PSMB4 | ENSG00000159377 | NCBI 5692

Details for: PSMB4

Gene ID: 5692

Symbol: PSMB4

Ensembl ID: ENSG00000159377

Description: proteasome 20S subunit beta 4

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 293.8052
Cell Significance Index: -45.7000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 167.5975
Cell Significance Index: -42.5100
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 151.6698
Cell Significance Index: -62.4800
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 118.9733
Cell Significance Index: -56.1700
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 116.6749
Cell Significance Index: -47.4000
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 104.2409
Cell Significance Index: -53.6200
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 83.9615
Cell Significance Index: -56.3400
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 50.2334
Cell Significance Index: -47.9600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 43.6431
Cell Significance Index: -53.8100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.3469
Cell Significance Index: -46.4700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 14.2928
Cell Significance Index: -56.4000
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.0883
Cell Significance Index: -40.2000
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.6945
Cell Significance Index: -16.8400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 5.7809
Cell Significance Index: 673.7100
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.0612
Cell Significance Index: 132.9800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.8820
Cell Significance Index: 258.4600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.6283
Cell Significance Index: 43.6300
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.6023
Cell Significance Index: 875.0300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.5605
Cell Significance Index: 45.8300
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 1.5443
Cell Significance Index: 23.4600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.5053
Cell Significance Index: 40.9700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.5035
Cell Significance Index: 664.7300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.4866
Cell Significance Index: 105.1400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.4319
Cell Significance Index: 258.1200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.3654
Cell Significance Index: 167.8900
Cell Name: peg cell (CL4033014)
Fold Change: 1.2007
Cell Significance Index: 27.7400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.1663
Cell Significance Index: 54.8200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.1590
Cell Significance Index: 54.0400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.1021
Cell Significance Index: 12.5200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9845
Cell Significance Index: 107.0800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.9473
Cell Significance Index: 111.7100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.9437
Cell Significance Index: 49.0200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.8934
Cell Significance Index: 25.6100
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.8872
Cell Significance Index: 8.1700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.8119
Cell Significance Index: 56.1500
Cell Name: lactocyte (CL0002325)
Fold Change: 0.7666
Cell Significance Index: 99.0400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.6155
Cell Significance Index: 32.0600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.6030
Cell Significance Index: 16.1000
Cell Name: odontoblast (CL0000060)
Fold Change: 0.6010
Cell Significance Index: 77.0500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.5897
Cell Significance Index: 10.9000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5059
Cell Significance Index: 10.9600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5057
Cell Significance Index: 86.3500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4969
Cell Significance Index: 29.8300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4500
Cell Significance Index: 33.5400
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.4035
Cell Significance Index: 10.6100
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.3526
Cell Significance Index: 7.3800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3233
Cell Significance Index: 64.8600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3027
Cell Significance Index: 57.6100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3019
Cell Significance Index: 59.9200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.2833
Cell Significance Index: 9.8500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1692
Cell Significance Index: 7.6700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1564
Cell Significance Index: 56.1000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1463
Cell Significance Index: 4.2200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1242
Cell Significance Index: 7.8300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0309
Cell Significance Index: 23.4200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0279
Cell Significance Index: 25.1700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0171
Cell Significance Index: 12.5100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0080
Cell Significance Index: -5.9200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0138
Cell Significance Index: -25.9500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0218
Cell Significance Index: -0.3700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0254
Cell Significance Index: -15.8600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0335
Cell Significance Index: -61.8300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0379
Cell Significance Index: -1.3300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0403
Cell Significance Index: -4.1100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0420
Cell Significance Index: -64.7000
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0473
Cell Significance Index: -4.6800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0477
Cell Significance Index: -64.9100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0572
Cell Significance Index: -36.3300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0617
Cell Significance Index: -34.8000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0673
Cell Significance Index: -10.9500
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0758
Cell Significance Index: -52.4000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0969
Cell Significance Index: -43.9600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1118
Cell Significance Index: -23.5500
Cell Name: kidney cell (CL1000497)
Fold Change: -0.1252
Cell Significance Index: -1.0000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1360
Cell Significance Index: -3.8000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1451
Cell Significance Index: -7.6200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1640
Cell Significance Index: -47.1900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1911
Cell Significance Index: -21.8100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2170
Cell Significance Index: -24.8600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2450
Cell Significance Index: -6.2600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2763
Cell Significance Index: -8.8500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2968
Cell Significance Index: -43.1500
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.3063
Cell Significance Index: -3.3300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3230
Cell Significance Index: -6.8800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3802
Cell Significance Index: -30.1100
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.3934
Cell Significance Index: -4.1800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3973
Cell Significance Index: -24.4200
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.4758
Cell Significance Index: -2.8800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4824
Cell Significance Index: -27.0700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4841
Cell Significance Index: -6.6100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5350
Cell Significance Index: -55.7100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5929
Cell Significance Index: -39.8700
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.6400
Cell Significance Index: -11.3100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.6417
Cell Significance Index: -16.0400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.6449
Cell Significance Index: -49.4900
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6720
Cell Significance Index: -17.9800
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.7524
Cell Significance Index: -6.3200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8971
Cell Significance Index: -55.0000
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.9333
Cell Significance Index: -8.0200
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.9617
Cell Significance Index: -13.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** The PSMB4 gene is a member of the proteasome family, which is composed of multiple subunits that form the 20S proteasome complex. The beta-4 subunit (PSMB4) is one of the seven beta subunits that make up the 20S proteasome. The PSMB4 protein is a 20-kDa polypeptide that is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. The 20S proteasome complex is a large protein complex that consists of 28 subunits, including two alpha subunits, eight beta subunits, and two mu subunits. The PSMB4 protein is a beta subunit that plays a crucial role in the degradation of proteins by the 20S proteasome complex. The protein is also involved in the processing of antigens for presentation by major histocompatibility complex (MHC) class I molecules. **Pathways and Functions** The PSMB4 gene is involved in various cellular pathways, including: 1. **Ubiquitin-proteasome system (UPS)**: The 20S proteasome complex is a key component of the UPS, which is responsible for protein degradation. The PSMB4 protein plays a crucial role in the degradation of proteins by the 20S proteasome complex. 2. **Antigen processing and presentation**: The PSMB4 protein is involved in the processing of antigens for presentation by MHC class I molecules. This process is essential for the initiation of immune responses against viral infections and tumor cells. 3. **Cell cycle regulation**: The 20S proteasome complex is involved in the regulation of cell cycle progression. The PSMB4 protein plays a crucial role in the degradation of proteins that regulate cell cycle progression. 4. **Apoptosis**: The PSMB4 protein is involved in the regulation of apoptosis, or programmed cell death. The protein is also involved in the processing of pro-apoptotic proteins. **Clinical Significance** Dysregulation of the PSMB4 gene has been implicated in various diseases, including: 1. **Cancer**: The PSMB4 gene is overexpressed in several types of cancer, including breast cancer and lung cancer. The protein is also involved in the processing of tumor antigens for presentation by MHC class I molecules. 2. **Autoimmune disorders**: The PSMB4 gene is involved in the regulation of immune responses, and dysregulation of the gene has been implicated in autoimmune disorders, such as rheumatoid arthritis and lupus. 3. **Neurodegenerative diseases**: The PSMB4 gene is involved in the regulation of protein degradation, and dysregulation of the gene has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, the PSMB4 gene plays a crucial role in various cellular pathways, including protein degradation, antigen processing, and cell cycle regulation. Dysregulation of the gene has been implicated in various diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. Further research is needed to fully understand the role of the PSMB4 gene in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

