PSMB6 | ENSG00000142507 | NCBI 5694

Details for: PSMB6

Gene ID: 5694

Symbol: PSMB6

Ensembl ID: ENSG00000142507

Description: proteasome 20S subunit beta 6

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 371.4675
Cell Significance Index: -57.7800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 243.6886
Cell Significance Index: -61.8100
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 190.0242
Cell Significance Index: -78.2800
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 160.9751
Cell Significance Index: -76.0000
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 142.5682
Cell Significance Index: -73.3400
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 114.1095
Cell Significance Index: -76.5700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 58.7856
Cell Significance Index: -72.4800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 20.0352
Cell Significance Index: -79.0600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 17.3208
Cell Significance Index: -53.2000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.2900
Cell Significance Index: -46.3200
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.7682
Cell Significance Index: -19.1900
Cell Name: kidney cell (CL1000497)
Fold Change: 3.7762
Cell Significance Index: 30.1500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 3.3706
Cell Significance Index: 548.2000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.3141
Cell Significance Index: 154.5200
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.8975
Cell Significance Index: 76.1900
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.8394
Cell Significance Index: 83.3900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.4751
Cell Significance Index: 116.3300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 2.3620
Cell Significance Index: 82.0800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.1673
Cell Significance Index: 29.5700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.1184
Cell Significance Index: 157.8800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.9585
Cell Significance Index: 18.0400
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.8882
Cell Significance Index: 1031.2100
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.8455
Cell Significance Index: 38.6300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.7630
Cell Significance Index: 317.8200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.7024
Cell Significance Index: 209.3300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.6889
Cell Significance Index: 746.6900
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.6864
Cell Significance Index: 108.8000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.6696
Cell Significance Index: 196.9000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.5395
Cell Significance Index: 108.8800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.4560
Cell Significance Index: 39.6300
Cell Name: lactocyte (CL0002325)
Fold Change: 1.4146
Cell Significance Index: 182.7600
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.4092
Cell Significance Index: 15.3200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.2604
Cell Significance Index: 173.0800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.1760
Cell Significance Index: 13.3600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.9944
Cell Significance Index: 127.4700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9639
Cell Significance Index: 95.3600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8579
Cell Significance Index: 44.5700
Cell Name: peg cell (CL4033014)
Fold Change: 0.8531
Cell Significance Index: 19.7100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.8140
Cell Significance Index: 15.0500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.6575
Cell Significance Index: 34.5200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5964
Cell Significance Index: 15.9300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.5789
Cell Significance Index: 16.6000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5239
Cell Significance Index: 11.3500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3576
Cell Significance Index: 61.0700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2769
Cell Significance Index: 17.4500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1895
Cell Significance Index: 37.6100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.1831
Cell Significance Index: 3.2400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1387
Cell Significance Index: 26.4000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1327
Cell Significance Index: 100.4400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1177
Cell Significance Index: 1.9700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1115
Cell Significance Index: 22.3600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0965
Cell Significance Index: 70.7300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0396
Cell Significance Index: 1.0600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0047
Cell Significance Index: -3.4600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0166
Cell Significance Index: -1.7000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0167
Cell Significance Index: -10.4300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0316
Cell Significance Index: -59.4300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0486
Cell Significance Index: -89.5700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0588
Cell Significance Index: -90.5000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0683
Cell Significance Index: -92.8700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0695
Cell Significance Index: -39.1700
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0754
Cell Significance Index: -1.1500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0918
Cell Significance Index: -58.2800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.1005
