MAPK11 | ENSG00000185386 | NCBI 5600

Details for: MAPK11

Gene ID: 5600

Symbol: MAPK11

Ensembl ID: ENSG00000185386

Description: mitogen-activated protein kinase 11

Associated with

Activated tak1 mediates p38 mapk activation
(R-HSA-450302)
Activation of ppargc1a (pgc-1alpha) by phosphorylation
(R-HSA-2151209)
Activation of the ap-1 family of transcription factors
(R-HSA-450341)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Erk/mapk targets
(R-HSA-198753)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-17 signaling
(R-HSA-448424)
Ksrp (khsrp) binds and destabilizes mrna
(R-HSA-450604)
Map kinase activation
(R-HSA-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-HSA-450282)
Metabolism of rna
(R-HSA-8953854)
Mitochondrial biogenesis
(R-HSA-1592230)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Myogenesis
(R-HSA-525793)
Nod1/2 signaling pathway
(R-HSA-168638)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Oxidative stress induced senescence
(R-HSA-2559580)
P38mapk events
(R-HSA-171007)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate nadph oxidases
(R-HSA-5668599)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by interleukins
(R-HSA-449147)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signalling to erks
(R-HSA-187687)
Signalling to ras
(R-HSA-167044)
Signal transduction
(R-HSA-162582)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Transcriptional regulation by tp53
(R-HSA-3700989)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Atp binding
(GO:0005524)
Bone development
(GO:0060348)
Cardiac muscle cell proliferation
(GO:0060038)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to uv-b
(GO:0071493)
Cellular response to virus
(GO:0098586)
Cellular senescence
(GO:0090398)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Intracellular signal transduction
(GO:0035556)
Map kinase activity
(GO:0004707)
Negative regulation of cardiac muscle cell proliferation
(GO:0060044)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Osteoblast differentiation
(GO:0001649)
P38mapk cascade
(GO:0038066)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of muscle cell differentiation
(GO:0051149)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Stress-activated mapk cascade
(GO:0051403)
Stress-activated protein kinase signaling cascade
(GO:0031098)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 62.4899
Cell Significance Index: -9.7200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 37.2176
Cell Significance Index: -9.4400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 7.8754
Cell Significance Index: -9.7100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 2.8759
Cell Significance Index: 176.3200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.4645
Cell Significance Index: -9.7300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.3872
Cell Significance Index: 30.0500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.8002
Cell Significance Index: 152.2900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7614
Cell Significance Index: 152.7400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.7526
Cell Significance Index: 8.5500
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.6636
Cell Significance Index: 10.0000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5852
Cell Significance Index: 57.8900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4770
Cell Significance Index: 430.7100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.4131
Cell Significance Index: 7.3000
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.3625
Cell Significance Index: 2.7800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.3585
Cell Significance Index: 10.2300
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.3160
Cell Significance Index: 6.9200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2957
Cell Significance Index: 48.1000
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.2628
Cell Significance Index: 2.9200
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 0.2564
Cell Significance Index: 3.4200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2390
Cell Significance Index: 26.0000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2092
Cell Significance Index: 4.4600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1715
Cell Significance Index: 10.8100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.1601
Cell Significance Index: 7.0800
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.1406
Cell Significance Index: 1.1900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.1363
Cell Significance Index: 5.1600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1280
Cell Significance Index: 45.9000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1168
Cell Significance Index: 8.0800
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.1015
Cell Significance Index: 1.2100
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.0869
Cell Significance Index: 1.2500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0758
Cell Significance Index: 4.5500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0652
Cell Significance Index: 4.0100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0483
Cell Significance Index: 21.3400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.0220
Cell Significance Index: 0.3000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0150
Cell Significance Index: 0.4200
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 0.0129
Cell Significance Index: 0.1800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0023
Cell Significance Index: 4.4100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0021
Cell Significance Index: 0.0600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0020
Cell Significance Index: 0.0500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0005
Cell Significance Index: 0.3000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0030
Cell Significance Index: -1.9000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0031
Cell Significance Index: -0.1100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0044
Cell Significance Index: -0.2000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0055
Cell Significance Index: -10.1000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0055
Cell Significance Index: -8.5200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0078
Cell Significance Index: -10.6000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0087
Cell Significance Index: -1.1900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0098
Cell Significance Index: -7.2000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0110
Cell Significance Index: -8.1300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0119
Cell Significance Index: -9.0000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0135
Cell Significance Index: -7.6100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0159
Cell Significance Index: -2.8700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0161
Cell Significance Index: -10.0600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0198
Cell Significance Index: -9.0000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0224
Cell Significance Index: -3.2600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0263
