Details for: PTBP1

Gene ID: 5725

Symbol: PTBP1

Ensembl ID: ENSG00000011304

Description: polypyrimidine tract binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 256.1956
    Cell Significance Index: -39.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 175.2855
    Cell Significance Index: -44.4600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 129.6767
    Cell Significance Index: -53.4200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 119.7147
    Cell Significance Index: -56.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 118.9887
    Cell Significance Index: -48.3400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 107.1570
    Cell Significance Index: -55.1200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.1970
    Cell Significance Index: -48.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.5424
    Cell Significance Index: -51.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.9129
    Cell Significance Index: -50.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.4869
    Cell Significance Index: -53.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.3459
    Cell Significance Index: -37.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.6533
    Cell Significance Index: -16.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.4888
    Cell Significance Index: 47.6000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.6045
    Cell Significance Index: 69.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.5994
    Cell Significance Index: 135.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.4429
    Cell Significance Index: 84.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1669
    Cell Significance Index: 58.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.0561
    Cell Significance Index: 334.4000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.7974
    Cell Significance Index: 19.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.7295
    Cell Significance Index: 46.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6669
    Cell Significance Index: 34.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5882
    Cell Significance Index: 71.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4170
    Cell Significance Index: 39.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3852
    Cell Significance Index: 274.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2804
    Cell Significance Index: 151.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2673
    Cell Significance Index: 59.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2167
    Cell Significance Index: 35.0600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.1836
    Cell Significance Index: 9.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1227
    Cell Significance Index: 138.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1125
    Cell Significance Index: 152.7800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.0634
    Cell Significance Index: 16.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0514
    Cell Significance Index: 189.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0290
    Cell Significance Index: 53.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9921
    Cell Significance Index: 28.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9818
    Cell Significance Index: 21.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9425
    Cell Significance Index: 416.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8934
    Cell Significance Index: 487.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8892
    Cell Significance Index: 66.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8734
    Cell Significance Index: 56.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8215
    Cell Significance Index: 21.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7818
    Cell Significance Index: 36.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6534
    Cell Significance Index: 83.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6485
    Cell Significance Index: 44.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6334
    Cell Significance Index: 81.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5339
    Cell Significance Index: 37.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4226
    Cell Significance Index: 84.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3074
    Cell Significance Index: 277.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3062
    Cell Significance Index: 58.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2673
    Cell Significance Index: 26.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2629
    Cell Significance Index: 44.8900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1901
    Cell Significance Index: 2.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1671
    Cell Significance Index: 59.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1365
    Cell Significance Index: 94.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0298
    Cell Significance Index: 56.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0227
    Cell Significance Index: 0.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0029
    Cell Significance Index: 2.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0020
    Cell Significance Index: 3.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0013
    Cell Significance Index: 0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0007
    Cell Significance Index: 1.2600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0034
    Cell Significance Index: -0.0600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0050
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0138
    Cell Significance Index: -10.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0166
    Cell Significance Index: -10.5700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0185
    Cell Significance Index: -0.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0193
    Cell Significance Index: -26.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0239
    Cell Significance Index: -17.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0278
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0326
    Cell Significance Index: -20.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0450
    Cell Significance Index: -4.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0688
    Cell Significance Index: -31.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0772
    Cell Significance Index: -43.5200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1024
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1290
    Cell Significance Index: -27.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1515
    Cell Significance Index: -17.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1550
    Cell Significance Index: -44.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1753
    Cell Significance Index: -6.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2027
    Cell Significance Index: -29.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2036
    Cell Significance Index: -23.3300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.2440
    Cell Significance Index: -0.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2548
    Cell Significance Index: -29.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2646
    Cell Significance Index: -8.4800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3019
    Cell Significance Index: -5.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3223
    Cell Significance Index: -9.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3280
    Cell Significance Index: -8.3800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.3844
    Cell Significance Index: -2.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3920
    Cell Significance Index: -30.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4459
    Cell Significance Index: -25.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4892
    Cell Significance Index: -50.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4990
    Cell Significance Index: -31.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5021
    Cell Significance Index: -12.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5221
    Cell Significance Index: -26.3900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5283
    Cell Significance Index: -4.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5334
    Cell Significance Index: -32.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5803
    Cell Significance Index: -39.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5900
    Cell Significance Index: -46.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6015
    Cell Significance Index: -31.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7909
    Cell Significance Index: -48.4900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.7989
    Cell Significance Index: -5.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9031
    Cell Significance Index: -39.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.9077
    Cell Significance Index: -20.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA-binding specificity:** PTBP1 exhibits a unique ability to bind to specific sequences within the RNA, specifically the polypyrimidine tracts (Py-py-py) and the downstream splicing enhancer elements (DSE). 2. **Alternative splicing regulation:** PTBP1 is a key regulator of alternative splicing, modulating the inclusion or exclusion of exons, and thereby affecting protein function and cellular behavior. 3. **Localization and subcellular distribution:** PTBP1 is primarily localized to the nucleus, where it interacts with various RNA-binding proteins, and also detected in the nucleolus and cytoplasm. 4. **Interactions with other proteins:** PTBP1 interacts with numerous RNA-binding proteins, including hnRNP A1, hnRNP F, and Argonaute 2, as well as transcription factors and signaling molecules. **Pathways and Functions:** 1. **RNA processing and splicing:** PTBP1 regulates alternative splicing by interacting with specific RNA sequences and modulating the activity of splicing factors, thereby influencing the production of diverse protein isoforms. 2. **Transcriptional control:** PTBP1 regulates transcription by interacting with RNA polymerase II and modulating the activity of transcription factors, such as NFATc1, which is involved in immune responses. 3. **Signaling pathways:** PTBP1 interacts with signaling molecules, including FGF receptors, and modulates the activity of receptor tyrosine kinases, influencing cell growth, differentiation, and survival. 4. **Cell differentiation and development:** PTBP1 regulates cell differentiation by modulating the expression of specific genes, including those involved in muscle and neural development. **Clinical Significance:** Dysregulation of PTBP1 has been implicated in various diseases, including: 1. **Muscular dystrophy:** Mutations in PTBP1 have been associated with muscular dystrophy, highlighting its role in muscle development and differentiation. 2. **Neurological disorders:** Altered PTBP1 expression has been linked to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 3. **Cancer:** PTBP1 has been implicated in cancer development and progression, with altered expression levels observed in various types of cancer, including breast, lung, and bladder cancer. 4. **Autoimmune diseases:** PTBP1 may play a role in the regulation of immune responses, with altered expression levels linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, PTBP1 is a multifaceted protein that regulates alternative splicing, RNA processing, and transcriptional control, with significant implications for cellular development, differentiation, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying PTBP1's functions and its potential as a therapeutic target.

