RPL8 | ENSG00000161016 | NCBI 6132

Details for: RPL8

Gene ID: 6132

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: RPL8

Ensembl ID: ENSG00000161016

Description: ribosomal protein L8

Cell Significance Landscape

Display Count:

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(R-HSA-163841)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Post-translational protein modification
(R-HSA-597592)
Protein hydroxylation
(R-HSA-9629569)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Focal adhesion
(GO:0005925)
Membrane
(GO:0016020)
Nucleoplasm
(GO:0005654)
Postsynapse
(GO:0098794)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Rrna binding
(GO:0019843)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

central memory CD4-positive, alpha-beta T cell CL0000904

CSI 161.36

rCSI 95.3%

PRS 2.43
hematopoietic stem cell CL0000037

CSI 150.43

rCSI 99.99%

PRS 2.07
CD4-positive, alpha-beta memory T cell CL0000897

CSI 141.13

rCSI 100%

PRS 2.37
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 140.67

rCSI 94.77%

PRS 2.1
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 137.76

rCSI 96.75%

PRS 5.31
naive T cell CL0000898

CSI 136.18

rCSI 94.78%

PRS 2.54
T follicular helper cell CL0002038

CSI 131.49

rCSI 98.4%

PRS 2.85
epithelial cell of lower respiratory tract CL0002632

CSI 131.33

rCSI 100%

PRS 1.66
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 131.19

rCSI 87.43%

PRS 4.94
class switched memory B cell CL0000972

CSI 129.96

rCSI 97.02%

PRS 2.94
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 129.75

rCSI 97.3%

PRS 5.25
group 3 innate lymphoid cell CL0001071

CSI 129.73

rCSI 97.48%

PRS 1.79
double negative thymocyte CL0002489

CSI 128.39

rCSI 89.26%

PRS 2.03
plasmacytoid dendritic cell, human CL0001058

CSI 126.43

rCSI 88.27%

PRS 1.83
epithelial cell of lung CL0000082

CSI 124.8

rCSI 100%

PRS 1.62
common myeloid progenitor CL0000049

CSI 123.63

rCSI 99.96%

PRS 1.7
CD4-positive helper T cell CL0000492

CSI 122.16

rCSI 92.41%

PRS 2.44
CD4-positive, alpha-beta thymocyte CL0000810

CSI 121.4

rCSI 97.25%

PRS 3.26
neural crest cell CL0011012

CSI 119.61

rCSI 94.54%

PRS 1.21
bronchus fibroblast of lung CL2000093

CSI 118.71

rCSI 96.46%

PRS 1.81
keratinocyte CL0000312

CSI 118.69

rCSI 99.49%

PRS 2.09
precursor B cell CL0000817

CSI 116.39

rCSI 100%

PRS 2.35
naive B cell CL0000788

CSI 114.77

rCSI 98.44%

PRS 5.66
granulocyte monocyte progenitor cell CL0000557

CSI 114.52

rCSI 99.16%

PRS 1.94
plasmablast CL0000980

CSI 114.23

rCSI 89.86%

PRS 2.07
T-helper 17 cell CL0000899

CSI 113.61

rCSI 90.21%

PRS 3.09
unswitched memory B cell CL0000970

CSI 113.24

rCSI 95.27%

PRS 2.93
immature B cell CL0000816

CSI 112.73

rCSI 83.75%

PRS 2.59
mature B cell CL0000785

CSI 112.73

rCSI 98%

PRS 2.14
intestine goblet cell CL0019031

CSI 112.66

rCSI 100%

PRS 1.74
mucosal invariant T cell CL0000940

CSI 112.2

rCSI 90.66%

PRS 4.57
skin fibroblast CL0002620

CSI 111.92

rCSI 96.48%

PRS 2.91
pro-B cell CL0000826

CSI 111.15

rCSI 92.05%

PRS 1.74
early lymphoid progenitor CL0000936

CSI 110.1

rCSI 96.7%

PRS 1.94
mature T cell CL0002419

CSI 107.9

rCSI 83.92%

PRS 2.5
effector CD8-positive, alpha-beta T cell CL0001050

CSI 107.62

rCSI 81.86%

PRS 2.31
goblet cell CL0000160

CSI 107.32

rCSI 100%

PRS 1.82
fibroblast of lung CL0002553

CSI 107.13

rCSI 99.71%

PRS 1.73
megakaryocyte-erythroid progenitor cell CL0000050

CSI 105.45

rCSI 95.23%

PRS 1.53
CD14-low, CD16-positive monocyte CL0002396

CSI 104.24

rCSI 80.31%

PRS 1.57
memory B cell CL0000787

CSI 103.06

rCSI 100%

PRS 7.72
