Details for: RALGDS
Gene ID: 5900
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: RALGDS
Ensembl ID: ENSG00000160271
Description: ral guanine nucleotide dissociation stimulator
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 12.13rCSI 25.81%PRS 60.99
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CSI 11.64rCSI 15.91%PRS 63.54
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CSI 9.52rCSI 21.07%PRS 59.83
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CSI 8.02rCSI 14.17%PRS 42.71
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CSI 7.32rCSI 10.35%PRS 67.07
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CSI 6.48rCSI 7.89%PRS 69.37
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CSI 5.06rCSI 4.02%PRS 82.91
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CSI 4.21rCSI 6.7%PRS 54.25
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CSI 4.09rCSI 3.11%PRS 74.91
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CSI 3.52rCSI 3.68%PRS 62.17
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CSI 3.44rCSI 19.23%PRS 68.53
-
CSI 3.31rCSI 1.95%PRS 79.2
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CSI 3.22rCSI 4.39%PRS 53.74
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CSI 3.22rCSI 4.91%PRS 71.24
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CSI 3.19rCSI 2.29%PRS 76.13
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CSI 3.15rCSI 13.4%PRS 55.59
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CSI 3.15rCSI 2.49%PRS 48.72
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CSI 3.09rCSI 3.89%PRS 73.72
-
CSI 3.02rCSI 8.67%PRS 81.53
-
CSI 2.96rCSI 8.77%PRS 71.9
-
CSI 2.84rCSI 2.15%PRS 75.65
-
CSI 2.8rCSI 2.55%PRS 76.43
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CSI 2.8rCSI 1.94%PRS 73.06
-
CSI 2.72rCSI 2.52%PRS 81.16
-
CSI 2.72rCSI 4.24%PRS 85.15
-
CSI 2.69rCSI 4.11%PRS 62.55
-
CSI 2.68rCSI 4.25%PRS 72.97
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CSI 2.67rCSI 5.33%PRS 79.04
-
CSI 2.65rCSI 2.55%PRS 52.51
-
CSI 2.63rCSI 3.86%PRS 55.45
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CSI 2.63rCSI 4.3%PRS 51.12
-
CSI 2.6rCSI 2.16%PRS 61.15
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CSI 2.56rCSI 2.65%PRS 67.56
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CSI 2.5rCSI 2.03%PRS 62.35
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CSI 2.45rCSI 2.57%PRS 58.3
-
CSI 2.44rCSI 1.64%PRS 75.01
-
CSI 2.37rCSI 1.99%PRS 66.21
-
CSI 2.33rCSI 4.4%PRS 80.05
-
CSI 2.3rCSI 1.78%PRS 63.79
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CSI 2.29rCSI 4.37%PRS 76.65
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CSI 2.24rCSI 8.71%PRS 81.8
-
CSI 2.23rCSI 2.59%PRS 69.39
-
CSI 2.21rCSI 4.59%PRS 59.08
-
CSI 2.2rCSI 3.81%PRS 52.06
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CSI 2.2rCSI 4%PRS 53.82
-
CSI 2.18rCSI 2.14%PRS 64.52
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CSI 2.17rCSI 5.65%PRS 61.7
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CSI 2.14rCSI 2.51%PRS 78.3