Cell Significance Index: -7.5800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0287
Cell Significance Index: -3.3500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0296
Cell Significance Index: -3.6400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0329
Cell Significance Index: -1.7300
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0346
Cell Significance Index: -4.4400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0387
Cell Significance Index: -3.9500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0410
Cell Significance Index: -7.0000
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0411
Cell Significance Index: -8.1600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0478
Cell Significance Index: -10.0700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0521
Cell Significance Index: -2.4300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0535
Cell Significance Index: -6.1300
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0543
Cell Significance Index: -7.0200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0557
Cell Significance Index: -3.9400
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0646
Cell Significance Index: -0.9200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0669
Cell Significance Index: -7.8900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0709
Cell Significance Index: -2.2700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0760
Cell Significance Index: -5.1100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0873
Cell Significance Index: -5.6300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0887
Cell Significance Index: -1.5200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0899
Cell Significance Index: -9.3600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0918
Cell Significance Index: -4.7700
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0978
Cell Significance Index: -1.4000
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.1001
Cell Significance Index: -1.4100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1039
Cell Significance Index: -8.2300
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.1056
Cell Significance Index: -1.8300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1087
Cell Significance Index: -8.3500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1089
Cell Significance Index: -2.2600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1094
Cell Significance Index: -8.1500
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1102
Cell Significance Index: -3.5100
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.1111
Cell Significance Index: -1.2100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1206
Cell Significance Index: -3.9500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1221
Cell Significance Index: -6.3600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1271
Cell Significance Index: -5.9800
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1464
Cell Significance Index: -3.5100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1497
Cell Significance Index: -8.4000
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1523
Cell Significance Index: -3.2600
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1676
Cell Significance Index: -5.8700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1694
Cell Significance Index: -4.6100
Cell Name: decidual cell (CL2000002)
Fold Change: -0.1882
Cell Significance Index: -3.0200
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.2153
Cell Significance Index: -5.3700
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2198
Cell Significance Index: -5.4800
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2245
Cell Significance Index: -4.4400
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2300
Cell Significance Index: -4.9700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2308
Cell Significance Index: -6.1800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2313
Cell Significance Index: -6.6300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2337
Cell Significance Index: -8.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** MAPK11 exhibits characteristics that distinguish it from other MAPK family members. Some of its notable features include: * **Cellular localization**: MAPK11 is primarily localized in the cytoplasm and nucleus, where it interacts with other signaling proteins. * **Phosphorylation**: MAPK11 is phosphorylated at specific sites, which regulates its activity and interactions with other proteins. * **Subcellular localization**: MAPK11 is involved in various subcellular processes, including cytoskeletal organization, vesicle trafficking, and nuclear events. **Pathways and Functions** MAPK11 is involved in numerous signaling pathways, including: * **Activating TAK1**: MAPK11 activates TAK1, a kinase that plays a crucial role in the regulation of immune responses and inflammation. * **P38 MAPK activation**: MAPK11 regulates the activation of p38 MAPK, a kinase involved in stress response and inflammation. * **AP-1 family activation**: MAPK11 activates the AP-1 family of transcription factors, which regulates gene expression in response to various stimuli. * **Interleukin-1 signaling**: MAPK11 is involved in the regulation of interleukin-1 (IL-1) signaling, which plays a crucial role in immune responses. MAPK11's functions include: * **Cell proliferation**: MAPK11 regulates cell proliferation in response to various stimuli, including growth factors and cytokines. * **Differentiation**: MAPK11 is involved in the regulation of cell differentiation, including the differentiation of immune cells and epithelial cells. * **Stress response**: MAPK11 regulates the cellular response to stress, including the activation of p38 MAPK and the activation of transcription factors. **Clinical Significance** MAPK11 has been implicated in various diseases, including: * **Inflammatory disorders**: MAPK11 has been linked to the regulation of inflammatory responses, including the activation of TAK1 and the regulation of IL-1 signaling. * **Cancer**: MAPK11 has been implicated in the regulation of cell proliferation and differentiation in various types of cancer. * **Neurological disorders**: MAPK11 has been linked to the regulation of neuronal development and function, including the regulation of neural stem cells and the regulation of synaptic plasticity. In conclusion, MAPK11 is a multifunctional gene that plays a crucial role in various cellular processes, including immune responses, cell proliferation, and differentiation. Further research is needed to fully elucidate the functions and clinical significance of MAPK11, but its role in regulating signaling pathways and gene expression makes it an essential component of the immune system and cellular biology.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Mitogen-activated protein kinase 11

Genular Protein ID: 3723793517

Symbol: MK11_HUMAN

Name: Mitogen-activated protein kinase 11

UniProtKB Accession Codes:

Q15759 A8K730 B0LPG1 B7Z630 E7ETQ1 L7RT27 O00284 O15472 Q2XNF2

Database IDs:

Citations:

PubMed ID: 8663524

Title: Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta).

