Details for: RALGDS

Gene ID: 5900

Symbol: RALGDS

Ensembl ID: ENSG00000160271

Description: ral guanine nucleotide dissociation stimulator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 236.6514
    Cell Significance Index: -36.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 143.7451
    Cell Significance Index: -36.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 73.6233
    Cell Significance Index: -29.9100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 73.5773
    Cell Significance Index: -30.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.4744
    Cell Significance Index: -30.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.5850
    Cell Significance Index: -37.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.2291
    Cell Significance Index: -32.7600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.9753
    Cell Significance Index: -33.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6407
    Cell Significance Index: -38.0400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.2662
    Cell Significance Index: -20.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.4136
    Cell Significance Index: 694.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7196
    Cell Significance Index: 89.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4634
    Cell Significance Index: 293.5600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.1389
    Cell Significance Index: 20.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0635
    Cell Significance Index: 23.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0352
    Cell Significance Index: 934.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8155
    Cell Significance Index: 23.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7616
    Cell Significance Index: 39.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6992
    Cell Significance Index: 19.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6823
    Cell Significance Index: 244.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6534
    Cell Significance Index: 71.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6298
    Cell Significance Index: 38.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5905
    Cell Significance Index: 76.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5121
    Cell Significance Index: 38.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5051
    Cell Significance Index: 23.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4941
    Cell Significance Index: 80.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4879
    Cell Significance Index: 21.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4684
    Cell Significance Index: 12.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4675
    Cell Significance Index: 21.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3989
    Cell Significance Index: 15.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3964
    Cell Significance Index: 48.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3882
    Cell Significance Index: 211.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3680
    Cell Significance Index: 16.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3461
    Cell Significance Index: 153.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3334
    Cell Significance Index: 60.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2993
    Cell Significance Index: 20.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2778
    Cell Significance Index: 52.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1532
    Cell Significance Index: 15.1500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1353
    Cell Significance Index: 3.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1162
    Cell Significance Index: 14.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0833
    Cell Significance Index: 16.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0293
    Cell Significance Index: 2.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0291
    Cell Significance Index: 4.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0198
    Cell Significance Index: 1.1100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0155
    Cell Significance Index: 0.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0068
    Cell Significance Index: 9.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0026
    Cell Significance Index: -4.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0026
    Cell Significance Index: -4.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0032
    Cell Significance Index: -0.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0043
    Cell Significance Index: -6.6700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0134
    Cell Significance Index: -0.2300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0229
    Cell Significance Index: -0.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0355
    Cell Significance Index: -26.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0368
    Cell Significance Index: -23.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0387
    Cell Significance Index: -28.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0426
    Cell Significance Index: -31.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0569
    Cell Significance Index: -32.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0641
    Cell Significance Index: -40.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0668
    Cell Significance Index: -30.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0696
    Cell Significance Index: -4.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0802
    Cell Significance Index: -8.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0850
    Cell Significance Index: -1.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0953
    Cell Significance Index: -6.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0970
    Cell Significance Index: -3.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1026
    Cell Significance Index: -17.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1102
    Cell Significance Index: -7.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1311
    Cell Significance Index: -15.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1442
    Cell Significance Index: -3.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1660
    Cell Significance Index: -24.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1827
    Cell Significance Index: -38.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2075
    Cell Significance Index: -24.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2286
    Cell Significance Index: -26.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2748
    Cell Significance Index: -5.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3516
    Cell Significance Index: -10.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3616
    Cell Significance Index: -37.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3808
    Cell Significance Index: -9.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3849
    Cell Significance Index: -10.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4117
    Cell Significance Index: -32.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4240
    Cell Significance Index: -22.2600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4410
    Cell Significance Index: -5.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4692
    Cell Significance Index: -29.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4813
    Cell Significance Index: -29.5100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4818
    Cell Significance Index: -8.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4977
    Cell Significance Index: -15.9400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4980
    Cell Significance Index: -14.2100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.5092
    Cell Significance Index: -5.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5346
    Cell Significance Index: -15.7000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6030
    Cell Significance Index: -6.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6072
    Cell Significance Index: -22.2900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6194
    Cell Significance Index: -8.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6195
    Cell Significance Index: -16.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6311
    Cell Significance Index: -16.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6346
    Cell Significance Index: -20.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6509
    Cell Significance Index: -21.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6836
    Cell Significance Index: -11.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6921
    Cell Significance Index: -18.4800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.7003
    Cell Significance Index: -7.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7085
    Cell Significance Index: -24.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7556
    Cell Significance Index: -26.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7819
    Cell Significance Index: -15.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RALGDS is a small protein (approximately 21 kDa) that belongs to the Ral GDS family of proteins. It is primarily expressed in various cell types, including astrocytes, glandular epithelial cells, and neurons, particularly in the central nervous system. RALGDS is characterized by its ability to stimulate the dissociation of GDP from Ras and Rab proteins, leading to their activation. This activation is crucial for various cellular processes, including cell growth, differentiation, and migration. **Pathways and Functions** RALGDS is involved in several signaling pathways, including: 1. **MAPK/ERK pathway**: RALGDS regulates the activation of MAPK/ERK signaling cascades, which are crucial for cell growth, differentiation, and survival. 2. **Ras protein signal transduction**: RALGDS stimulates the activation of Ras proteins, which are involved in cell growth, differentiation, and oncogenesis. 3. **Signaling by NTRK1/TRKA**: RALGDS regulates the activation of NTRK1/TRKA receptors, which are involved in cell growth, differentiation, and survival. 4. **Signaling by receptor tyrosine kinases**: RALGDS regulates the activation of receptor tyrosine kinases, which are involved in cell growth, differentiation, and survival. RALGDS also interacts with various proteins, including: 1. **Ras GTPases**: RALGDS stimulates the activation of Ras GTPases, leading to their dissociation from GDP and their activation. 2. **Rab GTPases**: RALGDS stimulates the activation of Rab GTPases, leading to their dissociation from GDP and their activation. 3. **ERK1/2**: RALGDS regulates the activation of ERK1/2, which are key components of the MAPK/ERK signaling cascade. **Clinical Significance** RALGDS dysregulation has been implicated in various diseases, including: 1. **Cancer**: RALGDS overexpression has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders**: RALGDS dysregulation has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Immune system disorders**: RALGDS dysregulation has been implicated in various immune system disorders, including autoimmune diseases and immunodeficiency disorders. In conclusion, RALGDS is a critical regulator of cellular processes, including signal transduction and cell growth regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of RALGDS in the context of immunological disorders. Further research is needed to elucidate the mechanisms of RALGDS dysregulation and to explore its potential therapeutic applications.

