Details for: RNF6

Gene ID: 6049

Symbol: RNF6

Ensembl ID: ENSG00000127870

Description: ring finger protein 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 114.9183
    Cell Significance Index: -17.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 75.1449
    Cell Significance Index: -19.0600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 48.8654
    Cell Significance Index: -20.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.6269
    Cell Significance Index: -18.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 40.1644
    Cell Significance Index: -20.6600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.9789
    Cell Significance Index: -18.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.7686
    Cell Significance Index: -20.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.5214
    Cell Significance Index: -17.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.3877
    Cell Significance Index: -21.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.8609
    Cell Significance Index: -14.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.8757
    Cell Significance Index: 50.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5951
    Cell Significance Index: 185.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2120
    Cell Significance Index: 76.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1132
    Cell Significance Index: 66.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0343
    Cell Significance Index: 112.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9858
    Cell Significance Index: 13.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8404
    Cell Significance Index: 136.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7030
    Cell Significance Index: 8.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4525
    Cell Significance Index: 90.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4520
    Cell Significance Index: 23.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4390
    Cell Significance Index: 53.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3762
    Cell Significance Index: 10.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3714
    Cell Significance Index: 36.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3695
    Cell Significance Index: 201.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3612
    Cell Significance Index: 65.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3466
    Cell Significance Index: 9.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3138
    Cell Significance Index: 8.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2865
    Cell Significance Index: 126.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2647
    Cell Significance Index: 17.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2618
    Cell Significance Index: 30.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2477
    Cell Significance Index: 88.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2319
    Cell Significance Index: 10.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2050
    Cell Significance Index: 9.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1984
    Cell Significance Index: 37.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1900
    Cell Significance Index: 8.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1727
    Cell Significance Index: 23.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1718
    Cell Significance Index: 12.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1455
    Cell Significance Index: 28.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1356
    Cell Significance Index: 15.5300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1285
    Cell Significance Index: 1.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1073
    Cell Significance Index: 18.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0800
    Cell Significance Index: 10.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0800
    Cell Significance Index: 5.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0776
    Cell Significance Index: 4.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0370
    Cell Significance Index: 4.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0277
    Cell Significance Index: 0.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0134
    Cell Significance Index: 1.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0037
    Cell Significance Index: 0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0012
    Cell Significance Index: -0.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -3.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0074
    Cell Significance Index: -4.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0086
    Cell Significance Index: -15.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0103
    Cell Significance Index: -15.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0108
    Cell Significance Index: -8.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0127
    Cell Significance Index: -17.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0152
    Cell Significance Index: -8.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0157
    Cell Significance Index: -9.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0232
    Cell Significance Index: -16.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0276
    Cell Significance Index: -12.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0423
    Cell Significance Index: -4.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0423
    Cell Significance Index: -8.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0497
    Cell Significance Index: -7.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0552
    Cell Significance Index: -15.8700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0563
    Cell Significance Index: -0.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0684
    Cell Significance Index: -2.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0790
    Cell Significance Index: -5.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0886
    Cell Significance Index: -4.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0979
    Cell Significance Index: -6.0200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1091
    Cell Significance Index: -0.8900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1126
    Cell Significance Index: -1.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1152
    Cell Significance Index: -2.3900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1217
    Cell Significance Index: -13.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1252
    Cell Significance Index: -3.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1485
    Cell Significance Index: -6.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1488
    Cell Significance Index: -7.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1509
    Cell Significance Index: -2.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1602
    Cell Significance Index: -3.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1613
    Cell Significance Index: -4.6300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1675
    Cell Significance Index: -3.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1762
    Cell Significance Index: -3.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1831
    Cell Significance Index: -4.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1854
    Cell Significance Index: -7.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1888
    Cell Significance Index: -3.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1936
    Cell Significance Index: -15.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2002
    Cell Significance Index: -20.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2187
    Cell Significance Index: -13.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2250
    Cell Significance Index: -6.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2389
    Cell Significance Index: -8.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2582
    Cell Significance Index: -8.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2816
    Cell Significance Index: -7.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2988
    Cell Significance Index: -7.6800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3497
    Cell Significance Index: -3.6200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3513
    Cell Significance Index: -4.9300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3530
    Cell Significance Index: -5.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3535
    Cell Significance Index: -17.8600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3710
    Cell Significance Index: -7.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3973
    Cell Significance Index: -10.1500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4081
    Cell Significance Index: -14.9800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4205
    Cell Significance Index: -10.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNF6 is a member of the ring finger protein family, characterized by its unique protein-protein interaction domain. Its ability to recognize and ubiquitinate specific substrates is crucial for regulating protein turnover, localization, and activity. Notably, RNF6 is involved in the ubiquitination of numerous targets, including proteins involved in immune response, cell signaling, and transcriptional regulation. **Pathways and Functions:** RNF6 participates in several key pathways, including: 1. **Adaptive Immune System:** RNF6 regulates the ubiquitination of key immune proteins, such as MHC class I and II molecules, influencing antigen presentation and immune response. 2. **Antigen Processing: Ubiquitination & Proteasome Degradation:** RNF6 is involved in the ubiquitination of proteins destined for proteasomal degradation, ensuring efficient antigen processing and presentation. 3. **Axon Extension and Negative Regulation:** RNF6 negatively regulates axon extension, suggesting its role in controlling neuronal development and plasticity. 4. **DNA-templated Transcription:** RNF6 modulates transcriptional regulation by ubiquitinating transcriptional regulators, influencing gene expression. 5. **Androgen Receptor Signaling Pathway:** RNF6 regulates the ubiquitination of androgen receptor substrates, impacting androgen-mediated gene expression. **Significance in Different Cell Types:** RNF6 is expressed in various cell types, including: 1. **Oogonial Cells:** RNF6 plays a crucial role in oogenesis, influencing the regulation of gene expression and protein turnover. 2. **Ciliated Cells:** RNF6 is involved in the regulation of cilia function and motility. 3. **Cardiac Endothelial Cells:** RNF6 modulates endothelial cell function, including angiogenesis and vascular tone regulation. 4. **Kidney Proximal Straight Tubule Epithelial Cells:** RNF6 regulates ion transport and reabsorption in the kidney. **Clinical Significance:** Dysregulation of RNF6 has been implicated in various disease states, including: 1. **Autoimmune Diseases:** RNF6 dysfunction contributes to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** RNF6 is involved in cancer progression, including tumor cell growth, invasion, and metastasis. 3. **Neurological Disorders:** RNF6 dysregulation is linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. In conclusion, RNF6 is a multifaceted protein with far-reaching implications in immune regulation, antigen processing, and transcriptional control. Further research is necessary to elucidate the complexities of RNF6 function and its role in disease states, ultimately informing the development of novel therapeutic strategies.