PubMed ID: 8663524

DOI: 10.1074/jbc.271.30.17920

PubMed ID: 9207191

Title: Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles.

PubMed ID: 9207191

DOI: 10.1006/bbrc.1997.6849

PubMed ID: 9430721

Title: Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.

PubMed ID: 9430721

DOI: 10.1074/jbc.273.3.1741

PubMed ID: 9218798

Title: Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.

PubMed ID: 9218798

DOI: 10.1093/emboj/16.12.3563

PubMed ID: 9235954

Title: p38-2, a novel mitogen-activated protein kinase with distinct properties.

PubMed ID: 9235954

DOI: 10.1074/jbc.272.31.19509

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9687510

Title: Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.

PubMed ID: 9687510

DOI: 10.1093/emboj/17.15.4426

PubMed ID: 10330143

Title: Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors.

PubMed ID: 10330143

DOI: 10.1128/mcb.19.6.4028

PubMed ID: 11359773

Title: A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs.

PubMed ID: 11359773

DOI: 10.1074/jbc.m101981200

PubMed ID: 11154262

Title: The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.

PubMed ID: 11154262

DOI: 10.1128/mcb.21.3.743-754.2001

PubMed ID: 15356147

Title: Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression.

PubMed ID: 15356147

DOI: 10.4049/jimmunol.173.6.3979

PubMed ID: 12452429

Title: In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance.

PubMed ID: 12452429

DOI: 10.1515/bc.2002.173

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20626350

Title: Mechanisms and functions of p38 MAPK signalling.

PubMed ID: 20626350

DOI: 10.1042/bj20100323

PubMed ID: 35857590

Title: ZAKalpha-driven ribotoxic stress response activates the human NLRP1 inflammasome.

PubMed ID: 35857590

DOI: 10.1126/science.abl6324

PubMed ID: 38270553

Title: Proline-directed yeast and human MAP kinases phosphorylate the Dot1p/DOT1L histone H3K79 methyltransferase.

PubMed ID: 38270553

DOI: 10.1111/febs.17062

PubMed ID: 19622861

Title: The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha.

PubMed ID: 19622861

DOI: 10.1107/s090744490901600x

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 364
Mass: 41357
Checksum: 68DA4C7B7C721475
Sequence:

MSGPRAGFYR QELNKTVWEV PQRLQGLRPV GSGAYGSVCS AYDARLRQKV AVKKLSRPFQ 
SLIHARRTYR ELRLLKHLKH ENVIGLLDVF TPATSIEDFS EVYLVTTLMG ADLNNIVKCQ 
ALSDEHVQFL VYQLLRGLKY IHSAGIIHRD LKPSNVAVNE DCELRILDFG LARQADEEMT 
GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLQGK ALFPGSDYID QLKRIMEVVG 
TPSPEVLAKI SSEHARTYIQ SLPPMPQKDL SSIFRGANPL AIDLLGRMLV LDSDQRVSAA 
EALAHAYFSQ YHDPEDEPEA EPYDESVEAK ERTLEEWKEL TYQEVLSFKP PEPPKPPGSL 
EIEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MAPK11

Associated with

Cells (max top 100)

Other Information

Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). PubMed ID: 8663524

Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. PubMed ID: 9207191

Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. PubMed ID: 9430721

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. PubMed ID: 9218798

p38-2, a novel mitogen-activated protein kinase with distinct properties. PubMed ID: 9235954

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 22. PubMed ID: 10591208

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. PubMed ID: 9687510

Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. PubMed ID: 10330143

A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs. PubMed ID: 11359773

The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. PubMed ID: 11154262

Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression. PubMed ID: 15356147

In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance. PubMed ID: 12452429

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Mechanisms and functions of p38 MAPK signalling. PubMed ID: 20626350

ZAKalpha-driven ribotoxic stress response activates the human NLRP1 inflammasome. PubMed ID: 35857590

Proline-directed yeast and human MAP kinases phosphorylate the Dot1p/DOT1L histone H3K79 methyltransferase. PubMed ID: 38270553

The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha. PubMed ID: 19622861

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846