Genular Protein ID: 3241726092

Symbol: GNDS_HUMAN

Name: Ral guanine nucleotide dissociation stimulator

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9365783

Title: Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1.

PubMed ID: 9365783

DOI: 10.1046/j.1469-1809.1997.6140299.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 7972015

Title: Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.

PubMed ID: 7972015

DOI: 10.1073/pnas.91.23.11089

PubMed ID: 27438768

Title: Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion of Intracellular Bacteria by Exocyst Complex.

PubMed ID: 27438768

DOI: 10.1016/j.immuni.2016.06.023

PubMed ID: 9302994

Title: Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling.

PubMed ID: 9302994

DOI: 10.1038/nsb0997-694

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 914
  • Mass: 100607
  • Checksum: EA5A5CF25AF3D523
  • Sequence:
  • MVQRMWAEAA GPAGGAEPLF PGSRRSRSVW DAVRLEVGVP DSCPVVLHSF TQLDPDLPRP 
    ESSTQEIGEE LINGVIYSIS LRKVQLHHGG NKGQRWLGYE NESALNLYET CKVRTVKAGT 
    LEKLVEHLVP AFQGSDLSYV TIFLCTYRAF TTTQQVLDLL FKRYGRCDAL TASSRYGCIL 
    PYSDEDGGPQ DQLKNAISSI LGTWLDQYSE DFCQPPDFPC LKQLVAYVQL NMPGSDLERR 
    AHLLLAQLEH SEPIEAEPEA LSPVPALKPT PELELALTPA RAPSPVPAPA PEPEPAPTPA 
    PGSELEVAPA PAPELQQAPE PAVGLESAPA PALELEPAPE QDPAPSQTLE LEPAPAPVPS 
    LQPSWPSPVV AENGLSEEKP HLLVFPPDLV AEQFTLMDAE LFKKVVPYHC LGSIWSQRDK 
    KGKEHLAPTI RATVTQFNSV ANCVITTCLG NRSTKAPDRA RVVEHWIEVA RECRILKNFS 
    SLYAILSALQ SNSIHRLKKT WEDVSRDSFR IFQKLSEIFS DENNYSLSRE LLIKEGTSKF 
    ATLEMNPKRA QKRPKETGII QGTVPYLGTF LTDLVMLDTA MKDYLYGRLI NFEKRRKEFE 
    VIAQIKLLQS ACNNYSIAPD EQFGAWFRAV ERLSETESYN LSCELEPPSE SASNTLRTKK 
    NTAIVKRWSD RQAPSTELST SGSSHSKSCD QLRCGPYLSS GDIADALSVH SAGSSSSDVE 
    EINISFVPES PDGQEKKFWE SASQSSPETS GISSASSSTS SSSASTTPVA ATRTHKRSVS 
    GLCNSSSALP LYNQQVGDCC IIRVSLDVDN GNMYKSILVT SQDKAPAVIR KAMDKHNLEE 
    EEPEDYELLQ ILSDDRKLKI PENANVFYAM NSTANYDFVL KKRTFTKGVK VKHGASSTLP 
    RMKQKGLKIA KGIF

Genular Protein ID: 4089828044

Symbol: Q8N4Y1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 411
  • Mass: 45526
  • Checksum: 114CF1F26F923B79
  • Sequence:
  • VSRDSFRIFQ KLSEIFSDEN NYSLSRELLI KEGTSKFATL EMNPKRAQKR PKETGIIQGT 
    VPYLGTFLTD LVMLDTAMKD YLYGRLINFE KRRKEFEVIA QIKLLQSACN NYSIAPDEQF 
    GAWFRAVERL SETESYNLSC ELEPPSESAS NTLRTKKNTA IVKRWSDRQA PSTELSTSGS 
    SHSKSCDQLR CGPYLSSGDI ADALSVHSAG SSSSDVEEIN ISFVPESPDG QEKKFWESAS 
    QSSPETSGIS SASSSTSSSS ASTTPVAATR THKRSVSGLC NSSSALPLYN QQVGDCCIIR 
    VSLDVDNGNM YKSILVTSQD KAPAVIRKAM DKHNLEEEEP EDYELLQILS DDRKLKIPEN 
    ANVFYAMNST ANYDFVLKKR TFTKGVKVKH GASSTLPRMK QKGLKIAKGI F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.