Details for: RECQL
Gene ID: 5965
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: RECQL
Ensembl ID: ENSG00000004700
Description: RecQ like helicase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 21.63rCSI 29.48%PRS 29.54
-
CSI 5.93rCSI 4.46%PRS 62.15
-
CSI 5.41rCSI 8.31%PRS 65.8
-
CSI 4.99rCSI 7.05%PRS 63.28
-
CSI 4.71rCSI 11.33%PRS 75.28
-
CSI 4.25rCSI 3.41%PRS 78.04
-
CSI 4.17rCSI 2.9%PRS 72.04
-
CSI 4.09rCSI 15.92%PRS 77.41
-
CSI 3.8rCSI 8.7%PRS 56.9
-
CSI 3.45rCSI 4.93%PRS 59.63
-
CSI 3.43rCSI 2.89%PRS 74.71
-
CSI 3.24rCSI 2.49%PRS 57.16
-
CSI 3.17rCSI 2.41%PRS 69.92
-
CSI 3.15rCSI 4.56%PRS 73.15
-
CSI 2.96rCSI 2.21%PRS 72.22
-
CSI 2.94rCSI 5.24%PRS 71.2
-
CSI 2.89rCSI 3.95%PRS 62.88
-
CSI 2.81rCSI 1.66%PRS 74.25
-
CSI 2.72rCSI 2.82%PRS 62.78
-
CSI 2.71rCSI 5.45%PRS 46.45
-
CSI 2.67rCSI 1.91%PRS 71.39
-
CSI 2.58rCSI 2.53%PRS 73.07
-
CSI 2.55rCSI 2.35%PRS 65.75
-
CSI 2.52rCSI 6.39%PRS 51.68
-
CSI 2.5rCSI 2.07%PRS 58.97
-
CSI 2.5rCSI 1.74%PRS 67.86
-
CSI 2.48rCSI 2.14%PRS 63.28
-
CSI 2.47rCSI 7.08%PRS 76.65
-
CSI 2.46rCSI 1.92%PRS 75.22
-
CSI 2.46rCSI 2.33%PRS 57.01
-
CSI 2.46rCSI 2.81%PRS 77.18
-
CSI 2.39rCSI 2.3%PRS 47.69
-
CSI 2.34rCSI 2.05%PRS 67.3
-
CSI 2.33rCSI 2.05%PRS 62.44
-
CSI 2.31rCSI 1.56%PRS 69.95
-
CSI 2.31rCSI 2.13%PRS 58.19
-
CSI 2.3rCSI 2.02%PRS 45.29
-
CSI 2.28rCSI 1.7%PRS 70.89
-
CSI 2.27rCSI 2.12%PRS 57.22
-
CSI 2.25rCSI 1.7%PRS 70.84
-
CSI 2.25rCSI 1.83%PRS 57.69
-
CSI 2.24rCSI 5.22%PRS 76.9
-
CSI 2.21rCSI 1.86%PRS 61.96
-
CSI 2.14rCSI 2.69%PRS 69.57
-
CSI 2.13rCSI 4.05%PRS 72.64
-
CSI 2.11rCSI 2.53%PRS 55.23
-
CSI 2.1rCSI 2.56%PRS 64.83
-
CSI 2.1rCSI 2.46%PRS 73.67
-
CSI 2.09rCSI 1.65%PRS 44.15
-
CSI 2.04rCSI 1.43%PRS 59.9
-
CSI 2rCSI 7.48%PRS 49.39
-
CSI 1.99rCSI 3.57%PRS 56.3
-
CSI 1.99rCSI 12.45%PRS 49.14
-
CSI 1.99rCSI 2.24%PRS 73.7
-
CSI 1.98rCSI 1.56%PRS 63.94
-
CSI 1.98rCSI 2.49%PRS 67.48
-
CSI 1.95rCSI 2.5%PRS 54.63
-
CSI 1.94rCSI 3.1%PRS 61.19
-
CSI 1.93rCSI 4.01%PRS 54.45
-
CSI 1.92rCSI 1.43%PRS 74.57
-
CSI 1.9rCSI 3.28%PRS 47.35
-
CSI 1.89rCSI 1.71%PRS 53.86
