PSMA5 | ENSG00000143106 | NCBI 5686

Details for: PSMA5

Gene ID: 5686

Symbol: PSMA5

Ensembl ID: ENSG00000143106

Description: proteasome 20S subunit alpha 5

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Neutrophil degranulation
(R-HSA-6798695)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 288.3406
Cell Significance Index: -44.8500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 164.9560
Cell Significance Index: -41.8400
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 150.0919
Cell Significance Index: -61.8300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 129.5850
Cell Significance Index: -61.1800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 117.6453
Cell Significance Index: -60.5200
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 91.3457
Cell Significance Index: -61.3000
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 45.4923
Cell Significance Index: -56.0900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 15.0024
Cell Significance Index: -59.2000
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 11.8771
Cell Significance Index: -36.4800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.4447
Cell Significance Index: -27.9800
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.8505
Cell Significance Index: -19.3700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 3.3627
Cell Significance Index: 98.7600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.9613
Cell Significance Index: 126.5300
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.6812
Cell Significance Index: 918.1600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.5888
Cell Significance Index: 74.6700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.5148
Cell Significance Index: 90.9400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.4997
Cell Significance Index: 184.4000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.4939
Cell Significance Index: 176.1800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.4747
Cell Significance Index: 13.5800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.4523
Cell Significance Index: 261.8100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.3887
Cell Significance Index: 37.0800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.2861
Cell Significance Index: 66.8100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.1415
Cell Significance Index: 80.7300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.0995
Cell Significance Index: 486.1200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.0749
Cell Significance Index: 147.6100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9937
Cell Significance Index: 161.6200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.9100
Cell Significance Index: 42.4300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7941
Cell Significance Index: 157.5900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7455
Cell Significance Index: 673.0900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.7405
Cell Significance Index: 15.5000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.7099
Cell Significance Index: 20.3500
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.7074
Cell Significance Index: 18.6000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7061
Cell Significance Index: 141.6500
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.6476
Cell Significance Index: 7.0400
Cell Name: peg cell (CL4033014)
Fold Change: 0.6298
Cell Significance Index: 14.5500
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.5859
Cell Significance Index: 15.7000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.5733
Cell Significance Index: 42.7300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5550
Cell Significance Index: 12.0300
Cell Name: lactocyte (CL0002325)
Fold Change: 0.5161
Cell Significance Index: 66.6800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.5107
Cell Significance Index: 65.4700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.4696
Cell Significance Index: 8.6800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4050
Cell Significance Index: 40.0600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3402
Cell Significance Index: 9.2600
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.3055
Cell Significance Index: 4.6400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3049
Cell Significance Index: 8.5200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.2872
Cell Significance Index: 9.9800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2694
Cell Significance Index: 46.0100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2011
Cell Significance Index: 72.1200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1462
Cell Significance Index: 27.8300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.1417
Cell Significance Index: 3.7900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1163
Cell Significance Index: 80.4100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0390
Cell Significance Index: 29.5400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0132
Cell Significance Index: 24.7800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0052
Cell Significance Index: -3.7800
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0096
Cell Significance Index: -17.6900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0101
Cell Significance Index: -7.5000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0105
Cell Significance Index: -16.1100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0144
Cell Significance Index: -8.9700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0152
Cell Significance Index: -0.2600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0271
Cell Significance Index: -17.1800
Cell Name: kidney cell (CL1000497)
Fold Change: -0.0301
Cell Significance Index: -0.2400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0345
Cell Significance Index: -46.9700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0428
Cell Significance Index: -1.1000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0507
Cell Significance Index: -5.1800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0722
Cell Significance Index: -40.7300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0732
Cell Significance Index: -33.2200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0838
Cell Significance Index: -5.2800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1074
Cell Significance Index: -1.2200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1107
Cell Significance Index: -5.8100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1243
Cell Significance Index: -26.1800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1707
Cell Significance Index: -49.1100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1806
Cell Significance Index: -21.0500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1853
Cell Significance Index: -4.7400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2110
Cell Significance Index: -16.2000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2170
Cell Significance Index: -31.5500
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2317
Cell Significance Index: -1.4000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2335
Cell Significance Index: -26.6500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2498
Cell Significance Index: -8.0000
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2968
Cell Significance Index: -5.0000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3052
Cell Significance Index: -34.9600
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.3526
Cell Significance Index: -3.0300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4458
Cell Significance Index: -27.4000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4987
Cell Significance Index: -33.5300
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.5332
Cell Significance Index: -13.0100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.5380
Cell Significance Index: -7.3400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5403
Cell Significance Index: -56.2600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5628
Cell Significance Index: -44.5700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5938
Cell Significance Index: -33.3200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.6142
Cell Significance Index: -27.8400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.6394
Cell Significance Index: -44.2200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.7049
Cell Significance Index: -20.3100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.7626
Cell Significance Index: -33.7300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8121
Cell Significance Index: -49.7900
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.8500
Cell Significance Index: -42.9600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.8987
Cell Significance Index: -34.0300
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.9063
Cell Significance Index: -13.5800
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.9254
Cell Significance Index: -9.5800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.9417
Cell Significance Index: -23.5400
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.9980
Cell Significance Index: -14.7300
Cell Name: retinal rod cell (CL0000604)
Fold Change: -1.1501
Cell Significance Index: -13.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** PSMA5 is a member of the proteasome 20S subunit family, which consists of seven alpha subunits and seven beta subunits. The alpha subunits, including PSMA5, are responsible for the degradation of proteins, while the beta subunits are involved in the catalytic activity of the proteasome. PSMA5 is highly conserved across species, suggesting its essential role in the UPS. The gene is also highly expressed in various tissues, including immune cells, indicating its importance in the immune system. **Pathways and Functions:** PSMA5 is involved in various cellular pathways, including: 1. **Immune response:** PSMA5 is highly expressed in immune cells, such as T cells, B cells, and dendritic cells, and plays a critical role in the degradation of proteins involved in immune response, including cytokines, chemokines, and antigen-presenting molecules. 2. **Cell cycle regulation:** PSMA5 is involved in the regulation of the cell cycle, particularly in the G1/S transition, by degrading proteins involved in cell cycle progression. 3. **Signal transduction:** PSMA5 is involved in the degradation of proteins involved in signal transduction, including growth factor receptors and second messengers. 4. **Apoptosis:** PSMA5 is involved in the regulation of apoptosis, particularly in the degradation of proteins involved in apoptosis, such as Bcl-2 and Bax. 5. **Protein degradation:** PSMA5 is involved in the degradation of proteins, particularly those involved in protein quality control, such as misfolded proteins and protein aggregates. **Clinical Significance:** Dysregulation of the UPS, including PSMA5, has been implicated in various diseases, including: 1. **Cancer:** PSMA5 has been shown to be overexpressed in various types of cancer, including prostate cancer, and is associated with poor prognosis. 2. **Autoimmune diseases:** PSMA5 has been implicated in autoimmune diseases, such as rheumatoid arthritis, and is associated with the degradation of autoantigens. 3. **Neurological disorders:** PSMA5 has been implicated in neurological disorders, such as Alzheimer's disease, and is associated with the degradation of proteins involved in neurodegeneration. 4. **Infectious diseases:** PSMA5 has been implicated in infectious diseases, such as HIV, and is associated with the degradation of proteins involved in immune response. In conclusion, the proteasome 20S subunit alpha 5 (PSMA5) gene is a critical component of the immune system and plays a central role in various cellular processes, including immune response, cell cycle regulation, and signal transduction. Dysregulation of PSMA5 has been implicated in various diseases, highlighting the importance of understanding its function and regulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Macropain zeta chain

