Details for: PURA

Gene ID: 5813

Symbol: PURA

Ensembl ID: ENSG00000185129

Description: purine rich element binding protein A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 347.4231
    Cell Significance Index: -54.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 215.6965
    Cell Significance Index: -54.7100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 143.7076
    Cell Significance Index: -59.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 120.9643
    Cell Significance Index: -57.1100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 113.7211
    Cell Significance Index: -46.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 102.6468
    Cell Significance Index: -52.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.6937
    Cell Significance Index: -46.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.9059
    Cell Significance Index: -56.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.5531
    Cell Significance Index: -52.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.9692
    Cell Significance Index: -52.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.4727
    Cell Significance Index: -57.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.1135
    Cell Significance Index: -28.7000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 5.1194
    Cell Significance Index: 39.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.6576
    Cell Significance Index: 36.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.2410
    Cell Significance Index: 117.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5741
    Cell Significance Index: 171.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5690
    Cell Significance Index: 314.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5321
    Cell Significance Index: 276.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5155
    Cell Significance Index: 186.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4690
    Cell Significance Index: 1326.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.4541
    Cell Significance Index: 75.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2912
    Cell Significance Index: 463.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1745
    Cell Significance Index: 161.2900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.1269
    Cell Significance Index: 18.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0150
    Cell Significance Index: 201.4400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8982
    Cell Significance Index: 7.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8696
    Cell Significance Index: 23.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8455
    Cell Significance Index: 39.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7933
    Cell Significance Index: 350.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7703
    Cell Significance Index: 420.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7335
    Cell Significance Index: 46.2300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.7300
    Cell Significance Index: 12.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6996
    Cell Significance Index: 47.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6352
    Cell Significance Index: 28.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5579
    Cell Significance Index: 16.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4895
    Cell Significance Index: 25.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4861
    Cell Significance Index: 62.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4227
    Cell Significance Index: 292.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4202
    Cell Significance Index: 68.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4095
    Cell Significance Index: 18.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3947
    Cell Significance Index: 11.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3498
    Cell Significance Index: 24.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3470
    Cell Significance Index: 24.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3404
    Cell Significance Index: 12.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2817
    Cell Significance Index: 13.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2514
    Cell Significance Index: 42.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2484
    Cell Significance Index: 19.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2140
    Cell Significance Index: 5.3500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2040
    Cell Significance Index: 2.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1369
    Cell Significance Index: 26.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1363
    Cell Significance Index: 3.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1234
    Cell Significance Index: 3.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0968
    Cell Significance Index: 71.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0919
    Cell Significance Index: 9.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0481
    Cell Significance Index: 90.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0460
    Cell Significance Index: 70.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0391
    Cell Significance Index: 24.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0229
    Cell Significance Index: 31.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0117
    Cell Significance Index: 21.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0045
    Cell Significance Index: 0.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0003
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0064
    Cell Significance Index: -4.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0142
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0327
    Cell Significance Index: -20.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0373
    Cell Significance Index: -21.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0403
    Cell Significance Index: -30.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0790
    Cell Significance Index: -10.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0936
    Cell Significance Index: -5.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1076
    Cell Significance Index: -10.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1213
    Cell Significance Index: -9.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1230
    Cell Significance Index: -25.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1539
    Cell Significance Index: -18.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1590
    Cell Significance Index: -10.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1677
    Cell Significance Index: -48.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2104
    Cell Significance Index: -30.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2237
    Cell Significance Index: -25.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3420
    Cell Significance Index: -9.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3427
    Cell Significance Index: -39.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3515
    Cell Significance Index: -40.9600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3802
    Cell Significance Index: -8.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4385
    Cell Significance Index: -34.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4504
    Cell Significance Index: -8.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4680
    Cell Significance Index: -8.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4897
    Cell Significance Index: -50.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5568
    Cell Significance Index: -33.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6098
    Cell Significance Index: -34.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6548
    Cell Significance Index: -13.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6619
    Cell Significance Index: -21.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6799
    Cell Significance Index: -34.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7147
    Cell Significance Index: -43.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7466
    Cell Significance Index: -16.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7731
    Cell Significance Index: -18.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8557
    Cell Significance Index: -7.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8786
    Cell Significance Index: -30.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0120
    Cell Significance Index: -26.6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.0167
    Cell Significance Index: -12.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0243
    Cell Significance Index: -21.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0606
    Cell Significance Index: -17.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0698
    Cell Significance Index: -27.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1592
    Cell Significance Index: -36.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulator:** PURA acts as a transcriptional regulator, binding to specific DNA sequences and influencing gene expression. Its ability to bind to purine-rich elements makes it a crucial component in the regulation of gene expression. 2. **Cell Cycle Progression:** PURA is involved in the regulation of cell cycle progression, particularly in the G2/M phase. Its expression is downregulated during mitosis, indicating a role in preventing premature cell division. 3. **Neurotransmission and Synapse Formation:** PURA is highly expressed in neurons, where it plays a role in regulating neurotransmitter release and synapse formation. Its involvement in glutamatergic and GABAergic neurotransmission underscores its importance in neuronal function. 4. **Immune Cell Regulation:** PURA is also expressed in immune cells, where it regulates T-cell and B-cell activation, proliferation, and differentiation. Its role in immune cell regulation highlights its potential as a therapeutic target in autoimmune diseases. **Pathways and Functions:** 1. **DNA Binding and Transcriptional Regulation:** PURA binds to specific DNA sequences, influencing gene expression and transcriptional regulation. Its binding to purine-rich elements makes it a key component in regulating gene expression. 2. **Cell Cycle Progression:** PURA regulates cell cycle progression, particularly in the G2/M phase. Its expression is downregulated during mitosis, indicating a role in preventing premature cell division. 3. **Neurotransmission and Synapse Formation:** PURA is involved in regulating neurotransmitter release and synapse formation in neurons. Its involvement in glutamatergic and GABAergic neurotransmission underscores its importance in neuronal function. 4. **Immune Cell Regulation:** PURA regulates T-cell and B-cell activation, proliferation, and differentiation in immune cells. Its role in immune cell regulation highlights its potential as a therapeutic target in autoimmune diseases. **Clinical Significance:** 1. **Autoimmune Diseases:** PURA's role in regulating immune cell function makes it a potential therapeutic target in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** PURA's involvement in cell cycle progression and DNA unwinding makes it a potential target for cancer therapy. Its expression is altered in various types of cancer, suggesting its potential role in tumorigenesis. 3. **Neurological Disorders:** PURA's role in neurotransmission and synapse formation makes it a potential therapeutic target in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Neurodevelopmental Disorders:** PURA's involvement in neuronal development and function makes it a potential therapeutic target in neurodevelopmental disorders, such as autism spectrum disorder. In conclusion, PURA is a complex gene that plays a multifaceted role in various cellular processes. Its involvement in transcriptional regulation, cell cycle progression, neurotransmission, and immune cell regulation highlights its importance in maintaining cellular homeostasis. Further research is necessary to fully elucidate the role of PURA in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1152827375