Genular Protein ID: 2028909846

Symbol: RNF6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y252 B4DDP0 Q5W0H0 Q9BZP5 Q9UF41

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10331950

Title: Cloning and characterization of RNF6, a novel RING finger gene mapping to 13q12.

PubMed ID: 10331950

DOI: 10.1006/geno.1999.5802

PubMed ID: 18368307

Title: Cloning and identification of a novel RNF6 transcriptional splice variant Spg2 in human development.

PubMed ID: 18368307

DOI: 10.1007/s11427-008-0047-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 19345326

Title: Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination.

PubMed ID: 19345326

DOI: 10.1016/j.ccr.2009.02.021

PubMed ID: 12154016

Title: Identification of somatic mutations of the RNF6 gene in human esophageal squamous cell carcinoma.

PubMed ID: 12154016

Sequence Information:

  • Length: 685
  • Mass: 78091
  • Checksum: 344584773F2E5EFC
  • Sequence:
    • MNQSRSRSDG GSEETLPQDH NHHENERRWQ QERLHREEAY YQFINELNDE DYRLMRDHNL 
LGTPGEITSE ELQQRLDGVK EQLASQPDLR DGTNYRDSEV PRESSHEDSL LEWLNTFRRT 
GNATRSGQNG NQTWRAVSRT NPNNGEFRFS LEIHVNHENR GFEIHGEDYT DIPLSDSNRD 
HTANRQQRST SPVARRTRSQ TSVNFNGSSS NIPRTRLASR GQNPAEGSFS TLGRLRNGIG 
GAAGIPRANA SRTNFSSHTN QSGGSELRQR EGQRFGAAHV WENGARSNVT VRNTNQRLEP 
IRLRSTSNSR SRSPIQRQSG TVYHNSQRES RPVQQTTRRS VRRRGRTRVF LEQDRERERR 
GTAYTPFSNS RLVSRITVEE GEESSRSSTA VRRHPTITLD LQVRRIRPGE NRDRDSIANR 
TRSRVGLAEN TVTIESNSGG FRRTISRLER SGIRTYVSTI TVPLRRISEN ELVEPSSVAL 
RSILRQIMTG FGELSSLMEA DSESELQRNG QHLPDMHSEL SNLGTDNNRS QHREGSSQDR 
QAQGDSTEMH GENETTQPHT RNSDSRGGRQ LRNPNNLVET GTLPILRLAH FFLLNESDDD 
DRIRGLTKEQ IDNLSTRHYE HNSIDSELGK ICSVCISDYV TGNKLRQLPC MHEFHIHCID 
RWLSENCTCP ICRQPVLGSN IANNG

Genular Protein ID: 3996463322

Symbol: A0A0S2Z4G9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4G9

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 IntAct 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RefSeq 3 SAM 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 176
  • Mass: 20721
  • Checksum: B58F5B57CB906134
  • Sequence:
    • MNQSRSRSDG GSEETLPQDH NHHENERRWQ QERLHREEAY YQFINELNDE DYRLMRDHNL 
LGTPGEITSE ELQQRLDGVK EQLASQPDLR DGTNYRDSEV PRESSHEDSL LEWLNTFRRT 
GNATRSGQNG NQTWRAACVK NNSRRRRRIQ QILNCCTTTS NNHTGPSSEK DPSWRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.