Details for: RPL8

Gene ID: 6132

Symbol: RPL8

Ensembl ID: ENSG00000161016

Description: ribosomal protein L8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 737.5452
    Cell Significance Index: -303.8300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 690.5233
    Cell Significance Index: -280.5300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 611.2607
    Cell Significance Index: -288.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 591.6966
    Cell Significance Index: -304.3600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 431.6847
    Cell Significance Index: -289.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 299.6828
    Cell Significance Index: -286.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 36.9971
    Cell Significance Index: -99.1100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 16.1584
    Cell Significance Index: 412.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 15.4795
    Cell Significance Index: 1581.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 13.3091
    Cell Significance Index: 625.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 12.5349
    Cell Significance Index: 335.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 11.3794
    Cell Significance Index: 299.2200
  • Cell Name: theca cell (CL0000503)
    Fold Change: 10.7812
    Cell Significance Index: 63.3400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 10.7726
    Cell Significance Index: 190.3700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 10.6683
    Cell Significance Index: 136.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 10.3197
    Cell Significance Index: 295.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 9.8217
    Cell Significance Index: 1268.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 9.5195
    Cell Significance Index: 330.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.8396
    Cell Significance Index: 1213.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 8.8357
    Cell Significance Index: 411.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.5247
    Cell Significance Index: 635.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.4931
    Cell Significance Index: 600.6700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 8.4323
    Cell Significance Index: 194.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.3282
    Cell Significance Index: 1501.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.3011
    Cell Significance Index: 1020.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.9262
    Cell Significance Index: 934.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.8269
    Cell Significance Index: 163.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.8224
    Cell Significance Index: 4272.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 7.8126
    Cell Significance Index: 3454.1500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 7.0939
    Cell Significance Index: 80.5900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.6735
    Cell Significance Index: 41.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 6.6588
    Cell Significance Index: 195.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.6266
    Cell Significance Index: 180.3700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 6.6100
    Cell Significance Index: 56.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.1490
    Cell Significance Index: 788.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.0408
    Cell Significance Index: 111.6500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.7445
    Cell Significance Index: 62.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.5821
    Cell Significance Index: 953.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.5738
    Cell Significance Index: 359.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.4756
    Cell Significance Index: 234.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.3146
    Cell Significance Index: 224.7400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.7036
    Cell Significance Index: 34.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 3.5298
    Cell Significance Index: 2671.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.2961
    Cell Significance Index: 88.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.1277
    Cell Significance Index: 2824.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4654
    Cell Significance Index: 489.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.9271
    Cell Significance Index: 87.3500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.8777
    Cell Significance Index: 39.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.7129
    Cell Significance Index: 1255.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1994
    Cell Significance Index: 228.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.1543
    Cell Significance Index: 91.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0716
    Cell Significance Index: 55.6700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5674
    Cell Significance Index: 4.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1811
    Cell Significance Index: 12.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1445
    Cell Significance Index: 23.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0826
    Cell Significance Index: -155.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1146
    Cell Significance Index: -84.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1806
    Cell Significance Index: -333.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1824
    Cell Significance Index: -36.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.2179
    Cell Significance Index: -335.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2642
    Cell Significance Index: -149.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2664
    Cell Significance Index: -362.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3455
    Cell Significance Index: -123.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3593
    Cell Significance Index: -224.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3802
    Cell Significance Index: -241.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5969
    Cell Significance Index: -270.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.6065
    Cell Significance Index: -60.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.7335
    Cell Significance Index: -154.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.9318
    Cell Significance Index: -268.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.0407
    Cell Significance Index: -119.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2305
    Cell Significance Index: -39.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.3615
    Cell Significance Index: -85.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.5825
    Cell Significance Index: -97.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.8602
    Cell Significance Index: -270.4000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.9038
    Cell Significance Index: -32.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.0086
    Cell Significance Index: -50.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -2.1620
    Cell Significance Index: -246.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.2488
    Cell Significance Index: -37.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.2905
    Cell Significance Index: -128.5300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.5456
    Cell Significance Index: -15.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.5887
    Cell Significance Index: -155.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.8132
    Cell Significance Index: -292.9200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.0459
    Cell Significance Index: -45.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.7651
    Cell Significance Index: -51.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.7664
    Cell Significance Index: -289.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.0914
    Cell Significance Index: -250.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.1561
    Cell Significance Index: -279.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.6186
    Cell Significance Index: -100.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -5.0425
    Cell Significance Index: -60.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.7248
    Cell Significance Index: -168.6200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -6.5309
    Cell Significance Index: -84.1100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -6.6644
    Cell Significance Index: -36.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -6.6957
    Cell Significance Index: -114.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -6.7926
    Cell Significance Index: -182.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -6.9004
    Cell Significance Index: -305.2200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -7.0226
    Cell Significance Index: -32.4300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -7.2739
    Cell Significance Index: -267.0200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -7.7042
    Cell Significance Index: -47.8700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -7.9782
    Cell Significance Index: -82.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -8.1138
    Cell Significance Index: -307.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ribosomal protein L8**: RPL8 is a 60S ribosomal protein, which is a crucial component of the large ribosomal subunit responsible for translation elongation. 2. **Highly expressed in various cell types**: RPL8 is significantly expressed in epithelial cells of the exocrine pancreas, myoepithelial cells of the mammary gland, malignant cells, and various immune cells, including CD38-negative naive B cells and NKp46-positive innate lymphoid cells. 3. **Conserved across species**: RPL8 is conserved across species, suggesting its essential role in translation and cellular processes. **Pathways and Functions:** 1. **Translation elongation**: RPL8 is involved in the translation elongation cycle, ensuring the accurate and efficient translation of mRNAs into proteins. 2. **Cellular responses to stress**: RPL8 is activated in response to cellular stress, starvation, and viral infections, regulating the expression of genes involved in stress response and immune responses. 3. **Cytoplasmic translation**: RPL8 plays a crucial role in cytoplasmic translation, regulating the translation of mRNAs into proteins. 4. **Regulation of protein synthesis**: RPL8 regulates the translation of specific mRNAs, influencing protein synthesis and cellular homeostasis. 5. **Involvement in viral infections**: RPL8 is involved in the translation of viral mRNAs, regulating viral replication and immune responses. **Clinical Significance:** 1. **Cancer**: Dysregulation of RPL8 has been linked to various cancers, including pancreatic cancer, where it is often overexpressed. 2. **Neurological disorders**: RPL8 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it is involved in protein synthesis and degradation. 3. **Immune responses**: RPL8 plays a crucial role in immune responses, regulating the expression of genes involved in immune responses and inflammation. 4. **Viral infections**: RPL8 is involved in the translation of viral mRNAs, regulating viral replication and immune responses. In conclusion, RPL8 is a crucial gene involved in various cellular processes, including translation, protein synthesis, and cell signaling. Its dysregulation has been linked to various diseases, including cancer and neurological disorders. Further research is needed to elucidate the mechanisms underlying RPL8's functions and to explore its therapeutic potential. **Recommendations:** 1. **Further research**: Conducting further research on RPL8's functions and mechanisms of action is essential to understand its role in various diseases. 2. **Therapeutic potential**: Exploring RPL8's therapeutic potential in various diseases, including cancer and neurological disorders, is crucial. 3. **Cellular analysis**: Analyzing RPL8's expression in various cell types and tissues can provide insights into its role in cellular processes. By understanding the key characteristics, pathways, functions, and clinical significance of RPL8, we can uncover its importance in maintaining cellular homeostasis and develop novel therapeutic strategies for various diseases.

