PSMD7 | ENSG00000103035 | NCBI 5713

Details for: PSMD7

Gene ID: 5713

Symbol: PSMD7

Ensembl ID: ENSG00000103035

Description: proteasome 26S subunit, non-ATPase 7

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Neutrophil degranulation
(R-HSA-6798695)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 291.7479
Cell Significance Index: -45.3800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 193.9337
Cell Significance Index: -49.1900
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 157.6353
Cell Significance Index: -64.9400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 134.7531
Cell Significance Index: -63.6200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 121.7959
Cell Significance Index: -62.6500
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 95.2800
Cell Significance Index: -63.9400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 47.8687
Cell Significance Index: -59.0200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 16.8990
Cell Significance Index: -45.2700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 16.0946
Cell Significance Index: -63.5100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.0752
Cell Significance Index: -40.1600
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.8733
Cell Significance Index: -19.4200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 5.2729
Cell Significance Index: 614.5000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.0215
Cell Significance Index: 278.1100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.3527
Cell Significance Index: 62.8200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.0610
Cell Significance Index: 60.5300
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.0513
Cell Significance Index: 18.8900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.9025
Cell Significance Index: 51.7900
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.6872
Cell Significance Index: 108.8500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.5180
Cell Significance Index: 107.3600
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.4701
Cell Significance Index: 802.8800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.4408
Cell Significance Index: 259.7300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.4285
Cell Significance Index: 40.9500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.4123
Cell Significance Index: 65.8500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.4043
Cell Significance Index: 72.9500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.3275
Cell Significance Index: 586.9200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.2846
Cell Significance Index: 157.9500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1496
Cell Significance Index: 1037.9900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.9552
Cell Significance Index: 71.1900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.9498
Cell Significance Index: 19.8800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.9344
Cell Significance Index: 185.4400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.8703
Cell Significance Index: 119.5100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.8390
Cell Significance Index: 98.9400
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.8070
Cell Significance Index: 21.2200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.7748
Cell Significance Index: 26.9300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.7660
Cell Significance Index: 36.0000
Cell Name: lactocyte (CL0002325)
Fold Change: 0.7618
Cell Significance Index: 98.4200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6866
Cell Significance Index: 137.7300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.6195
Cell Significance Index: 11.4500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5561
Cell Significance Index: 90.4500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5133
Cell Significance Index: 11.1200
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.5096
Cell Significance Index: 5.5400
Cell Name: odontoblast (CL0000060)
Fold Change: 0.5042
Cell Significance Index: 64.6300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4918
Cell Significance Index: 14.1700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.4374
Cell Significance Index: 22.9700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3102
Cell Significance Index: 14.0600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.2262
Cell Significance Index: 2.5700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2255
Cell Significance Index: 80.8900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1975
Cell Significance Index: 33.7200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1931
Cell Significance Index: 14.8200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0939
Cell Significance Index: 2.5100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0851
Cell Significance Index: 16.2000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0524
Cell Significance Index: 5.1800
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0474
Cell Significance Index: 32.7600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0282
Cell Significance Index: 53.0200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0221
Cell Significance Index: 1.3900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0208
Cell Significance Index: 15.7800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0007
Cell Significance Index: -1.1300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0044
Cell Significance Index: -8.1100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0053
Cell Significance Index: -3.9500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0085
Cell Significance Index: -3.8700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0158
Cell Significance Index: -21.4200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0178
Cell Significance Index: -13.0600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0383
Cell Significance Index: -23.9300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0397
Cell Significance Index: -0.6700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0449
Cell Significance Index: -28.5200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0519
Cell Significance Index: -5.3000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0712
Cell Significance Index: -40.1400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1119
Cell Significance Index: -23.5600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1345
Cell Significance Index: -8.0800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1443
Cell Significance Index: -16.5400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1860
Cell Significance Index: -53.5300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1930
Cell Significance Index: -4.1100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2220
Cell Significance Index: -12.4600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2276
Cell Significance Index: -6.3600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2521
Cell Significance Index: -8.8600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2672
Cell Significance Index: -6.8300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2768
Cell Significance Index: -40.2300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.3178
Cell Significance Index: -1.9200
Cell Name: peg cell (CL4033014)
Fold Change: -0.3324
Cell Significance Index: -7.6800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3828
Cell Significance Index: -23.5300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3886
Cell Significance Index: -44.3600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5211
Cell Significance Index: -35.0400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.5394
Cell Significance Index: -7.3600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5743
Cell Significance Index: -59.8000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6042
Cell Significance Index: -47.8600
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.6107
Cell Significance Index: -7.2800
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.6274
Cell Significance Index: -6.5000
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.6791
Cell Significance Index: -12.0000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7715
Cell Significance Index: -24.7100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.7800
Cell Significance Index: -20.8700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7981
Cell Significance Index: -48.9300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.8882
Cell Significance Index: -26.1600
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.8898
Cell Significance Index: -44.9700
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.9031
Cell Significance Index: -7.7600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.9366
Cell Significance Index: -41.4300
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.9403
Cell Significance Index: -14.0900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.9774
Cell Significance Index: -25.1300
Cell Name: type I muscle cell (CL0002211)
Fold Change: -1.0918
Cell Significance Index: -26.6400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.1321
Cell Significance Index: -42.8700
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.1969
Cell Significance Index: -17.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Proteasome Subunit:** PSMD7 is a non-ATPase regulatory subunit of the 26S proteasome, which is a large protein complex responsible for degrading damaged or misfolded proteins. 2. **Multiple Cellular Expressions:** PSMD7 is expressed in a wide range of cell types, including epithelial cells, fibroblasts, immune cells, and progenitor cells, highlighting its role in various cellular processes. 3. **Antigen Processing and Presentation:** PSMD7 is involved in the regulation of antigen processing and presentation by the major histocompatibility complex (MHC) class I and II molecules. 4. **Regulation of Cell Cycle and Apoptosis:** PSMD7 plays a role in regulating the cell cycle and apoptosis by targeting specific proteins for degradation. **Pathways and Functions:** 1. **Adaptive Immune Response:** PSMD7 is involved in the regulation of the adaptive immune response, including the activation of T-cells and the presentation of antigens to T-cells. 2. **Antigen Processing-Cross Presentation:** PSMD7 is involved in the regulation of antigen processing and cross-presentation by the MHC class I and II molecules. 3. **Apoptosis:** PSMD7 plays a role in regulating apoptosis by targeting specific proteins for degradation. 4. **Cell Cycle Regulation:** PSMD7 is involved in regulating the cell cycle by targeting specific proteins for degradation. 5. **Innate Immune Response:** PSMD7 is involved in the regulation of the innate immune response, including the activation of immune cells such as neutrophils and macrophages. **Clinical Significance:** 1. **Immunodeficiency Diseases:** Mutations in the PSMD7 gene have been associated with immunodeficiency diseases, highlighting its importance in immune function. 2. **Cancer:** PSMD7 is involved in the regulation of cell cycle and apoptosis, making it a potential target for cancer therapy. 3. **Infectious Diseases:** PSMD7 plays a role in the regulation of the innate immune response, making it a potential target for the treatment of infectious diseases. 4. **Autoimmune Diseases:** PSMD7 is involved in the regulation of antigen processing and presentation, making it a potential target for the treatment of autoimmune diseases. In conclusion, PSMD7 is a multifaceted gene that plays a crucial role in immune regulation, cellular homeostasis, and disease. Further research is needed to fully understand the mechanisms by which PSMD7 regulates these processes and to identify potential therapeutic targets for the treatment of diseases associated with PSMD7 dysfunction.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