-
CSI 1.89rCSI 3.01%PRS 50.07
-
CSI 1.81rCSI 3.25%PRS 50.29
-
CSI 1.79rCSI 2.34%PRS 70.55
-
CSI 1.77rCSI 2.19%PRS 53.37
-
CSI 1.76rCSI 5.71%PRS 58.23
-
CSI 1.75rCSI 8.39%PRS 57.01
-
CSI 1.74rCSI 2.77%PRS 49.57
-
CSI 1.74rCSI 1.86%PRS 56.12
-
CSI 1.73rCSI 1.67%PRS 57.4
-
CSI 1.73rCSI 1.76%PRS 70.58
-
CSI 1.69rCSI 4.79%PRS 55.51
-
CSI 1.68rCSI 13.64%PRS 50.28
-
CSI 1.68rCSI 3.16%PRS 67.79
-
CSI 1.55rCSI 1.97%PRS 63.48
-
CSI 1.55rCSI 2.74%PRS 38.55
-
CSI 1.55rCSI 2.44%PRS 59
-
CSI 1.5rCSI 1.73%PRS 50.66
-
CSI 1.49rCSI 6.03%PRS 55.81
-
CSI 1.47rCSI 2.53%PRS 66.29
-
CSI 1.45rCSI 1.75%PRS 65.79
-
CSI 1.44rCSI 1.96%PRS 69.12
-
CSI 1.43rCSI 1.23%PRS 61.94
-
CSI 1.41rCSI 1.69%PRS 77.13
-
CSI 1.38rCSI 1.84%PRS 63.32
-
CSI 1.37rCSI 3.62%PRS 66
-
CSI 1.37rCSI 1.19%PRS 67.71
-
CSI 1.32rCSI 1.93%PRS 53.96
-
CSI 1.27rCSI 2.54%PRS 75.17
-
CSI 1.08rCSI 0.87%PRS 58.41
-
CSI 1.03rCSI 1.49%PRS 66.78
-
CSI 1rCSI 2.24%PRS 64.71
-
CSI 0.99rCSI 3.58%PRS 76.78
-
CSI 0.82rCSI 1.99%PRS 38.23
-
CSI 0.79rCSI 3.49%PRS 56.47
-
CSI 0.77rCSI 1.16%PRS 60.69
-
CSI 0.77rCSI 3.85%PRS 69.61
-
CSI 0.76rCSI 0.88%PRS 47.24
-
CSI 0.74rCSI 2.13%PRS 69.84
-
CSI 0.3rCSI 1.5%PRS 67.1%
-
CSI 0.3rCSI 1.9%PRS 71.2%
-
CSI 0.3rCSI 1.8%PRS 67.1%
-
CSI 0.5rCSI 1.5%PRS 58.8%
-
CSI 0.6rCSI 3.3%PRS 66.8%
-
CSI 0.6rCSI 2.8%PRS 68.5%
-
CSI 0.7rCSI 2.1%PRS 69.8%
-
CSI 0.8rCSI 0.9%PRS 47.2%
-
CSI 0.8rCSI 3.9%PRS 69.6%
-
CSI 0.8rCSI 1.2%PRS 60.7%
-
CSI 0.8rCSI 3.5%PRS 56.5%
-
CSI 0.8rCSI 2.0%PRS 38.2%
-
CSI 1.0rCSI 3.6%PRS 76.8%
-
CSI 1.0rCSI 2.2%PRS 64.7%
-
CSI 1.0rCSI 1.5%PRS 66.8%
-
CSI 1.1rCSI 0.9%PRS 58.4%
-
CSI 1.3rCSI 2.5%PRS 75.2%
-
CSI 1.3rCSI 1.9%PRS 54.0%
-
CSI 1.4rCSI 1.2%PRS 67.7%
-
CSI 1.4rCSI 3.6%PRS 66.0%
-
CSI 1.4rCSI 1.8%PRS 63.3%
-
CSI 1.4rCSI 1.7%PRS 77.1%
-
CSI 1.4rCSI 1.2%PRS 61.9%
-
CSI 1.4rCSI 2.0%PRS 69.1%
-
CSI 1.5rCSI 1.8%PRS 65.8%
-
CSI 1.5rCSI 2.5%PRS 66.3%
-
CSI 1.5rCSI 6.0%PRS 55.8%
-
CSI 1.5rCSI 1.7%PRS 50.7%
-
CSI 1.6rCSI 2.4%PRS 59.0%
-
CSI 1.6rCSI 2.7%PRS 38.6%
-
CSI 1.6rCSI 2.0%PRS 63.5%
-
CSI 1.7rCSI 3.2%PRS 67.8%