fallopian tube secretory epithelial cell CL4030006

CSI 102.78

rCSI 98.94%

PRS 1.81
activated CD4-positive, alpha-beta T cell CL0000896

CSI 102.01

rCSI 94.3%

PRS 3.19
respiratory basal cell CL0002633

CSI 100.7

rCSI 100%

PRS 2.04
pancreatic D cell CL0000173

CSI 96.05

rCSI 94.46%

PRS 1.92
ciliated epithelial cell CL0000067

CSI 95.74

rCSI 84.19%

PRS 1.26
intestinal epithelial cell CL0002563

CSI 94.15

rCSI 98.41%

PRS 1.87
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 93.73

rCSI 85.37%

PRS 2.72
secretory cell CL0000151

CSI 93.11

rCSI 97.15%

PRS 1.78
elicited macrophage CL0000861

CSI 92.58

rCSI 85%

PRS 1.99
IgA plasma cell CL0000987

CSI 90.74

rCSI 92.89%

PRS 3.29
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 90.58

rCSI 88.95%

PRS 2.78
double-positive, alpha-beta thymocyte CL0000809

CSI 90.54

rCSI 92.27%

PRS 2.53
hematopoietic precursor cell CL0008001

CSI 90.2

rCSI 92.8%

PRS 2.79
small pre-B-II cell CL0000954

CSI 90.04

rCSI 86.59%

PRS 3.81
pancreatic A cell CL0000171

CSI 86.79

rCSI 90.92%

PRS 1.88
multi-ciliated epithelial cell CL0005012

CSI 86.56

rCSI 86.39%

PRS 1.46
CD8-positive, alpha-beta memory T cell CL0000909

CSI 84.94

rCSI 88.71%

PRS 5.62
gamma-delta T cell CL0000798

CSI 84.26

rCSI 98.97%

PRS 17.71
transit amplifying cell of colon CL0009011

CSI 81.95

rCSI 96.25%

PRS 2.13
ionocyte CL0005006

CSI 81.86

rCSI 87.74%

PRS 1.6
colon epithelial cell CL0011108

CSI 81.32

rCSI 85.19%

PRS 1.62
alveolar type 1 fibroblast cell CL4028004

CSI 81.08

rCSI 88.8%

PRS 2.05
fraction A pre-pro B cell CL0002045

CSI 81

rCSI 92.72%

PRS 3.63
CD1c-positive myeloid dendritic cell CL0002399

CSI 80.5

rCSI 97.23%

PRS 2
respiratory suprabasal cell CL4033048

CSI 79.45

rCSI 100%

PRS 2.01
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 78.58

rCSI 90.74%

PRS 1.63
M cell of gut CL0000682

CSI 77.93

rCSI 82.8%

PRS 3.18
nasal mucosa goblet cell CL0002480

CSI 77.77

rCSI 90.2%

PRS 2.6
activated type II NK T cell CL0000931

CSI 77.54

rCSI 87.27%

PRS 2.93
activated CD8-positive, alpha-beta T cell CL0000906

CSI 77.04

rCSI 75.72%

PRS 5.21
B cell CL0000236

CSI 76.87

rCSI 100%

PRS 10.7
melanocyte CL0000148

CSI 76.77

rCSI 56.86%

PRS 1.66
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 75.8

rCSI 95.25%

PRS 9.6
mature NK T cell CL0000814

CSI 75.68

rCSI 96.8%

PRS 8.1
extravillous trophoblast CL0008036

CSI 75.59

rCSI 93.51%

PRS 1.54
enteroendocrine cell CL0000164

CSI 75.42

rCSI 100%

PRS 1.92
pulmonary ionocyte CL0017000

CSI 75.09

rCSI 91.4%

PRS 2.2
myofibroblast cell CL0000186

CSI 74.66

rCSI 100%

PRS 2.51
common dendritic progenitor CL0001029

CSI 73.99

rCSI 92.86%

PRS 2.2
renal alpha-intercalated cell CL0005011

CSI 73.68

rCSI 98.5%

PRS 2.37
conventional dendritic cell CL0000990

CSI 73.59

rCSI 61.43%

PRS 5.78
pancreatic acinar cell CL0002064

CSI 73.31

rCSI 97.43%

PRS 1.91
mesodermal cell CL0000222

CSI 72.96

rCSI 87.57%

PRS 1.74
club cell CL0000158

CSI 72.31

rCSI 100%

PRS 2.06
endothelial cell of artery CL1000413

CSI 71.74

rCSI 100%

PRS 10.75
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 71.39

rCSI 97.25%

PRS 4.37
lung ciliated cell CL1000271

CSI 71.32

rCSI 82.47%

PRS 1.26
CD4-positive, alpha-beta T cell CL0000624

CSI 70.96

rCSI 90.81%

PRS 38.01
pulmonary artery endothelial cell CL1001568

CSI 70.92

rCSI 96.5%

PRS 2.66
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 70.48

rCSI 96.83%

PRS 3.74
peripheral nervous system neuron CL2000032

CSI 70.34

rCSI 95.84%

PRS 1.59
promyelocyte CL0000836

CSI 68.87

rCSI 99.33%

PRS 2.41