26 kDa prosomal protein

Genular Protein ID: 369515738

Symbol: PSB4_HUMAN

Name: 26 kDa prosomal protein

UniProtKB Accession Codes:

P28070 B2R9L3 P31148 Q5SZS5 Q6IBI4 Q969L6

Database IDs:

Citations:

PubMed ID: 7918633

Title: Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues.

PubMed ID: 7918633

DOI: 10.1016/0167-4781(94)90060-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 8013624

Title: Cloning and expression of a human pro(tea)some beta-subunit cDNA: a homologue of the yeast PRE4-subunit essential for peptidylglutamyl-peptide hydrolase activity.

PubMed ID: 8013624

DOI: 10.1016/0014-5793(94)00454-4

PubMed ID: 2306472

Title: Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome).

PubMed ID: 2306472

DOI: 10.1016/0167-4838(90)90165-c

PubMed ID: 7811265

Title: Human proteasome subunits from 2-dimensional gels identified by partial sequencing.

PubMed ID: 7811265

DOI: 10.1006/bbrc.1994.2876

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 8610016

Title: A role for the proteasome regulator PA28alpha in antigen presentation.

PubMed ID: 8610016

DOI: 10.1038/381166a0

PubMed ID: 8692272

Title: Effects on NF-kappa B1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome.

PubMed ID: 8692272

DOI: 10.1038/381328a0

PubMed ID: 9344905

Title: HsN3 proteasomal subunit as a target for human immunodeficiency virus type 1 Nef protein.