Genular Protein ID: 3029050888

Symbol: RL8_HUMAN

Name: 60S ribosomal protein L8

UniProtKB Accession Codes:

P62917 A8K094 D3DWN2 P25120 Q567Q7 Q969V7 Q9BWQ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 14 EMDB 67 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 82 PDBsum 82 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 14 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7506540

Title: Characterization by cDNA cloning of the mRNA of human ribosomal protein L8.

PubMed ID: 7506540

DOI: 10.1006/bbrc.1993.2607

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 9531480

Title: Functional implications of ribosomal protein L2 in protein biosynthesis as shown by in vivo replacement studies.

PubMed ID: 9531480

DOI: 10.1042/bj3310423

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23103944

Title: Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.

PubMed ID: 23103944

DOI: 10.1038/nchembio.1093

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 257
  • Mass: 28025
  • Checksum: CE1610449749318B
  • Sequence:
    • MGRVIRGQRK GAGSVFRAHV KHRKGAARLR AVDFAERHGY IKGIVKDIIH DPGRGAPLAK 
VVFRDPYRFK KRTELFIAAE GIHTGQFVYC GKKAQLNIGN VLPVGTMPEG TIVCCLEEKP 
GDRGKLARAS GNYATVISHN PETKKTRVKL PSGSKKVISS ANRAVVGVVA GGGRIDKPIL 
KAGRAYHKYK AKRNCWPRVR GVAMNPVEHP FGGGNHQHIG KPSTIRRDAP AGRKVGLIAA 
RRTGRLRGTK TVQEKEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.