common lymphoid progenitor CL0000051

CSI 68.08

rCSI 90.97%

PRS 3.33
mucous neck cell CL0000651

CSI 68.01

rCSI 98.02%

PRS 2.83
IgG plasma cell CL0000985

CSI 67.81

rCSI 81.23%

PRS 3.02
epithelial cell CL0000066

CSI 67.31

rCSI 100%

PRS 2.53
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 67.25

rCSI 80.29%

PRS 3.03
plasma cell CL0000786

CSI 67.24

rCSI 88.12%

PRS 9.44
CD14-positive monocyte CL0001054

CSI 67.07

rCSI 83.53%

PRS 2.58

pvalb GABAergic cortical interneuron CL4023018

CSI -53.4

rCSI -66.5%

PRS 1.1%
VIP GABAergic cortical interneuron CL4023016

CSI -46.4

rCSI -55.4%

PRS 1.2%
sst GABAergic cortical interneuron CL4023017

CSI -41.8

rCSI -53.9%

PRS 1.2%
vascular leptomeningeal cell CL4023051

CSI -41.0

rCSI -71.8%

PRS 1.4%
lamp5 GABAergic cortical interneuron CL4023011

CSI -31.9

rCSI -53.6%

PRS 1.2%
sncg GABAergic cortical interneuron CL4023015

CSI -27.7

rCSI -44.5%

PRS 1.4%
inhibitory interneuron CL0000498

CSI -27.1

rCSI -62.6%

PRS 1.8%
cerebral cortex neuron CL0010012

CSI -25.2

rCSI -100.0%

PRS 2.5%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI -24.5

rCSI -43.3%

PRS 1.1%
mature astrocyte CL0002627

CSI -23.3

rCSI -99.1%

PRS 4.6%
astrocyte of the cerebral cortex CL0002605

CSI -22.6

rCSI -50.6%

PRS 1.2%
GABAergic neuron CL0000617

CSI -20.5

rCSI -68.6%

PRS 1.9%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -19.6

rCSI -47.5%

PRS 1.1%
L6b glutamatergic cortical neuron CL4023038

CSI -17.4

rCSI -54.3%

PRS 1.2%
adipocyte CL0000136

CSI -16.9

rCSI -21.7%

PRS 2.3%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI -16.5

rCSI -59.5%

PRS 1.0%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -14.3

rCSI -44.7%

PRS 1.4%
OFFx cell CL4033036

CSI -13.5

rCSI -63.4%

PRS 5.2%
near-projecting glutamatergic cortical neuron CL4023012

CSI -12.5

rCSI -47.4%

PRS 1.2%
retinal bipolar neuron CL0000748

CSI -11.7

rCSI -22.0%

PRS 1.5%
kidney interstitial alternatively activated macrophage CL1000695

CSI -11.7

rCSI -30.6%

PRS 2.2%
professional antigen presenting cell CL0000145

CSI -11.0

rCSI -37.9%

PRS 8.0%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -10.7

rCSI -63.1%

PRS 1.4%
erythroid lineage cell CL0000764

CSI -10.3

rCSI -66.5%

PRS 5.0%
kidney proximal convoluted tubule epithelial cell CL1000838

CSI -10.2

rCSI -100.0%

PRS 27.6%
epicardial adipocyte CL1000309

CSI -10.2

rCSI -33.1%

PRS 3.2%
glutamatergic neuron CL0000679

CSI -9.8

rCSI -20.2%

PRS 2.1%
invaginating midget bipolar cell CL4033034

CSI -8.8

rCSI -52.2%

PRS 4.4%
cell of skeletal muscle CL0000188

CSI -8.4

rCSI -91.5%

PRS 12.5%
neural cell CL0002319

CSI -7.8

rCSI -29.4%

PRS 4.1%
primordial germ cell CL0000670

CSI -7.6

rCSI -38.0%

PRS 14.2%
diffuse bipolar 6 cell CL4033032

CSI -7.3

rCSI -38.1%

PRS 5.4%
cord blood hematopoietic stem cell CL2000095

CSI -6.9

rCSI -100.0%

PRS 15.3%
periportal region hepatocyte CL0019026

CSI -6.2

rCSI -24.0%

PRS 3.1%
kidney interstitial fibroblast CL1000692

CSI -5.8

rCSI -30.8%

PRS 13.2%
kidney granular cell CL0000648

CSI -5.4

rCSI -77.5%

PRS 22.3%
regular ventricular cardiac myocyte CL0002131

CSI -5.1

rCSI -31.9%

PRS 1.5%
midzonal region hepatocyte CL0019028

CSI -5.1

rCSI -11.9%

PRS 3.2%
endocrine cell CL0000163

CSI -5.0

rCSI -25.7%

PRS 8.3%
cerebral cortex endothelial cell CL1001602

CSI -4.8

rCSI -8.4%

PRS 1.3%
exhausted T cell CL0011025

CSI -4.8

rCSI -81.0%

PRS 10.1%
diffuse bipolar 2 cell CL4033028

CSI -4.7

rCSI -36.1%

PRS 5.0%
rod bipolar cell CL0000751

CSI -4.6

rCSI -8.2%

PRS 1.5%
diffuse bipolar 3b cell CL4033030

