Details for: RAB3B

Gene ID: 5865

Symbol: RAB3B

Ensembl ID: ENSG00000169213

Description: RAB3B, member RAS oncogene family

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 67.3759
    Cell Significance Index: -10.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.5544
    Cell Significance Index: -10.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 22.0282
    Cell Significance Index: -10.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.5405
    Cell Significance Index: -10.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.8944
    Cell Significance Index: -8.8900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.9353
    Cell Significance Index: 48.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6281
    Cell Significance Index: 35.6500
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 1.3293
    Cell Significance Index: 0.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2456
    Cell Significance Index: 33.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0145
    Cell Significance Index: 916.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6789
    Cell Significance Index: 129.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6492
    Cell Significance Index: 64.2200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.6483
    Cell Significance Index: 4.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5967
    Cell Significance Index: 64.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5818
    Cell Significance Index: 94.6300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.5460
    Cell Significance Index: 5.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5001
    Cell Significance Index: 25.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4381
    Cell Significance Index: 26.3000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.4307
    Cell Significance Index: 5.5900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4116
    Cell Significance Index: 5.1100
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.3446
    Cell Significance Index: 2.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3440
    Cell Significance Index: 23.7900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2818
    Cell Significance Index: 194.9000
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.2584
    Cell Significance Index: 2.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2463
    Cell Significance Index: 15.1400
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.1994
    Cell Significance Index: 2.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1882
    Cell Significance Index: 5.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1648
    Cell Significance Index: 59.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1455
    Cell Significance Index: 16.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1292
    Cell Significance Index: 25.9100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0792
    Cell Significance Index: 1.9000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0764
    Cell Significance Index: 0.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0670
    Cell Significance Index: 13.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0663
    Cell Significance Index: 3.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0606
    Cell Significance Index: 2.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0603
    Cell Significance Index: 4.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0382
    Cell Significance Index: 1.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0347
    Cell Significance Index: 4.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0317
    Cell Significance Index: 1.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0283
    Cell Significance Index: 4.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0266
    Cell Significance Index: 0.7000
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.0264
    Cell Significance Index: 0.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0256
    Cell Significance Index: 13.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0090
    Cell Significance Index: 6.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0060
    Cell Significance Index: 0.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0051
    Cell Significance Index: 0.2700
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.0050
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0031
    Cell Significance Index: 0.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0024
    Cell Significance Index: 1.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0007
    Cell Significance Index: -0.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0033
    Cell Significance Index: -6.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0039
    Cell Significance Index: -7.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0049
    Cell Significance Index: -7.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0071
    Cell Significance Index: -9.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0088
    Cell Significance Index: -0.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0089
    Cell Significance Index: -1.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0105
    Cell Significance Index: -1.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0108
    Cell Significance Index: -0.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0132
    Cell Significance Index: -8.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0135
    Cell Significance Index: -9.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0140
    Cell Significance Index: -10.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0182
    Cell Significance Index: -2.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0185
    Cell Significance Index: -0.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0202
    Cell Significance Index: -9.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0225
    Cell Significance Index: -1.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0240
    Cell Significance Index: -3.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0265
    Cell Significance Index: -0.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0269
    Cell Significance Index: -0.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0270
