Details for: TRIM27

Gene ID: 5987

Symbol: TRIM27

Ensembl ID: ENSG00000204713

Description: tripartite motif containing 27

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 173.7758
    Cell Significance Index: -27.0300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 97.5779
    Cell Significance Index: -24.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.8204
    Cell Significance Index: -26.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 59.6440
    Cell Significance Index: -30.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.1647
    Cell Significance Index: -26.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.4639
    Cell Significance Index: -28.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.2208
    Cell Significance Index: -27.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.4720
    Cell Significance Index: -29.4900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.1497
    Cell Significance Index: -21.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.8302
    Cell Significance Index: -12.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8678
    Cell Significance Index: 50.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5279
    Cell Significance Index: 1379.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1978
    Cell Significance Index: 237.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7261
    Cell Significance Index: 396.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7254
    Cell Significance Index: 130.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6780
    Cell Significance Index: 35.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6527
    Cell Significance Index: 45.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6515
    Cell Significance Index: 30.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6332
    Cell Significance Index: 127.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6155
    Cell Significance Index: 75.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5645
    Cell Significance Index: 77.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5294
    Cell Significance Index: 12.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4787
    Cell Significance Index: 22.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4474
    Cell Significance Index: 12.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4216
    Cell Significance Index: 68.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3940
    Cell Significance Index: 11.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3801
    Cell Significance Index: 24.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3423
    Cell Significance Index: 122.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3358
    Cell Significance Index: 17.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3209
    Cell Significance Index: 11.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3171
    Cell Significance Index: 6.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3170
    Cell Significance Index: 14.3700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2989
    Cell Significance Index: 5.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2910
    Cell Significance Index: 16.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2907
    Cell Significance Index: 201.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2727
    Cell Significance Index: 35.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2668
    Cell Significance Index: 117.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2641
    Cell Significance Index: 19.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2422
    Cell Significance Index: 28.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2118
    Cell Significance Index: 6.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1352
    Cell Significance Index: 13.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1217
    Cell Significance Index: 20.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1212
    Cell Significance Index: 8.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1114
    Cell Significance Index: 8.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1007
    Cell Significance Index: 19.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0886
    Cell Significance Index: 2.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0879
    Cell Significance Index: 1.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0817
    Cell Significance Index: 2.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0555
    Cell Significance Index: 7.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0333
    Cell Significance Index: 62.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0082
    Cell Significance Index: 12.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0069
    Cell Significance Index: 4.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0041
    Cell Significance Index: 7.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0034
    Cell Significance Index: 0.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0072
    Cell Significance Index: -0.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0096
    Cell Significance Index: -13.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0098
    Cell Significance Index: -7.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0200
    Cell Significance Index: -0.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0216
    Cell Significance Index: -15.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0218
    Cell Significance Index: -9.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0264
    Cell Significance Index: -19.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0371
    Cell Significance Index: -0.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0406
    Cell Significance Index: -4.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0408
    Cell Significance Index: -22.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0489
    Cell Significance Index: -7.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0546
    Cell Significance Index: -34.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0559
    Cell Significance Index: -0.9400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0792
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0820
    Cell Significance Index: -9.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0995
    Cell Significance Index: -11.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1033
    Cell Significance Index: -1.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1045
    Cell Significance Index: -30.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1102
    Cell Significance Index: -2.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1370
    Cell Significance Index: -9.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1513
    Cell Significance Index: -31.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1526
    Cell Significance Index: -1.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1599
    Cell Significance Index: -10.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1998
    Cell Significance Index: -6.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2002
    Cell Significance Index: -5.7400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2078
    Cell Significance Index: -4.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2182
    Cell Significance Index: -11.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2278
    Cell Significance Index: -5.8200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2422
    Cell Significance Index: -3.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2510
    Cell Significance Index: -26.1300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2759
    Cell Significance Index: -2.2500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3088
    Cell Significance Index: -6.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3361
    Cell Significance Index: -5.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3393
    Cell Significance Index: -26.8700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3533
    Cell Significance Index: -4.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3563
    Cell Significance Index: -15.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3892
    Cell Significance Index: -23.8600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4022
    Cell Significance Index: -2.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4233
    Cell Significance Index: -16.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4676
    Cell Significance Index: -6.3800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5458
    Cell Significance Index: -7.8500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5493
    Cell Significance Index: -16.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5523
    Cell Significance Index: -15.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5785
    Cell Significance Index: -14.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6219
    Cell Significance Index: -20.3600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6246
    Cell Significance Index: -6.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRIM27 is a member of the tripartite motif (TRIM) family, characterized by the presence of three domains: RING, B-box, and coiled-coil. This unique structure enables TRIM27 to interact with multiple proteins, influencing various cellular processes. Notably, TRIM27 is a negative regulator of immune responses, as evidenced by its involvement in the regulation of adaptive and innate immune responses, autophagy, and apoptosis. **Pathways and Functions:** TRIM27 is involved in numerous signaling pathways, including: 1. **Innate Immune Response:** TRIM27 negatively regulates the production of type I and II interferons, as well as the activation of immune cells, such as macrophages and T cells. 2. **Autophagy:** TRIM27 inhibits autophagy by interacting with autophagy-related proteins, thereby maintaining cellular homeostasis. 3. **Apoptosis:** TRIM27 suppresses apoptosis by regulating the activity of pro-apoptotic proteins and promoting the expression of anti-apoptotic proteins. 4. **Cell Signaling:** TRIM27 interacts with various signaling molecules, including AKT and PI3K, to regulate cell survival, proliferation, and differentiation. 5. **Protein Modification:** TRIM27 is involved in the regulation of protein ubiquitination, sumoylation, and acetylation, which are essential for maintaining protein homeostasis. **Clinical Significance:** The dysregulation of TRIM27 has been implicated in various diseases, including: 1. **Infectious Diseases:** TRIM27 plays a crucial role in regulating the immune response to mycobacterial infections, such as tuberculosis. 2. **Cancer:** TRIM27 has been shown to suppress tumor growth and metastasis by regulating cell signaling and protein modification pathways. 3. **Neurological Disorders:** TRIM27 has been implicated in the regulation of neuronal function and survival, with potential implications in neurodegenerative diseases, such as Alzheimer's and Parkinson's. **Significantly Expressed Cells:** TRIM27 is expressed in various cell types, including extravillous trophoblast, pancreatic acinar cell, primordial germ cell, choroid plexus epithelial cell, cardiac muscle cell, and cell in vitro. **Proteins:** The primary protein product of TRIM27 is TRI27_HUMAN (Zinc finger protein RFP), which is involved in various cellular processes, including protein binding and regulation. In conclusion, TRIM27 is a multifaceted protein that plays a crucial role in regulating immune responses, cell signaling, and protein modification. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms of TRIM27 in maintaining immune homeostasis and promoting cellular health.