CSI -4.6

rCSI -30.2%

PRS 4.6%
H2 horizontal cell CL0004218

CSI -4.5

rCSI -22.5%

PRS 3.6%
differentiation-committed oligodendrocyte precursor CL4023059

CSI -4.5

rCSI -8.2%

PRS 2.1%
Bergmann glial cell CL0000644

CSI -4.3

rCSI -5.9%

PRS 2.0%
glycinergic amacrine cell CL4030028

CSI -4.2

rCSI -10.9%

PRS 2.8%
ON midget ganglion cell CL4033046

CSI -2.7

rCSI -54.7%

PRS 2.3%
cerebellar granule cell CL0001031

CSI -2.5

rCSI -3.6%

PRS 1.9%
cardiac endothelial cell CL0010008

CSI -2.2

rCSI -8.8%

PRS 2.1%
indirect pathway medium spiny neuron CL4023029

CSI -2.0

rCSI -47.0%

PRS 1.4%
OFF midget ganglion cell CL4033047

CSI -1.9

rCSI -39.5%

PRS 2.5%
renal interstitial pericyte CL1001318

CSI -1.9

rCSI -5.2%

PRS 2.0%
fast muscle cell CL0000190

CSI -1.8

rCSI -7.1%

PRS 10.9%
diffuse bipolar 3a cell CL4033029

CSI -1.5

rCSI -9.8%

PRS 4.4%
kidney resident macrophage CL1000698

CSI -0.8

rCSI -15.4%

PRS 45.2%
platelet CL0000233

CSI -0.1

rCSI -0.6%

PRS 5.5%
immature innate lymphoid cell CL0001082

CSI 0.4

rCSI 13.0%

PRS 32.1%
kidney collecting duct principal cell CL1001431

CSI 0.5

rCSI 2.3%

PRS 12.3%
GABAergic amacrine cell CL4030027

CSI 1.0

rCSI 3.3%

PRS 2.6%
cardiac muscle cell CL0000746

CSI 1.3

rCSI 1.9%

PRS 1.6%
Purkinje cell CL0000121

CSI 1.4

rCSI 18.5%

PRS 18.4%
tracheobronchial goblet cell CL0019003

CSI 2.2

rCSI 35.6%

PRS 43.1%
retinal cone cell CL0000573

CSI 2.3

rCSI 3.7%

PRS 1.4%
endocardial cell CL0002350

CSI 2.3

rCSI 11.2%

PRS 3.1%
cardiac blood vessel endothelial cell CL0010006

CSI 2.5

rCSI 17.4%

PRS 5.9%
group 3 innate lymphoid cell, human CL0001078

CSI 2.5

rCSI 53.8%

PRS 35.4%
hepatic pit cell CL2000054

CSI 2.9

rCSI 39.4%

PRS 22.4%
B-1 B cell CL0000819

CSI 2.9

rCSI 75.1%

PRS 11.0%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 3.0

rCSI 92.5%

PRS 24.8%
cholangiocyte CL1000488

CSI 3.1

rCSI 18.3%

PRS 4.1%
kidney connecting tubule principal cell CL4030018

CSI 3.2

rCSI 22.9%

PRS 26.8%
forebrain neuroblast CL1000042

CSI 3.2

rCSI 34.6%

PRS 27.1%
pluripotent stem cell CL0002248

CSI 3.2

rCSI 97.3%

PRS 4.5%
odontoblast CL0000060

CSI 3.5

rCSI 78.6%

PRS 10.6%
neuron CL0000540

CSI 3.6

rCSI 9.6%

PRS 2.6%
mesenchymal lymphangioblast CL0005021

CSI 3.6

rCSI 95.2%

PRS 10.2%
slow muscle cell CL0000189

CSI 3.8

rCSI 50.0%

PRS 24.5%
retinal ganglion cell CL0000740

CSI 3.8

rCSI 8.5%

PRS 1.3%
epithelial cell of urethra CL1000296

CSI 3.9

rCSI 97.0%

PRS 6.3%
osteoblast CL0000062

CSI 3.9

rCSI 97.4%

PRS 17.4%
prostate gland microvascular endothelial cell CL2000059

CSI 4.1

rCSI 96.9%

PRS 6.6%
Merkel cell CL0000242

CSI 4.1

rCSI 94.7%

PRS 13.1%
kidney loop of Henle epithelial cell CL1000909

CSI 4.2

rCSI 88.7%

PRS 16.6%
lung microvascular endothelial cell CL2000016

CSI 4.4

rCSI 85.3%

PRS 6.4%
epithelial cell of proximal tubule segment 3 CL4030011

CSI 4.4

rCSI 35.2%

PRS 25.3%
retinal rod cell CL0000604

CSI 4.5

rCSI 7.9%

PRS 2.0%
cone retinal bipolar cell CL0000752

CSI 4.5

rCSI 58.9%

PRS 12.6%
B-2 B cell CL0000822

CSI 4.6

rCSI 96.7%

PRS 11.6%
eye photoreceptor cell CL0000287

CSI 4.6

rCSI 51.6%

PRS 7.6%
renal intercalated cell CL0005010

CSI 4.7

rCSI 41.5%

PRS 17.2%
microglial cell CL0000129

CSI 4.7

rCSI 19.1%

PRS 8.8%
macula densa epithelial cell CL1000850

CSI 4.8

rCSI 68.4%

PRS 27.4%
cytotoxic T cell CL0000910

CSI 4.8

rCSI 27.4%

PRS 2.8%
amacrine cell CL0000561

CSI 4.8

rCSI 13.8%

PRS 1.7%
immature alpha-beta T cell CL0000790

CSI 4.9

rCSI 69.8%

PRS 29.1%
uterine smooth muscle cell CL0002601

CSI 4.9

rCSI 32.3%

PRS 13.7%
