Details for: RAP2B

Gene ID: 5912

Symbol: RAP2B

Ensembl ID: ENSG00000181467

Description: RAP2B, member of RAS oncogene family

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 148.8313
    Cell Significance Index: -23.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 98.9973
    Cell Significance Index: -25.1100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.2728
    Cell Significance Index: -24.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 52.3732
    Cell Significance Index: -26.9400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 41.9807
    Cell Significance Index: -28.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.5847
    Cell Significance Index: -25.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.8288
    Cell Significance Index: -26.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9259
    Cell Significance Index: -27.3300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.9120
    Cell Significance Index: -21.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.2957
    Cell Significance Index: -11.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.0534
    Cell Significance Index: 262.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.7134
    Cell Significance Index: 128.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.4935
    Cell Significance Index: 664.8400
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.0834
    Cell Significance Index: 9.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.4754
    Cell Significance Index: 53.6300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.6895
    Cell Significance Index: 24.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6673
    Cell Significance Index: 75.5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.6318
    Cell Significance Index: 30.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5778
    Cell Significance Index: 45.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5386
    Cell Significance Index: 250.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4158
    Cell Significance Index: 1278.3900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.0951
    Cell Significance Index: 8.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0770
    Cell Significance Index: 69.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0222
    Cell Significance Index: 125.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9901
    Cell Significance Index: 46.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9569
    Cell Significance Index: 104.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8253
    Cell Significance Index: 148.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6693
    Cell Significance Index: 295.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5490
    Cell Significance Index: 75.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5408
    Cell Significance Index: 69.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4849
    Cell Significance Index: 12.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4844
    Cell Significance Index: 34.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4810
    Cell Significance Index: 96.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4524
    Cell Significance Index: 247.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4355
    Cell Significance Index: 29.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3553
    Cell Significance Index: 10.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3180
    Cell Significance Index: 4.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3095
    Cell Significance Index: 9.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2650
    Cell Significance Index: 2.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2456
    Cell Significance Index: 5.2300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2340
    Cell Significance Index: 26.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2023
    Cell Significance Index: 5.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2021
    Cell Significance Index: 19.9900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.1762
    Cell Significance Index: 1.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0976
    Cell Significance Index: 11.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0817
    Cell Significance Index: 10.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0451
    Cell Significance Index: 16.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0411
    Cell Significance Index: 55.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0337
    Cell Significance Index: 2.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0119
    Cell Significance Index: 5.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0117
    Cell Significance Index: 2.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0085
    Cell Significance Index: 1.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0015
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0068
    Cell Significance Index: -5.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0078
    Cell Significance Index: -12.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0082
    Cell Significance Index: -15.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0099
    Cell Significance Index: -6.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0100
    Cell Significance Index: -18.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0145
    Cell Significance Index: -8.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0147
    Cell Significance Index: -1.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0186
    Cell Significance Index: -14.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0205
    Cell Significance Index: -2.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0278
    Cell Significance Index: -20.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0310
    Cell Significance Index: -21.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0347
    Cell Significance Index: -22.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0441
    Cell Significance Index: -1.0200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0528
    Cell Significance Index: -0.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0607
    Cell Significance Index: -2.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0654
    Cell Significance Index: -18.8300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0672
    Cell Significance Index: -1.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0718
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0746
    Cell Significance Index: -15.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0787
    Cell Significance Index: -9.1700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1139
    Cell Significance Index: -0.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1510
    Cell Significance Index: -6.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1574
    Cell Significance Index: -22.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1661
    Cell Significance Index: -4.7600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1664
    Cell Significance Index: -1.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1712
    Cell Significance Index: -10.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1740
    Cell Significance Index: -6.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1752
    Cell Significance Index: -4.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2064
    Cell Significance Index: -3.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2533
    Cell Significance Index: -26.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2569
    Cell Significance Index: -7.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2940
    Cell Significance Index: -16.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3130
    Cell Significance Index: -24.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3329
    Cell Significance Index: -25.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3524
    Cell Significance Index: -17.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3603
    Cell Significance Index: -11.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3798
    Cell Significance Index: -13.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3949
    Cell Significance Index: -24.8900
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.4058
    Cell Significance Index: -2.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4116
    Cell Significance Index: -21.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4425
    Cell Significance Index: -27.1300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4505
    Cell Significance Index: -18.4600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4552
    Cell Significance Index: -2.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4627
    Cell Significance Index: -16.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4796
    Cell Significance Index: -25.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5136
    Cell Significance Index: -13.1200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.5355
    Cell Significance Index: -7.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RAP2B is a small GTP-binding protein that belongs to the RAS oncogene family, which is known for its involvement in signal transduction pathways. Key characteristics of RAP2B include: 1. **GTPase activity**: RAP2B exhibits GTPase activity, which allows it to regulate its own activity and interact with downstream effectors. 2. **Cell signaling**: RAP2B is involved in various signaling pathways, including those regulating cell migration, differentiation, and survival. 3. **Immune system modulation**: RAP2B is expressed in immune cells, such as monocytes and macrophages, and plays a role in modulating immune responses. 4. **Tissue-specific expression**: RAP2B is expressed in epithelial cells, stem cells, and immune cells, indicating its involvement in tissue homeostasis and immune function. **Pathways and Functions** RAP2B is involved in numerous signaling pathways, including: 1. **Cell-cell contact zone**: RAP2B regulates the establishment of tight junctions between epithelial cells, which is crucial for maintaining tissue integrity. 2. **Immune system**: RAP2B modulates immune responses by regulating the activity of immune cells, such as monocytes and macrophages. 3. **Endothelial barrier**: RAP2B is involved in the establishment of the endothelial barrier, which is critical for maintaining vascular homeostasis. 4. **Protein autophosphorylation**: RAP2B regulates the autophosphorylation of proteins, which is essential for signal transduction and cell signaling. 5. **GTP binding**: RAP2B binds GTP, which activates its GTPase activity and allows it to interact with downstream effectors. **Clinical Significance** Dysregulation of RAP2B has been implicated in various diseases, including: 1. **Cancer**: RAP2B overexpression has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Inflammatory disorders**: RAP2B is involved in the regulation of immune responses, and its dysregulation has been implicated in inflammatory disorders, such as rheumatoid arthritis and atherosclerosis. 3. **Neurological disorders**: RAP2B has been implicated in the regulation of neuronal signaling and has been associated with neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, RAP2B is a critical regulator of various cellular processes, including cell signaling, migration, and differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its role in maintaining tissue homeostasis and immune function.

