RPL31 | ENSG00000071082 | NCBI 6160

Details for: RPL31

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Membrane
(GO:0016020)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

hematopoietic stem cell CL0000037

CSI 135.95

rCSI 90.36%

PRS 1.42
common myeloid progenitor CL0000049

CSI 103.4

rCSI 83.6%

PRS 1.17
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 102.78

rCSI 69.25%

PRS 1.44
granulocyte monocyte progenitor cell CL0000557

CSI 100.59

rCSI 87.09%

PRS 1.33
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 99.95

rCSI 70.19%

PRS 3.64
keratinocyte CL0000312

CSI 96.37

rCSI 80.78%

PRS 1.43
megakaryocyte-erythroid progenitor cell CL0000050

CSI 92.2

rCSI 83.27%

PRS 1.05
epithelial cell of lung CL0000082

CSI 91.59

rCSI 75.93%

PRS 1.11
intestinal epithelial cell CL0002563

CSI 89.07

rCSI 93.09%

PRS 1.27
mature B cell CL0000785

CSI 88.24

rCSI 76.71%

PRS 1.47
early lymphoid progenitor CL0000936

CSI 86.67

rCSI 76.12%

PRS 1.33
epithelial cell of lower respiratory tract CL0002632

CSI 86.09

rCSI 66.74%

PRS 1.13
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 83.48

rCSI 62.6%

PRS 3.6
CD4-positive helper T cell CL0000492

CSI 83.05

rCSI 62.82%

PRS 1.67
naive B cell CL0000788

CSI 81.99

rCSI 70.33%

PRS 3.88
class switched memory B cell CL0000972

CSI 81.34

rCSI 60.72%

PRS 2.02
fallopian tube secretory epithelial cell CL4030006

CSI 78.77

rCSI 75.82%

PRS 1.24
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 78.73

rCSI 52.47%

PRS 3.39
T-helper 17 cell CL0000899

CSI 76.87

rCSI 61.04%

PRS 2.12
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 76.42

rCSI 45.13%

PRS 1.67
intestine goblet cell CL0019031

CSI 75.39

rCSI 66.92%

PRS 1.2
CD4-positive, alpha-beta thymocyte CL0000810

CSI 75.14

rCSI 60.19%

PRS 2.24
plasmablast CL0000980

CSI 73.99

rCSI 58.21%

PRS 1.42
mucosal invariant T cell CL0000940

CSI 73.6

rCSI 59.47%

PRS 3.13
double-positive, alpha-beta thymocyte CL0000809

CSI 72.69

rCSI 74.09%

PRS 1.73
memory B cell CL0000787

CSI 71.71

rCSI 70.81%

PRS 5.29
common dendritic progenitor CL0001029

CSI 71.47

rCSI 89.7%

PRS 1.51
ciliated epithelial cell CL0000067

CSI 71.12

rCSI 62.54%

PRS 0.87
pro-B cell CL0000826

CSI 68.71

rCSI 56.9%

PRS 1.19
plasmacytoid dendritic cell, human CL0001058

CSI 68.65

rCSI 47.93%

PRS 1.26
T follicular helper cell CL0002038

CSI 68.56

rCSI 51.31%

PRS 1.96
group 3 innate lymphoid cell CL0001071

CSI 68.43

rCSI 51.41%

PRS 1.23
fraction A pre-pro B cell CL0002045

CSI 67.86

rCSI 77.68%

PRS 2.49
CD4-positive, alpha-beta memory T cell CL0000897

CSI 66.44

rCSI 47.7%

PRS 1.62
transit amplifying cell of colon CL0009011

CSI 65.24

rCSI 76.62%

PRS 1.46
unswitched memory B cell CL0000970

CSI 65.17

rCSI 54.83%

PRS 2.01
immature B cell CL0000816

CSI 63.11

rCSI 46.89%

PRS 1.78
peripheral nervous system neuron CL2000032

CSI 62.35

rCSI 84.95%

PRS 1.09
multi-ciliated epithelial cell CL0005012

CSI 61.38

rCSI 61.26%

PRS 1
double negative thymocyte CL0002489

CSI 61.02

rCSI 42.42%

PRS 1.39
naive T cell CL0000898

CSI 60.5

rCSI 42.1%

PRS 1.74
pancreatic A cell CL0000171

CSI 59.63

rCSI 62.47%

PRS 1.29
promyelocyte CL0000836

CSI 59.44

rCSI 85.73%

PRS 1.66
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 59.27

rCSI 74.48%

PRS 6.58
