Details for: RAB4A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 271.2394
Cell Significance Index: -42.1900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 151.4725
Cell Significance Index: -38.4200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 96.3521
Cell Significance Index: -45.4900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 94.7922
Cell Significance Index: -38.5100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 86.1805
Cell Significance Index: -44.3300 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 67.6729
Cell Significance Index: -45.4100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 41.0477
Cell Significance Index: -39.1900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 37.2803
Cell Significance Index: -45.9700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 15.0773
Cell Significance Index: -40.3900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.9360
Cell Significance Index: -47.1000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 11.6590
Cell Significance Index: -35.8100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.2939
Cell Significance Index: 200.2000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 4.0642
Cell Significance Index: 55.4500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.6713
Cell Significance Index: 72.7100 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.4243
Cell Significance Index: 22.3300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.3062
Cell Significance Index: 283.5700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.9712
Cell Significance Index: 139.4100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.8840
Cell Significance Index: 339.6200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.6285
Cell Significance Index: 323.1800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.5401
Cell Significance Index: 841.1100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.3589
Cell Significance Index: 70.5900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.3126
Cell Significance Index: 213.4800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.3073
Cell Significance Index: 59.2600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.0953
Cell Significance Index: 484.2500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.0840
Cell Significance Index: 74.9700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0241
Cell Significance Index: 205.4300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.9793
Cell Significance Index: 134.4900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.8858
Cell Significance Index: 55.8300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.8829
Cell Significance Index: 18.4800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7894
Cell Significance Index: 22.7500 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.7765
Cell Significance Index: 100.3200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.7715
Cell Significance Index: 57.5000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.7205
Cell Significance Index: 33.8700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5995
Cell Significance Index: 102.3700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.5434
Cell Significance Index: 35.0600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.5387
Cell Significance Index: 63.5300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.4906
Cell Significance Index: 25.7600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4794
Cell Significance Index: 171.9500 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.4530
Cell Significance Index: 5.4000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.3956
Cell Significance Index: 20.6100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3886
Cell Significance Index: 73.9500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.3571
Cell Significance Index: 12.4100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3310
Cell Significance Index: 32.7400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.3206
Cell Significance Index: 41.1000 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.3163
Cell Significance Index: 4.7400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2630
Cell Significance Index: 20.1900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1671
Cell Significance Index: 10.2700 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.1435
Cell Significance Index: 1.5600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1336
Cell Significance Index: 4.7000 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0308
Cell Significance Index: 0.8100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0182
Cell Significance Index: 33.5200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0075
Cell Significance Index: 0.2000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0055
Cell Significance Index: 2.5100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0055
Cell Significance Index: 10.2900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0023
Cell Significance Index: 0.0400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0036
Cell Significance Index: -2.6800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0083
Cell Significance Index: -6.1000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0103
Cell Significance Index: -6.4100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0143
Cell Significance Index: -22.0300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0162
Cell Significance Index: -12.2600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0251
Cell Significance Index: -15.9100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0259
Cell Significance Index: -35.2700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0317
Cell Significance Index: -0.3600 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0353
Cell Significance Index: -0.5900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0406
Cell Significance Index: -4.1500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0521
Cell Significance Index: -29.3900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0612
Cell Significance Index: -1.9600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0868
Cell Significance Index: -9.9500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0981
Cell Significance Index: -20.6600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1172
Cell Significance Index: -3.3600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1342
Cell Significance Index: -38.6100 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.1726
Cell Significance Index: -3.6000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2045
Cell Significance Index: -29.7200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2122
Cell Significance Index: -24.7300 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.2220
Cell Significance Index: -3.1600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2662
Cell Significance Index: -7.1200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2728
Cell Significance Index: -5.8100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2803
Cell Significance Index: -15.7300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3006
Cell Significance Index: -8.4000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3529
Cell Significance Index: -23.7300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3580
Cell Significance Index: -10.5200 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3723
Cell Significance Index: -9.5100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3978
Cell Significance Index: -45.4100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.3996
Cell Significance Index: -9.9900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4039
Cell Significance Index: -42.0600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4218
Cell Significance Index: -33.4100 - Cell Name: peg cell (CL4033014)
Fold Change: -0.4610
Cell Significance Index: -10.6500 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.4665
Cell Significance Index: -3.7200 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.4687
Cell Significance Index: -7.9000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.6003
Cell Significance Index: -13.0100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6408
Cell Significance Index: -39.2900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.6485
Cell Significance Index: -19.1000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6551
Cell Significance Index: -16.8400 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.6612
Cell Significance Index: -6.8500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6647
Cell Significance Index: -29.4000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.6656
Cell Significance Index: -17.8400 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.7063
Cell Significance Index: -16.9400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.7532
Cell Significance Index: -28.5200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.7574
Cell Significance Index: -38.2800 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.7911
Cell Significance Index: -16.9100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1962549898
Symbol: RAB4A_HUMAN
Name: Ras-related protein Rab-4A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2501306
Title: The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.
PubMed ID: 2501306
PubMed ID: 16935861
Title: Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection.
PubMed ID: 16935861
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1902553
Title: Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2.
PubMed ID: 1902553
DOI: 10.1038/350715a0
PubMed ID: 1425574
Title: Reversible phosphorylation-dephosphorylation determines the localization of rab4 during the cell cycle.
PubMed ID: 1425574
PubMed ID: 10698684
Title: Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles.
PubMed ID: 10698684
DOI: 10.1042/bj3460593
PubMed ID: 11786538
Title: Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein.
PubMed ID: 11786538
PubMed ID: 11788822
Title: Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes.
PubMed ID: 11788822
DOI: 10.1038/ncb744
PubMed ID: 15280022
Title: Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis.
PubMed ID: 15280022
PubMed ID: 14617813
Title: Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes.
PubMed ID: 14617813
PubMed ID: 17786215
Title: The N-Myc down regulated Gene1 (NDRG1) is a Rab4a effector involved in vesicular recycling of E-cadherin.
PubMed ID: 17786215
PubMed ID: 20098723
Title: Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes.
PubMed ID: 20098723
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 29425100
Title: The Rab-effector protein RABEP2 regulates endosomal trafficking to mediate vascular endothelial growth factor receptor-2 (VEGFR2)-dependent signaling.
PubMed ID: 29425100
PubMed ID: 15907487
Title: High resolution crystal structures of human Rab4a in its active and inactive conformations.
PubMed ID: 15907487
PubMed ID: 16034420
Title: Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
PubMed ID: 16034420
DOI: 10.1038/nature03798
Sequence Information:
- Length: 218
- Mass: 24390
- Checksum: 983D65E1162741B0
- Sequence:
MSQTAMSETY DFLFKFLVIG NAGTGKSCLL HQFIEKKFKD DSNHTIGVEF GSKIINVGGK YVKLQIWDTA GQERFRSVTR SYYRGAAGAL LVYDITSRET YNALTNWLTD ARMLASQNIV IILCGNKKDL DADREVTFLE ASRFAQENEL MFLETSALTG ENVEEAFVQC ARKILNKIES GELDPERMGS GIQYGDAALR QLRSPRRAQA PNAQECGC
Genular Protein ID: 130736416
Symbol: A0A087WYT5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
Sequence Information:
- Length: 113
- Mass: 12505
- Checksum: 53C0262D48CC378F
- Sequence:
MISPDARMLA SQNIVIILCG NKKDLDADRE VTFLEASRFA QENELMFLET SALTGENVEE AFVQCARKIL NKIESGELDP ERMGSGIQYG DAALRQLRSP RRAQAPNAQE CGC
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.