Details for: RFX3
Gene ID: 5991
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: RFX3
Ensembl ID: ENSG00000080298
Description: regulatory factor X3
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 56.64rCSI 92.76%PRS 32.12
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CSI 44.87rCSI 91.06%PRS 24.71
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CSI 40.37rCSI 55.23%PRS 37.6
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CSI 38.82rCSI 27.26%PRS 63.56
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CSI 33.77rCSI 54.31%PRS 28.36
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CSI 33.66rCSI 73.02%PRS 31.57
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CSI 33.55rCSI 41.73%PRS 24.98
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CSI 31.8rCSI 53.38%PRS 26.37
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CSI 31.1rCSI 37.14%PRS 26.28
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CSI 31.04rCSI 64.4%PRS 38.74
-
CSI 28.47rCSI 36.7%PRS 27.25
-
CSI 27.07rCSI 65.79%PRS 25.6
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CSI 25.74rCSI 57.72%PRS 26.97
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CSI 24.42rCSI 43.12%PRS 25.45
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CSI 22.81rCSI 48.59%PRS 21.45
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CSI 21.81rCSI 18.71%PRS 49.78
-
CSI 21.56rCSI 24.93%PRS 31.44
-
CSI 20.35rCSI 17.89%PRS 30.69
-
CSI 19.45rCSI 33.64%PRS 32.01
-
CSI 19.31rCSI 69.5%PRS 25.31
-
CSI 19.26rCSI 39.76%PRS 47.53
-
CSI 18.1rCSI 20.9%PRS 35.44
-
CSI 18rCSI 46.27%PRS 43.69
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CSI 17.61rCSI 15.31%PRS 48.94
-
CSI 17.44rCSI 54.54%PRS 29.52
-
CSI 17.43rCSI 65.87%PRS 27.24
-
CSI 16.24rCSI 50.77%PRS 27.45
-
CSI 15.63rCSI 37.37%PRS 30.84
-
CSI 15rCSI 39.93%PRS 33.65
-
CSI 14.64rCSI 33.22%PRS 46.19
-
CSI 14.64rCSI 14.12%PRS 31.88
-
CSI 14.32rCSI 31.52%PRS 27.9
-
CSI 13.58rCSI 35.4%PRS 39.5
-
CSI 12.73rCSI 11.15%PRS 49.84
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CSI 12.27rCSI 19.58%PRS 34.94
-
CSI 12rCSI 18.1%PRS 42.11
-
CSI 11.83rCSI 44.63%PRS 35.53
-
CSI 11.79rCSI 26.04%PRS 30.03
-
CSI 11.7rCSI 11.26%PRS 41.08
-
CSI 11.6rCSI 30.77%PRS 53.87
-
CSI 11.43rCSI 42.83%PRS 34.46
-
CSI 11.4rCSI 15.84%PRS 40.15
-
CSI 11.36rCSI 22.8%PRS 31.28
-