extravillous trophoblast CL0008036

CSI 57.86

rCSI 71.58%

PRS 1.05
elicited macrophage CL0000861

CSI 56.18

rCSI 51.58%

PRS 1.35
mesodermal cell CL0000222

CSI 56.02

rCSI 67.24%

PRS 1.19
CD14-low, CD16-positive monocyte CL0002396

CSI 55.87

rCSI 43.05%

PRS 1.07
pancreatic D cell CL0000173

CSI 54.59

rCSI 53.69%

PRS 1.32
CD8-positive, alpha-beta memory T cell CL0000909

CSI 53.46

rCSI 55.83%

PRS 3.85
mucous neck cell CL0000651

CSI 52.72

rCSI 75.99%

PRS 1.94
precursor B cell CL0000817

CSI 52.46

rCSI 45.95%

PRS 1.61
CD1c-positive myeloid dendritic cell CL0002399

CSI 50.85

rCSI 61.42%

PRS 1.37
enteroendocrine cell CL0000164

CSI 50.73

rCSI 69.32%

PRS 1.32
common lymphoid progenitor CL0000051

CSI 50.7

rCSI 67.75%

PRS 2.28
hematopoietic precursor cell CL0008001

CSI 49.81

rCSI 51.24%

PRS 1.82
T-helper 1 cell CL0000545

CSI 49.36

rCSI 89.09%

PRS 3.8
colon epithelial cell CL0011108

CSI 48.87

rCSI 51.2%

PRS 1.11
activated CD4-positive, alpha-beta T cell CL0000896

CSI 48.09

rCSI 44.46%

PRS 2.19
promonocyte CL0000559

CSI 48.06

rCSI 82.34%

PRS 1.59
gamma-delta T cell CL0000798

CSI 47.6

rCSI 55.91%

PRS 12.14
effector CD8-positive, alpha-beta T cell CL0001050

CSI 47.44

rCSI 36.09%

PRS 1.58
secretory cell CL0000151

CSI 47.12

rCSI 49.17%

PRS 1.22
transit amplifying cell CL0009010

CSI 46.33

rCSI 70.87%

PRS 1.95
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 45.44

rCSI 61.9%

PRS 3
pancreatic acinar cell CL0002064

CSI 44.98

rCSI 59.79%

PRS 1.31
small pre-B-II cell CL0000954

CSI 44.71

rCSI 43%

PRS 2.61
M cell of gut CL0000682

CSI 44.69

rCSI 47.49%

PRS 2.18
colonocyte CL1000347

CSI 44.31

rCSI 63.52%

PRS 1.68
nasal mucosa goblet cell CL0002480

CSI 44

rCSI 51.03%

PRS 1.78
CD4-positive, alpha-beta T cell CL0000624

CSI 43.31

rCSI 55.42%

PRS 26.2
goblet cell CL0000160

CSI 43.22

rCSI 40.84%

PRS 1.25
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 42.59

rCSI 41.83%

PRS 1.91
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 42.16

rCSI 38.4%

PRS 1.86
placental villous trophoblast CL2000060

CSI 42.1

rCSI 65.06%

PRS 1.13
activated type II NK T cell CL0000931

CSI 41.39

rCSI 46.58%

PRS 2.01
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 40.39

rCSI 80.53%

PRS 2.16
skin fibroblast CL0002620

CSI 40.28

rCSI 34.72%

PRS 2
dendritic cell CL0000451

CSI 39.79

rCSI 49.02%

PRS 3.96
kidney epithelial cell CL0002518

CSI 39.78

rCSI 75.93%

PRS 2.96
mature NK T cell CL0000814

CSI 39.46

rCSI 50.48%

PRS 5.56
neural crest cell CL0011012

CSI 39.41

rCSI 31.15%

PRS 0.83
epithelial cell CL0000066

CSI 39.12

rCSI 60.12%

PRS 1.74
lung ciliated cell CL1000271

CSI 38.65

rCSI 44.69%

PRS 0.86
enterocyte CL0000584

CSI 38.62

rCSI 62.27%

PRS 1.94
club cell CL0000158

CSI 38

rCSI 55.66%

PRS 1.41
colon goblet cell CL0009039

CSI 37.69

rCSI 89.59%

PRS 1.83
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 37.25

rCSI 63.73%

PRS 2.75
B cell CL0000236

CSI 37.06

rCSI 49.58%

PRS 7.34
IgA plasma cell CL0000987

CSI 37.03

rCSI 37.91%

PRS 2.26
CD8-positive, alpha-beta thymocyte CL0000811

CSI 36.98

rCSI 57.66%

PRS 3.13
conventional dendritic cell CL0000990

CSI 36.38

rCSI 30.37%

PRS 4.13
progenitor cell CL0011026

CSI 36.37

rCSI 77.36%

PRS 2.41
mature T cell CL0002419

CSI 36

rCSI 28%