26S proteasome non-ATPase regulatory subunit 7

Genular Protein ID: 2086325913

Symbol: PSMD7_HUMAN

Name: 26S proteasome non-ATPase regulatory subunit 7

UniProtKB Accession Codes:

P51665 D3DWS9 Q6PKI2 Q96E97

Database IDs:

Citations:

PubMed ID: 7755639

Title: cDNA cloning of p40, a regulatory subunit of the human 26S proteasome, and a homolog of the Mov-34 gene product.

PubMed ID: 7755639

DOI: 10.1006/bbrc.1995.1701

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1317798

Title: Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.

PubMed ID: 1317798

DOI: 10.1111/j.1432-1033.1992.tb16961.x

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22078707

Title: TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions.

PubMed ID: 22078707

DOI: 10.1186/1742-4690-8-93

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 17559875

Title: The crystal structure of the human Mov34 MPN domain reveals a metal-free dimer.

PubMed ID: 17559875

DOI: 10.1016/j.jmb.2007.04.084

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

Sequence Information:

Length: 324
Mass: 37025
Checksum: 3F7B343996B102B7
Sequence:

MPELAVQKVV VHPLVLLSVV DHFNRIGKVG NQKRVVGVLL GSWQKKVLDV SNSFAVPFDE 
DDKDDSVWFL DHDYLENMYG MFKKVNARER IVGWYHTGPK LHKNDIAINE LMKRYCPNSV 
LVIIDVKPKD LGLPTEAYIS VEEVHDDGTP TSKTFEHVTS EIGAEEAEEV GVEHLLRDIK 
DTTVGTLSQR ITNQVHGLKG LNSKLLDIRS YLEKVATGKL PINHQIIYQL QDVFNLLPDV 
SLQEFVKAFY LKTNDQMVVV YLASLIRSVV ALHNLINNKI ANRDAEKKEG QEKEESKKDR 
KEDKEKDKDK EKSDVKKEEK KEKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMD7

Associated with

Cells (max top 100)

Other Information

cDNA cloning of p40, a regulatory subunit of the human 26S proteasome, and a homolog of the Mov-34 gene product. PubMed ID: 7755639

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. PubMed ID: 1317798

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. PubMed ID: 22078707

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The crystal structure of the human Mov34 MPN domain reveals a metal-free dimer. PubMed ID: 17559875

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858