PRKCE | ENSG00000171132 | NCBI 5581

Details for: PRKCE

Gene ID: 5581

Symbol: PRKCE

Ensembl ID: ENSG00000171132

Description: protein kinase C epsilon

Associated with

Dag and ip3 signaling
(R-HSA-1489509)
Effects of pip2 hydrolysis
(R-HSA-114508)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
G alpha (q) signalling events
(R-HSA-416476)
G alpha (z) signalling events
(R-HSA-418597)
Gpcr downstream signalling
(R-HSA-388396)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Intracellular signaling by second messengers
(R-HSA-9006925)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Signaling by erbb2
(R-HSA-1227986)
Signaling by gpcr
(R-HSA-372790)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
14-3-3 protein binding
(GO:0071889)
Actin monomer binding
(GO:0003785)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Cell-substrate adhesion
(GO:0031589)
Cell division
(GO:0051301)
Cell periphery
(GO:0071944)
Cellular response to ethanol
(GO:0071361)
Cellular response to hypoxia
(GO:0071456)
Cellular response to prostaglandin e stimulus
(GO:0071380)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Diacylglycerol-dependent, calcium-independent serine/threonine kinase activity
(GO:0004699)
Diacylglycerol-dependent serine/threonine kinase activity
(GO:0004697)
Endoplasmic reticulum
(GO:0005783)
Enzyme activator activity
(GO:0008047)
Enzyme binding
(GO:0019899)
Establishment of localization in cell
(GO:0051649)
Ethanol binding
(GO:0035276)
Fc-gamma receptor signaling pathway involved in phagocytosis
(GO:0038096)
Golgi apparatus
(GO:0005794)
Insulin secretion
(GO:0030073)
Intermediate filament cytoskeleton
(GO:0045111)
Intracellular membrane-bounded organelle
(GO:0043231)
Intracellular signal transduction
(GO:0035556)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Locomotory exploration behavior
(GO:0035641)
Macrophage activation involved in immune response
(GO:0002281)
Mapk cascade
(GO:0000165)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Mucus secretion
(GO:0070254)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of sodium ion transmembrane transport
(GO:1902306)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of actin filament polymerization
(GO:0030838)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell-substrate adhesion
(GO:0010811)
Positive regulation of cellular glucuronidation
(GO:2001031)
Positive regulation of cytokinesis
(GO:0032467)
Positive regulation of epithelial cell migration
(GO:0010634)
Positive regulation of fibroblast migration
(GO:0010763)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of lipid catabolic process
(GO:0050996)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of mucus secretion
(GO:0070257)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Positive regulation of superoxide anion generation
(GO:0032930)
Positive regulation of synaptic transmission, gabaergic
(GO:0032230)
Positive regulation of wound healing
(GO:0090303)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0061178)
Regulation of release of sequestered calcium ion into cytosol
(GO:0051279)
Response to morphine
(GO:0043278)
Signaling receptor activator activity
(GO:0030546)
Signal transduction
(GO:0007165)
Synapse
(GO:0045202)
Synaptic transmission, gabaergic
(GO:0051932)
Toxin catabolic process
(GO:0009407)
Tram-dependent toll-like receptor 4 signaling pathway
(GO:0035669)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 417.9492
Cell Significance Index: -65.0100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 255.9499
Cell Significance Index: -64.9200
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 130.8285
Cell Significance Index: -53.1500
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 55.8370
Cell Significance Index: -53.3100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 52.7756
Cell Significance Index: -65.0700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 16.5862
Cell Significance Index: -65.4500
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 5.6653
Cell Significance Index: 161.6700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 5.1039
Cell Significance Index: 343.1900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.1774
Cell Significance Index: 637.3800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.8782
Cell Significance Index: 220.8700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.5707
Cell Significance Index: 922.0700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.5338
Cell Significance Index: 65.1300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.4868
Cell Significance Index: 152.8500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.4622
Cell Significance Index: 108.9100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.4213
Cell Significance Index: 91.6900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.2579
Cell Significance Index: 1561.6700
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 2.1205
Cell Significance Index: 27.5000
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 2.1120
Cell Significance Index: 22.0000
Cell Name: preadipocyte (CL0002334)
Fold Change: 2.0797
Cell Significance Index: 40.5900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.0524
Cell Significance Index: 115.1700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.9559
Cell Significance Index: 54.6600
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.8376
Cell Significance Index: 26.4300
Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.5957
Cell Significance Index: 38.2700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.4943
Cell Significance Index: 296.5400
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.9936
Cell Significance Index: 8.8200
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 0.8344
Cell Significance Index: 11.1300
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.6594
Cell Significance Index: 6.8300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.6442
Cell Significance Index: 11.0400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.5163
Cell Significance Index: 327.8800
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.4930
Cell Significance Index: 12.0300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3771
Cell Significance Index: 24.3300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3275
Cell Significance Index: 295.6700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.3004
Cell Significance Index: 15.6500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1791
Cell Significance Index: 5.1600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1631
Cell Significance Index: 74.0400
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.1330
Cell Significance Index: 1.0200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1213
Cell Significance Index: 186.7300
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1111
Cell Significance Index: 204.9500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0834
Cell Significance Index: 15.8700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0763
Cell Significance Index: 12.4100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0570
Cell Significance Index: 5.6400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0538
Cell Significance Index: 101.2700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0255
Cell Significance Index: 3.1300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0230
Cell Significance Index: 4.1600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0205
Cell Significance Index: 27.8900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0134