    Cell Significance Index: -7.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0273
    Cell Significance Index: -1.7200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0293
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0337
    Cell Significance Index: -3.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0470
    Cell Significance Index: -5.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0520
    Cell Significance Index: -5.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0547
    Cell Significance Index: -1.5300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0738
    Cell Significance Index: -0.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0741
    Cell Significance Index: -9.5700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0792
    Cell Significance Index: -1.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0882
    Cell Significance Index: -10.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0941
    Cell Significance Index: -3.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0949
    Cell Significance Index: -7.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1031
    Cell Significance Index: -10.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1114
    Cell Significance Index: -7.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1147
    Cell Significance Index: -1.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1225
    Cell Significance Index: -3.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1233
    Cell Significance Index: -5.7500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1234
    Cell Significance Index: -2.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1249
    Cell Significance Index: -3.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1265
    Cell Significance Index: -9.7100
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: -0.1448
    Cell Significance Index: -1.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1509
    Cell Significance Index: -4.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1513
    Cell Significance Index: -9.7600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1534
    Cell Significance Index: -2.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1749
    Cell Significance Index: -9.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1769
    Cell Significance Index: -7.6900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1820
    Cell Significance Index: -4.5400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1843
    Cell Significance Index: -1.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1877
    Cell Significance Index: -8.8200
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1948
    Cell Significance Index: -1.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RAB3B is a small GTPase that belongs to the RAS oncogene family, which consists of several members that regulate various cellular processes. RAB3B is specifically expressed in endocrine cells, neurons, and other specialized cells, where it plays a crucial role in regulating vesicle trafficking and exocytosis. Its expression is also detected in the brain, where it is involved in the regulation of synaptic transmission and dopamine uptake. **Pathways and Functions:** RAB3B is involved in several key pathways, including: 1. **Antigen Processing and Presentation:** RAB3B regulates the processing and presentation of antigens by endocrine cells, which is essential for the immune system's ability to recognize and respond to pathogens. 2. **Exocytosis:** RAB3B is involved in the regulation of exocytosis, the process by which cells release vesicles containing molecules such as neurotransmitters, hormones, and proteins. 3. **Protein Secretion:** RAB3B regulates the secretion of proteins by endocrine cells and neurons, which is essential for various physiological processes, including hormone regulation and neurotransmission. 4. **Golgi Apparatus and Endosome:** RAB3B is involved in the regulation of vesicle trafficking between the Golgi apparatus and endosomes, which is essential for the proper functioning of endocrine cells and neurons. **Clinical Significance:** RAB3B has significant implications in various immunological contexts, including: 1. **Autoimmune Diseases:** Dysregulation of RAB3B has been implicated in autoimmune diseases, such as multiple sclerosis, where it contributes to the dysregulation of antigen processing and presentation. 2. **Neurodegenerative Diseases:** RAB3B has been implicated in neurodegenerative diseases, such as Parkinson's disease, where it contributes to the regulation of dopamine uptake and synaptic transmission. 3. **Cancer:** RAB3B has been implicated in cancer, where it contributes to the regulation of protein secretion and exocytosis, leading to the development of cancer cells. 4. **Immunodeficiency Disorders:** RAB3B has been implicated in immunodeficiency disorders, such as chronic granulomatous disease, where it contributes to the regulation of antigen processing and presentation. In conclusion, RAB3B is a critical regulator of cellular processes, including antigen processing and presentation, exocytosis, and protein secretion. Its dysregulation has significant implications in various immunological contexts, including autoimmune diseases, neurodegenerative diseases, cancer, and immunodeficiency disorders. Further research is necessary to fully understand the role of RAB3B in these contexts and to develop targeted therapies to modulate its activity.

Genular Protein ID: 2367377144

Symbol: RAB3B_HUMAN

Name: Ras-related protein Rab-3B

UniProtKB Accession Codes:

P20337 Q5VUL2 Q9BSI1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2501306

Title: The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.

PubMed ID: 2501306

DOI: 10.1016/s0021-9258(18)63872-4

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 29125462

Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

PubMed ID: 29125462

DOI: 10.7554/elife.31012

Sequence Information:

  • Length: 219
  • Mass: 24758
  • Checksum: B73A014B4295A60D
  • Sequence:
    • MASVTDGKTG VKDASDQNFD YMFKLLIIGN SSVGKTSFLF RYADDTFTPA FVSTVGIDFK 
VKTVYRHEKR VKLQIWDTAG QERYRTITTA YYRGAMGFIL MYDITNEESF NAVQDWATQI 
KTYSWDNAQV ILVGNKCDME EERVVPTEKG QLLAEQLGFD FFEASAKENI SVRQAFERLV 
DAICDKMSDS LDTDPSMLGS SKNTRLSDTP PLLQQNCSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.