Details for: RAB6A

Gene ID: 5870

Symbol: RAB6A

Ensembl ID: ENSG00000175582

Description: RAB6A, member RAS oncogene family

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 460.0591
    Cell Significance Index: -71.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 287.1354
    Cell Significance Index: -72.8300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 164.2370
    Cell Significance Index: -77.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 162.8771
    Cell Significance Index: -66.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 145.5913
    Cell Significance Index: -74.8900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 115.5849
    Cell Significance Index: -77.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 69.8198
    Cell Significance Index: -66.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 60.2211
    Cell Significance Index: -74.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.0797
    Cell Significance Index: -67.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.4952
    Cell Significance Index: -62.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.3535
    Cell Significance Index: -76.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.8843
    Cell Significance Index: -41.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.9901
    Cell Significance Index: 106.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5913
    Cell Significance Index: 519.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.9967
    Cell Significance Index: 716.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8079
    Cell Significance Index: 358.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.3538
    Cell Significance Index: 59.8800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3428
    Cell Significance Index: 928.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2987
    Cell Significance Index: 49.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.2236
    Cell Significance Index: 75.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1794
    Cell Significance Index: 79.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1694
    Cell Significance Index: 32.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1323
    Cell Significance Index: 123.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0544
    Cell Significance Index: 63.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9541
    Cell Significance Index: 117.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9538
    Cell Significance Index: 171.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8741
    Cell Significance Index: 25.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7627
    Cell Significance Index: 42.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7206
    Cell Significance Index: 650.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6781
    Cell Significance Index: 35.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6615
    Cell Significance Index: 50.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6239
    Cell Significance Index: 32.5000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6227
    Cell Significance Index: 17.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6224
    Cell Significance Index: 28.2100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6004
    Cell Significance Index: 14.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5988
    Cell Significance Index: 82.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4914
    Cell Significance Index: 268.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4239
    Cell Significance Index: 187.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3601
    Cell Significance Index: 678.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3378
    Cell Significance Index: 64.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3060
    Cell Significance Index: 416.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3014
    Cell Significance Index: 6.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2801
    Cell Significance Index: 7.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2714
    Cell Significance Index: 26.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2682
    Cell Significance Index: 412.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2554
    Cell Significance Index: 6.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2376
    Cell Significance Index: 30.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1809
    Cell Significance Index: 114.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1703
    Cell Significance Index: 314.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1336
    Cell Significance Index: 2.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1329
    Cell Significance Index: 60.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1018
    Cell Significance Index: 5.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0999
    Cell Significance Index: 1.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0749
    Cell Significance Index: 12.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0530
    Cell Significance Index: 8.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0332
    Cell Significance Index: 1.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0125
    Cell Significance Index: 0.9300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0018
    Cell Significance Index: 0.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0223
    Cell Significance Index: -0.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0230
    Cell Significance Index: -2.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0318
    Cell Significance Index: -23.5500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0402
    Cell Significance Index: -0.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0443
    Cell Significance Index: -33.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0459
    Cell Significance Index: -5.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0560
    Cell Significance Index: -41.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0602
    Cell Significance Index: -6.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0628
