Details for: RNF5

Gene ID: 6048

Symbol: RNF5

Ensembl ID: ENSG00000204308

Description: ring finger protein 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 114.8219
    Cell Significance Index: -17.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 111.0812
    Cell Significance Index: -28.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.1034
    Cell Significance Index: -39.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 82.9155
    Cell Significance Index: -33.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 70.4142
    Cell Significance Index: -36.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.2053
    Cell Significance Index: -32.3100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.3638
    Cell Significance Index: -36.9500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 7.2886
    Cell Significance Index: 181.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.2606
    Cell Significance Index: -19.4500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.7232
    Cell Significance Index: -20.6500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.3097
    Cell Significance Index: 34.4100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.2258
    Cell Significance Index: -7.0600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.3429
    Cell Significance Index: 19.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6635
    Cell Significance Index: 34.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4515
    Cell Significance Index: 15.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.4132
    Cell Significance Index: 37.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1275
    Cell Significance Index: 30.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0308
    Cell Significance Index: 35.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9341
    Cell Significance Index: 69.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7829
    Cell Significance Index: 96.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7403
    Cell Significance Index: 101.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7376
    Cell Significance Index: 15.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7297
    Cell Significance Index: 131.5400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7228
    Cell Significance Index: 10.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7123
    Cell Significance Index: 37.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6439
    Cell Significance Index: 40.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6093
    Cell Significance Index: 78.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6035
    Cell Significance Index: 329.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5698
    Cell Significance Index: 73.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5589
    Cell Significance Index: 247.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5411
    Cell Significance Index: 25.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5164
    Cell Significance Index: 84.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4886
    Cell Significance Index: 31.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4838
    Cell Significance Index: 57.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4824
    Cell Significance Index: 5.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4437
    Cell Significance Index: 23.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4432
    Cell Significance Index: 20.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4134
    Cell Significance Index: 29.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3711
    Cell Significance Index: 40.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3569
    Cell Significance Index: 11.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3444
    Cell Significance Index: 10.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3323
    Cell Significance Index: 3.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3268
    Cell Significance Index: 9.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2835
    Cell Significance Index: 56.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2482
    Cell Significance Index: 24.5500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2245
    Cell Significance Index: 2.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1406
    Cell Significance Index: 26.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1318
    Cell Significance Index: 5.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0371
    Cell Significance Index: 28.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0340
    Cell Significance Index: 1.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0194
    Cell Significance Index: 3.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0188
    Cell Significance Index: 13.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0137
    Cell Significance Index: 0.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0048
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0056
    Cell Significance Index: -0.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0128
    Cell Significance Index: -24.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0157
    Cell Significance Index: -1.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0213
    Cell Significance Index: -7.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0235
    Cell Significance Index: -43.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0286
    Cell Significance Index: -0.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0289
    Cell Significance Index: -44.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0346
    Cell Significance Index: -47.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0383
    Cell Significance Index: -1.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0444
    Cell Significance Index: -28.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0455
    Cell Significance Index: -33.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0502
    Cell Significance Index: -1.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0548
    Cell Significance Index: -2.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0556
    Cell Significance Index: -31.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0559
    Cell Significance Index: -6.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0756
    Cell Significance Index: -34.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0870
    Cell Significance Index: -54.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1246
    Cell Significance Index: -1.4900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1317
    Cell Significance Index: -2.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1372
    Cell Significance Index: -39.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1596
    Cell Significance Index: -4.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1966
    Cell Significance Index: -22.9100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2062
    Cell Significance Index: -2.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2100
    Cell Significance Index: -30.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2200
    Cell Significance Index: -46.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2445
    Cell Significance Index: -7.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2564
    Cell Significance Index: -20.3100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3086
    Cell Significance Index: -4.3900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3293
    Cell Significance Index: -5.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3428
    Cell Significance Index: -7.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3695
    Cell Significance Index: -7.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3702
    Cell Significance Index: -38.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3806
    Cell Significance Index: -11.2100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.4086
    Cell Significance Index: -2.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4311
    Cell Significance Index: -24.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4529
    Cell Significance Index: -34.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4823
    Cell Significance Index: -6.5800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.4851
    Cell Significance Index: -6.8000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.6148
    Cell Significance Index: -4.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6283
    Cell Significance Index: -38.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6337
    Cell Significance Index: -33.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6377
    Cell Significance Index: -15.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7077
    Cell Significance Index: -18.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7790
    Cell Significance Index: -13.3500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.7848
    Cell Significance Index: -13.2000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.7907
    Cell Significance Index: -4.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ubiquitin Ligase Activity:** RNF5 possesses E3 ubiquitin ligase activity, which enables it to recognize and tag specific proteins for degradation through the ubiquitin-proteasome pathway. 2. **ER Stress Response:** RNF5 is involved in the regulation of ER stress, a condition characterized by the accumulation of misfolded proteins in the ER. RNF5 helps to mitigate ER stress by promoting the degradation of aberrant proteins. 3. **Autophagy Regulation:** RNF5 regulates autophagy, a cellular process that degrades damaged organelles and proteins. Dysregulation of autophagy has been implicated in various diseases, including cancer and neurodegenerative disorders. 4. **Immune Response:** RNF5 is expressed in various immune cells, including myeloid dendritic cells and CD14-low, CD16-positive monocytes. Its expression is associated with the regulation of immune responses, particularly in the context of bacterial infections. **Pathways and Functions:** 1. **Protein Quality Control:** RNF5 mediates the degradation of misfolded or aberrant proteins through the ubiquitin-proteasome pathway, thereby maintaining protein homeostasis. 2. **ER Stress Response:** RNF5 regulates ER stress by promoting the degradation of aberrant proteins, thereby preventing ER stress-induced apoptosis. 3. **Autophagy Regulation:** RNF5 regulates autophagy by modulating the activity of key autophagy-related proteins. 4. **Immune Response:** RNF5 is involved in the regulation of immune responses, particularly in the context of bacterial infections. Its expression is associated with the regulation of cytokine production and the activation of immune cells. **Clinical Significance:** 1. **Diseases Associated with RNF5 Dysfunction:** Dysregulation of RNF5 has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. 2. **Therapeutic Targeting:** RNF5 may serve as a therapeutic target for the treatment of diseases associated with protein quality control and immune dysfunction. 3. **Immunotherapeutic Applications:** RNF5's role in regulating immune responses makes it an attractive target for immunotherapeutic interventions, particularly in the context of bacterial infections. In conclusion, RNF5 plays a critical role in regulating protein quality control, ER stress, and immune response. Its dysregulation has been implicated in various diseases, and its therapeutic potential makes it an attractive target for future research.

