Details for: PPP3CC

Gene ID: 5533

Symbol: PPP3CC

Ensembl ID: ENSG00000120910

Description: protein phosphatase 3 catalytic subunit gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 267.1892
    Cell Significance Index: -41.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 165.1039
    Cell Significance Index: -41.8800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 93.2914
    Cell Significance Index: -44.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 93.0938
    Cell Significance Index: -37.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 84.6642
    Cell Significance Index: -43.5500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.6966
    Cell Significance Index: -37.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.8512
    Cell Significance Index: -42.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.1795
    Cell Significance Index: -37.9900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.8690
    Cell Significance Index: -28.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.5841
    Cell Significance Index: -35.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.0452
    Cell Significance Index: -43.5900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 4.2825
    Cell Significance Index: 104.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.5738
    Cell Significance Index: 197.5100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.3327
    Cell Significance Index: 33.5500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.1186
    Cell Significance Index: 33.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.0914
    Cell Significance Index: 53.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8838
    Cell Significance Index: 377.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.7520
    Cell Significance Index: 34.2000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.5699
    Cell Significance Index: 25.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5665
    Cell Significance Index: 561.8900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.5305
    Cell Significance Index: 18.2500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.1567
    Cell Significance Index: 24.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0800
    Cell Significance Index: 214.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0759
    Cell Significance Index: 126.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7406
    Cell Significance Index: 73.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6560
    Cell Significance Index: 453.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5735
    Cell Significance Index: 35.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4582
    Cell Significance Index: 845.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4507
    Cell Significance Index: 85.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4491
    Cell Significance Index: 691.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4412
    Cell Significance Index: 24.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4344
    Cell Significance Index: 16.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3911
    Cell Significance Index: 24.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3758
    Cell Significance Index: 61.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3618
    Cell Significance Index: 681.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3579
    Cell Significance Index: 15.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3495
    Cell Significance Index: 23.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3482
    Cell Significance Index: 8.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2978
    Cell Significance Index: 19.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1758
    Cell Significance Index: 79.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1688
    Cell Significance Index: 107.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1382
    Cell Significance Index: 187.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1320
    Cell Significance Index: 3.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0862
    Cell Significance Index: 2.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0850
    Cell Significance Index: 10.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0575
    Cell Significance Index: 10.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0494
    Cell Significance Index: 5.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0431
    Cell Significance Index: 38.8900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0411
    Cell Significance Index: 0.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0362
    Cell Significance Index: 0.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0237
    Cell Significance Index: 0.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0232
    Cell Significance Index: 10.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0040
    Cell Significance Index: 0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0007
    Cell Significance Index: 0.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0063
    Cell Significance Index: -3.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0200
    Cell Significance Index: -2.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0250
    Cell Significance Index: -0.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0252
    Cell Significance Index: -3.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0283
    Cell Significance Index: -0.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0292
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0335
    Cell Significance Index: -24.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0487
    Cell Significance Index: -35.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0516
    Cell Significance Index: -39.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0535
    Cell Significance Index: -1.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0605
    Cell Significance Index: -34.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0641
    Cell Significance Index: -4.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0665
    Cell Significance Index: -4.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0750
    Cell Significance Index: -46.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0868
    Cell Significance Index: -11.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1041
    Cell Significance Index: -13.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1163
    Cell Significance Index: -2.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1165
    Cell Significance Index: -1.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1194
    Cell Significance Index: -6.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1276
    Cell Significance Index: -36.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1381
    Cell Significance Index: -14.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1409
    Cell Significance Index: -8.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1775
    Cell Significance Index: -9.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2052
    Cell Significance Index: -43.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2419
    Cell Significance Index: -28.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2460
    Cell Significance Index: -11.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2782
    Cell Significance Index: -31.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2996
    Cell Significance Index: -13.9700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3504
    Cell Significance Index: -4.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3717
    Cell Significance Index: -7.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3732
    Cell Significance Index: -19.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3944
    Cell Significance Index: -8.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4182
    Cell Significance Index: -29.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4808
    Cell Significance Index: -13.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4813
    Cell Significance Index: -29.5100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5198
    Cell Significance Index: -6.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5246
    Cell Significance Index: -41.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5404
    Cell Significance Index: -14.7100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5528
    Cell Significance Index: -3.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6024
    Cell Significance Index: -13.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6208
    Cell Significance Index: -10.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6236
    Cell Significance Index: -16.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6287
    Cell Significance Index: -20.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6424
    Cell Significance Index: -20.4600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6470
    Cell Significance Index: -8.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6616
    Cell Significance Index: -21.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PP3γ possesses several key characteristics that distinguish it from other phosphatase subunits. Firstly, its ability to bind to calmodulin, a calcium-binding protein, confers upon it the capacity to regulate calcium-dependent protein serine/threonine phosphatase activity. This interaction also enables PP3γ to modulate calcineurin-mediated signaling pathways, which are critical for the regulation of gene expression and cell survival. Additionally, PP3γ's capacity to interact with various signaling molecules, such as G-proteins and opioid receptors, underscores its role in modulating diverse signaling cascades. Furthermore, PP3γ's ability to dephosphorylate and regulate protein kinases, including the Bad protein and the BH3-only proteins, highlights its involvement in the intrinsic pathway of apoptosis. This capacity to modulate protein kinase activity also underscores its role in the regulation of cell growth, differentiation, and survival. **Pathways and Functions** The PPP3CC gene encodes a protein that is involved in numerous signaling pathways, including: 1. **Calcineurin-mediated signaling**: PP3γ interacts with calmodulin to regulate calcineurin activity, which is critical for the regulation of gene expression and cell survival. 2. **Apoptosis**: PP3γ dephosphorylates and regulates protein kinases involved in the intrinsic pathway of apoptosis, including the Bad protein and BH3-only proteins. 3. **Calcium-dependent protein serine/threonine phosphatase activity**: PP3γ's ability to bind calmodulin enables it to regulate calcium-dependent protein serine/threonine phosphatase activity. 4. **G-protein signaling**: PP3γ interacts with G-proteins to modulate signaling cascades involved in various physiological processes. 5. **Opioid signaling**: PP3γ dephosphorylates and regulates opioid receptors, highlighting its role in modulating pain and analgesia. **Clinical Significance** The PPP3CC gene has significant clinical implications, particularly in the context of: 1. **Neurological disorders**: Dysregulation of PP3γ has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Cancer**: PP3γ's role in regulating apoptosis and cell growth makes it a potential target for cancer therapy. 3. **Immunological disorders**: PP3γ's involvement in immune cell function and signaling pathways underscores its potential role in immunological disorders, such as autoimmune diseases and immunodeficiency syndromes. 4. **Muscular dystrophy**: PP3γ's expression in muscle cells highlights its potential role in muscular dystrophy and other muscle disorders. In conclusion, the PPP3CC gene encodes a protein phosphatase 3 catalytic subunit gamma that plays a critical role in various cellular processes, including calcium signaling, protein dephosphorylation, and programmed cell death. Its widespread expression and involvement in multiple signaling pathways underscore its importance in both physiological and pathological contexts, making it a valuable target for future research and therapeutic interventions.

