Details for: TRPC7

Gene ID: 57113

Symbol: TRPC7

Ensembl ID: ENSG00000069018

Description: transient receptor potential cation channel subfamily C member 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 4.4495
    Cell Significance Index: 36.4300
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 3.0731
    Cell Significance Index: 17.2300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.9840
    Cell Significance Index: 10.2500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5530
    Cell Significance Index: 8.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3682
    Cell Significance Index: 254.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3336
    Cell Significance Index: 8.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2694
    Cell Significance Index: 96.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.2261
    Cell Significance Index: 6.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2005
    Cell Significance Index: 4.1600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1575
    Cell Significance Index: 1.3000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1468
    Cell Significance Index: 1.7800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.1233
    Cell Significance Index: 3.9000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1021
    Cell Significance Index: 2.5500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0786
    Cell Significance Index: 0.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0638
    Cell Significance Index: 1.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0607
    Cell Significance Index: 1.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0498
    Cell Significance Index: 3.0600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0349
    Cell Significance Index: 0.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0307
    Cell Significance Index: 22.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0246
    Cell Significance Index: 4.9400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0130
    Cell Significance Index: 0.0900
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: 0.0097
    Cell Significance Index: 0.1200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0010
    Cell Significance Index: 0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0004
    Cell Significance Index: 0.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0009
    Cell Significance Index: -1.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.1200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0058
    Cell Significance Index: -0.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0062
    Cell Significance Index: -3.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0066
    Cell Significance Index: -3.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0069
    Cell Significance Index: -3.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0077
    Cell Significance Index: -4.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0090
    Cell Significance Index: -1.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0132
    Cell Significance Index: -0.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0134
    Cell Significance Index: -3.8600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0158
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0165
    Cell Significance Index: -3.4700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0182
    Cell Significance Index: -0.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0191
    Cell Significance Index: -3.4500
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.0217
    Cell Significance Index: -0.2700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0224
    Cell Significance Index: -0.3400
  • Cell Name: giant bipolar cell (CL4033035)
    Fold Change: -0.0231
    Cell Significance Index: -0.2700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0266
    Cell Significance Index: -0.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0268
    Cell Significance Index: -3.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0277
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0288
    Cell Significance Index: -4.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0288
    Cell Significance Index: -0.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0319
    Cell Significance Index: -0.6900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0369
    Cell Significance Index: -0.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0379
    Cell Significance Index: -4.6600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0380
    Cell Significance Index: -0.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0419
    Cell Significance Index: -2.8200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0421
    Cell Significance Index: -0.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0437
    Cell Significance Index: -2.4500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0444
    Cell Significance Index: -0.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0445
    Cell Significance Index: -1.9700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0450
    Cell Significance Index: -1.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0475
    Cell Significance Index: -1.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0489
    Cell Significance Index: -5.0900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0523
    Cell Significance Index: -0.5400
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.0537
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0544
    Cell Significance Index: -6.2300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0575
    Cell Significance Index: -0.7000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0576
    Cell Significance Index: -0.3900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0578
    Cell Significance Index: -0.5000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0648
    Cell Significance Index: -0.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0653
    Cell Significance Index: -5.0100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0657
    Cell Significance Index: -0.8300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.0708
    Cell Significance Index: -0.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0726
    Cell Significance Index: -3.8100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0786
    Cell Significance Index: -1.0300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0789
    Cell Significance Index: -1.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0854
    Cell Significance Index: -2.4600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0856
    Cell Significance Index: -1.1200
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: -0.0879
    Cell Significance Index: -1.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0898
    Cell Significance Index: -2.2400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0932
    Cell Significance Index: -0.8300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0935
    Cell Significance Index: -1.2100
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0962
    Cell Significance Index: -1.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0970
    Cell Significance Index: -5.0500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0996
    Cell Significance Index: -2.0000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1014
    Cell Significance Index: -2.2200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1036
    Cell Significance Index: -1.2500
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1055
    Cell Significance Index: -1.0100
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1062
    Cell Significance Index: -1.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1078
    Cell Significance Index: -3.5300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1090
    Cell Significance Index: -2.6600
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1133
    Cell Significance Index: -1.4500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1159
    Cell Significance Index: -1.6500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1168
    Cell Significance Index: -1.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1181
    Cell Significance Index: -5.5500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1210
    Cell Significance Index: -4.2400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1241
    Cell Significance Index: -0.6500
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1247
    Cell Significance Index: -1.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1253
    Cell Significance Index: -3.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1288
    Cell Significance Index: -2.7900
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1292
    Cell Significance Index: -1.3800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1331
    Cell Significance Index: -0.3000
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1354
    Cell Significance Index: -1.2100
  • Cell Name: diffuse bipolar 3b cell (CL4033030)
    Fold Change: -0.1361
    Cell Significance Index: -1.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRPC7 channels possess a unique structure, consisting of six transmembrane domains and a pore-forming region. These channels are activated by a variety of stimuli, including calcium ion influx, receptor activation, and store-operated calcium entry. TRPC7 channels are characterized by their ability to regulate cytosolic calcium ion concentration, which is crucial for maintaining cellular homeostasis and modulating immune responses. The channel's activity is also influenced by its interactions with other proteins, such as calmodulin and the endoplasmic reticulum calcium ATPase (SERCA). **Pathways and Functions:** TRPC7 channels participate in numerous signaling pathways, including: 1. **Calcium channel activity:** TRPC7 channels contribute to the regulation of cytosolic calcium ion concentration, which is essential for various cellular processes, including signaling, proliferation, and differentiation. 2. **Axon guidance:** TRPC7 channels play a role in axon guidance, a critical process during neural development and regeneration. 3. **G protein-coupled receptor (GPCR) signaling:** TRPC7 channels interact with GPCRs, modulating downstream signaling events and influencing cellular responses. 4. **Store-operated calcium entry (SOCE):** TRPC7 channels participate in SOCE, a process by which calcium ions are released from the endoplasmic reticulum in response to store depletion. 5. **Platelet activation and aggregation:** TRPC7 channels contribute to the regulation of platelet calcium homeostasis, influencing platelet activation and aggregation. **Clinical Significance:** Dysregulation of TRPC7 channels has been implicated in various diseases, including: 1. **Immunological disorders:** TRPC7 channels play a crucial role in regulating immune responses, and alterations in TRPC7 expression or function may contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Neurological disorders:** TRPC7 channels are involved in axon guidance and neural development, and dysregulation of TRPC7 channels may contribute to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular diseases:** TRPC7 channels regulate platelet activation and aggregation, and alterations in TRPC7 expression or function may contribute to cardiovascular diseases, such as atherosclerosis and thrombosis. 4. **Cancer:** TRPC7 channels have been implicated in cancer progression, and dysregulation of TRPC7 channels may contribute to cancer metastasis and resistance to chemotherapy. In conclusion, TRPC7 channels play a multifaceted role in regulating immune responses, cellular homeostasis, and signaling pathways. Further research is necessary to fully elucidate the mechanisms underlying TRPC7 channel function and its implications in various diseases.