Genular Protein ID: 4258608516

Symbol: TRI27_HUMAN

Name: Zinc finger protein RFP

UniProtKB Accession Codes:

P14373 A2BE15 Q5RJA8 Q5ST26 Q6LA73 Q6NXR9 Q9BZY6 Q9UJL3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 18 Ensembl 10 ExpressionAtlas 1 GO 40 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3380101

Title: Developmentally regulated expression of a human 'finger'-containing gene encoded by the 5' half of the ret transforming gene.

PubMed ID: 3380101

DOI: 10.1128/mcb.8.4.1853-1856.1988

PubMed ID: 11331580

Title: The tripartite motif family identifies cell compartments.

PubMed ID: 11331580

DOI: 10.1093/emboj/20.9.2140

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3037315

Title: ret transforming gene encodes a fusion protein homologous to tyrosine kinases.

PubMed ID: 3037315

DOI: 10.1128/mcb.7.4.1378-1385.1987

PubMed ID: 1437549

Title: RFP is a DNA binding protein associated with the nuclear matrix.

PubMed ID: 1437549

DOI: 10.1093/nar/20.20.5305

PubMed ID: 9247190

Title: Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution.

PubMed ID: 9247190

DOI: 10.1242/jcs.110.14.1563

PubMed ID: 9570750

Title: Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML.

PubMed ID: 9570750

DOI: 10.1242/jcs.111.10.1319

PubMed ID: 10504338

Title: Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.

PubMed ID: 10504338

DOI: 10.1242/jcs.112.19.3331

PubMed ID: 10976108

Title: RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions.

PubMed ID: 10976108

DOI: 10.1074/jbc.m006585200

PubMed ID: 12445133

Title: Differential expression of RET finger protein in testicular germ cell tumors.

PubMed ID: 12445133

DOI: 10.1046/j.1440-1827.2002.01401.x

PubMed ID: 12807881

Title: The Ret finger protein induces apoptosis via its RING finger-B box-coiled-coil motif.