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CSI 2.14rCSI 8%PRS 53.96
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CSI 2.1rCSI 1.93%PRS 70.81
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CSI 2.06rCSI 4.71%PRS 61.8
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CSI 2.05rCSI 1.8%PRS 49.73
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CSI 2.02rCSI 2.59%PRS 59.06
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CSI 2rCSI 4.66%PRS 79.46
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CSI 1.97rCSI 3.96%PRS 50.94
-
CSI 1.94rCSI 1.46%PRS 76.98
-
CSI 1.92rCSI 46.45%PRS 43.55
-
CSI 1.9rCSI 2.92%PRS 57.78
-
CSI 1.9rCSI 45.54%PRS 42.67
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CSI 1.86rCSI 2.81%PRS 66.1
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CSI 1.75rCSI 3.99%PRS 53.69
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CSI 1.71rCSI 4.89%PRS 74.28
-
CSI 1.64rCSI 4.15%PRS 69.93
-
CSI 1.63rCSI 2.42%PRS 67.26
-
CSI 1.6rCSI 2.35%PRS 73.49
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CSI 1.6rCSI 4.23%PRS 73.33
-
CSI 1.59rCSI 2.18%PRS 55.46
-
CSI 1.59rCSI 1.9%PRS 43.39
-
CSI 1.59rCSI 1.98%PRS 41.73
-
CSI 1.57rCSI 2.64%PRS 43.64
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CSI 1.57rCSI 4.62%PRS 64.91
-
CSI 1.54rCSI 1.79%PRS 51.96
-
CSI 1.54rCSI 2.46%PRS 66.04
-
CSI 1.51rCSI 1.34%PRS 59.88
-
CSI 1.5rCSI 1.13%PRS 67.38
-
CSI 1.5rCSI 3.7%PRS 60.29
-
CSI 1.45rCSI 1.75%PRS 70.82
-
CSI 1.45rCSI 1.67%PRS 55.03
-
CSI 1.42rCSI 2.34%PRS 67.13
-
CSI 1.41rCSI 3.72%PRS 80.1
-
CSI 1.41rCSI 2.28%PRS 58.48
-
CSI 1.35rCSI 1.52%PRS 78.02
-
CSI 1.35rCSI 1.74%PRS 44.94
-
CSI 1.33rCSI 3.08%PRS 51.05
-
CSI 1.33rCSI 5.35%PRS 60.63
-
CSI 1.32rCSI 1.32%PRS 55.13
-
CSI 1.31rCSI 1.26%PRS 61.96
-
CSI 1.31rCSI 1.21%PRS 63.33
-
CSI 1.28rCSI 2.81%PRS 66.22
-
CSI 1.27rCSI 1.7%PRS 62.15
-
CSI 1.26rCSI 2.99%PRS 65.58
-
CSI 1.25rCSI 2.37%PRS 72.41
-
CSI 1.23rCSI 1.52%PRS 58.47
-
CSI 1.14rCSI 2.57%PRS 44.36
-
CSI 1.02rCSI 1.31%PRS 66.63
-
CSI 1.01rCSI 1.73%PRS 79.73
-
CSI 1.01rCSI 2.08%PRS 52.25
-
CSI 1rCSI 1.36%PRS 73.64
-
CSI 0.97rCSI 4.88%PRS 74.42
-
CSI 0.93rCSI 4.03%PRS 74.39
-
CSI 0.2rCSI 4.7%PRS 52.8%
-
CSI 0.3rCSI 4.6%PRS 76.4%
-
CSI 0.4rCSI 5.3%PRS 53.0%
-
CSI 0.5rCSI 3.2%PRS 74.7%
-
CSI 0.6rCSI 1.6%PRS 51.6%
-
CSI 0.6rCSI 2.2%PRS 44.4%
-
CSI 0.6rCSI 1.8%PRS 45.3%
-
CSI 0.6rCSI 3.2%PRS 74.1%
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CSI 0.6rCSI 1.9%PRS 47.8%
-
CSI 0.6rCSI 2.1%PRS 65.7%
-
CSI 0.7rCSI 1.5%PRS 48.1%
-
CSI 0.7rCSI 2.3%PRS 47.2%
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CSI 0.8rCSI 4.4%PRS 44.9%
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CSI 0.8rCSI 1.9%PRS 42.3%
-
CSI 0.8rCSI 1.8%PRS 73.0%
-
CSI 0.8rCSI 1.9%PRS 58.2%
-
CSI 0.8rCSI 3.0%PRS 42.1%
-
CSI 0.9rCSI 1.4%PRS 58.2%
-
CSI 0.9rCSI 1.5%PRS 45.7%
-
CSI 0.9rCSI 2.1%PRS 69.7%
-
CSI 0.9rCSI 4.0%PRS 74.4%
-
CSI 1.0rCSI 4.9%PRS 74.4%
-
CSI 1.0rCSI 1.4%PRS 73.6%
-
CSI 1.0rCSI 2.1%PRS 52.3%
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CSI 1.0rCSI 1.7%PRS 79.7%
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CSI 1.0rCSI 1.3%PRS 66.6%