Genular Protein ID: 959087873

Symbol: TRPC7_HUMAN

Name: Short transient receptor potential channel 7

UniProtKB Accession Codes:

Q9HCX4 A1A4Z4 F5H5U9 Q70T26 Q8IWP7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 4 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15757897

Title: MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.

PubMed ID: 15757897

DOI: 10.1074/jbc.m500391200

PubMed ID: 17850865

Title: RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC.

PubMed ID: 17850865

DOI: 10.1016/j.ceca.2007.07.009

PubMed ID: 21402151

Title: Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Ialpha.

PubMed ID: 21402151

DOI: 10.1016/j.cellsig.2011.03.005

Sequence Information:

  • Length: 862
  • Mass: 99562
  • Checksum: C516E59E80AEF4B0
  • Sequence:
    • MLRNSTFKNM QRRHTTLREK GRRQAIRGPA YMFNEKGTSL TPEEERFLDS AEYGNIPVVR 
KMLEESKTLN FNCVDYMGQN ALQLAVGNEH LEVTELLLKK ENLARVGDAL LLAISKGYVR 
IVEAILNHPA FAQGQRLTLS PLEQELRDDD FYAYDEDGTR FSHDITPIIL AAHCQEYEIV 
HILLLKGARI ERPHDYFCKC NECTEKQRKD SFSHSRSRMN AYKGLASAAY LSLSSEDPVL 
TALELSNELA RLANIETEFK NDYRKLSMQC KDFVVGVLDL CRDTEEVEAI LNGDVNFQVW 
SDHHRPSLSR IKLAIKYEVK KFVAHPNCQQ QLLTMWYENL SGLRQQSIAV KFLAVFGVSI 
GLPFLAIAYW IAPCSKLGRT LRSPFMKFVA HAVSFTIFLG LLVVNASDRF EGVKTLPNET 
FTDYPKQIFR VKTTQFSWTE MLIMKWVLGM IWSECKEIWE EGPREYVLHL WNLLDFGMLS 
IFVASFTARF MAFLKATEAQ LYVDQHVQDD TLHNVSLPPE VAYFTYARDK WWPSDPQIIS 
EGLYAIAVVL SFSRIAYILP ANESFGPLQI SLGRTVKDIF KFMVIFIMVF VAFMIGMFNL 
YSYYRGAKYN PAFTTVEESF KTLFWSIFGL SEVISVVLKY DHKFIENIGY VLYGVYNVTM 
VVVLLNMLIA MINNSYQEIE EDADVEWKFA RAKLWLSYFD EGRTLPAPFN LVPSPKSFYY 
LIMRIKMCLI KLCKSKAKSC ENDLEMGMLN SKFKKTRYQA GMRNSENLTA NNTLSKPTRY 
QKIMKRLIKR YVLKAQVDRE NDEVNEGELK EIKQDISSLR YELLEEKSQA TGELADLIQQ 
LSEKFGKNLN KDHLRVNKGK DI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.