pre-conventional dendritic cell CL0002010

CSI 5.0

rCSI 65.5%

PRS 6.1%
kidney collecting duct intercalated cell CL1001432

CSI 5.2

rCSI 37.1%

PRS 8.1%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [RPL8](/details-gene/6132) (Ribosomal Protein L8) is a protein-coding gene located on chromosome 8q24.3. It encodes a core structural component of the 60S large subunit of the ribosome. As an integral part of the cell's translational machinery, [RPL8](/details-gene/6132) plays a fundamental role in protein synthesis. Its expression profile indicates it is a crucial housekeeping gene, with particularly high significance in metabolically active and proliferative cells. **Overall**, it is most significant in hematopoietic and immune cell lineages, including [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904)s and [hematopoietic stem cell](/details-cell/CL0000037)s, suggesting a vital role in immune function and cellular differentiation. ## Cellular Roles and Expression Landscape The expression landscape of [RPL8](/details-gene/6132) underscores its essential function in protein synthesis across diverse cell types, with a clear enrichment in the immune system. **Overall**, the gene shows the highest significance in various lymphocyte populations, including [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904) (CSI: 161.36), [CD4-positive, alpha-beta memory T cell](/details-cell/CL0000897) (CSI: 141.13), and [naive T cell](/details-cell/CL0000898)s (CSI: 136.18), as well as in progenitor cells like the [hematopoietic stem cell](/details-cell/CL0000037) (CSI: 150.43). Its high significance extends to innate immune cells such as [CD16-positive, CD56-dim natural killer cell, human](/details-cell/CL0000939) and [plasmacytoid dendritic cell, human](/details-cell/CL0001058), indicating that robust translational capacity is critical for both adaptive and innate immune cell functions. The gene is also highly expressed in non-immune cells with high metabolic turnover, such as [epithelial cell of lower respiratory tract](/details-cell/CL0002632). In stark contrast, [RPL8](/details-gene/6132) exhibits significantly low expression in terminally differentiated, post-mitotic cells of the central nervous system. Its lowest significance scores are found in multiple types of [inhibitory interneuron](/details-cell/CL0000498)s, such as [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: -53.44) and [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: -46.40), as well as glial cells like [mature astrocyte](/details-cell/CL0002627). This suggests that while essential, the demand for the translational machinery component encoded by [RPL8](/details-gene/6132) is relatively lower in these specialized neuronal populations compared to the highly dynamic cells of the immune system. ## Pathways and Molecular Function Functionally, [RPL8](/details-gene/6132) is annotated as a `structural constituent of ribosome` ([GO:0003735](https://www.ebi.ac.uk/QuickGO/term/GO:0003735)) located within the `cytosolic large ribosomal subunit` ([GO:0022625](https://www.ebi.ac.uk/QuickGO/term/GO:0022625)). Its primary molecular functions involve `rRNA binding` ([GO:0019843](https://www.ebi.ac.uk/QuickGO/term/GO:0019843)) to facilitate the biological process of `cytoplasmic translation` ([GO:0002181](https://www.ebi.ac.uk/QuickGO/term/GO:0002181)). Consistent with its role as a core ribosomal protein, [RPL8](/details-gene/6132) is implicated in a vast array of Reactome pathways centered on protein synthesis, including `Translation` ([R-HSA-72766](https://reactome.org/content/detail/R-HSA-72766)), `Metabolism