-
CSI 1.7rCSI 13.6%PRS 50.3%
-
CSI 1.7rCSI 4.8%PRS 55.5%
-
CSI 1.7rCSI 1.8%PRS 70.6%
-
CSI 1.7rCSI 1.7%PRS 57.4%
-
CSI 1.7rCSI 1.9%PRS 56.1%
-
CSI 1.7rCSI 2.8%PRS 49.6%
-
CSI 1.8rCSI 8.4%PRS 57.0%
-
CSI 1.8rCSI 5.7%PRS 58.2%
-
CSI 1.8rCSI 2.2%PRS 53.4%
-
CSI 1.8rCSI 2.3%PRS 70.6%
-
CSI 1.8rCSI 3.3%PRS 50.3%
-
CSI 1.9rCSI 3.0%PRS 50.1%
-
CSI 1.9rCSI 1.7%PRS 53.9%
-
CSI 1.9rCSI 3.3%PRS 47.4%
-
CSI 1.9rCSI 1.4%PRS 74.6%
-
CSI 1.9rCSI 4.0%PRS 54.5%
-
CSI 1.9rCSI 3.1%PRS 61.2%
-
CSI 2.0rCSI 2.5%PRS 54.6%
-
CSI 2.0rCSI 2.5%PRS 67.5%
-
CSI 2.0rCSI 1.6%PRS 63.9%
-
CSI 2.0rCSI 2.2%PRS 73.7%
-
CSI 2.0rCSI 12.5%PRS 49.1%
-
CSI 2.0rCSI 3.6%PRS 56.3%
-
CSI 2.0rCSI 7.5%PRS 49.4%
-
CSI 2.0rCSI 1.4%PRS 59.9%
-
CSI 2.1rCSI 1.7%PRS 44.2%
-
CSI 2.1rCSI 2.5%PRS 73.7%
-
CSI 2.1rCSI 2.6%PRS 64.8%
-
CSI 2.1rCSI 2.5%PRS 55.2%
-
CSI 2.1rCSI 4.1%PRS 72.6%
-
CSI 2.1rCSI 2.7%PRS 69.6%
-
CSI 2.2rCSI 1.9%PRS 62.0%
-
CSI 2.2rCSI 5.2%PRS 76.9%
-
CSI 2.3rCSI 1.8%PRS 57.7%
-
CSI 2.3rCSI 1.7%PRS 70.8%
-
CSI 2.3rCSI 2.1%PRS 57.2%
-
CSI 2.3rCSI 1.7%PRS 70.9%
-
CSI 2.3rCSI 2.0%PRS 45.3%
-
CSI 2.3rCSI 2.1%PRS 58.2%
-
CSI 2.3rCSI 1.6%PRS 70.0%
-
CSI 2.3rCSI 2.1%PRS 62.4%
-
CSI 2.3rCSI 2.1%PRS 67.3%
-
CSI 2.4rCSI 2.3%PRS 47.7%
-
CSI 2.5rCSI 2.8%PRS 77.2%
-
CSI 2.5rCSI 2.3%PRS 57.0%
-
CSI 2.5rCSI 1.9%PRS 75.2%
-
CSI 2.5rCSI 7.1%PRS 76.7%
-
CSI 2.5rCSI 2.1%PRS 63.3%
-
CSI 2.5rCSI 1.7%PRS 67.9%
-
CSI 2.5rCSI 2.1%PRS 59.0%
-
CSI 2.5rCSI 6.4%PRS 51.7%
-
CSI 2.6rCSI 2.4%PRS 65.8%
-
CSI 2.6rCSI 2.5%PRS 73.1%
-
CSI 2.7rCSI 1.9%PRS 71.4%
-
CSI 2.7rCSI 5.5%PRS 46.5%
-
CSI 2.7rCSI 2.8%PRS 62.8%
-
CSI 2.8rCSI 1.7%PRS 74.3%
-
CSI 2.9rCSI 4.0%PRS 62.9%
-
CSI 2.9rCSI 5.2%PRS 71.2%
-
CSI 3.0rCSI 2.2%PRS 72.2%
-
CSI 3.2rCSI 4.6%PRS 73.2%
-
CSI 3.2rCSI 2.4%PRS 69.9%
-
CSI 3.2rCSI 2.5%PRS 57.2%
-
CSI 3.4rCSI 2.9%PRS 74.7%
-
CSI 3.5rCSI 4.9%PRS 59.6%
-
CSI 3.8rCSI 8.7%PRS 56.9%
-
CSI 4.1rCSI 15.9%PRS 77.4%
-
CSI 4.2rCSI 2.9%PRS 72.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 926536905
Symbol: RECQ1_HUMAN