PubMed ID: 12807881

DOI: 10.1074/jbc.m304062200

PubMed ID: 14530259

Title: Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities.

PubMed ID: 14530259

DOI: 10.1074/jbc.m309198200

PubMed ID: 12787916

Title: Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient.

PubMed ID: 12787916

DOI: 10.1016/s0027-5107(03)00056-3

PubMed ID: 15837424

Title: Selective ablation of retinoblastoma protein function by the RET finger protein.

PubMed ID: 15837424

DOI: 10.1016/j.molcel.2005.03.009

PubMed ID: 17156811

Title: Unique features of TRIM5alpha among closely related human TRIM family members.

PubMed ID: 17156811

DOI: 10.1016/j.virol.2006.10.035

PubMed ID: 20864041

Title: MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.

PubMed ID: 20864041

DOI: 10.1016/j.molcel.2010.08.029

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22128329

Title: Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2beta.

PubMed ID: 22128329

DOI: 10.1073/pnas.1111233109

PubMed ID: 22829933

Title: TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation.

PubMed ID: 22829933

DOI: 10.1371/journal.pone.0041255

PubMed ID: 23452853

Title: Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination.

PubMed ID: 23452853

DOI: 10.1016/j.cell.2013.01.051

PubMed ID: 24144979

Title: Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates tumor necrosis factor alpha-induced apoptosis.

PubMed ID: 24144979

DOI: 10.1128/mcb.00465-13

PubMed ID: 25320289

Title: Identification of TRIM27 as a novel degradation target of Herpes Simplex Virus 1 ICP0.

PubMed ID: 25320289

DOI: 10.1128/jvi.02635-14

PubMed ID: 26365382

Title: USP7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal Protein Recycling and Is Mutated in a Human Neurodevelopmental Disorder.

PubMed ID: 26365382

DOI: 10.1016/j.molcel.2015.07.033

PubMed ID: 26358190

Title: Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27.

PubMed ID: 26358190

DOI: 10.1038/cr.2015.108

PubMed ID: 27698396

Title: The ubiquitin ligase TRIM27 functions as a host restriction factor antagonized by Mycobacterium tuberculosis PtpA during mycobacterial infection.

PubMed ID: 27698396

DOI: 10.1038/srep34827

PubMed ID: 29688809

Title: USP7-TRIM27 axis negatively modulates antiviral type I IFN signaling.

PubMed ID: 29688809

DOI: 10.1096/fj.201700473rr

PubMed ID: 30847745

Title: TRIM27 Promotes Hepatitis C Virus Replication by Suppressing Type I Interferon Response.

PubMed ID: 30847745

DOI: 10.1007/s10753-019-00992-5

PubMed ID: 36111389

Title: TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1.

PubMed ID: 36111389

DOI: 10.1111/febs.16628

PubMed ID: 35670107

Title: TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis.

PubMed ID: 35670107

DOI: 10.15252/embj.2021109777

Sequence Information:

  • Length: 513
  • Mass: 58490
  • Checksum: 6F963D9048D8A731
  • Sequence:
    • MASGSVAECL QQETTCPVCL QYFAEPMMLD CGHNICCACL ARCWGTAETN VSCPQCRETF 
PQRHMRPNRH LANVTQLVKQ LRTERPSGPG GEMGVCEKHR EPLKLYCEED QMPICVVCDR 
SREHRGHSVL PLEEAVEGFK EQIQNQLDHL KRVKDLKKRR RAQGEQARAE LLSLTQMERE 
KIVWEFEQLY HSLKEHEYRL LARLEELDLA IYNSINGAIT QFSCNISHLS SLIAQLEEKQ 
QQPTRELLQD IGDTLSRAER IRIPEPWITP PDLQEKIHIF AQKCLFLTES LKQFTEKMQS 
DMEKIQELRE AQLYSVDVTL DPDTAYPSLI LSDNLRQVRY SYLQQDLPDN PERFNLFPCV 
LGSPCFIAGR HYWEVEVGDK AKWTIGVCED SVCRKGGVTS APQNGFWAVS LWYGKEYWAL 
TSPMTALPLR TPLQRVGIFL DYDAGEVSFY NVTERCHTFT FSHATFCGPV RPYFSLSYSG 
GKSAAPLIIC PMSGIDGFSG HVGNHGHSME TSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.