CSI 11.03rCSI 8.72%PRS 29.33
-
CSI 11rCSI 17.83%PRS 39.23
-
CSI 10.8rCSI 23.79%PRS 54.94
-
CSI 10.77rCSI 9.81%PRS 54.91
-
CSI 10.72rCSI 13.76%PRS 36.83
-
CSI 10.64rCSI 7.88%PRS 34.79
-
CSI 10.57rCSI 59.14%PRS 53.86
-
CSI 10.56rCSI 16.86%PRS 43.76
-
CSI 10.48rCSI 55.12%PRS 38.97
-
CSI 10.47rCSI 61.63%PRS 27.6
-
CSI 10.26rCSI 14.02%PRS 43.13
-
CSI 10.16rCSI 24.82%PRS 37.1
-
CSI 10.01rCSI 22.81%PRS 39.42
-
CSI 10rCSI 32.86%PRS 30.26
-
CSI 9.85rCSI 13.97%PRS 37.76
-
CSI 9.69rCSI 17%PRS 33.53
-
CSI 9.67rCSI 9.65%PRS 35.18
-
CSI 9.24rCSI 11.86%PRS 38.57
-
CSI 9.19rCSI 37.43%PRS 38.75
-
CSI 9.01rCSI 20.8%PRS 33.23
-
CSI 8.96rCSI 18.41%PRS 36.12
-
CSI 8.91rCSI 16.19%PRS 34.85
-
CSI 8.88rCSI 14.29%PRS 32.15
-
CSI 8.87rCSI 14.1%PRS 34.41
-
CSI 8.72rCSI 19.95%PRS 39.91
-
CSI 8.44rCSI 62%PRS 29.56
-
CSI 8.3rCSI 12.2%PRS 37.1
-
CSI 8.11rCSI 25.94%PRS 37.62
-
CSI 8.08rCSI 31.23%PRS 59.48
-
CSI 7.97rCSI 7.42%PRS 40.32
-
CSI 7.84rCSI 10.69%PRS 34.75
-
CSI 7.66rCSI 16.86%PRS 44.2
-
CSI 7.58rCSI 42.85%PRS 28.07
-
CSI 7.56rCSI 18.72%PRS 38.62
-
CSI 7.51rCSI 12.37%PRS 45.69
-
CSI 7.42rCSI 11.31%PRS 37.46
-
CSI 7.37rCSI 12.99%PRS 39.32
-
CSI 7.26rCSI 20.01%PRS 37.61
-
CSI 7.22rCSI 11.03%PRS 41
-
CSI 6.95rCSI 7.61%PRS 44.23
-
CSI 6.92rCSI 33.13%PRS 38.87
-
CSI 6.9rCSI 7.04%PRS 52.83
-
CSI 6.69rCSI 12.53%PRS 31.27
-
CSI 6.68rCSI 22.14%PRS 41.71
-
CSI 6.57rCSI 37.9%PRS 43.15
-
CSI 6.56rCSI 8.77%PRS 42.16
-
CSI 6.54rCSI 8.13%PRS 43.01
-
CSI 6.49rCSI 5.38%PRS 41.3
-
CSI 6.33rCSI 18%PRS 40.64
-
CSI 6.24rCSI 11.21%PRS 34.56
-
CSI 6.14rCSI 40.78%PRS 39.57
-
CSI 6.14rCSI 9.39%PRS 44.82
-
CSI 6.13rCSI 15.85%PRS 37.01
-
CSI 6.07rCSI 4.7%PRS 40.64
-
CSI 5.96rCSI 15.74%PRS 47.49
-
CSI 5.96rCSI 29.61%PRS 40.68
-
CSI 5.89rCSI 9.13%PRS 50.61
-
CSI 0.3rCSI 0.6%PRS 42.3%
-
CSI 0.6rCSI 3.1%PRS 63.7%
-
CSI 0.7rCSI 1.7%PRS 37.2%
-
CSI 0.8rCSI 2.8%PRS 53.8%
-
CSI 1.1rCSI 4.2%PRS 43.6%
-
CSI 1.1rCSI 3.7%PRS 50.7%
-
CSI 1.1rCSI 6.9%PRS 63.4%
-
CSI 1.1rCSI 2.1%PRS 60.5%
-
CSI 1.2rCSI 1.4%PRS 38.7%
-
CSI 1.3rCSI 8.0%PRS 33.7%
-
CSI 1.4rCSI 2.5%PRS 56.3%
-
CSI 1.5rCSI 6.4%PRS 38.1%
-
CSI 1.5rCSI 1.8%PRS 36.6%
-
CSI 1.5rCSI 3.4%PRS 59.0%
-
CSI 1.5rCSI 12.0%PRS 35.9%
-
CSI 1.5rCSI 4.3%PRS 58.0%
-
CSI 1.5rCSI 15.8%PRS 42.5%
-
CSI 1.5rCSI 6.2%PRS 52.4%
-
CSI 1.5rCSI 6.0%PRS 60.2%
-
CSI 1.6rCSI 4.6%PRS 41.7%
-
CSI 1.6rCSI 5.3%PRS 40.0%
-
CSI 1.7rCSI 4.0%PRS 50.8%
