Details for: RPL31

Gene ID: 6160

Symbol: RPL31

Ensembl ID: ENSG00000071082

Description: ribosomal protein L31

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 8.16
    Marker Score: 4600
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 5.46
    Marker Score: 2817.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.32
    Marker Score: 6933
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.22
    Marker Score: 3790
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 5.22
    Marker Score: 21760
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 5.18
    Marker Score: 3651
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.14
    Marker Score: 2643
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 5.13
    Marker Score: 1890
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.09
    Marker Score: 50439.5
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 5.03
    Marker Score: 3241
  • Cell Name: theca cell (CL0000503)
    Fold Change: 5.03
    Marker Score: 3605
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 4.96
    Marker Score: 3740
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.93
    Marker Score: 14402
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 4.9
    Marker Score: 2768
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.72
    Marker Score: 4211.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.71
    Marker Score: 63260
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 4.66
    Marker Score: 3547
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 4.6
    Marker Score: 3978
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.59
    Marker Score: 7867
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.52
    Marker Score: 23777
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.51
    Marker Score: 238276
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.49
    Marker Score: 9405
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.44
    Marker Score: 14002.5
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.42
    Marker Score: 1436
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.4
    Marker Score: 6783
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.38
    Marker Score: 1046
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.37
    Marker Score: 57603
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.35
    Marker Score: 1868
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.31
    Marker Score: 2620
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.3
    Marker Score: 11873
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.21
    Marker Score: 10276
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.19
    Marker Score: 3569
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.15
    Marker Score: 2211
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.11
    Marker Score: 47808
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.1
    Marker Score: 2401
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 4.06
    Marker Score: 819
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 4.03
    Marker Score: 24461
  • Cell Name: club cell (CL0000158)
    Fold Change: 4.02
    Marker Score: 4691.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.02
    Marker Score: 7550
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.99
    Marker Score: 4262
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.99
    Marker Score: 223051
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.97
    Marker Score: 2055
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.97
    Marker Score: 25867
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.94
    Marker Score: 8975
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.93
    Marker Score: 5716
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.92
    Marker Score: 1766
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.91
    Marker Score: 10978
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.89
    Marker Score: 16686
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 3.89
    Marker Score: 2654
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.88
    Marker Score: 3041
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.86
    Marker Score: 884
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.82
    Marker Score: 4250
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.82
    Marker Score: 24398
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.81
    Marker Score: 1390
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.8
    Marker Score: 3748
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.8
    Marker Score: 18666
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.8
    Marker Score: 3672
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 3.8
    Marker Score: 1583
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 3.78
    Marker Score: 880
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.75
    Marker Score: 27942
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.74
    Marker Score: 3529
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.71
    Marker Score: 4478
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.7
    Marker Score: 3299.5
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.7
    Marker Score: 973
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.68
    Marker Score: 9160
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.67
    Marker Score: 1042
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.67
    Marker Score: 2776.5
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.67
    Marker Score: 2466
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.67
    Marker Score: 1643
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.63
    Marker Score: 23635
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.63
    Marker Score: 1507
  • Cell Name: glial cell (CL0000125)
    Fold Change: 3.63
    Marker Score: 3990.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.62
    Marker Score: 64188
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.62
    Marker Score: 1190
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.61
    Marker Score: 5740
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.61
    Marker Score: 3764
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.6
    Marker Score: 3202
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.6
    Marker Score: 8168
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.6
    Marker Score: 1986
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.6
    Marker Score: 3170
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.58
    Marker Score: 3056
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.58
    Marker Score: 1855
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.57
    Marker Score: 121458
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.55
    Marker Score: 1013
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.54
    Marker Score: 1523
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.54
    Marker Score: 938
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.54
    Marker Score: 997
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.54
    Marker Score: 3418
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.53
    Marker Score: 1679
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.53
    Marker Score: 4854
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 3.53
    Marker Score: 877
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 3.52
    Marker Score: 935
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.52
    Marker Score: 3029
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 3.52
    Marker Score: 1040
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.51
    Marker Score: 6395
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.5
    Marker Score: 2302
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 3.5
    Marker Score: 1051
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.5
    Marker Score: 1205
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.49
    Marker Score: 9139
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.49
    Marker Score: 4303

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Other Information

**Key characteristics:** * RPL31 is a large protein with a molecular weight of approximately 110 kDa. * It is a member of the ribosomal protein L31 family. * RPL31 is required for the initiation of protein synthesis in eukaryotic cells. * It is involved in the processing of mRNA and the initiation of translation. * It is a key regulator of protein synthesis. **Pathways and functions:** * RPL31 is involved in the initiation of protein synthesis through the binding of its initiator protein, EF-Tu. * It is also involved in the processing of mRNA and the initiation of translation. * It is a key regulator of protein synthesis, and its expression is often regulated by growth factors and other signaling molecules. **Clinical significance:** * Mutations in RPL31 have been linked to a number of human diseases, including cancer and neurodegenerative disorders. * RPL31 is a potential target for the treatment of these diseases. **Other important points:** * RPL31 is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. * It is a well-characterized protein that has been extensively studied. * It is a key enzyme in the initiation of protein synthesis, and its dysfunction can lead to a variety of diseases.

Genular Protein ID: 1685518882

Symbol: RL31_HUMAN

Name: 60S ribosomal protein L31

UniProtKB Accession Codes:

P62899 B7Z4K2 D3DVJ4 P12947 Q53SQ5 Q6IRZ0 Q6LBJ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 59 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 75 PDBsum 71 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 13 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2780320

Title: cDNA sequence of human ribosomal protein L31.

PubMed ID: 2780320

DOI: 10.1093/nar/17.17.7105

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2597680

Title: Identification of a human ribosomal protein mRNA with increased expression in colorectal tumours.

PubMed ID: 2597680

DOI: 10.1016/0167-4781(89)90119-x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 125
  • Mass: 14463
  • Checksum: BA9DBE79B9E1C071
  • Sequence:
    • MAPAKKGGEK KKGRSAINEV VTREYTINIH KRIHGVGFKK RAPRALKEIR KFAMKEMGTP 
DVRIDTRLNK AVWAKGIRNV PYRIRVRLSR KRNEDEDSPN KLYTLVTYVP VTTFKNLQTV 
NVDEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.