of proteins` ([R-HSA-392499](https://reactome.org/content/detail/R-HSA-392499)), and specific steps like `Eukaryotic translation initiation` ([R-HSA-72613](https://reactome.org/content/detail/R-HSA-72613)) and `Peptide chain elongation` ([R-HSA-156902](https://reactome.org/content/detail/R-HSA-156902)). Its involvement in pathways like `Influenza infection` ([R-HSA-168255](https://reactome.org/content/detail/R-HSA-168255)) and `Viral mRNA translation` ([R-HSA-192823](https://reactome.org/content/detail/R-HSA-192823)) highlights how viral pathogens hijack the host's translational machinery for their replication, a process highly relevant in cell types where [RPL8](/details-gene/6132) is prominently expressed, such as respiratory epithelial cells and lymphocytes. ## Research Directions The expression profile of [RPL8](/details-gene/6132) provides a foundation for several testable hypotheses regarding its role in cellular physiology and disease. 1. **Hypothesis 1:** The exceptionally high significance of [RPL8](/details-gene/6132) in memory T cell populations, such as [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904)s, suggests that its expression level is a rate-limiting factor for the rapid protein synthesis required for clonal expansion and effector function upon secondary antigen exposure. Consequently, subtle variations in [RPL8](/details-gene/6132) expression may modulate the efficacy and speed of an adaptive memory immune response. 2. **Hypothesis 2:** Given its fundamental role, dysregulation of [RPL8](/details-gene/6132) may be a feature of diseases characterized by aberrant protein synthesis, such as cancer. In rapidly proliferating tumors, elevated [RPL8](/details-gene/6132) expression could serve as a biomarker of high translational demand, potentially correlating with tumor aggressiveness, metabolic reprogramming, and sensitivity to therapies targeting the ribosome. **Proposed Experiment:** To test the first hypothesis regarding the role of [RPL8](/details-gene/6132) in T cell memory function, one could perform a CRISPR-interference (CRISPRi) knockdown of the gene in primary human naive CD4+ T cells. These modified cells, along with non-targeting controls, would be activated *in vitro* to differentiate into central memory T cells. Following a rest period, the cells would be re-stimulated with anti-CD3/CD28 antibodies to mimic a secondary antigen encounter. The impact of [RPL8](/details-gene/6132) knockdown would be assessed by measuring key memory response outputs, including proliferation rates via CFSE dilution assays and effector cytokine production (e.g., IFN-gamma, IL-2, TNF-alpha) using flow cytometry and ELISA. A significant reduction in proliferation and cytokine secretion in the knockdown group would support the hypothesis that [RPL8](/details-gene/6132) levels are critical for robust memory T cell function. **Therapeutic Potential:** As a core, ubiquitously expressed component of the ribosome, [RPL8](/details-gene/6132) is a poor candidate for direct therapeutic inhibition, as this would likely lead to severe, non-specific cytotoxicity. However, its expression level may hold significant value as a prognostic biomarker. In oncology, for instance, quantifying [RPL8](/details-gene/6132) mRNA or protein in tumor biopsies could provide an index of the tumor's proliferative and protein synthesis capacity, potentially helping to stratify patients or predict response to treatments that affect translation, such as mTOR inhibitors.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S ribosomal protein L8

