Details for: RAB4A

Gene ID: 5867

Symbol: RAB4A

Ensembl ID: ENSG00000168118

Description: RAB4A, member RAS oncogene family

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 271.2394
    Cell Significance Index: -42.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 151.4725
    Cell Significance Index: -38.4200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 96.3521
    Cell Significance Index: -45.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 94.7922
    Cell Significance Index: -38.5100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 86.1805
    Cell Significance Index: -44.3300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 67.6729
    Cell Significance Index: -45.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.0477
    Cell Significance Index: -39.1900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 37.2803
    Cell Significance Index: -45.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.0773
    Cell Significance Index: -40.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.9360
    Cell Significance Index: -47.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.6590
    Cell Significance Index: -35.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.2939
    Cell Significance Index: 200.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 4.0642
    Cell Significance Index: 55.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6713
    Cell Significance Index: 72.7100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.4243
    Cell Significance Index: 22.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3062
    Cell Significance Index: 283.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.9712
    Cell Significance Index: 139.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8840
    Cell Significance Index: 339.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6285
    Cell Significance Index: 323.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5401
    Cell Significance Index: 841.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3589
    Cell Significance Index: 70.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3126
    Cell Significance Index: 213.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3073
    Cell Significance Index: 59.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0953
    Cell Significance Index: 484.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0840
    Cell Significance Index: 74.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0241
    Cell Significance Index: 205.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9793
    Cell Significance Index: 134.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8858
    Cell Significance Index: 55.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8829
    Cell Significance Index: 18.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7894
    Cell Significance Index: 22.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7765
    Cell Significance Index: 100.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7715
    Cell Significance Index: 57.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7205
    Cell Significance Index: 33.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5995
    Cell Significance Index: 102.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5434
    Cell Significance Index: 35.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5387
    Cell Significance Index: 63.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4906
    Cell Significance Index: 25.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4794
    Cell Significance Index: 171.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4530
    Cell Significance Index: 5.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3956
    Cell Significance Index: 20.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3886
    Cell Significance Index: 73.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3571
    Cell Significance Index: 12.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3310
    Cell Significance Index: 32.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3206
    Cell Significance Index: 41.1000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3163
    Cell Significance Index: 4.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2630
    Cell Significance Index: 20.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1671
    Cell Significance Index: 10.2700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1435
    Cell Significance Index: 1.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1336
    Cell Significance Index: 4.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0308
    Cell Significance Index: 0.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0182
    Cell Significance Index: 33.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0075
    Cell Significance Index: 0.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0055
    Cell Significance Index: 2.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0055
    Cell Significance Index: 10.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0023
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0036
    Cell Significance Index: -2.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0083
    Cell Significance Index: -6.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0103
    Cell Significance Index: -6.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0143
    Cell Significance Index: -22.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0162
    Cell Significance Index: -12.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0251
    Cell Significance Index: -15.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0259
    Cell Significance Index: -35.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0317
    Cell Significance Index: -0.3600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0353
    Cell Significance Index: -0.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0406
    Cell Significance Index: -4.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0521
    Cell Significance Index: -29.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0612
    Cell Significance Index: -1.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0868
    Cell Significance Index: -9.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0981
    Cell Significance Index: -20.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1172
    Cell Significance Index: -3.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1342
    Cell Significance Index: -38.6100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1726
    Cell Significance Index: -3.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2045
    Cell Significance Index: -29.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2122
    Cell Significance Index: -24.7300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2220
    Cell Significance Index: -3.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2662
    Cell Significance Index: -7.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2728
    Cell Significance Index: -5.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2803
    Cell Significance Index: -15.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3006
    Cell Significance Index: -8.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3529
    Cell Significance Index: -23.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3580
    Cell Significance Index: -10.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3723
    Cell Significance Index: -9.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3978
    Cell Significance Index: -45.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3996
    Cell Significance Index: -9.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4039
    Cell Significance Index: -42.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4218
    Cell Significance Index: -33.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4610
    Cell Significance Index: -10.6500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4665
    Cell Significance Index: -3.7200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4687
    Cell Significance Index: -7.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6003
    Cell Significance Index: -13.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6408
    Cell Significance Index: -39.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6485
    Cell Significance Index: -19.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6551
    Cell Significance Index: -16.8400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6612
    Cell Significance Index: -6.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6647
    Cell Significance Index: -29.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6656
    Cell Significance Index: -17.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7063
    Cell Significance Index: -16.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7532
    Cell Significance Index: -28.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7574
    Cell Significance Index: -38.2800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7911
    Cell Significance Index: -16.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RAB4A is a small GTPase that belongs to the RAS superfamily, which is known for its regulatory functions in various cellular processes. Key characteristics of RAB4A include: 1. **GTPase activity**: RAB4A exhibits GTPase activity, which is essential for its regulatory function in membrane trafficking pathways. 2. **Geranylgeranylation**: RAB4A undergoes geranylgeranylation, a post-translational modification that is required for its activation and function in membrane trafficking. 3. **Binding to GDP and GTP**: RAB4A binds to both GDP and GTP, which are essential for its activation and deactivation states. 4. **Regulation of endocytosis and exocytosis**: RAB4A regulates endocytosis and exocytosis by interacting with various proteins involved in these processes. **Pathways and Functions** RAB4A is involved in various membrane trafficking pathways, including: 1. **Antigen processing and presentation**: RAB4A regulates the processing and presentation of antigens in the endoplasmic reticulum and Golgi apparatus. 2. **Cytoplasmic vesicle membrane**: RAB4A regulates the formation and trafficking of cytoplasmic vesicles. 3. **Early endosome membrane**: RAB4A regulates the formation and trafficking of early endosomes. 4. **Extracellular exosome**: RAB4A regulates the formation and trafficking of exosomes. 5. **Membrane trafficking**: RAB4A regulates the transport of proteins and lipids within cells. RAB4A's functions include: 1. **Regulation of endocytosis**: RAB4A regulates the internalization of receptors and other molecules. 2. **Regulation of exocytosis**: RAB4A regulates the release of molecules from the cell. 3. **Regulation of protein transport**: RAB4A regulates the transport of proteins within cells. 4. **Regulation of lipid metabolism**: RAB4A regulates the transport of lipids within cells. **Clinical Significance** RAB4A's dysregulation has been implicated in various diseases, including: 1. **Neurodegenerative diseases**: RAB4A's dysregulation has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: RAB4A's dysregulation has been implicated in cancer, including breast cancer and lung cancer. 3. **Metabolic disorders**: RAB4A's dysregulation has been implicated in metabolic disorders, such as diabetes and obesity. In conclusion, RAB4A is a critical regulator of membrane trafficking pathways, and its dysregulation has significant implications for various diseases. Further research is needed to fully understand the mechanisms by which RAB4A regulates membrane trafficking and its role in disease.