Genular Protein ID: 3583190180

Symbol: PSA5_HUMAN

Name: Macropain zeta chain

UniProtKB Accession Codes:

P28066 B2R8F6 B4E2V4 Q3T1C1 Q6IBF7

Database IDs:

Citations:

PubMed ID: 1888762

Title: The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous.

PubMed ID: 1888762

DOI: 10.1016/0167-4838(91)90020-z

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 8610016

Title: A role for the proteasome regulator PA28alpha in antigen presentation.

PubMed ID: 8610016

DOI: 10.1038/381166a0

PubMed ID: 11771738

Title: Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome.

PubMed ID: 11771738

DOI: 10.1007/978-3-7091-6262-0_10

PubMed ID: 12181345

Title: Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

PubMed ID: 12181345

DOI: 10.1091/mbc.e02-03-0122

PubMed ID: 15244466

Title: 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone.

PubMed ID: 15244466

DOI: 10.1021/bm049957a

PubMed ID: 16251969

Title: A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes.

PubMed ID: 16251969

DOI: 10.1038/nature04106

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19734940

Title: Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2).

PubMed ID: 19734940

DOI: 10.1038/onc.2009.264

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23495936

Title: Molecular architecture and assembly of the eukaryotic proteasome.

PubMed ID: 23495936

DOI: 10.1146/annurev-biochem-060410-150257

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27176742

Title: Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.

PubMed ID: 27176742

DOI: 10.1515/hsz-2016-0176

PubMed ID: 26133119

Title: Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.

PubMed ID: 26133119

DOI: 10.1038/ncomms8573

PubMed ID: 25599644

Title: Crystal structure of the human 20S proteasome in complex with carfilzomib.

PubMed ID: 25599644

DOI: 10.1016/j.str.2014.11.017

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 27493187

Title: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.

PubMed ID: 27493187

DOI: 10.1126/science.aaf8993

PubMed ID: 34711951

Title: AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

PubMed ID: 34711951

DOI: 10.1038/s41586-021-04035-8

Sequence Information:

Length: 241
Mass: 26411
Checksum: 5610CDA00469120A
Sequence:

MFLTRSEYDR GVNTFSPEGR LFQVEYAIEA IKLGSTAIGI QTSEGVCLAV EKRITSPLME 
PSSIEKIVEI DAHIGCAMSG LIADAKTLID KARVETQNHW FTYNETMTVE SVTQAVSNLA 
LQFGEEDADP GAMSRPFGVA LLFGGVDEKG PQLFHMDPSG TFVQCDARAI GSASEGAQSS 
LQEVYHKSMT LKEAIKSSLI ILKQVMEEKL NATNIELATV QPGQNFHMFT KEELEEVIKD 
I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMA5

Associated with

Cells (max top 100)

Other Information

The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous. PubMed ID: 1888762

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. PubMed ID: 1286667

A role for the proteasome regulator PA28alpha in antigen presentation. PubMed ID: 8610016

Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome. PubMed ID: 11771738

Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. PubMed ID: 12181345

20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone. PubMed ID: 15244466

A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. PubMed ID: 16251969

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2). PubMed ID: 19734940

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Molecular architecture and assembly of the eukaryotic proteasome. PubMed ID: 23495936

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Human 20S proteasome activity towards fluorogenic peptides of various chain lengths. PubMed ID: 27176742

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core. PubMed ID: 26133119

Crystal structure of the human 20S proteasome in complex with carfilzomib. PubMed ID: 25599644

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858

The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. PubMed ID: 27493187

AKIRIN2 controls the nuclear import of proteasomes in vertebrates. PubMed ID: 34711951