Cell Significance Index: 0.4700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0148
Cell Significance Index: -1.0300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0315
Cell Significance Index: -4.5800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0338
Cell Significance Index: -21.0800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0383
Cell Significance Index: -28.3600
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0531
Cell Significance Index: -28.9900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0660
Cell Significance Index: -37.2100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0743
Cell Significance Index: -54.4800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0843
Cell Significance Index: -37.2700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0844
Cell Significance Index: -63.9000
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.1100
Cell Significance Index: -1.5800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.1338
Cell Significance Index: -14.5600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1715
Cell Significance Index: -20.2300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1837
Cell Significance Index: -1.1100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1965
Cell Significance Index: -56.5500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2038
Cell Significance Index: -42.9300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.2161
Cell Significance Index: -36.9000
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2578
Cell Significance Index: -5.5100
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2813
Cell Significance Index: -5.9700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.3039
Cell Significance Index: -41.7300
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.3063
Cell Significance Index: -3.8200
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3135
Cell Significance Index: -4.4900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.3143
Cell Significance Index: -6.8100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.3369
Cell Significance Index: -15.2700
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3566
Cell Significance Index: -41.5600
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.3641
Cell Significance Index: -7.2000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3808
Cell Significance Index: -39.6500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3820
Cell Significance Index: -43.7700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.3899
Cell Significance Index: -39.8300
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3900
Cell Significance Index: -7.8300
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.4167
Cell Significance Index: -4.5400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.4231
Cell Significance Index: -54.6600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.4384
Cell Significance Index: -26.3200
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.4429
Cell Significance Index: -5.5900
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.4623
Cell Significance Index: -6.4700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4667
Cell Significance Index: -15.2800
Cell Name: odontoblast (CL0000060)
Fold Change: -0.4972
Cell Significance Index: -63.7400
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5121
Cell Significance Index: -7.5600
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5157
Cell Significance Index: -58.8700
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.5696
Cell Significance Index: -5.4200
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.5790
Cell Significance Index: -18.4400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.5808
Cell Significance Index: -30.1700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.6273
Cell Significance Index: -15.6800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.6362
Cell Significance Index: -29.9000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.7281
Cell Significance Index: -38.2300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7316
Cell Significance Index: -57.9500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7428
Cell Significance Index: -45.5400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.7565
Cell Significance Index: -56.3800
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.7735
Cell Significance Index: -13.0300
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.7859
Cell Significance Index: -11.6000
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.8500
Cell Significance Index: -18.3700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.8617
Cell Significance Index: -27.6000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.9266
Cell Significance Index: -65.5300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.9660
Cell Significance Index: -60.8900
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.1044
Cell Significance Index: -38.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** PRKCE is a member of the PKC family, which is characterized by the presence of a characteristic "FXFP" motif, which binds to the regulatory proteins 14-3-3. The gene product, PRKCE, exhibits diacylglycerol-dependent activity, which is mediated by the binding of diacylglycerol to the C-terminal domain of the protein. This binding event triggers a conformational change in the protein, allowing it to interact with and phosphorylate downstream targets. PRKCE also exhibits a high degree of specificity, with a preference for phosphorylating serine and threonine residues. **Pathways and Functions** PRKCE is involved in a wide range of cellular processes, including: 1. **Signaling by Second Messengers**: PRKCE is activated by diacylglycerol, a second messenger that plays a key role in various signaling pathways, including those involved in cell proliferation, differentiation, and survival. 2. **Cell Cycle Regulation**: PRKCE has been shown to regulate the cell cycle by phosphorylating and activating proteins involved in the G1/S transition. 3. **Apoptosis**: PRKCE has been implicated in the regulation of apoptosis, with some studies suggesting that it may play a role in promoting cell survival. 4. **Neurotransmission**: PRKCE is widely expressed in the nervous system and has been implicated in the regulation of neurotransmitter release and synaptic transmission. 5. **Immune Response**: PRKCE has been shown to regulate the immune response by phosphorylating and activating proteins involved in the activation of immune cells. **Clinical Significance** PRKCE has been implicated in a range of diseases, including: 1. **Neurological Disorders**: PRKCE has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 2. **Cancer**: PRKCE has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer. 3. **Cardiovascular Disease**: PRKCE has been implicated in the regulation of cardiovascular function and has been shown to be involved in the pathogenesis of cardiovascular disease. 4. **Immune System Disorders**: PRKCE has been implicated in the regulation of the immune response and has been shown to be involved in the pathogenesis of immune system disorders, including autoimmune diseases. In conclusion, PRKCE is a critical regulator of cellular processes, including signaling, differentiation, and survival. Its dysregulation has been implicated in a range of diseases, highlighting the importance of further research into the mechanisms of PRKCE and its role in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Protein kinase C epsilon type

