Details for: PURB

Gene ID: 5814

Symbol: PURB

Ensembl ID: ENSG00000146676

Description: purine rich element binding protein B

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Mrna binding
    (GO:0003729)
  • Mrna regulatory element binding translation repressor activity
    (GO:0000900)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of translation
    (GO:0017148)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Purine-rich negative regulatory element binding
    (GO:0032422)
  • Regulation of myeloid cell differentiation
    (GO:0045637)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna binding
    (GO:0003723)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Single-stranded dna binding
    (GO:0003697)
  • Smad binding
    (GO:0046332)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 218.0716
    Cell Significance Index: -33.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 131.7795
    Cell Significance Index: -33.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 77.4375
    Cell Significance Index: -36.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 73.4510
    Cell Significance Index: -29.8400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.7702
    Cell Significance Index: -34.8600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 54.6033
    Cell Significance Index: -36.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.3540
    Cell Significance Index: -29.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.9710
    Cell Significance Index: -35.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.4722
    Cell Significance Index: -36.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.1370
    Cell Significance Index: -36.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.5823
    Cell Significance Index: -26.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1631
    Cell Significance Index: -11.3000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.0161
    Cell Significance Index: 15.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8925
    Cell Significance Index: 25.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3979
    Cell Significance Index: 38.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3229
    Cell Significance Index: 79.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2191
    Cell Significance Index: 132.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1700
    Cell Significance Index: 73.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9491
    Cell Significance Index: 116.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8981
    Cell Significance Index: 24.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8766
    Cell Significance Index: 175.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7047
    Cell Significance Index: 45.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6821
    Cell Significance Index: 110.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6544
    Cell Significance Index: 18.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6306
    Cell Significance Index: 32.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6133
    Cell Significance Index: 271.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6001
    Cell Significance Index: 13.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5966
    Cell Significance Index: 107.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5570
    Cell Significance Index: 110.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5555
    Cell Significance Index: 25.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5469
    Cell Significance Index: 75.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4932
    Cell Significance Index: 269.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4775
    Cell Significance Index: 33.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.4268
    Cell Significance Index: 266.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3750
    Cell Significance Index: 134.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3425
    Cell Significance Index: 16.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3154
    Cell Significance Index: 21.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2777
    Cell Significance Index: 12.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2233
    Cell Significance Index: 22.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1542
    Cell Significance Index: 9.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1540
    Cell Significance Index: 5.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1488
    Cell Significance Index: 19.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1467
    Cell Significance Index: 4.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1456
    Cell Significance Index: 16.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1373
    Cell Significance Index: 9.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1243
    Cell Significance Index: 2.1300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1132
    Cell Significance Index: 1.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1002
    Cell Significance Index: 19.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0984
    Cell Significance Index: 2.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0920
    Cell Significance Index: 83.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0837
    Cell Significance Index: 57.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0697
    Cell Significance Index: 1.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0560
    Cell Significance Index: 3.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0525
    Cell Significance Index: 8.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0467
    Cell Significance Index: 3.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0232
    Cell Significance Index: 0.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0196
    Cell Significance Index: 2.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0088
    Cell Significance Index: 6.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0058
    Cell Significance Index: 10.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0034
    Cell Significance Index: 0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0030
    Cell Significance Index: -4.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0062
    Cell Significance Index: -0.0700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0075
    Cell Significance Index: -0.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0087
    Cell Significance Index: -5.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0115
    Cell Significance Index: -21.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0160
    Cell Significance Index: -11.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0201
    Cell Significance Index: -1.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0247
    Cell Significance Index: -0.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0264
    Cell Significance Index: -14.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0301
    Cell Significance Index: -22.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0362
    Cell Significance Index: -16.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0462
    Cell Significance Index: -6.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0549
    Cell Significance Index: -6.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0554
    Cell Significance Index: -15.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0817
    Cell Significance Index: -17.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0830
    Cell Significance Index: -8.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1011
    Cell Significance Index: -11.9200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1167
    Cell Significance Index: -2.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1202
    Cell Significance Index: -14.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1398
    Cell Significance Index: -7.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2622
    Cell Significance Index: -13.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3100
    Cell Significance Index: -13.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3101
    Cell Significance Index: -10.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3181
    Cell Significance Index: -33.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3442
    Cell Significance Index: -5.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3543
    Cell Significance Index: -28.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3578
    Cell Significance Index: -8.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3688
    Cell Significance Index: -13.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3848
    Cell Significance Index: -9.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3989
    Cell Significance Index: -10.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4261
    Cell Significance Index: -26.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4683
    Cell Significance Index: -10.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4920
    Cell Significance Index: -14.0400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5286
    Cell Significance Index: -9.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5352
    Cell Significance Index: -27.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5604
    Cell Significance Index: -17.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5668
    Cell Significance Index: -14.5700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6707
    Cell Significance Index: -27.4800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6952
    Cell Significance Index: -4.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation**: PURB acts as a transcriptional regulator by binding to specific DNA sequences, modulating the expression of target genes. 2. **RNA Polymerase II Specificity**: PURB exhibits specificity for RNA polymerase II, a key enzyme involved in transcriptional regulation. 3. **DNA Binding**: PURB binds to purine-rich negative regulatory elements, influencing the expression of genes involved in developmental processes. 4. **Cell Type Specificity**: PURB is highly expressed in various cell types, including skeletal muscle satellite stem cells, eye photoreceptor cells, and glandular epithelial cells. 5. **Regulation of Myeloid Cell Differentiation**: PURB plays a crucial role in regulating myeloid cell differentiation, a process essential for immune system development and function. **Pathways and Functions:** 1. **DNA Binding Transcription Factor Activity**: PURB binds to specific DNA sequences, modulating the expression of target genes. 2. **RNA Polymerase II- Specific Transcription Factor Activity**: PURB exhibits specificity for RNA polymerase II, influencing the expression of genes involved in transcriptional regulation. 3. **Negative Regulation of Transcription by RNA Polymerase II**: PURB acts as a negative regulator of transcription by RNA polymerase II, modulating the expression of genes involved in developmental processes. 4. **Positive Regulation of Transcription by RNA Polymerase II**: PURB also exhibits positive regulatory activity on transcription by RNA polymerase II, influencing the expression of genes involved in cell growth and differentiation. 5. **Regulation of Myeloid Cell Differentiation**: PURB plays a crucial role in regulating myeloid cell differentiation, a process essential for immune system development and function. **Clinical Significance:** Dysregulation of PURB has been implicated in various diseases, including cancer, where aberrant expression of PURB has been observed in several types of tumors. Furthermore, PURB has been shown to play a role in regulating the expression of genes involved in immune system development and function, highlighting its potential as a therapeutic target in immunological disorders. Additionally, PURB's role in regulating myeloid cell differentiation makes it an important consideration in the treatment of hematological malignancies. In conclusion, the PURB gene is a critical transcriptional regulator that plays a significant role in various cellular processes, including myeloid cell differentiation, regulation of transcription by RNA polymerase II, and negative regulation of transcription. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of PURB and its potential as a therapeutic target.