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CSI 1.1rCSI 2.6%PRS 44.4%
-
CSI 1.2rCSI 1.5%PRS 58.5%
-
CSI 1.3rCSI 2.4%PRS 72.4%
-
CSI 1.3rCSI 3.0%PRS 65.6%
-
CSI 1.3rCSI 1.7%PRS 62.2%
-
CSI 1.3rCSI 2.8%PRS 66.2%
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CSI 1.3rCSI 1.2%PRS 63.3%
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CSI 1.3rCSI 1.3%PRS 62.0%
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CSI 1.3rCSI 1.3%PRS 55.1%
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CSI 1.3rCSI 5.4%PRS 60.6%
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CSI 1.3rCSI 3.1%PRS 51.1%
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CSI 1.4rCSI 1.7%PRS 44.9%
-
CSI 1.4rCSI 1.5%PRS 78.0%
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CSI 1.4rCSI 2.3%PRS 58.5%
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CSI 1.4rCSI 3.7%PRS 80.1%
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CSI 1.4rCSI 2.3%PRS 67.1%
-
CSI 1.5rCSI 1.7%PRS 55.0%
-
CSI 1.5rCSI 1.8%PRS 70.8%
-
CSI 1.5rCSI 3.7%PRS 60.3%
-
CSI 1.5rCSI 1.1%PRS 67.4%
-
CSI 1.5rCSI 1.3%PRS 59.9%
-
CSI 1.5rCSI 2.5%PRS 66.0%
-
CSI 1.5rCSI 1.8%PRS 52.0%
-
CSI 1.6rCSI 4.6%PRS 64.9%
-
CSI 1.6rCSI 2.6%PRS 43.6%
-
CSI 1.6rCSI 2.0%PRS 41.7%
-
CSI 1.6rCSI 1.9%PRS 43.4%
-
CSI 1.6rCSI 2.2%PRS 55.5%
-
CSI 1.6rCSI 4.2%PRS 73.3%
-
CSI 1.6rCSI 2.4%PRS 73.5%
-
CSI 1.6rCSI 2.4%PRS 67.3%
-
CSI 1.6rCSI 4.2%PRS 69.9%
-
CSI 1.7rCSI 4.9%PRS 74.3%
-
CSI 1.8rCSI 4.0%PRS 53.7%
-
CSI 1.9rCSI 2.8%PRS 66.1%
-
CSI 1.9rCSI 45.5%PRS 42.7%
-
CSI 1.9rCSI 2.9%PRS 57.8%
-
CSI 1.9rCSI 46.5%PRS 43.6%
-
CSI 1.9rCSI 1.5%PRS 77.0%
-
CSI 2.0rCSI 4.0%PRS 50.9%
-
CSI 2.0rCSI 4.7%PRS 79.5%
-
CSI 2.0rCSI 2.6%PRS 59.1%
-
CSI 2.1rCSI 1.8%PRS 49.7%
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CSI 2.1rCSI 4.7%PRS 61.8%
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CSI 2.1rCSI 1.9%PRS 70.8%
-
CSI 2.1rCSI 8.0%PRS 54.0%
-
CSI 2.1rCSI 2.5%PRS 78.3%
-
CSI 2.2rCSI 5.7%PRS 61.7%
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CSI 2.2rCSI 2.1%PRS 64.5%
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CSI 2.2rCSI 4.0%PRS 53.8%
-
CSI 2.2rCSI 3.8%PRS 52.1%
-
CSI 2.2rCSI 4.6%PRS 59.1%
-
CSI 2.2rCSI 2.6%PRS 69.4%
-
CSI 2.2rCSI 8.7%PRS 81.8%
-
CSI 2.3rCSI 4.4%PRS 76.7%
-
CSI 2.3rCSI 1.8%PRS 63.8%
-
CSI 2.3rCSI 4.4%PRS 80.1%
-
CSI 2.4rCSI 2.0%PRS 66.2%
-
CSI 2.4rCSI 1.6%PRS 75.0%
-
CSI 2.5rCSI 2.6%PRS 58.3%
-
CSI 2.5rCSI 2.0%PRS 62.4%
-
CSI 2.6rCSI 2.7%PRS 67.6%
-
CSI 2.6rCSI 2.2%PRS 61.2%
-
CSI 2.6rCSI 4.3%PRS 51.1%
-
CSI 2.6rCSI 3.9%PRS 55.5%
-
CSI 2.7rCSI 2.6%PRS 52.5%
-
CSI 2.7rCSI 5.3%PRS 79.0%
-
CSI 2.7rCSI 4.3%PRS 73.0%
-
CSI 2.7rCSI 4.1%PRS 62.6%
-
CSI 2.7rCSI 4.2%PRS 85.2%
-
CSI 2.7rCSI 2.5%PRS 81.2%
-
CSI 2.8rCSI 1.9%PRS 73.1%
-
CSI 2.8rCSI 2.6%PRS 76.4%
-
CSI 2.8rCSI 2.2%PRS 75.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3241726092
Symbol: GNDS_HUMAN
Name: Ral guanine nucleotide dissociation stimulator
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9365783
Title: Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1.