PubMed ID: 9344905

DOI: 10.1006/viro.1997.8752

PubMed ID: 11571290

Title: Proteasomal degradation of Smad1 induced by bone morphogenetic proteins.

PubMed ID: 11571290

DOI: 10.1074/jbc.m105500200

PubMed ID: 12097147

Title: A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs).

PubMed ID: 12097147

DOI: 10.1186/1471-2121-3-15

PubMed ID: 12181345

Title: Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

PubMed ID: 12181345

DOI: 10.1091/mbc.e02-03-0122

PubMed ID: 14550573

Title: Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.

PubMed ID: 14550573

DOI: 10.1016/s0014-5793(03)01025-1

PubMed ID: 15244466

Title: 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone.

PubMed ID: 15244466

DOI: 10.1021/bm049957a

PubMed ID: 15660529

Title: Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome.

PubMed ID: 15660529

DOI: 10.1042/bj20041517

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 17367606

Title: Fibrolamellar carcinomas show overexpression of genes in the RAS, MAPK, PIK3, and xenobiotic degradation pathways.

PubMed ID: 17367606

DOI: 10.1016/j.humpath.2006.07.019

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23495936

Title: Molecular architecture and assembly of the eukaryotic proteasome.

PubMed ID: 23495936

DOI: 10.1146/annurev-biochem-060410-150257

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26524591

Title: Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production.

PubMed ID: 26524591

DOI: 10.1172/jci81260

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27176742

Title: Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.

PubMed ID: 27176742

DOI: 10.1515/hsz-2016-0176

PubMed ID: 26133119

Title: Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.

PubMed ID: 26133119

DOI: 10.1038/ncomms8573

PubMed ID: 25599644

Title: Crystal structure of the human 20S proteasome in complex with carfilzomib.

PubMed ID: 25599644

DOI: 10.1016/j.str.2014.11.017

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 27493187

Title: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.

PubMed ID: 27493187

DOI: 10.1126/science.aaf8993

PubMed ID: 34711951

Title: AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

PubMed ID: 34711951

DOI: 10.1038/s41586-021-04035-8

Sequence Information:

Length: 264
Mass: 29204
Checksum: B8701C565069F563
Sequence:

MEAFLGSRSG LWAGGPAPGQ FYRIPSTPDS FMDPASALYR GPITRTQNPM VTGTSVLGVK 
FEGGVVIAAD MLGSYGSLAR FRNISRIMRV NNSTMLGASG DYADFQYLKQ VLGQMVIDEE 
LLGDGHSYSP RAIHSWLTRA MYSRRSKMNP LWNTMVIGGY ADGESFLGYV DMLGVAYEAP 
SLATGYGAYL AQPLLREVLE KQPVLSQTEA RDLVERCMRV LYYRDARSYN RFQIATVTEK 
GVEIEGPLST ETNWDIAHMI SGFE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMB4

Associated with

Cells (max top 100)

Other Information

Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues. PubMed ID: 7918633

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Cloning and expression of a human pro(tea)some beta-subunit cDNA: a homologue of the yeast PRE4-subunit essential for peptidylglutamyl-peptide hydrolase activity. PubMed ID: 8013624

Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome). PubMed ID: 2306472

Human proteasome subunits from 2-dimensional gels identified by partial sequencing. PubMed ID: 7811265

Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. PubMed ID: 1286667

A role for the proteasome regulator PA28alpha in antigen presentation. PubMed ID: 8610016

Effects on NF-kappa B1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome. PubMed ID: 8692272

HsN3 proteasomal subunit as a target for human immunodeficiency virus type 1 Nef protein. PubMed ID: 9344905

Proteasomal degradation of Smad1 induced by bone morphogenetic proteins. PubMed ID: 11571290

A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs). PubMed ID: 12097147

Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. PubMed ID: 12181345

Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. PubMed ID: 14550573

20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone. PubMed ID: 15244466

Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome. PubMed ID: 15660529

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Fibrolamellar carcinomas show overexpression of genes in the RAS, MAPK, PIK3, and xenobiotic degradation pathways. PubMed ID: 17367606

A strategy for precise and large scale identification of core fucosylated glycoproteins. PubMed ID: 19139490

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Molecular architecture and assembly of the eukaryotic proteasome. PubMed ID: 23495936

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production. PubMed ID: 26524591

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Human 20S proteasome activity towards fluorogenic peptides of various chain lengths. PubMed ID: 27176742

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core. PubMed ID: 26133119

Crystal structure of the human 20S proteasome in complex with carfilzomib. PubMed ID: 25599644

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858

The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. PubMed ID: 27493187

AKIRIN2 controls the nuclear import of proteasomes in vertebrates. PubMed ID: 34711951