Details for: RNPEP

Gene ID: 6051

Symbol: RNPEP

Ensembl ID: ENSG00000176393

Description: arginyl aminopeptidase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 100.8108
    Cell Significance Index: -25.5700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 66.4648
    Cell Significance Index: -27.3800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 62.9158
    Cell Significance Index: -25.5600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.0435
    Cell Significance Index: -28.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 54.4922
    Cell Significance Index: -28.0300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 42.8898
    Cell Significance Index: -28.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.7507
    Cell Significance Index: -25.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.1297
    Cell Significance Index: -27.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.1755
    Cell Significance Index: -24.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0197
    Cell Significance Index: -27.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.5376
    Cell Significance Index: -20.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.4053
    Cell Significance Index: -11.8300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.4466
    Cell Significance Index: 55.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.4501
    Cell Significance Index: 147.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.1550
    Cell Significance Index: 234.4000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.8422
    Cell Significance Index: 13.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4659
    Cell Significance Index: 20.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2015
    Cell Significance Index: 56.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1685
    Cell Significance Index: 31.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9412
    Cell Significance Index: 48.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9137
    Cell Significance Index: 63.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8963
    Cell Significance Index: 177.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8309
    Cell Significance Index: 23.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8293
    Cell Significance Index: 452.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7798
    Cell Significance Index: 21.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6452
    Cell Significance Index: 104.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5748
    Cell Significance Index: 103.6100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5724
    Cell Significance Index: 10.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5130
    Cell Significance Index: 102.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4633
    Cell Significance Index: 63.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4368
    Cell Significance Index: 15.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4285
    Cell Significance Index: 386.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4182
    Cell Significance Index: 31.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4168
    Cell Significance Index: 184.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4091
    Cell Significance Index: 50.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3795
    Cell Significance Index: 9.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3409
    Cell Significance Index: 15.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3396
    Cell Significance Index: 9.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3240
    Cell Significance Index: 55.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2987
    Cell Significance Index: 19.2700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2533
    Cell Significance Index: 3.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2479
    Cell Significance Index: 88.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2292
    Cell Significance Index: 16.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2021
    Cell Significance Index: 19.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1989
    Cell Significance Index: 6.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1811
    Cell Significance Index: 8.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1761
    Cell Significance Index: 33.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1568
    Cell Significance Index: 3.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1562
    Cell Significance Index: 20.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1106
    Cell Significance Index: 14.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0916
    Cell Significance Index: 3.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0728
    Cell Significance Index: 0.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0450
    Cell Significance Index: 5.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0278
    Cell Significance Index: 51.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0263
    Cell Significance Index: 40.4700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0238
    Cell Significance Index: 0.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0215
    Cell Significance Index: 40.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0159
    Cell Significance Index: 10.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0099
    Cell Significance Index: 7.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0024
    Cell Significance Index: 0.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0016
    Cell Significance Index: 2.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0020
    Cell Significance Index: -1.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0141
    Cell Significance Index: -1.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0153
    Cell Significance Index: -11.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0191
    Cell Significance Index: -11.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0235
    Cell Significance Index: -17.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0258
    Cell Significance Index: -1.4500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0270
    Cell Significance Index: -0.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0275
    Cell Significance Index: -12.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0287
    Cell Significance Index: -0.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0323
    Cell Significance Index: -18.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0454
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0745
    Cell Significance Index: -15.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0758
    Cell Significance Index: -3.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0764
    Cell Significance Index: -21.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0934
    Cell Significance Index: -10.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0942
    Cell Significance Index: -6.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1092
    Cell Significance Index: -15.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1164
    Cell Significance Index: -13.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1183
    Cell Significance Index: -3.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1263
    Cell Significance Index: -7.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1327
    Cell Significance Index: -3.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1436
    Cell Significance Index: -3.1100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.1487
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1495
    Cell Significance Index: -17.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1760
    Cell Significance Index: -5.1700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2274
    Cell Significance Index: -1.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2436
    Cell Significance Index: -25.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2521
    Cell Significance Index: -11.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2699
    Cell Significance Index: -14.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2978
    Cell Significance Index: -18.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3113
    Cell Significance Index: -11.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3186
    Cell Significance Index: -25.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3698
    Cell Significance Index: -10.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3898
    Cell Significance Index: -6.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4236
    Cell Significance Index: -10.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4373
    Cell Significance Index: -12.8800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4388
    Cell Significance Index: -6.1600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4570
    Cell Significance Index: -8.9200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4599
    Cell Significance Index: -5.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RNPEP is a metalloexopeptidase enzyme, which means it requires a metal ion (zinc) to facilitate its catalytic activity. This unique characteristic allows it to hydrolyze peptide bonds at the amino-terminal end, resulting in the release of amino acids and peptides. RNPEP is also a member of the aminopeptidase family, which includes a range of enzymes that share similar catalytic mechanisms. The enzyme's substrate specificity is broad, allowing it to hydrolyze a variety of peptides and proteins. **Pathways and Functions** RNPEP is involved in multiple cellular pathways, including: 1. **Proteolysis**: RNPEP plays a crucial role in the regulation of protein degradation, which is essential for maintaining cellular homeostasis. By hydrolyzing peptide bonds, RNPEP can regulate the levels of various proteins, including growth factors, hormones, and signaling molecules. 2. **Extracellular Matrix Remodeling**: RNPEP has been shown to regulate the degradation of extracellular matrix proteins, which is essential for tissue remodeling and repair. 3. **Immune Response**: RNPEP has been implicated in the regulation of immune responses, particularly in the context of inflammation. The enzyme can hydrolyze peptides derived from pathogens, thereby regulating the immune response. 4. **Cell Signaling**: RNPEP has been shown to regulate cell signaling pathways, including the regulation of growth factor receptors and signaling molecules. **Clinical Significance** The dysregulation of RNPEP has been implicated in various diseases, including: 1. **Cancer**: Overexpression of RNPEP has been observed in various types of cancer, including lung, breast, and colon cancer. The enzyme's role in regulating protein degradation and cell signaling pathways makes it a potential target for cancer therapy. 2. **Inflammatory Disorders**: RNPEP has been implicated in the regulation of immune responses, particularly in the context of inflammatory disorders such as arthritis and asthma. 3. **Neurological Disorders**: RNPEP has been shown to regulate the degradation of proteins involved in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, RNPEP is a multifaceted peptidase enzyme that plays a crucial role in various cellular processes. Its involvement in proteolysis, extracellular matrix remodeling, immune response, and cell signaling pathways highlights the importance of this enzyme in maintaining cellular homeostasis. Further research is needed to fully understand the role of RNPEP in disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2819351902