PubMed ID: 9365783
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10718198
Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10718198
PubMed ID: 7972015
Title: Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.
PubMed ID: 7972015
PubMed ID: 27438768
Title: Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion of Intracellular Bacteria by Exocyst Complex.
PubMed ID: 27438768
PubMed ID: 9302994
Title: Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling.
PubMed ID: 9302994
DOI: 10.1038/nsb0997-694
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 914
- Mass: 100607
- Checksum: EA5A5CF25AF3D523
- Sequence:
MVQRMWAEAA GPAGGAEPLF PGSRRSRSVW DAVRLEVGVP DSCPVVLHSF TQLDPDLPRP ESSTQEIGEE LINGVIYSIS LRKVQLHHGG NKGQRWLGYE NESALNLYET CKVRTVKAGT LEKLVEHLVP AFQGSDLSYV TIFLCTYRAF TTTQQVLDLL FKRYGRCDAL TASSRYGCIL PYSDEDGGPQ DQLKNAISSI LGTWLDQYSE DFCQPPDFPC LKQLVAYVQL NMPGSDLERR AHLLLAQLEH SEPIEAEPEA LSPVPALKPT PELELALTPA RAPSPVPAPA PEPEPAPTPA PGSELEVAPA PAPELQQAPE PAVGLESAPA PALELEPAPE QDPAPSQTLE LEPAPAPVPS LQPSWPSPVV AENGLSEEKP HLLVFPPDLV AEQFTLMDAE LFKKVVPYHC LGSIWSQRDK KGKEHLAPTI RATVTQFNSV ANCVITTCLG NRSTKAPDRA RVVEHWIEVA RECRILKNFS SLYAILSALQ SNSIHRLKKT WEDVSRDSFR IFQKLSEIFS DENNYSLSRE LLIKEGTSKF ATLEMNPKRA QKRPKETGII QGTVPYLGTF LTDLVMLDTA MKDYLYGRLI NFEKRRKEFE VIAQIKLLQS ACNNYSIAPD EQFGAWFRAV ERLSETESYN LSCELEPPSE SASNTLRTKK NTAIVKRWSD RQAPSTELST SGSSHSKSCD QLRCGPYLSS GDIADALSVH SAGSSSSDVE EINISFVPES PDGQEKKFWE SASQSSPETS GISSASSSTS SSSASTTPVA ATRTHKRSVS GLCNSSSALP LYNQQVGDCC IIRVSLDVDN GNMYKSILVT SQDKAPAVIR KAMDKHNLEE EEPEDYELLQ ILSDDRKLKI PENANVFYAM NSTANYDFVL KKRTFTKGVK VKHGASSTLP RMKQKGLKIA KGIF
Genular Protein ID: 4089828044
Symbol: Q8N4Y1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 411
- Mass: 45526
- Checksum: 114CF1F26F923B79
- Sequence:
VSRDSFRIFQ KLSEIFSDEN NYSLSRELLI KEGTSKFATL EMNPKRAQKR PKETGIIQGT VPYLGTFLTD LVMLDTAMKD YLYGRLINFE KRRKEFEVIA QIKLLQSACN NYSIAPDEQF GAWFRAVERL SETESYNLSC ELEPPSESAS NTLRTKKNTA IVKRWSDRQA PSTELSTSGS SHSKSCDQLR CGPYLSSGDI ADALSVHSAG SSSSDVEEIN ISFVPESPDG QEKKFWESAS QSSPETSGIS SASSSTSSSS ASTTPVAATR THKRSVSGLC NSSSALPLYN QQVGDCCIIR VSLDVDNGNM YKSILVTSQD KAPAVIRKAM DKHNLEEEEP EDYELLQILS DDRKLKIPEN ANVFYAMNST ANYDFVLKKR TFTKGVKVKH GASSTLPRMK QKGLKIAKGI F