Details for: PSMD10

Gene ID: 5716

Symbol: PSMD10

Ensembl ID: ENSG00000101843

Description: proteasome 26S subunit, non-ATPase 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 114.2754
    Cell Significance Index: -17.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.6146
    Cell Significance Index: -17.1500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 47.9187
    Cell Significance Index: -19.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.3529
    Cell Significance Index: -20.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.7316
    Cell Significance Index: -17.3600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 38.1621
    Cell Significance Index: -19.6300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 31.3104
    Cell Significance Index: -21.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.2772
    Cell Significance Index: -17.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.9049
    Cell Significance Index: -19.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.1672
    Cell Significance Index: -19.2000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 5.4499
    Cell Significance Index: 41.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1317
    Cell Significance Index: -20.2500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.7241
    Cell Significance Index: -14.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0027
    Cell Significance Index: 905.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0019
    Cell Significance Index: 108.9800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8666
    Cell Significance Index: 7.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7564
    Cell Significance Index: 10.3200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.7153
    Cell Significance Index: 9.1600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.7002
    Cell Significance Index: 7.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6992
    Cell Significance Index: 113.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5852
    Cell Significance Index: 30.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5617
    Cell Significance Index: 15.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5477
    Cell Significance Index: 299.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5419
    Cell Significance Index: 14.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5281
    Cell Significance Index: 64.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5211
    Cell Significance Index: 36.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5209
    Cell Significance Index: 32.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4394
    Cell Significance Index: 23.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4393
    Cell Significance Index: 10.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4033
    Cell Significance Index: 72.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3917
    Cell Significance Index: 46.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2883
    Cell Significance Index: 7.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2760
    Cell Significance Index: 37.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2547
    Cell Significance Index: 112.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2183
    Cell Significance Index: 10.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2091
    Cell Significance Index: 6.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1973
    Cell Significance Index: 4.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1860
    Cell Significance Index: 18.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1783
    Cell Significance Index: 12.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1749
    Cell Significance Index: 3.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1632
    Cell Significance Index: 20.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1327
    Cell Significance Index: 4.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1289
    Cell Significance Index: 24.5300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1245
    Cell Significance Index: 0.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1240
    Cell Significance Index: 9.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1155
    Cell Significance Index: 3.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1153
    Cell Significance Index: 5.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1013
    Cell Significance Index: 2.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0960
    Cell Significance Index: 19.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0774
    Cell Significance Index: 2.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0757
    Cell Significance Index: 12.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0686
    Cell Significance Index: 24.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0599
    Cell Significance Index: 11.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0566
    Cell Significance Index: 7.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0556
    Cell Significance Index: 1.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0157
    Cell Significance Index: 1.0200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0149
    Cell Significance Index: 0.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0064
    Cell Significance Index: 0.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0015
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0051
    Cell Significance Index: -3.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0055
    Cell Significance Index: -10.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0071
    Cell Significance Index: -5.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0110
    Cell Significance Index: -20.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0143
    Cell Significance Index: -22.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0152
    Cell Significance Index: -20.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0178
    Cell Significance Index: -1.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0230
    Cell Significance Index: -0.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0232
    Cell Significance Index: -13.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0241
    Cell Significance Index: -15.3000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0262
    Cell Significance Index: -0.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0308
    Cell Significance Index: -0.3500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0313
    Cell Significance Index: -0.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0352
    Cell Significance Index: -10.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0366
    Cell Significance Index: -1.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0377
    Cell Significance Index: -17.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0392
    Cell Significance Index: -8.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0444
    Cell Significance Index: -5.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0602
    Cell Significance Index: -7.0100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0724
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0764
    Cell Significance Index: -8.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0772
    Cell Significance Index: -4.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1033
    Cell Significance Index: -15.0100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1045
    Cell Significance Index: -2.6700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1145
    Cell Significance Index: -0.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1456
    Cell Significance Index: -8.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1578
    Cell Significance Index: -4.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1661
    Cell Significance Index: -11.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1858
    Cell Significance Index: -3.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1942
    Cell Significance Index: -15.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1975
    Cell Significance Index: -20.5600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2038
    Cell Significance Index: -2.1100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2217
    Cell Significance Index: -2.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2341
    Cell Significance Index: -14.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2412
    Cell Significance Index: -18.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2416
    Cell Significance Index: -2.8800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2668
    Cell Significance Index: -3.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2727
    Cell Significance Index: -15.3000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2743
    Cell Significance Index: -2.6100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2748
    Cell Significance Index: -4.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Proteasome subunit:** PSMD10 is a non-ATPase subunit of the 26S proteasome, a large protein complex responsible for degrading proteins. 2. **Ubiquitin-proteasome pathway:** PSMD10 is involved in the ubiquitin-proteasome pathway, which is essential for protein degradation and regulation of various cellular processes. 3. **Cellular expression:** PSMD10 is expressed in various cell types, including immune cells, oogonial cells, and ovarian surface epithelial cells. 4. **Regulation of protein degradation:** PSMD10 regulates protein degradation by interacting with other proteins and influencing the ubiquitin-proteasome pathway. **Pathways and Functions:** 1. **Adaptive immune system:** PSMD10 is involved in the adaptive immune system, where it regulates the degradation of proteins involved in immune responses. 2. **Antigen processing and presentation:** PSMD10 is implicated in antigen processing and presentation, where it degrades proteins involved in the presentation of antigens to T-cells. 3. **Apoptosis:** PSMD10 regulates apoptosis by degrading proteins involved in cell death pathways. 4. **Cell cycle regulation:** PSMD10 regulates cell cycle progression by degrading proteins involved in cell cycle checkpoints. 5. **Innate immune system:** PSMD10 is involved in the innate immune system, where it regulates the degradation of proteins involved in immune responses. **Clinical Significance:** 1. **Cancer:** PSMD10 has been implicated in various cancers, including breast, lung, and colon cancer, where it regulates protein degradation and immune responses. 2. **Autoimmune disorders:** PSMD10 has been implicated in autoimmune disorders, including rheumatoid arthritis and lupus, where it regulates protein degradation and immune responses. 3. **Infectious diseases:** PSMD10 has been implicated in infectious diseases, including HIV and tuberculosis, where it regulates protein degradation and immune responses. 4. **Neurological disorders:** PSMD10 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it regulates protein degradation and immune responses. In conclusion, PSMD10 is a complex gene that plays a crucial role in regulating protein degradation, immune response, and various cellular processes. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, infectious diseases, and neurological disorders. Further research is needed to fully understand the mechanisms of PSMD10 and its role in human disease.