Genular Protein ID: 1962549898

Symbol: RAB4A_HUMAN

Name: Ras-related protein Rab-4A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2501306

Title: The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.

PubMed ID: 2501306

DOI: 10.1016/s0021-9258(18)63872-4

PubMed ID: 16935861

Title: Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection.

PubMed ID: 16935861

DOI: 10.1074/jbc.m606301200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1902553

Title: Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2.

PubMed ID: 1902553

DOI: 10.1038/350715a0

PubMed ID: 1425574

Title: Reversible phosphorylation-dephosphorylation determines the localization of rab4 during the cell cycle.

PubMed ID: 1425574

DOI: 10.1002/j.1460-2075.1992.tb05538.x

PubMed ID: 10698684

Title: Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles.

PubMed ID: 10698684

DOI: 10.1042/bj3460593

PubMed ID: 11786538

Title: Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein.

PubMed ID: 11786538

DOI: 10.1074/jbc.m108665200

PubMed ID: 11788822

Title: Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes.

PubMed ID: 11788822

DOI: 10.1038/ncb744

PubMed ID: 15280022

Title: Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis.

PubMed ID: 15280022

DOI: 10.1016/j.febslet.2004.06.068

PubMed ID: 14617813

Title: Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes.

PubMed ID: 14617813

DOI: 10.1091/mbc.e03-05-0343

PubMed ID: 17786215

Title: The N-Myc down regulated Gene1 (NDRG1) is a Rab4a effector involved in vesicular recycling of E-cadherin.

PubMed ID: 17786215

DOI: 10.1371/journal.pone.0000844

PubMed ID: 20098723

Title: Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes.

PubMed ID: 20098723

DOI: 10.1371/journal.pbio.1000283

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29425100

Title: The Rab-effector protein RABEP2 regulates endosomal trafficking to mediate vascular endothelial growth factor receptor-2 (VEGFR2)-dependent signaling.

PubMed ID: 29425100

DOI: 10.1074/jbc.m117.812172

PubMed ID: 15907487

Title: High resolution crystal structures of human Rab4a in its active and inactive conformations.

PubMed ID: 15907487

DOI: 10.1016/j.febslet.2005.04.020

PubMed ID: 16034420

Title: Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.

PubMed ID: 16034420

DOI: 10.1038/nature03798

Sequence Information:

  • Length: 218
  • Mass: 24390
  • Checksum: 983D65E1162741B0
  • Sequence:
  • MSQTAMSETY DFLFKFLVIG NAGTGKSCLL HQFIEKKFKD DSNHTIGVEF GSKIINVGGK 
    YVKLQIWDTA GQERFRSVTR SYYRGAAGAL LVYDITSRET YNALTNWLTD ARMLASQNIV 
    IILCGNKKDL DADREVTFLE ASRFAQENEL MFLETSALTG ENVEEAFVQC ARKILNKIES 
    GELDPERMGS GIQYGDAALR QLRSPRRAQA PNAQECGC

Genular Protein ID: 130736416

Symbol: A0A087WYT5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 113
  • Mass: 12505
  • Checksum: 53C0262D48CC378F
  • Sequence:
  • MISPDARMLA SQNIVIILCG NKKDLDADRE VTFLEASRFA QENELMFLET SALTGENVEE 
    AFVQCARKIL NKIESGELDP ERMGSGIQYG DAALRQLRSP RRAQAPNAQE CGC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.