Details for: RPL3L

Gene ID: 6123

Symbol: RPL3L

Ensembl ID: ENSG00000140986

Description: ribosomal protein L3 like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 9.8254
    Cell Significance Index: 125.9900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.6099
    Cell Significance Index: 63.6800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.3954
    Cell Significance Index: 38.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.5623
    Cell Significance Index: 119.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9473
    Cell Significance Index: 24.3500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5734
    Cell Significance Index: 5.2800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.2653
    Cell Significance Index: 3.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1918
    Cell Significance Index: 34.5800
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.1649
    Cell Significance Index: 2.1600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.1594
    Cell Significance Index: 2.0900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.1531
    Cell Significance Index: 2.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1088
    Cell Significance Index: 1.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0856
    Cell Significance Index: 3.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0381
    Cell Significance Index: 7.5700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0210
    Cell Significance Index: 0.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0064
    Cell Significance Index: 4.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0056
    Cell Significance Index: 0.2900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0027
    Cell Significance Index: 0.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0007
    Cell Significance Index: 0.2900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0015
    Cell Significance Index: -0.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0028
    Cell Significance Index: -4.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0039
    Cell Significance Index: -5.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0049
    Cell Significance Index: -3.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0052
    Cell Significance Index: -0.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0060
    Cell Significance Index: -0.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0064
    Cell Significance Index: -0.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0070
    Cell Significance Index: -3.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0076
    Cell Significance Index: -4.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0087
    Cell Significance Index: -2.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0087
    Cell Significance Index: -6.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0088
    Cell Significance Index: -1.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0098
    Cell Significance Index: -0.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0103
    Cell Significance Index: -3.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0118
    Cell Significance Index: -6.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0169
    Cell Significance Index: -2.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0234
    Cell Significance Index: -0.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0252
    Cell Significance Index: -1.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0253
    Cell Significance Index: -0.2900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0290
    Cell Significance Index: -0.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0303
    Cell Significance Index: -4.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0327
    Cell Significance Index: -4.2300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0348
    Cell Significance Index: -0.4100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0357
    Cell Significance Index: -0.3300
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0364
    Cell Significance Index: -0.3600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0369
    Cell Significance Index: -0.7200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0392
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0410
    Cell Significance Index: -4.7000
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0412
    Cell Significance Index: -0.4500
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0416
    Cell Significance Index: -0.4600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0435
    Cell Significance Index: -1.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0438
    Cell Significance Index: -4.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0445
    Cell Significance Index: -1.2100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0446
    Cell Significance Index: -0.3200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0452
    Cell Significance Index: -0.2800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0460
    Cell Significance Index: -0.5000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0496
    Cell Significance Index: -0.5000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0497
    Cell Significance Index: -0.3300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0504
    Cell Significance Index: -0.1900
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0532
    Cell Significance Index: -0.4200
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0539
    Cell Significance Index: -0.5300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0550
    Cell Significance Index: -0.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0570
    Cell Significance Index: -4.2500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0592
    Cell Significance Index: -0.9500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0603
    Cell Significance Index: -0.6300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0646
    Cell Significance Index: -0.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0654
    Cell Significance Index: -4.2200
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0695
    Cell Significance Index: -0.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0715
    Cell Significance Index: -3.3600
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0793
    Cell Significance Index: -0.8200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0800
    Cell Significance Index: -0.4900
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0831
    Cell Significance Index: -0.8900
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0836
    Cell Significance Index: -0.8700
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.0850
    Cell Significance Index: -0.5300
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0868
    Cell Significance Index: -0.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0884
    Cell Significance Index: -4.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0901
    Cell Significance Index: -3.1300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0903
    Cell Significance Index: -0.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0912
    Cell Significance Index: -5.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0945
    Cell Significance Index: -3.3100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0997
    Cell Significance Index: -0.6500
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.0998
    Cell Significance Index: -0.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1002
    Cell Significance Index: -5.2600
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.1024
    Cell Significance Index: -0.9100
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1026
    Cell Significance Index: -0.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1051
    Cell Significance Index: -4.6500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1076
    Cell Significance Index: -2.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1087
    Cell Significance Index: -3.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1105
    Cell Significance Index: -3.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1157
    Cell Significance Index: -3.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1170
    Cell Significance Index: -4.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1244
    Cell Significance Index: -4.3700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1268
    Cell Significance Index: -1.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1321
    Cell Significance Index: -3.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1321
    Cell Significance Index: -4.2300
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1322
    Cell Significance Index: -1.5000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1400
    Cell Significance Index: -1.1900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1435
    Cell Significance Index: -2.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ribosomal protein L3-like**: The RPL3L gene encodes a protein with a high degree of sequence similarity to ribosomal protein L3 (RPL3), a key component of the large ribosomal subunit in eukaryotic cells. 2. **Significant expression in various cell types**: RPL3L is expressed in a wide range of cell types, including cardiac myocytes, endothelial cells, kidney proximal convoluted tubule epithelial cells, and neurons. 3. **Involvement in translation initiation, elongation, and termination**: RPL3L plays a crucial role in the regulation of protein synthesis, particularly in the initiation, elongation, and termination phases of translation. 4. **Regulation of cell differentiation and survival**: RPL3L has been shown to regulate the differentiation of cardiac myoblasts and the survival of neurons, highlighting its importance in cellular development and maintenance. **Pathways and Functions** 1. **Translation initiation**: RPL3L participates in the initiation phase of translation, where it helps to recruit ribosomal subunits to the mRNA and facilitate the binding of initiation factors. 2. **Elongation and termination**: RPL3L is involved in the elongation and termination phases of translation, where it helps to regulate the assembly of the ribosome and the release of completed polypeptide chains. 3. **Regulation of protein synthesis**: RPL3L regulates protein synthesis by modulating the activity of translation initiation and elongation factors, as well as by influencing the expression of genes involved in protein synthesis. 4. **Cell differentiation and survival**: RPL3L regulates cell differentiation and survival by modulating the expression of genes involved in cellular development and maintenance. **Clinical Significance** 1. **Cardiovascular diseases**: Alterations in RPL3L expression have been linked to cardiovascular diseases, such as heart failure and cardiac arrhythmias. 2. **Neurodegenerative diseases**: RPL3L has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Cancer**: RPL3L has been shown to regulate the expression of genes involved in cancer development and progression. 4. **Infectious diseases**: RPL3L has been implicated in the regulation of viral replication and translation, highlighting its potential as a target for antiviral therapy. In conclusion, the RPL3L gene plays a critical role in regulating protein synthesis and cellular homeostasis, and its dysregulation has been implicated in various diseases, including cardiovascular, neurodegenerative, and infectious diseases. Further research is needed to fully elucidate the mechanisms by which RPL3L regulates protein synthesis and its potential as a therapeutic target.