Name: DNA helicase, RecQ-like type 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7961977
Title: Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ.
PubMed ID: 7961977
PubMed ID: 7527136
Title: Molecular cloning of cDNA encoding human DNA helicase Q1 which has homology to Escherichia coli Rec Q helicase and localization of the gene at chromosome 12p12.
PubMed ID: 7527136
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8056767
Title: Purification of two DNA-dependent adenosinetriphosphatases having DNA helicase activity from HeLa cells and comparison of the properties of the two enzymes.
PubMed ID: 8056767
PubMed ID: 15886194
Title: RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination.
PubMed ID: 15886194
PubMed ID: 18426915
Title: FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.
PubMed ID: 18426915
DOI: 10.1128/mcb.02210-07
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 35025765
Title: RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1.
PubMed ID: 35025765
DOI: 10.1172/jci147301
PubMed ID: 19151156
Title: Structure of the human RECQ1 helicase reveals a putative strand-separation pin.
PubMed ID: 19151156
PubMed ID: 25831490
Title: Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures.
PubMed ID: 25831490
Sequence Information:
- Length: 649
- Mass: 73457
- Checksum: F616DC3191F79391
- Sequence:
MASVSALTEE LDSITSELHA VEIQIQELTE RQQELIQKKK VLTKKIKQCL EDSDAGASNE YDSSPAAWNK EDFPWSGKVK DILQNVFKLE KFRPLQLETI NVTMAGKEVF LVMPTGGGKS LCYQLPALCS DGFTLVICPL ISLMEDQLMV LKQLGISATM LNASSSKEHV KWVHAEMVNK NSELKLIYVT PEKIAKSKMF MSRLEKAYEA RRFTRIAVDE VHCCSQWGHD FRPDYKALGI LKRQFPNASL IGLTATATNH VLTDAQKILC IEKCFTFTAS FNRPNLYYEV RQKPSNTEDF IEDIVKLING RYKGQSGIIY CFSQKDSEQV TVSLQNLGIH AGAYHANLEP EDKTTVHRKW SANEIQVVVA TVAFGMGIDK PDVRFVIHHS MSKSMENYYQ ESGRAGRDDM KADCILYYGF GDIFRISSMV VMENVGQQKL YEMVSYCQNI SKCRRVLMAQ HFDEVWNSEA CNKMCDNCCK DSAFERKNIT EYCRDLIKIL KQAEELNEKL TPLKLIDSWM GKGAAKLRVA GVVAPTLPRE DLEKIIAHFL IQQYLKEDYS FTAYATISYL KIGPKANLLN NEAHAITMQV TKSTQNSFRA ESSQTCHSEQ GDKKMEEKNS GNFQKKAANM LQQSGSKNTG AKKRKIDDA