Genular Protein ID: 3494823871

Symbol: PURB_HUMAN

Name: Transcriptional regulator protein Pur-beta

UniProtKB Accession Codes:

Q96QR8 A4D2L7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1448097

Title: Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein.

PubMed ID: 1448097

DOI: 10.1128/mcb.12.12.5673-5682.1992

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11417483

Title: Deletions of PURA, at 5q31, and PURB, at 7p13, in myelodysplastic syndrome and progression to acute myelogenous leukemia.

PubMed ID: 11417483

DOI: 10.1038/sj.leu.2402108

PubMed ID: 12933792

Title: Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure.

PubMed ID: 12933792

DOI: 10.1074/jbc.m307696200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 312
  • Mass: 33241
  • Checksum: E39E84E8D2957A18
  • Sequence:
    • MADGDSGSER GGGGGPCGFQ PASRGGGEQE TQELASKRLD IQNKRFYLDV KQNAKGRFLK 
IAEVGAGGSK SRLTLSMAVA AEFRDSLGDF IEHYAQLGPS SPEQLAAGAE EGGGPRRALK 
SEFLVRENRK YYLDLKENQR GRFLRIRQTV NRGGGGFGAG PGPGGLQSGQ TIALPAQGLI 
EFRDALAKLI DDYGGEDDEL AGGPGGGAGG PGGGLYGELP EGTSITVDSK RFFFDVGCNK 
YGVFLRVSEV KPSYRNAITV PFKAWGKFGG AFCRYADEMK EIQERQRDKL YERRGGGSGG 
GEESEGEEVD ED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.