Details for: PKN1

Gene ID: 5585

Symbol: PKN1

Ensembl ID: ENSG00000123143

Description: protein kinase N1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 200.1347
    Cell Significance Index: -31.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 106.8823
    Cell Significance Index: -27.1100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.6111
    Cell Significance Index: -28.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 64.1348
    Cell Significance Index: -32.9900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.3223
    Cell Significance Index: -28.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.5078
    Cell Significance Index: -31.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.4257
    Cell Significance Index: -25.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.0739
    Cell Significance Index: -31.8600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.8432
    Cell Significance Index: -24.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.3093
    Cell Significance Index: 120.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.6370
    Cell Significance Index: 43.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3842
    Cell Significance Index: 89.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3007
    Cell Significance Index: 128.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2470
    Cell Significance Index: 1125.9300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.8999
    Cell Significance Index: 14.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7011
    Cell Significance Index: 114.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6588
    Cell Significance Index: 359.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6391
    Cell Significance Index: 69.5200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6325
    Cell Significance Index: 11.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6274
    Cell Significance Index: 29.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6024
    Cell Significance Index: 82.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5771
    Cell Significance Index: 114.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5477
    Cell Significance Index: 11.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3232
    Cell Significance Index: 38.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3129
    Cell Significance Index: 216.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3007
    Cell Significance Index: 20.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2680
    Cell Significance Index: 48.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2474
    Cell Significance Index: 49.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2466
    Cell Significance Index: 88.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1909
    Cell Significance Index: 8.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1815
    Cell Significance Index: 34.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1614
    Cell Significance Index: 4.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1468
    Cell Significance Index: 3.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1155
    Cell Significance Index: 8.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1000
    Cell Significance Index: 12.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0999
    Cell Significance Index: 6.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0679
    Cell Significance Index: 8.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0600
    Cell Significance Index: 10.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0354
    Cell Significance Index: 1.0400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0199
    Cell Significance Index: 0.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0096
    Cell Significance Index: 0.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0092
    Cell Significance Index: 17.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0090
    Cell Significance Index: 12.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0034
    Cell Significance Index: 5.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0012
    Cell Significance Index: 0.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0006
    Cell Significance Index: -1.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0146
    Cell Significance Index: -0.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0177
    Cell Significance Index: -7.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0212
    Cell Significance Index: -0.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0219
    Cell Significance Index: -9.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0225
    Cell Significance Index: -14.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0226
    Cell Significance Index: -17.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0312
    Cell Significance Index: -23.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0348
    Cell Significance Index: -25.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0461
    Cell Significance Index: -4.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0541
    Cell Significance Index: -30.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0596
    Cell Significance Index: -37.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0618
    Cell Significance Index: -2.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0890
    Cell Significance Index: -10.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0904
    Cell Significance Index: -1.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0931
    Cell Significance Index: -13.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0952
    Cell Significance Index: -27.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1047
    Cell Significance Index: -7.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1224
    Cell Significance Index: -3.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1230
    Cell Significance Index: -14.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1284
    Cell Significance Index: -6.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1387
    Cell Significance Index: -7.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1710
    Cell Significance Index: -36.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1973
    Cell Significance Index: -5.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2728
    Cell Significance Index: -28.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2946
    Cell Significance Index: -19.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3156
    Cell Significance Index: -16.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3385
    Cell Significance Index: -23.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3678
    Cell Significance Index: -7.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3690
    Cell Significance Index: -29.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3916
    Cell Significance Index: -17.3200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4197
    Cell Significance Index: -9.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4278
    Cell Significance Index: -7.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4785
    Cell Significance Index: -18.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5050
    Cell Significance Index: -17.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5367
    Cell Significance Index: -15.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5417
    Cell Significance Index: -33.2100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5453
    Cell Significance Index: -4.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5577
    Cell Significance Index: -15.1800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5607
    Cell Significance Index: -8.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5657
    Cell Significance Index: -14.5400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5782
    Cell Significance Index: -5.9900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5813
    Cell Significance Index: -13.9400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5864
    Cell Significance Index: -8.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6800
    Cell Significance Index: -23.8200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6899
    Cell Significance Index: -10.1900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6910
    Cell Significance Index: -12.2100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.6962
    Cell Significance Index: -1.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7038
    Cell Significance Index: -16.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7052
    Cell Significance Index: -14.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7242
    Cell Significance Index: -21.3300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7555
    Cell Significance Index: -16.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7903
    Cell Significance Index: -15.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8026
    Cell Significance Index: -21.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PKN1 is a member of the protein kinase N (PKN) family, which is characterized by their ability to bind to and regulate the activity of small GTPases, such as Rac1, RhoA, and RhoB. PKN1 is a serine/threonine kinase that exhibits specificity for phosphorylating serine and threonine residues on target proteins. The enzyme is activated by phosphatidylinositol 4,5-bisphosphate (PIP2) and diacylglycerol (DAG), which are key regulators of cellular signaling pathways. **Pathways and Functions:** PKN1 is involved in various signaling pathways, including: 1. **Androgen Receptor Signaling:** PKN1 stimulates the transcription of androgen-regulated genes, such as KLK2 and KLK3, which are essential for prostate development and function. 2. **B Cell Homeostasis:** PKN1 regulates B cell proliferation and apoptosis, ensuring the proper development and maintenance of the immune system. 3. **Cell Migration:** PKN1 is involved in the regulation of epithelial cell migration, which is essential for tissue development and repair. 4. **Signaling by Rho GTPases:** PKN1 interacts with Rho GTPases, such as Rac1 and RhoA, to regulate their activity and downstream signaling pathways. PKN1's functions include: 1. **Phosphorylation of Target Proteins:** PKN1 phosphorylates and regulates the activity of various target proteins, including transcription factors, kinases, and GTPases. 2. **Regulation of Transcription:** PKN1 stimulates the transcription of target genes by phosphorylating and activating transcription factors. 3. **Regulation of Cell Cycle:** PKN1 regulates the cell cycle by phosphorylating and activating cyclin-dependent kinases. **Clinical Significance:** PKN1's dysregulation has been implicated in various immune-related disorders, including: 1. **Prostate Cancer:** PKN1's role in androgen receptor signaling has been implicated in prostate cancer development and progression. 2. **Autoimmune Diseases:** PKN1's regulation of B cell homeostasis and apoptosis has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Immunodeficiency Disorders:** PKN1's role in regulating T cell function and development has been implicated in immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, PKN1 is a multifaceted regulator of cellular processes and immune function. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of PKN1 in maintaining immune homeostasis and preventing disease. Further research is needed to fully elucidate PKN1's role in immune function and its potential as a therapeutic target for immune-related disorders.

