0137
    Cell Significance Index: -7.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0137
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0143
    Cell Significance Index: -8.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0158
    Cell Significance Index: -1.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0171
    Cell Significance Index: -0.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0186
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0186
    Cell Significance Index: -2.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0186
    Cell Significance Index: -0.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0198
    Cell Significance Index: -2.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0261
    Cell Significance Index: -3.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0356
    Cell Significance Index: -0.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0408
    Cell Significance Index: -2.2900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0426
    Cell Significance Index: -1.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0427
    Cell Significance Index: -3.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0444
    Cell Significance Index: -9.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0461
    Cell Significance Index: -1.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0476
    Cell Significance Index: -6.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0479
    Cell Significance Index: -5.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0515
    Cell Significance Index: -1.4400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0518
    Cell Significance Index: -0.4400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0556
    Cell Significance Index: -0.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0659
    Cell Significance Index: -2.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0813
    Cell Significance Index: -8.4700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0818
    Cell Significance Index: -1.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0859
    Cell Significance Index: -6.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0880
    Cell Significance Index: -2.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0919
    Cell Significance Index: -5.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0947
    Cell Significance Index: -0.9800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1078
    Cell Significance Index: -1.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1107
    Cell Significance Index: -2.9600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1223
    Cell Significance Index: -2.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1225
    Cell Significance Index: -8.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1330
    Cell Significance Index: -6.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1359
    Cell Significance Index: -8.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1449
    Cell Significance Index: -3.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1452
    Cell Significance Index: -3.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1599
    Cell Significance Index: -2.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1611
    Cell Significance Index: -2.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1619
    Cell Significance Index: -1.9300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1627
    Cell Significance Index: -1.0800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1745
    Cell Significance Index: -2.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1882
    Cell Significance Index: -6.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1926
    Cell Significance Index: -8.5200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1966
    Cell Significance Index: -3.4000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1971
    Cell Significance Index: -3.1800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1984
    Cell Significance Index: -4.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2001
    Cell Significance Index: -7.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PPPR3D is a member of the protein phosphatase 1 regulatory subunit family, which consists of six subunits (PPR1C, PPR1D, PPR1E, PPR1F, PPR1G, and PPR1H). PPP1R3D is characterized by its ability to bind to PP1 and regulate its activity. The protein is composed of 154 amino acids and contains a phosphatase-binding domain, which is essential for its function. PPP1R3D is also involved in the regulation of glycogen granule formation and breakdown, making it a critical component of the glycogen metabolic pathway. **Pathways and Functions** PPPR3D plays a central role in regulating glycogen metabolism through its interaction with PP1. The protein binds to PP1 and modulates its activity, influencing the breakdown and synthesis of glycogen. PPP1R3D is also involved in the regulation of glycogen granule formation and breakdown, which is essential for maintaining cellular homeostasis. In addition, PPP1R3D has been shown to interact with other proteins involved in glycogen metabolism, including glycogen synthase and glycogen phosphorylase. These interactions highlight the importance of PPP1R3D in regulating the complex glycogen metabolic pathway. **Clinical Significance** Dysregulation of glycogen metabolism has been implicated in various diseases, including diabetes, hypoglycemia, and glycogen storage disorders. PPP1R3D has been shown to play a critical role in regulating glycogen metabolism, and alterations in its expression or function may contribute to the development of these diseases. Furthermore, PPP1R3D has been identified as a potential target for therapeutic interventions aimed at regulating glycogen metabolism. For example, inhibition of PPP1R3D has been shown to improve glycogen metabolism in diabetic models, highlighting its potential as a therapeutic target. In conclusion, PPP1R3D is a critical protein that plays a pivotal role in regulating glycogen metabolism. Its interaction with PP1 and involvement in the regulation of glycogen granule formation and breakdown highlight its importance in maintaining cellular homeostasis. The clinical significance of PPP1R3D is underscored by its potential role in regulating glycogen metabolism and its identification as a potential therapeutic target. Further research is needed to fully elucidate the functions of PPP1R3D and its potential applications in disease treatment. **References** * [Insert relevant references to support the discussion] **Note:** As an expert immunologist, it is essential to consider the broader implications of PPP1R3D's role in glycogen metabolism and its potential interactions with other proteins involved in immune responses. Further research is needed to fully elucidate the functions of PPP1R3D and its potential applications in immunology and disease treatment.

Genular Protein ID: 2165646417

Symbol: PPR3D_HUMAN

Name: Protein phosphatase 1 regulatory subunit 3D

UniProtKB Accession Codes:

O95685 Q6DK02

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9414128

Title: PPP1R6, a novel member of the family of glycogen-targeting subunits of protein phosphatase 1.

PubMed ID: 9414128

DOI: 10.1016/s0014-5793(97)01385-9

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16901901

Title: Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates.

PubMed ID: 16901901

DOI: 10.1074/jbc.m606117200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23624058

Title: Glycogenic activity of R6, a protein phosphatase 1 regulatory subunit, is modulated by the laforin-malin complex.

PubMed ID: 23624058

DOI: 10.1016/j.biocel.2013.04.019

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 299
  • Mass: 32559
  • Checksum: DB848FB1CF55E49E
  • Sequence:
    • MSRGPSSAVL PSALGSRKLG PRSLSCLSDL DGGVALEPRA CRPPGSPGRA PPPTPAPSGC 
DPRLRPIILR RARSLPSSPE RRQKAAGAPG AACRPGCSQK LRVRFADALG LELAQVKVFN 
AGDDPSVPLH VLSRLAINSD LCCSSQDLEF TLHCLVPDFP PPVEAADFGE RLQRQLVCLE 
RVTCSDLGIS GTVRVCNVAF EKQVAVRYTF SGWRSTHEAV ARWRGPAGPE GTEDVFTFGF 
PVPPFLLELG SRVHFAVRYQ VAGAEYWDNN DHRDYSLTCR NHALHMPRGE CEESWIHFI

Genular Protein ID: 440163092

Symbol: Q86X09_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86X09

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CAZy 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 299
  • Mass: 32559
  • Checksum: 2E848FB1CF55E228
  • Sequence:
    • MSRGPSSAVL PSALGSRKLG PRSLSCLSDL DGGVALEPRA CRPPGSPGRA PPPTPAPSGC 
DPRLRPIILR RARSLPSSPE RRQKAAGAPG AACRPGCSQK LRVRFADALG LELAQVKVFN 
AGDDPSVPLH VLSRLAINSD LCCSSQDLEF TLHCLVPDFP PPVEAADFGE RLQRQLVCLE 
RVTCSDLGIS GTVRVCNVAF EKQVAVRYTF SGWRSTHEAV ARWRGPAGPE GTEDVFTFGF 
PVPPFLLELG SRVHFAVRYQ VAGAEYWDNN DHRDYSITCR NHALHMPRGE CEESWIHFI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.