-
CSI 1.8rCSI 2.2%PRS 59.2%
-
CSI 1.8rCSI 3.6%PRS 40.2%
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CSI 1.9rCSI 1.4%PRS 39.0%
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CSI 1.9rCSI 29.6%PRS 43.8%
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CSI 1.9rCSI 3.6%PRS 50.0%
-
CSI 1.9rCSI 10.6%PRS 64.9%
-
CSI 1.9rCSI 22.2%PRS 36.0%
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CSI 2.0rCSI 5.7%PRS 32.8%
-
CSI 2.1rCSI 9.2%PRS 35.0%
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CSI 2.2rCSI 13.8%PRS 59.9%
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CSI 2.3rCSI 16.0%PRS 35.7%
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CSI 2.3rCSI 21.0%PRS 60.3%
-
CSI 2.3rCSI 19.2%PRS 37.3%
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CSI 2.3rCSI 3.0%PRS 45.0%
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CSI 2.3rCSI 33.2%PRS 33.7%
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CSI 2.4rCSI 3.5%PRS 45.1%
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CSI 2.4rCSI 5.3%PRS 37.8%
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CSI 2.7rCSI 17.3%PRS 47.6%
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CSI 2.7rCSI 55.1%PRS 35.1%
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CSI 2.8rCSI 12.3%PRS 39.0%
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CSI 2.8rCSI 14.5%PRS 50.0%
-
CSI 2.8rCSI 12.3%PRS 28.0%
-
CSI 2.8rCSI 13.2%PRS 60.4%
-
CSI 2.9rCSI 2.8%PRS 42.7%
-
CSI 2.9rCSI 70.1%PRS 26.7%
-
CSI 2.9rCSI 70.3%PRS 25.8%
-
CSI 3.1rCSI 62.0%PRS 33.8%
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CSI 3.1rCSI 9.7%PRS 52.6%
-
CSI 3.1rCSI 4.5%PRS 32.8%
-
CSI 3.2rCSI 2.2%PRS 48.4%
-
CSI 3.2rCSI 7.7%PRS 46.2%
-
CSI 3.3rCSI 8.3%PRS 48.3%
-
CSI 3.3rCSI 2.6%PRS 46.5%
-
CSI 3.3rCSI 15.6%PRS 38.9%
-
CSI 3.3rCSI 8.7%PRS 40.4%
-
CSI 3.4rCSI 24.5%PRS 37.0%
-
CSI 3.4rCSI 8.3%PRS 57.7%
-
CSI 3.5rCSI 15.4%PRS 65.6%
-
CSI 3.6rCSI 13.8%PRS 35.0%
-
CSI 3.6rCSI 4.5%PRS 51.4%
-
CSI 3.7rCSI 8.1%PRS 50.3%
-
CSI 3.7rCSI 15.8%PRS 38.6%
-
CSI 3.8rCSI 18.0%PRS 42.4%
-
CSI 3.8rCSI 14.8%PRS 19.1%
-
CSI 3.8rCSI 6.7%PRS 48.7%
-
CSI 3.8rCSI 5.2%PRS 53.0%
-
CSI 3.9rCSI 10.4%PRS 49.2%
-
CSI 4.0rCSI 6.1%PRS 49.1%
-
CSI 4.0rCSI 18.8%PRS 66.9%
-
CSI 4.1rCSI 35.9%PRS 29.9%
-
CSI 4.1rCSI 20.1%PRS 51.6%
-
CSI 4.2rCSI 4.8%PRS 63.6%
-
CSI 4.2rCSI 12.4%PRS 51.9%