Symbol: PURA_HUMAN

Name: Transcriptional activator protein Pur-alpha

UniProtKB Accession Codes:

Q00577

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 26 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1448097

Title: Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein.

PubMed ID: 1448097

DOI: 10.1128/mcb.12.12.5673-5682.1992

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20976240

Title: Of bits and bugs--on the use of bioinformatics and a bacterial crystal structure to solve a eukaryotic repeat-protein structure.

PubMed ID: 20976240

DOI: 10.1371/journal.pone.0013402

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25439098

Title: Mutations in PURA cause profound neonatal hypotonia, seizures, and encephalopathy in 5q31.3 microdeletion syndrome.

PubMed ID: 25439098

DOI: 10.1016/j.ajhg.2014.09.014

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25342064

Title: Whole exome sequencing in family trios reveals de novo mutations in PURA as a cause of severe neurodevelopmental delay and learning disability.

PubMed ID: 25342064

DOI: 10.1136/jmedgenet-2014-102798

Sequence Information:

  • Length: 322
  • Mass: 34911
  • Checksum: 797968504D01B356
  • Sequence:
    • MADRDSGSEQ GGAALGSGGS LGHPGSGSGS GGGGGGGGGG GGSGGGGGGA PGGLQHETQE 
LASKRVDIQN KRFYLDVKQN AKGRFLKIAE VGAGGNKSRL TLSMSVAVEF RDYLGDFIEH 
YAQLGPSQPP DLAQAQDEPR RALKSEFLVR ENRKYYMDLK ENQRGRFLRI RQTVNRGPGL 
GSTQGQTIAL PAQGLIEFRD ALAKLIDDYG VEEEPAELPE GTSLTVDNKR FFFDVGSNKY 
GVFMRVSEVK PTYRNSITVP YKVWAKFGHT FCKYSEEMKK IQEKQREKRA ACEQLHQQQQ 
QQQEETAAAT LLLQGEEEGE ED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.