Genular Protein ID: 3344440466

Symbol: PTBP1_HUMAN

Name: Polypyrimidine tract-binding protein 1

UniProtKB Accession Codes:

P26599 Q9BUQ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 4 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 11 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1906035

Title: Characterization of cDNAs encoding the polypyrimidine tract-binding protein.

PubMed ID: 1906035

DOI: 10.1101/gad.5.7.1224

PubMed ID: 1906036

Title: Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing.

PubMed ID: 1906036

DOI: 10.1101/gad.5.7.1237

PubMed ID: 1641332

Title: hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs.

PubMed ID: 1641332

DOI: 10.1093/nar/20.14.3671

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 10653975

Title: Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB.

PubMed ID: 10653975

DOI: 10.1002/(sici)1097-4644(20000315)76:4<559::aid-jcb4>3.3.co;2-l

PubMed ID: 11003644

Title: Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein.

PubMed ID: 11003644

DOI: 10.1128/mcb.20.20.7463-7479.2000

PubMed ID: 15009664

Title: Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.

PubMed ID: 15009664

DOI: 10.1046/j.1471-4159.2003.02232.x

PubMed ID: 14966131

Title: An intronic polypyrimidine-rich element downstream of the donor site modulates cystic fibrosis transmembrane conductance regulator exon 9 alternative splicing.

PubMed ID: 14966131

DOI: 10.1074/jbc.m313439200

PubMed ID: 16260624

Title: Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB.

PubMed ID: 16260624

DOI: 10.1128/mcb.25.22.10111-10121.2005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20010808

Title: HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.

PubMed ID: 20010808

DOI: 10.1038/nature08697

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21518792

Title: RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing.

PubMed ID: 21518792

DOI: 10.1083/jcb.201007131

PubMed ID: 21518806

Title: Activation of picornaviral IRESs by PTB shows differential dependence on each PTB RNA-binding domain.

PubMed ID: 21518806

DOI: 10.1261/rna.2549411

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30538201

Title: Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.

PubMed ID: 30538201

DOI: 10.1073/pnas.1818012115

PubMed ID: 10856256

Title: Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold.

PubMed ID: 10856256

DOI: 10.1093/emboj/19.12.3132

PubMed ID: 15341728

Title: Structure and RNA interactions of the N-terminal RRM domains of PTB.

PubMed ID: 15341728

DOI: 10.1016/j.str.2004.07.008

PubMed ID: 16179478

Title: Structure of PTB bound to RNA: specific binding and implications for splicing regulation.

PubMed ID: 16179478

DOI: 10.1126/science.1114066

PubMed ID: 16362043

Title: Structure of the two most C-terminal RNA recognition motifs of PTB using segmental isotope labeling.

PubMed ID: 16362043

DOI: 10.1038/sj.emboj.7600911

Sequence Information:

  • Length: 557
  • Mass: 59633
  • Checksum: DAFE52BAC0E4BE5C
  • Sequence:
    • MDGIVPDIAV GTKRGSDELF STCVTNGPFI MSSNSASAAN GNDSKKFKGD SRSAGVPSRV 
IHIRKLPIDV TEGEVISLGL PFGKVTNLLM LKGKNQAFIE MNTEEAANTM VNYYTSVTPV 
LRGQPIYIQF SNHKELKTDS SPNQARAQAA LQAVNSVQSG NLALAASAAA VDAGMAMAGQ 
SPVLRIIVEN LFYPVTLDVL HQIFSKFGTV LKIITFTKNN QFQALLQYAD PVSAQHAKLS 
LDGQNIYNAC CTLRIDFSKL TSLNVKYNND KSRDYTRPDL PSGDSQPSLD QTMAAAFGAP 
GIISASPYAG AGFPPTFAIP QAAGLSVPNV HGALAPLAIP SAAAAAAAAG RIAIPGLAGA 
GNSVLLVSNL NPERVTPQSL FILFGVYGDV QRVKILFNKK ENALVQMADG NQAQLAMSHL 
NGHKLHGKPI RITLSKHQNV QLPREGQEDQ GLTKDYGNSP LHRFKKPGSK NFQNIFPPSA 
TLHLSNIPPS VSEEDLKVLF SSNGGVVKGF KFFQKDRKMA LIQMGSVEEA VQALIDLHNH 
DLGENHHLRV SFSKSTI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.