Genular Protein ID: 3029050888

Symbol: RL8_HUMAN

Name: 60S ribosomal protein L8

UniProtKB Accession Codes:

P62917 A8K094 D3DWN2 P25120 Q567Q7 Q969V7 Q9BWQ9

Database IDs:

Citations:

PubMed ID: 7506540

Title: Characterization by cDNA cloning of the mRNA of human ribosomal protein L8.

PubMed ID: 7506540

DOI: 10.1006/bbrc.1993.2607

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 9531480

Title: Functional implications of ribosomal protein L2 in protein biosynthesis as shown by in vivo replacement studies.

PubMed ID: 9531480

DOI: 10.1042/bj3310423

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23103944

Title: Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.

PubMed ID: 23103944

DOI: 10.1038/nchembio.1093

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

Length: 257
Mass: 28025
Checksum: CE1610449749318B
Sequence:

MGRVIRGQRK GAGSVFRAHV KHRKGAARLR AVDFAERHGY IKGIVKDIIH DPGRGAPLAK 
VVFRDPYRFK KRTELFIAAE GIHTGQFVYC GKKAQLNIGN VLPVGTMPEG TIVCCLEEKP 
GDRGKLARAS GNYATVISHN PETKKTRVKL PSGSKKVISS ANRAVVGVVA GGGRIDKPIL 
KAGRAYHKYK AKRNCWPRVR GVAMNPVEHP FGGGNHQHIG KPSTIRRDAP AGRKVGLIAA 
RRTGRLRGTK TVQEKEN

Details for: RPL8

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Characterization by cDNA cloning of the mRNA of human ribosomal protein L8. PubMed ID: 7506540

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. PubMed ID: 12962325

Functional implications of ribosomal protein L2 in protein biosynthesis as shown by in vivo replacement studies. PubMed ID: 9531480

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Initial characterization of the human central proteome. PubMed ID: 21269460

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. PubMed ID: 23103944

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. PubMed ID: 32669547