Genular Protein ID: 3077078227

Symbol: RNF5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99942 A2BFI6 B2R4K3 Q0VDB7 Q9UMQ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 19 Ensembl 7 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9533025

Title: Cloning, expression and mapping of a novel RING-finger gene (RNF5), a human homologue of a putative zinc-finger gene from Caenorhabditis elegans.

PubMed ID: 9533025

DOI: 10.1159/000134695

PubMed ID: 11329381

Title: Rma1, a novel type of RING finger protein conserved from Arabidopsis to human, is a membrane-bound ubiquitin ligase.

PubMed ID: 11329381

DOI: 10.1242/jcs.114.10.1949

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12861019

Title: RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization.

PubMed ID: 12861019

DOI: 10.1128/mcb.23.15.5331-5345.2003

PubMed ID: 16176924

Title: Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1.

PubMed ID: 16176924

DOI: 10.1074/jbc.m506309200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19285439

Title: The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA.

PubMed ID: 19285439

DOI: 10.1016/j.immuni.2009.01.008

PubMed ID: 19269966

Title: Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP).

PubMed ID: 19269966

DOI: 10.1074/jbc.m808222200

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23093945

Title: Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection.

PubMed ID: 23093945

DOI: 10.1371/journal.pgen.1003007

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25489052

Title: Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.

PubMed ID: 25489052

DOI: 10.1093/hmg/ddu611

Sequence Information:

  • Length: 180
  • Mass: 19881
  • Checksum: E5AFA4DE6DE85942
  • Sequence:
    • MAAAEEEDGG PEGPNRERGG AGATFECNIC LETAREAVVS VCGHLYCWPC LHQWLETRPE 
RQECPVCKAG ISREKVVPLY GRGSQKPQDP RLKTPPRPQG QRPAPESRGG FQPFGDTGGF 
HFSFGVGAFP FGFFTTVFNA HEPFRRGTGV DLGQGHPASS WQDSLFLFLA IFFFFWLLSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.