Symbol: AMPB_HUMAN

Name: Aminopeptidase B

UniProtKB Accession Codes:

Q9H4A4 Q9BVM9 Q9H1D4 Q9NPT7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 6 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 650
  • Mass: 72596
  • Checksum: 4C04FE09689F2487
  • Sequence:
    • MASGEHSPGS GAARRPLHSA QAVDVASASN FRAFELLHLH LDLRAEFGPP GPGAGSRGLS 
GTAVLDLRCL EPEGAAELRL DSHPCLEVTA AALRRERPGS EEPPAEPVSF YTQPFSHYGQ 
ALCVSFPQPC RAAERLQVLL TYRVGEGPGV CWLAPEQTAG KKKPFVYTQG QAVLNRAFFP 
CFDTPAVKYK YSALIEVPDG FTAVMSASTW EKRGPNKFFF QMCQPIPSYL IALAIGDLVS 
AEVGPRSRVW AEPCLIDAAK EEYNGVIEEF LATGEKLFGP YVWGRYDLLF MPPSFPFGGM 
ENPCLTFVTP CLLAGDRSLA DVIIHEISHS WFGNLVTNAN WGEFWLNEGF TMYAQRRIST 
ILFGAAYTCL EAATGRALLR QHMDITGEEN PLNKLRVKIE PGVDPDDTYN ETPYEKGFCF 
VSYLAHLVGD QDQFDSFLKA YVHEFKFRSI LADDFLDFYL EYFPELKKKR VDIIPGFEFD 
RWLNTPGWPP YLPDLSPGDS LMKPAEELAQ LWAAEELDMK AIEAVAISPW KTYQLVYFLD 
KILQKSPLPP GNVKKLGDTY PSISNARNAE LRLRWGQIVL KNDHQEDFWK VKEFLHNQGK 
QKYTLPLYHA MMGGSEVAQT LAKETFASTA SQLHSNVVNY VQQIVAPKGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.