-
CSI 4.3rCSI 9.1%PRS 61.6%
-
CSI 4.3rCSI 11.5%PRS 34.2%
-
CSI 4.3rCSI 32.3%PRS 37.1%
-
CSI 4.3rCSI 4.5%PRS 42.9%
-
CSI 4.4rCSI 18.2%PRS 41.8%
-
CSI 4.5rCSI 10.7%PRS 43.0%
-
CSI 4.5rCSI 11.7%PRS 45.9%
-
CSI 4.6rCSI 39.7%PRS 43.0%
-
CSI 4.8rCSI 4.9%PRS 46.1%
-
CSI 4.8rCSI 16.0%PRS 30.2%
-
CSI 4.8rCSI 19.3%PRS 39.1%
-
CSI 4.9rCSI 11.2%PRS 34.7%
-
CSI 4.9rCSI 19.7%PRS 52.0%
-
CSI 4.9rCSI 42.3%PRS 28.9%
-
CSI 5.0rCSI 27.4%PRS 44.7%
-
CSI 5.1rCSI 16.2%PRS 48.6%
-
CSI 5.1rCSI 39.3%PRS 38.8%
-
CSI 5.1rCSI 17.4%PRS 33.4%
-
CSI 5.1rCSI 6.4%PRS 49.6%
-
CSI 5.1rCSI 30.3%PRS 39.0%
-
CSI 5.3rCSI 4.8%PRS 37.2%
-
CSI 5.4rCSI 36.6%PRS 38.6%
-
CSI 5.4rCSI 13.7%PRS 32.0%
-
CSI 5.4rCSI 4.2%PRS 56.5%
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CSI 5.5rCSI 9.8%PRS 39.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3214289378
Symbol: RFX3_HUMAN
Name: Transcription factor RFX3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8289803
Title: RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.
PubMed ID: 8289803
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10330134
Title: Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.
PubMed ID: 10330134
PubMed ID: 12411430
Title: Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter.
PubMed ID: 12411430
PubMed ID: 20148032
Title: Rfx6 directs islet formation and insulin production in mice and humans.
PubMed ID: 20148032
DOI: 10.1038/nature08748
Sequence Information:
- Length: 749
- Mass: 83530
- Checksum: 531F5CFCA7A707C7
- Sequence:
MQTSETGSDT GSTVTLQTSV ASQAAVPTQV VQQVPVQQQV QQVQTVQQVQ HVYPAQVQYV EGSDTVYTNG AIRTTTYPYT ETQMYSQNTG GNYFDTQGSS AQVTTVVSSH SMVGTGGIQM GVTGGQLISS SGGTYLIGNS MENSGHSVTH TTRASPATIE MAIETLQKSD GLSTHRSSLL NSHLQWLLDN YETAEGVSLP RSTLYNHYLR HCQEHKLDPV NAASFGKLIR SIFMGLRTRR LGTRGNSKYH YYGIRVKPDS PLNRLQEDMQ YMAMRQQPMQ QKQRYKPMQK VDGVADGFTG SGQQTGTSVE QTVIAQSQHH QQFLDASRAL PEFGEVEISS LPDGTTFEDI KSLQSLYREH CEAILDVVVN LQFSLIEKLW QTFWRYSPST PTDGTTITES SNLSEIESRL PKAKLITLCK HESILKWMCN CDHGMYQALV EILIPDVLRP IPSALTQAIR NFAKSLEGWL SNAMNNIPQR MIQTKVAAVS AFAQTLRRYT SLNHLAQAAR AVLQNTSQIN QMLSDLNRVD FANVQEQASW VCQCDDNMVQ RLETDFKMTL QQQSTLEQWA AWLDNVMMQA LKPYEGRPSF PKAARQFLLK WSFYSSMVIR DLTLRSAASF GSFHLIRLLY DEYMFYLVEH RVAQATGETP IAVMGEFGDL NAVSPGNLDK DEGSEVESEM DEELDDSSEP QAKREKTELS QAFPVGCMQP VLETGVQPSL LNPIHSEHIV TSTQTIRQCS ATGNTYTAV