Genular Protein ID: 3034855729

Symbol: KPCE_HUMAN

Name: Protein kinase C epsilon type

UniProtKB Accession Codes:

Q02156 B0LPH7 Q32MQ3 Q53SL4 Q53SM5 Q9UE81

Database IDs:

Citations:

PubMed ID: 1382605

Title: Sequence and expression of human protein kinase C-epsilon.

PubMed ID: 1382605

DOI: 10.1016/0167-4781(92)90006-l

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1374067

Title: PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18.

PubMed ID: 1374067

DOI: 10.1083/jcb.117.3.583

PubMed ID: 11964154

Title: Regulation of novel protein kinase C epsilon by phosphorylation.

PubMed ID: 11964154

DOI: 10.1042/0264-6021:3630537

PubMed ID: 11884385

Title: Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues.

PubMed ID: 11884385

DOI: 10.1074/jbc.c200104200

PubMed ID: 15355962

Title: Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator.

PubMed ID: 15355962

DOI: 10.1074/jbc.m408113200

PubMed ID: 15632189

Title: Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C.

PubMed ID: 15632189

DOI: 10.1074/jbc.m409301200

PubMed ID: 16757566

Title: Trif-related adapter molecule is phosphorylated by PKCepsilon during Toll-like receptor 4 signaling.

PubMed ID: 16757566

DOI: 10.1073/pnas.0600462103

PubMed ID: 17875724

Title: Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer.

PubMed ID: 17875724

DOI: 10.1158/0008-5472.can-07-1604

PubMed ID: 17603037

Title: Protein kinase C alpha and epsilon differentially modulate hepatocyte growth factor-induced epithelial proliferation and migration.

PubMed ID: 17603037

DOI: 10.1016/j.exer.2007.05.004

PubMed ID: 17875639

Title: Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits.

PubMed ID: 17875639

DOI: 10.1074/jbc.m707233200

PubMed ID: 12473185

Title: Protein kinase C-epsilon (PKC-epsilon): its unique structure and function.

PubMed ID: 12473185

DOI: 10.1093/oxfordjournals.jbchem.a003296

PubMed ID: 16584980

Title: TNF-related apoptosis-inducing ligand (TRAIL) and erythropoiesis: a role for PKC epsilon.

PubMed ID: 16584980

PubMed ID: 18637121

Title: Protein kinase Cepsilon: function in neurons.

PubMed ID: 18637121

DOI: 10.1111/j.1742-4658.2008.06556.x

PubMed ID: 18637120

Title: Protein kinase Cepsilon: multiple roles in the function of, and signaling mediated by, the cytoskeleton.

PubMed ID: 18637120

DOI: 10.1111/j.1742-4658.2008.06557.x

PubMed ID: 18408015

Title: Protein kinase Cepsilon binds peripherin and induces its aggregation, which is accompanied by apoptosis of neuroblastoma cells.

PubMed ID: 18408015

DOI: 10.1074/jbc.m710436200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19542546

Title: MATER protein as substrate of PKCepsilon in human cumulus cells.

PubMed ID: 19542546

DOI: 10.1093/molehr/gap048

PubMed ID: 20350291

Title: The substrates and binding partners of protein kinase Cepsilon.

PubMed ID: 20350291

DOI: 10.1042/bj20091302

PubMed ID: 20353823

Title: Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response.