Genular Protein ID: 3189524743

Symbol: PSD10_HUMAN

Name: 26S proteasome non-ATPase regulatory subunit 10

UniProtKB Accession Codes:

O75832 Q5U0B2 Q8IZK9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 19 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 59 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9714768

Title: cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome.

PubMed ID: 9714768

DOI: 10.1016/s0378-1119(98)00309-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10613832

Title: Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas.

PubMed ID: 10613832

DOI: 10.1038/71600

PubMed ID: 11900540

Title: Novel insights into the INK4-CDK4/6-Rb pathway: counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb.

PubMed ID: 11900540

DOI: 10.1021/bi011550s

PubMed ID: 11779854

Title: Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome.

PubMed ID: 11779854

DOI: 10.1074/jbc.m107313200

PubMed ID: 16023600

Title: The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53.

PubMed ID: 16023600

DOI: 10.1016/j.ccr.2005.06.006

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 18040287

Title: Oncoprotein p28 GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export.

PubMed ID: 18040287

DOI: 10.1038/cr.2007.99

PubMed ID: 19490896

Title: Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones.

PubMed ID: 19490896

DOI: 10.1016/j.cell.2009.05.008

PubMed ID: 19729910

Title: Involvement of the mitochondrial pathway in p53-independent apoptosis induced by p28GANK knockdown in Hep3B cells.

PubMed ID: 19729910

DOI: 10.1159/000227831

PubMed ID: 20628200

Title: Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells.

PubMed ID: 20628200

DOI: 10.1172/jci42542

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 15379554

Title: Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure-function relationship.

PubMed ID: 15379554

DOI: 10.1021/bi049116o

PubMed ID: 14573599

Title: The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53.

PubMed ID: 14573599

DOI: 10.1074/jbc.m310265200

PubMed ID: 14997555

Title: X-ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma.

PubMed ID: 14997555

DOI: 10.1002/prot.20028

Sequence Information:

  • Length: 226
  • Mass: 24428
  • Checksum: 57158E33146EC7C8
  • Sequence:
    • MEGCVSNLMV CNLAYSGKLE ELKESILADK SLATRTDQDS RTALHWACSA GHTEIVEFLL 
QLGVPVNDKD DAGWSPLHIA ASAGRDEIVK ALLGKGAQVN AVNQNGCTPL HYAASKNRHE 
IAVMLLEGGA NPDAKDHYEA TAMHRAAAKG NLKMIHILLY YKASTNIQDT EGNTPLHLAC 
DEERVEEAKL LVSQGASIYI ENKEEKTPLQ VAKGGLGLIL KRMVEG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.