Cell Significance Index: -36.0700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.1114
Cell Significance Index: -77.0200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1456
Cell Significance Index: -30.6700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1562
Cell Significance Index: -70.9100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1948
Cell Significance Index: -56.0500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2458
Cell Significance Index: -6.2800
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.2760
Cell Significance Index: -3.2900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2805
Cell Significance Index: -32.1400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.3092
Cell Significance Index: -10.8700
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.3160
Cell Significance Index: -1.9400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3614
Cell Significance Index: -10.1000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3713
Cell Significance Index: -42.3800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4164
Cell Significance Index: -48.5300
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.4256
Cell Significance Index: -5.4500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4480
Cell Significance Index: -35.4900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.4654
Cell Significance Index: -67.6500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.4661
Cell Significance Index: -27.9800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4757
Cell Significance Index: -10.1300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.4961
Cell Significance Index: -22.4900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.6012
Cell Significance Index: -65.4000
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.6339
Cell Significance Index: -3.8300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6632
Cell Significance Index: -21.2400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.6805
Cell Significance Index: -41.8300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.7576
Cell Significance Index: -78.8800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.8395
Cell Significance Index: -47.1100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.9139
Cell Significance Index: -70.1400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.0101
Cell Significance Index: -27.0700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.0181
Cell Significance Index: -68.4600
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.1259
Cell Significance Index: -16.8700
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.1851
Cell Significance Index: -9.9600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2386
Cell Significance Index: -75.9400
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.3119
Cell Significance Index: -38.6400
Cell Name: type I muscle cell (CL0002211)
Fold Change: -1.4332
Cell Significance Index: -34.9700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.6704
Cell Significance Index: -73.8900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.7279
Cell Significance Index: -63.4300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.7472
Cell Significance Index: -44.9100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.9717
Cell Significance Index: -74.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** PSMB6 is a beta subunit of the 20S proteasome, which is composed of 28 subunits, including 7 alpha and 19 beta subunits. The beta subunits, including PSMB6, are responsible for the degradation of proteins that are targeted by the ubiquitin-proteasome pathway. PSMB6 is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. **Pathways and Functions:** PSMB6 is involved in various cellular processes, including: 1. **Antigen Processing and Presentation:** PSMB6 plays a crucial role in the degradation of antigens, which are then processed and presented to T-cells by MHC class I molecules. 2. **Apoptosis:** PSMB6 is involved in the regulation of apoptosis, or programmed cell death, by degrading pro-apoptotic proteins. 3. **Cell Cycle Regulation:** PSMB6 is involved in the regulation of the cell cycle, particularly in the G2/M phase, by degrading proteins that inhibit cell cycle progression. 4. **Immune Response:** PSMB6 is essential for the proper functioning of the immune system, particularly in the adaptive immune response, where it helps to activate T-cells and B-cells. **Clinical Significance:** Dysregulation of PSMB6 has been implicated in various diseases, including: 1. **Autoimmune Diseases:** Mutations in PSMB6 have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where the immune system is dysregulated. 2. **Cancer:** Overexpression of PSMB6 has been observed in certain types of cancer, such as multiple myeloma and lymphoma, where it contributes to tumor progression. 3. **Neurodegenerative Diseases:** PSMB6 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it is thought to contribute to protein aggregation and neuronal damage. **Significantly Expressed Cells:** PSMB6 is highly expressed in various cell types, including: 1. **Embryonic Stem Cells:** PSMB6 is essential for the development and maintenance of embryonic stem cells. 2. **Erythroid Progenitor Cells:** PSMB6 is involved in the regulation of erythropoiesis, or the production of red blood cells. 3. **Stratified Epithelial Cells:** PSMB6 is expressed in stratified epithelial cells, which are involved in the formation of epithelial tissues. In conclusion, PSMB6 is a critical component of the proteasome complex, playing a central role in the degradation and processing of proteins within the cell. Its dysregulation has been implicated in various diseases, highlighting the importance of PSMB6 in maintaining cellular homeostasis and immune function. Further research is needed to fully understand the role of PSMB6 in human disease and to develop therapeutic strategies to target its dysregulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Macropain delta chain
A0A087X2I4_HUMAN