PubMed ID: 20353823

DOI: 10.1016/j.cellsig.2010.03.012

PubMed ID: 21681677

Title: The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases.

PubMed ID: 21681677

DOI: 10.1007/s11684-011-0119-9

PubMed ID: 21810427

Title: PKC-delta and PKC-epsilon: Foes of the same family or strangers?

PubMed ID: 21810427

DOI: 10.1016/j.yjmcc.2011.07.013

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 34593629

Title: Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs.

PubMed ID: 34593629

DOI: 10.1073/pnas.2018899118

PubMed ID: 36040231

Title: PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.

PubMed ID: 36040231

DOI: 10.1042/bcj20220308

PubMed ID: 19662078

Title: Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon.

PubMed ID: 19662078

DOI: 10.1038/embor.2009.150

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 737
Mass: 83674
Checksum: 85032D0A091A1F7F
Sequence:

MVVFNGLLKI KICEAVSLKP TAWSLRHAVG PRPQTFLLDP YIALNVDDSR IGQTATKQKT 
NSPAWHDEFV TDVCNGRKIE LAVFHDAPIG YDDFVANCTI QFEELLQNGS RHFEDWIDLE 
PEGRVYVIID LSGSSGEAPK DNEERVFRER MRPRKRQGAV RRRVHQVNGH KFMATYLRQP 
TYCSHCRDFI WGVIGKQGYQ CQVCTCVVHK RCHELIITKC AGLKKQETPD QVGSQRFSVN 
MPHKFGIHNY KVPTFCDHCG SLLWGLLRQG LQCKVCKMNV HRRCETNVAP NCGVDARGIA 
KVLADLGVTP DKITNSGQRR KKLIAGAESP QPASGSSPSE EDRSKSAPTS PCDQEIKELE 
NNIRKALSFD NRGEEHRAAS SPDGQLMSPG ENGEVRQGQA KRLGLDEFNF IKVLGKGSFG 
KVMLAELKGK DEVYAVKVLK KDVILQDDDV DCTMTEKRIL ALARKHPYLT QLYCCFQTKD 
RLFFVMEYVN GGDLMFQIQR SRKFDEPRSR FYAAEVTSAL MFLHQHGVIY RDLKLDNILL 
DAEGHCKLAD FGMCKEGILN GVTTTTFCGT PDYIAPEILQ ELEYGPSVDW WALGVLMYEM 
MAGQPPFEAD NEDDLFESIL HDDVLYPVWL SKEAVSILKA FMTKNPHKRL GCVASQNGED 
AIKQHPFFKE IDWVLLEQKK IKPPFKPRIK TKRDVNNFDQ DFTREEPVLT LVDEAIVKQI 
NQEEFKGFSY FGEDLMP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRKCE

Associated with

Cells (max top 100)

Other Information

Sequence and expression of human protein kinase C-epsilon. PubMed ID: 1382605

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18. PubMed ID: 1374067

Regulation of novel protein kinase C epsilon by phosphorylation. PubMed ID: 11964154

Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. PubMed ID: 11884385

Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator. PubMed ID: 15355962

Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C. PubMed ID: 15632189

Trif-related adapter molecule is phosphorylated by PKCepsilon during Toll-like receptor 4 signaling. PubMed ID: 16757566

Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer. PubMed ID: 17875724

Protein kinase C alpha and epsilon differentially modulate hepatocyte growth factor-induced epithelial proliferation and migration. PubMed ID: 17603037

Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. PubMed ID: 17875639

Protein kinase C-epsilon (PKC-epsilon): its unique structure and function. PubMed ID: 12473185

TNF-related apoptosis-inducing ligand (TRAIL) and erythropoiesis: a role for PKC epsilon. PubMed ID: 16584980

Protein kinase Cepsilon: function in neurons. PubMed ID: 18637121

Protein kinase Cepsilon: multiple roles in the function of, and signaling mediated by, the cytoskeleton. PubMed ID: 18637120

Protein kinase Cepsilon binds peripherin and induces its aggregation, which is accompanied by apoptosis of neuroblastoma cells. PubMed ID: 18408015

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

MATER protein as substrate of PKCepsilon in human cumulus cells. PubMed ID: 19542546

The substrates and binding partners of protein kinase Cepsilon. PubMed ID: 20350291

Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response. PubMed ID: 20353823

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases. PubMed ID: 21681677

PKC-delta and PKC-epsilon: Foes of the same family or strangers? PubMed ID: 21810427

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs. PubMed ID: 34593629

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain. PubMed ID: 36040231

Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon. PubMed ID: 19662078

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846