    Cell Significance Index: -2.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0863
    Cell Significance Index: -53.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0985
    Cell Significance Index: -55.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1164
    Cell Significance Index: -11.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1326
    Cell Significance Index: -9.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2321
    Cell Significance Index: -48.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2330
    Cell Significance Index: -3.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2341
    Cell Significance Index: -15.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2354
    Cell Significance Index: -67.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2516
    Cell Significance Index: -36.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2941
    Cell Significance Index: -6.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3575
    Cell Significance Index: -9.7300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3595
    Cell Significance Index: -5.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3988
    Cell Significance Index: -46.4800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4419
    Cell Significance Index: -2.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4649
    Cell Significance Index: -11.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4657
    Cell Significance Index: -29.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4693
    Cell Significance Index: -48.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5711
    Cell Significance Index: -19.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5739
    Cell Significance Index: -65.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6176
    Cell Significance Index: -16.5500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6426
    Cell Significance Index: -5.2400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.7611
    Cell Significance Index: -10.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7935
    Cell Significance Index: -23.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8451
    Cell Significance Index: -66.9300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.9346
    Cell Significance Index: -13.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0534
    Cell Significance Index: -33.7400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -1.1193
    Cell Significance Index: -11.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.1485
    Cell Significance Index: -15.6700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1551
    Cell Significance Index: -13.7700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.2246
    Cell Significance Index: -15.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2486
    Cell Significance Index: -76.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.2589
    Cell Significance Index: -26.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3128
    Cell Significance Index: -41.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **RAB6A's Role in Membrane Trafficking**: RAB6A is a small GTPase that regulates membrane trafficking, including endocytosis, exocytosis, and retrograde transport. It interacts with various proteins, such as RAB GTPase-activating proteins (RABGAPs), to control the activity of its effector proteins. 2. **Protein Localization and Binding**: RAB6A regulates the localization of proteins to specific compartments within the cell, including the Golgi apparatus, endosomes, and plasma membrane. It also interacts with proteins involved in protein modification, such as peptidyl-cysteine methylation. 3. **Signaling Pathways**: RAB6A is involved in various signaling pathways, including the Notch signaling pathway, which regulates cell fate decisions and differentiation. It also interacts with proteins involved in immune responses, such as neutrophil degranulation. **Pathways and Functions** RAB6A's involvement in multiple cellular pathways highlights its importance in maintaining cellular homeostasis and function. Some of the key pathways and functions associated with RAB6A include: 1. **Acrosomal Membrane Formation**: RAB6A regulates the formation of the acrosomal membrane in sperm cells, which is essential for fertilization. 2. **Antigen Processing and Presentation**: RAB6A is involved in the processing and presentation of antigens to the immune system, which is critical for immune responses. 3. **Golgi-to-ER Retrograde Transport**: RAB6A regulates the retrograde transport of proteins from the Golgi apparatus to the endoplasmic reticulum, which is essential for protein modification and secretion. 4. **Immune System Function**: RAB6A is involved in the regulation of immune responses, including neutrophil degranulation and the presentation of antigens to T-cells. 5. **Neuron Projection Development**: RAB6A regulates the development of neuron projections, which is essential for neural function and behavior. **Clinical Significance** RAB6A's involvement in various cellular pathways and its role in immune responses make it an important gene for understanding human disease. Some potential clinical applications of RAB6A research include: 1. **Cancer Research**: RAB6A's involvement in cell signaling pathways makes it a potential target for cancer therapy. 2. **Neurological Disorders**: RAB6A's role in neuron projection development and immune responses makes it an important gene for understanding neurological disorders, such as Alzheimer's disease and multiple sclerosis. 3. **Immune System Disorders**: RAB6A's involvement in immune responses makes it an important gene for understanding immune system disorders, such as autoimmune diseases and immunodeficiency disorders. In conclusion, RAB6A is a critical gene involved in regulating various cellular processes, including membrane trafficking, protein localization, and signaling pathways. Its involvement in multiple cellular pathways highlights its importance in maintaining cellular homeostasis and function, and its potential clinical significance makes it an important gene for understanding human disease.