Genular Protein ID: 4256919181

Symbol: PSB6_HUMAN

Name: Macropain delta chain

UniProtKB Accession Codes:

P28072 Q96J55

Database IDs:

Citations:

PubMed ID: 8066462

Title: cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y.

PubMed ID: 8066462

DOI: 10.1126/science.8066462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1888762

Title: The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous.

PubMed ID: 1888762

DOI: 10.1016/0167-4838(91)90020-z

PubMed ID: 2306472

Title: Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome).

PubMed ID: 2306472

DOI: 10.1016/0167-4838(90)90165-c

PubMed ID: 8163024

Title: Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon-gamma for acquirement of the functional diversity responsible for antigen processing.

PubMed ID: 8163024

DOI: 10.1016/0014-5793(94)80612-8

PubMed ID: 8610016

Title: A role for the proteasome regulator PA28alpha in antigen presentation.

PubMed ID: 8610016

DOI: 10.1038/381166a0

PubMed ID: 12181345

Title: Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

PubMed ID: 12181345

DOI: 10.1091/mbc.e02-03-0122

PubMed ID: 14550573

Title: Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.

PubMed ID: 14550573

DOI: 10.1016/s0014-5793(03)01025-1

PubMed ID: 15244466

Title: 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone.

PubMed ID: 15244466

DOI: 10.1021/bm049957a

PubMed ID: 15613457

Title: Comprehensive gene expression profiling of anaplastic thyroid cancers with cDNA microarray of 25 344 genes.

PubMed ID: 15613457

DOI: 10.1677/erc.1.00818

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23495936

Title: Molecular architecture and assembly of the eukaryotic proteasome.

PubMed ID: 23495936

DOI: 10.1146/annurev-biochem-060410-150257

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27176742

Title: Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.

PubMed ID: 27176742

DOI: 10.1515/hsz-2016-0176

PubMed ID: 26133119

Title: Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.

PubMed ID: 26133119

DOI: 10.1038/ncomms8573

PubMed ID: 25599644

Title: Crystal structure of the human 20S proteasome in complex with carfilzomib.

PubMed ID: 25599644

DOI: 10.1016/j.str.2014.11.017

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 27493187

Title: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.

PubMed ID: 27493187

DOI: 10.1126/science.aaf8993

PubMed ID: 34711951

Title: AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

PubMed ID: 34711951

DOI: 10.1038/s41586-021-04035-8

Sequence Information:

Length: 239
Mass: 25358
Checksum: 7DF4081DC735930C
Sequence:

MAATLLAARG AGPAPAWGPE AFTPDWESRE VSTGTTIMAV QFDGGVVLGA DSRTTTGSYI 
ANRVTDKLTP IHDRIFCCRS GSAADTQAVA DAVTYQLGFH SIELNEPPLV HTAASLFKEM 
CYRYREDLMA GIIIAGWDPQ EGGQVYSVPM GGMMVRQSFA IGGSGSSYIY GYVDATYREG 
MTKEECLQFT ANALALAMER DGSSGGVIRL AAIAESGVER QVLLGDQIPK FAVATLPPA

Genular Protein ID: 1286282443

Symbol: A0A087X2I4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X2I4

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

Length: 213
Mass: 23100
Checksum: 544AA171650A7BD8
Sequence:

MAATLLAARG AGPAPAWGPE AFTPDWESRE VSTGTTIMAV QFDGGVVLGA DSRTTTGSYI 
ANRVTDKLTP IHDRIFCCRS GSAADTQAVA DAVTYQLGFH SIELNEPPLV HTAASLFKEM 
CYRYREDLMA GIIIAGWDPQ EGGQVYSVPM GGMMVRQSFA IGGSGSSYIY GYVDATYREG 
MTKEECLQFT ANAFFFYPQL SLWPWSGMAP VEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMB6

Associated with

Cells (max top 100)

Other Information

cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y. PubMed ID: 8066462

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous. PubMed ID: 1888762

Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome). PubMed ID: 2306472

Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon-gamma for acquirement of the functional diversity responsible for antigen processing. PubMed ID: 8163024

A role for the proteasome regulator PA28alpha in antigen presentation. PubMed ID: 8610016

Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. PubMed ID: 12181345

Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. PubMed ID: 14550573

20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone. PubMed ID: 15244466

Comprehensive gene expression profiling of anaplastic thyroid cancers with cDNA microarray of 25 344 genes. PubMed ID: 15613457

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Molecular architecture and assembly of the eukaryotic proteasome. PubMed ID: 23495936

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Human 20S proteasome activity towards fluorogenic peptides of various chain lengths. PubMed ID: 27176742

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core. PubMed ID: 26133119

Crystal structure of the human 20S proteasome in complex with carfilzomib. PubMed ID: 25599644

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858

The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. PubMed ID: 27493187

AKIRIN2 controls the nuclear import of proteasomes in vertebrates. PubMed ID: 34711951

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Database document:

PubMed ID: 8066462

PubMed ID: 15489334

PubMed ID: 1888762

PubMed ID: 2306472

PubMed ID: 8163024

PubMed ID: 8610016

PubMed ID: 12181345

PubMed ID: 14550573

PubMed ID: 15244466

PubMed ID: 15613457

PubMed ID: 17323924

PubMed ID: 21269460

PubMed ID: 22814378

PubMed ID: 23495936

PubMed ID: 23186163

PubMed ID: 27176742

PubMed ID: 26133119

PubMed ID: 25599644

PubMed ID: 27428775

PubMed ID: 27342858

PubMed ID: 27493187

PubMed ID: 34711951

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 16625196

PubMed ID: 17323924

PubMed ID: 21269460

PubMed ID: 22814378

PubMed ID: 23186163