Genular Protein ID: 1229595273

Symbol: PP2BC_HUMAN

Name: Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

UniProtKB Accession Codes:

P48454 B4DRT5 Q9BSS6 Q9H4M5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 17 ChiTaRS 1 ComplexPortal 4 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1339277

Title: Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A).

PubMed ID: 1339277

DOI: 10.1016/0006-291x(92)92379-c

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19154138

Title: The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding.

PubMed ID: 19154138

DOI: 10.1021/bi8019355

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 34446558

Title: SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.

PubMed ID: 34446558

DOI: 10.1073/pnas.2106673118

Sequence Information:

  • Length: 512
  • Mass: 58129
  • Checksum: 1C3AA7996660D575
  • Sequence:
    • MSGRRFHLST TDRVIKAVPF PPTQRLTFKE VFENGKPKVD VLKNHLVKEG RLEEEVALKI 
INDGAAILRQ EKTMIEVDAP ITVCGDIHGQ FFDLMKLFEV GGSPSNTRYL FLGDYVDRGY 
FSIECVLYLW SLKINHPKTL FLLRGNHECR HLTDYFTFKQ ECRIKYSEQV YDACMETFDC 
LPLAALLNQQ FLCVHGGMSP EITSLDDIRK LDRFTEPPAF GPVCDLLWSD PSEDYGNEKT 
LEHYTHNTVR GCSYFYSYPA VCEFLQNNNL LSIIRAHEAQ DAGYRMYRKS QATGFPSLIT 
IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF NCSPHPYWLP NFMDVFTWSL PFVGEKVTEM 
LVNVLNICSD DELISDDEAE GSTTVRKEII RNKIRAIGKM ARVFSILRQE SESVLTLKGL 
TPTGTLPLGV LSGGKQTIET ATVEAVEARE AIRGFSLQHK IRSFEEARGL DRINERMPPR 
KDSIHAGGPM KSVTSAHSHA AHRSDQGKKA HS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.