Genular Protein ID: 4139518744

Symbol: RAB6A_HUMAN

Name: Ras-related protein Rab-6A

UniProtKB Accession Codes:

P20340 A8K133 B7Z772 F5H668 Q1W5D8 Q5U0A8 Q9UBE4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 18 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 7 RefSeq 4 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2501306

Title: The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.

PubMed ID: 2501306

DOI: 10.1016/s0021-9258(18)63872-4

PubMed ID: 10996854

Title: Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells.

PubMed ID: 10996854

DOI: 10.1002/1097-4644(20001215)79:4<628::aid-jcb120>3.0.co;2-t

PubMed ID: 11054569

Title: Rab6c, a new member of the Rab gene family, is involved in drug resistance in MCF7/AdrR cells.

PubMed ID: 11054569

DOI: 10.1016/s0378-1119(00)00395-4

PubMed ID: 11071909

Title: Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms.

PubMed ID: 11071909

DOI: 10.1091/mbc.11.11.3819

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10202141

Title: Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome.

PubMed ID: 10202141

DOI: 10.1093/emboj/18.7.1772

PubMed ID: 12447383

Title: Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex.

PubMed ID: 12447383

DOI: 10.1038/ncb891

PubMed ID: 15878329

Title: Characterization of the human GARP (Golgi associated retrograde protein) complex.

PubMed ID: 15878329

DOI: 10.1016/j.yexcr.2005.01.022

PubMed ID: 17698061

Title: Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic.

PubMed ID: 17698061

DOI: 10.1016/j.yexcr.2007.07.010

PubMed ID: 18044744

Title: Rab6 family proteins interact with the dynein light chain protein DYNLRB1.

PubMed ID: 18044744

DOI: 10.1002/cm.20254

PubMed ID: 18997784

Title: Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golgin.

PubMed ID: 18997784

DOI: 10.1038/ng.252

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20643351

Title: Pitchfork regulates primary cilia disassembly and left-right asymmetry.

PubMed ID: 20643351

DOI: 10.1016/j.devcel.2010.06.005

PubMed ID: 20386726

Title: Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry.

PubMed ID: 20386726

DOI: 10.1371/journal.pbio.1000350

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21411515

Title: A role for the small GTPase Rab6 in assembly of human cytomegalovirus.

PubMed ID: 21411515

DOI: 10.1128/jvi.02605-10

PubMed ID: 21822290

Title: Modulation of Rab GTPase function by a protein phosphocholine transferase.

PubMed ID: 21822290

DOI: 10.1038/nature10335

PubMed ID: 23091056

Title: Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase.

PubMed ID: 23091056

DOI: 10.1074/jbc.m112.414565

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23664119

Title: Molecular defects in the motor adaptor BICD2 cause proximal spinal muscular atrophy with autosomal-dominant inheritance.

PubMed ID: 23664119

DOI: 10.1016/j.ajhg.2013.04.013

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23737971

Title: A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6.

PubMed ID: 23737971

DOI: 10.1371/journal.pone.0064149

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25492866

Title: Cohen syndrome-associated protein COH1 physically and functionally interacts with the small GTPase RAB6 at the Golgi complex and directs neurite outgrowth.

PubMed ID: 25492866

DOI: 10.1074/jbc.m114.608174

PubMed ID: 25962623

Title: Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport.

PubMed ID: 25962623

DOI: 10.1016/j.bbamcr.2015.05.005

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16332443

Title: Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution.

PubMed ID: 16332443

DOI: 10.1016/j.jsb.2005.10.001

PubMed ID: 16034420

Title: Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.

PubMed ID: 16034420

DOI: 10.1038/nature03798

PubMed ID: 18243103

Title: Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185.

PubMed ID: 18243103

DOI: 10.1016/j.cell.2007.11.048

PubMed ID: 19141279

Title: Structural basis for recruitment of Rab6-interacting protein 1 to Golgi via a RUN domain.

PubMed ID: 19141279

DOI: 10.1016/j.str.2008.10.014

Sequence Information:

  • Length: 208
  • Mass: 23593
  • Checksum: C9A3C2DDBF6C3E9E
  • Sequence:
    • MSTGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF LSKTMYLEDR 
TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNVNS FQQTTKWIDD VRTERGSDVI 
IMLVGNKTDL ADKRQVSIEE GERKAKELNV MFIETSAKAG YNVKQLFRRV AAALPGMEST 
QDRSREDMID IKLEKPQEQP VSEGGCSC

Genular Protein ID: 2017913064

Symbol: Q53ET8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53ET8

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 4 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 4 SMR 1 SUPFAM 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 208
  • Mass: 23563
  • Checksum: DF55AD4B67EFE764
  • Sequence:
    • MSTGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF LSKTMYLEDR 
TIRLQLWDTA GQERFRSLIP SYIRDSAAAV VVYDITNVNS FQQTTKWIDD VRTERGSDII 
IMLVGNKTDL ADKRQVSIEE GERKAKELNV MFIETSAKAG YNVKQLFRRV AAALPGMEST 
QDRSREDMID IKLEKPQEQP VSEGGCSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.