Genular Protein ID: 3209952767

Symbol: RAP2B_HUMAN

Name: Ras-related protein Rap-2b

UniProtKB Accession Codes:

P61225 P17964 Q96EG5 Q9CXG0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2115998

Title: cDNA sequence of a new ras-related gene (rap2b) isolated from human platelets with sequence homology to rap2.

PubMed ID: 2115998

DOI: 10.1093/nar/18.14.4281

PubMed ID: 2118648

Title: RAP2B: a RAS-related GTP-binding protein from platelets.

PubMed ID: 2118648

DOI: 10.1073/pnas.87.17.6527

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8424780

Title: Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated.

PubMed ID: 8424780

DOI: 10.1042/bj2890349

PubMed ID: 11877431

Title: Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B.

PubMed ID: 11877431

DOI: 10.1074/jbc.m112024200

PubMed ID: 12444546

Title: Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon.

PubMed ID: 12444546

DOI: 10.1038/sj.onc.1206003

PubMed ID: 15143162

Title: Rap2B-dependent stimulation of phospholipase C-epsilon by epidermal growth factor receptor mediated by c-Src phosphorylation of RasGRP3.

PubMed ID: 15143162

DOI: 10.1128/mcb.24.11.4664-4676.2004

PubMed ID: 16540189

Title: Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involved in vesiculation.

PubMed ID: 16540189

DOI: 10.1016/j.bbamcr.2006.02.001

PubMed ID: 17509819

Title: Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.

PubMed ID: 17509819

DOI: 10.1016/j.ygeno.2007.03.013

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 183
  • Mass: 20504
  • Checksum: A1139C2D5E7F5865
  • Sequence:
    • MREYKVVVLG SGGVGKSALT VQFVTGSFIE KYDPTIEDFY RKEIEVDSSP SVLEILDTAG 
TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI IRVKRYERVP MILVGNKVDL 
EGEREVSYGE GKALAEEWSC PFMETSAKNK ASVDELFAEI VRQMNYAAQP NGDEGCCSAC 
VIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.