Genular Protein ID: 3621822655

Symbol: PKN1_HUMAN

Name: Serine/threonine-protein kinase N1

UniProtKB Accession Codes:

Q16512 A8K7W5 B2R9R4 B3KVN3 Q15143 Q504U4 Q8IUV5 Q9UD44

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 5 CORUM 1 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 ELM 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 2 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 Rhea 6 SABIO-RK 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8135837

Title: A novel protein kinase with leucine zipper-like sequences: its catalytic domain is highly homologous to that of protein kinase C.

PubMed ID: 8135837

DOI: 10.1006/bbrc.1994.1313

PubMed ID: 7851406

Title: Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family.

PubMed ID: 7851406

DOI: 10.1111/j.1432-1033.1995.tb20395.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7988719

Title: Identification of multiple, novel, protein kinase C-related gene products.

PubMed ID: 7988719

DOI: 10.1016/0014-5793(94)01202-4

PubMed ID: 8557118

Title: PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163.

PubMed ID: 8557118

DOI: 10.1016/0014-5793(95)01454-3

PubMed ID: 8621664

Title: PKN associates and phosphorylates the head-rod domain of neurofilament protein.

PubMed ID: 8621664

DOI: 10.1074/jbc.271.16.9816

PubMed ID: 8571126

Title: Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho.

PubMed ID: 8571126

DOI: 10.1126/science.271.5249.645

PubMed ID: 9175763

Title: Domain-specific phosphorylation of vimentin and glial fibrillary acidic protein by PKN.

PubMed ID: 9175763

DOI: 10.1006/bbrc.1997.6669

PubMed ID: 9478917

Title: PRK1 is targeted to endosomes by the small GTPase, RhoB.

PubMed ID: 9478917

DOI: 10.1074/jbc.273.9.4811

PubMed ID: 9751706

Title: Proteolytic activation of PKN by caspase-3 or related protease during apoptosis.

PubMed ID: 9751706

DOI: 10.1073/pnas.95.20.11566

PubMed ID: 10792047

Title: Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton.

PubMed ID: 10792047

DOI: 10.1073/pnas.090491897

PubMed ID: 11104762

Title: Phosphorylation of tau is regulated by PKN.

PubMed ID: 11104762

DOI: 10.1074/jbc.m007427200

PubMed ID: 12514133

Title: A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer.