Genular Protein ID: 1085381129

Symbol: RL3L_HUMAN

Name: Large ribosomal subunit protein uL3-like

UniProtKB Accession Codes:

Q92901

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8921388

Title: A novel ribosomal protein L3-like gene (RPL3L) maps to the autosomal dominant polycystic kidney disease gene region.

PubMed ID: 8921388

DOI: 10.1006/geno.1996.0538

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 32870709

Title: Categorized genetic analysis in childhood-onset cardiomyopathy.

PubMed ID: 32870709

DOI: 10.1161/circgen.120.002969

PubMed ID: 32514796

Title: Bi-allelic missense disease-causing variants in RPL3L associate neonatal dilated cardiomyopathy with muscle-specific ribosome biogenesis.

PubMed ID: 32514796

DOI: 10.1007/s00439-020-02188-6

PubMed ID: 36291431

Title: Compound heterozygous missense variants in RPL3L genes associated with severe forms of dilated cardiomyopathy: a case report and literature review.

PubMed ID: 36291431

DOI: 10.3390/children9101495

PubMed ID: 35323613

Title: Further evidence of autosomal recessive inheritance of RPL3L pathogenic variants with rapidly progressive neonatal dilated cardiomyopathy.

PubMed ID: 35323613

DOI: 10.3390/jcdd9030065

Sequence Information:

  • Length: 407
  • Mass: 46296
  • Checksum: 1965327E225F80D2
  • Sequence:
    • MSHRKFSAPR HGHLGFLPHK RSHRHRGKVK TWPRDDPSQP VHLTAFLGYK AGMTHTLREV 
HRPGLKISKR EEVEAVTIVE TPPLVVVGVV GYVATPRGLR SFKTIFAEHL SDECRRRFYK 
DWHKSKKKAF TKACKRWRDT DGKKQLQKDF AAMKKYCKVI RVIVHTQMKL LPFRQKKAHI 
MEIQLNGGTV AEKVAWAQAR LEKQVPVHSV FSQSEVIDVI AVTKGRGVKG VTSRWHTKKL 
PRKTHKGLRK VACIGAWHPA RVGCSIARAG QKGYHHRTEL NKKIFRIGRG PHMEDGKLVK 
NNASTSYDVT AKSITPLGGF PHYGEVNNDF VMLKGCIAGT KKRVITLRKS LLVHHSRQAV 
ENIELKFIDT TSKFGHGRFQ TAQEKRAFMG PQKKHLEKET PETSGDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.