PubMed ID: 12514133

DOI: 10.1093/emboj/cdg023

PubMed ID: 16611232

Title: A Salmonella type III secretion effector interacts with the mammalian serine/threonine protein kinase PKN1.

PubMed ID: 16611232

DOI: 10.1111/j.1462-5822.2005.00670.x

PubMed ID: 16331689

Title: Pkn is a novel partner of cyclin T2a in muscle differentiation.

PubMed ID: 16331689

DOI: 10.1002/jcp.20566

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17332740

Title: Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis.

PubMed ID: 17332740

DOI: 10.1038/sj.emboj.7601637

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18066052

Title: Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation.

PubMed ID: 18066052

DOI: 10.1038/ncb1668

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20188095

Title: Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases.

PubMed ID: 20188095

DOI: 10.1016/j.febslet.2010.02.057

PubMed ID: 20228790

Title: Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.

PubMed ID: 20228790

DOI: 10.1038/nature08839

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21224381

Title: A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in alpha1-adrenergic receptor-induced p38 activation.

PubMed ID: 21224381

DOI: 10.1074/jbc.m110.185645

PubMed ID: 21754995

Title: Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration.

PubMed ID: 21754995

DOI: 10.1371/journal.pone.0021732

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10619026

Title: The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1.

PubMed ID: 10619026

DOI: 10.1016/s1097-2765(00)80389-5

PubMed ID: 10388627

Title: Biochemical and crystallographic characterization of a Rho effector domain of the protein serine/threonine kinase N in a complex with RhoA.

PubMed ID: 10388627

DOI: 10.1006/jsbi.1999.4114

PubMed ID: 14514689

Title: Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1).

PubMed ID: 14514689

DOI: 10.1074/jbc.m304313200

PubMed ID: 18006505

Title: The Rac1 polybasic region is required for interaction with its effector PRK1.

PubMed ID: 18006505

DOI: 10.1074/jbc.m706760200

PubMed ID: 24248594

Title: Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase.

PubMed ID: 24248594

DOI: 10.1128/mcb.01360-13

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 942
  • Mass: 103932
  • Checksum: 61360295EC70BB8E
  • Sequence:
    • MASDAVQSEP RSWSLLEQLG LAGADLAAPG VQQQLELERE RLRREIRKEL KLKEGAENLR 
RATTDLGRSL GPVELLLRGS SRRLDLLHQQ LQELHAHVVL PDPAATHDGP QSPGAGGPTC 
SATNLSRVAG LEKQLAIELK VKQGAENMIQ TYSNGSTKDR KLLLTAQQML QDSKTKIDII 
RMQLRRALQA GQLENQAAPD DTQGSPDLGA VELRIEELRH HFRVEHAVAE GAKNVLRLLS 
AAKAPDRKAV SEAQEKLTES NQKLGLLREA LERRLGELPA DHPKGRLLRE ELAAASSAAF 
STRLAGPFPA THYSTLCKPA PLTGTLEVRV VGCRDLPETI PWNPTPSMGG PGTPDSRPPF 
LSRPARGLYS RSGSLSGRSS LKAEAENTSE VSTVLKLDNT VVGQTSWKPC GPNAWDQSFT 
LELERARELE LAVFWRDQRG LCALKFLKLE DFLDNERHEV QLDMEPQGCL VAEVTFRNPV 
IERIPRLRRQ KKIFSKQQGK AFQRARQMNI DVATWVRLLR RLIPNATGTG TFSPGASPGS 
EARTTGDISV EKLNLGTDSD SSPQKSSRDP PSSPSSLSSP IQESTAPELP SETQETPGPA 
LCSPLRKSPL TLEDFKFLAV LGRGHFGKVL LSEFRPSGEL FAIKALKKGD IVARDEVESL 
MCEKRILAAV TSAGHPFLVN LFGCFQTPEH VCFVMEYSAG GDLMLHIHSD VFSEPRAIFY 
SACVVLGLQF LHEHKIVYRD LKLDNLLLDT EGYVKIADFG LCKEGMGYGD RTSTFCGTPE 
FLAPEVLTDT SYTRAVDWWG LGVLLYEMLV GESPFPGDDE EEVFDSIVND EVRYPRFLSA 
EAIGIMRRLL RRNPERRLGS SERDAEDVKK QPFFRTLGWE ALLARRLPPP FVPTLSGRTD 
VSNFDEEFTG EAPTLSPPRD ARPLTAAEQA AFLDFDFVAG GC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.