PRS 1.71
classical monocyte CL0000860

CSI 35.72

rCSI 52.95%

PRS 14.52
plasmacytoid dendritic cell CL0000784

CSI 35.38

rCSI 35.83%

PRS 8
myeloid dendritic cell CL0000782

CSI 35.02

rCSI 50.73%

PRS 1.75
bronchus fibroblast of lung CL2000093

CSI 33.62

rCSI 27.32%

PRS 1.24
respiratory hillock cell CL4030023

CSI 33.18

rCSI 59.17%

PRS 2.06
stromal cell of ovary CL0002132

CSI 32.86

rCSI 90.29%

PRS 2.02

L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -28.0

rCSI -68.0%

PRS 0.8%
cerebral cortex endothelial cell CL1001602

CSI -24.2

rCSI -41.9%

PRS 0.9%
sncg GABAergic cortical interneuron CL4023015

CSI -24.2

rCSI -38.9%

PRS 1.0%
cardiac neuron CL0010022

CSI -22.7

rCSI -72.7%

PRS 1.0%
pulmonary capillary endothelial cell CL4028001

CSI -21.6

rCSI -41.2%

PRS 1.9%
differentiation-committed oligodendrocyte precursor CL4023059

CSI -21.4

rCSI -39.0%

PRS 1.5%
cardiac endothelial cell CL0010008

CSI -21.0

rCSI -84.6%

PRS 1.5%
kidney interstitial alternatively activated macrophage CL1000695

CSI -19.4

rCSI -50.5%

PRS 1.5%
astrocyte of the cerebral cortex CL0002605

CSI -19.3

rCSI -43.4%

PRS 0.8%
renal interstitial pericyte CL1001318

CSI -16.1

rCSI -44.4%

PRS 1.3%
Schwann cell CL0002573

CSI -15.3

rCSI -43.4%

PRS 1.7%
pvalb GABAergic cortical interneuron CL4023018

CSI -14.9

rCSI -18.6%

PRS 0.7%
retinal bipolar neuron CL0000748

CSI -14.9

rCSI -27.8%

PRS 1.0%
rod bipolar cell CL0000751

CSI -13.7

rCSI -24.6%

PRS 1.1%
near-projecting glutamatergic cortical neuron CL4023012

CSI -13.5

rCSI -51.2%

PRS 0.9%
L6b glutamatergic cortical neuron CL4023038

CSI -13.1

rCSI -41.0%

PRS 0.8%
inhibitory interneuron CL0000498

CSI -12.0

rCSI -27.6%

PRS 1.2%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -11.0

rCSI -34.3%

PRS 1.0%
neural cell CL0002319

CSI -10.2

rCSI -38.3%

PRS 2.9%
squamous epithelial cell CL0000076

CSI -10.1

rCSI -24.0%

PRS 1.6%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -10.0

rCSI -58.6%

PRS 0.9%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI -9.7

rCSI -34.9%

PRS 0.7%
platelet CL0000233

CSI -9.4

rCSI -38.9%

PRS 3.8%
alpha-beta T cell CL0000789

CSI -9.1

rCSI -10.7%

PRS 2.0%
kidney proximal convoluted tubule epithelial cell CL1000838

CSI -9.1

rCSI -96.0%

PRS 23.4%
epicardial adipocyte CL1000309

CSI -9.0

rCSI -29.3%

PRS 2.3%
adipocyte CL0000136

CSI -8.8

rCSI -11.4%

PRS 1.6%
cerebral cortex neuron CL0010012

CSI -7.8

rCSI -31.8%

PRS 1.7%
VIP GABAergic cortical interneuron CL4023016

CSI -7.0

rCSI -8.4%

PRS 0.8%
mature microglial cell CL0002629

CSI -6.6

rCSI -27.6%

PRS 4.6%
sst GABAergic cortical interneuron CL4023017

CSI -6.3

rCSI -8.1%

PRS 0.8%
central nervous system neuron CL2000029

CSI -6.2

rCSI -45.2%

PRS 0.6%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI -6.0

rCSI -14.3%

PRS 0.9%
kidney interstitial fibroblast CL1000692

CSI -5.2

rCSI -27.7%

PRS 10.9%
vascular leptomeningeal cell CL4023051

CSI -5.2

rCSI -9.1%

PRS 1.0%
hepatic stellate cell CL0000632

CSI -5.0

rCSI -18.6%

PRS 1.1%
GABAergic neuron CL0000617

CSI -4.8

rCSI -16.1%

PRS 1.3%
endothelial cell of arteriole CL1000412

CSI -4.6

rCSI -25.7%

PRS 6.7%
diffuse bipolar 2 cell CL4033028

CSI -4.3

rCSI -33.6%

PRS 3.6%
lung interstitial macrophage CL4033043

CSI -4.3

rCSI -9.6%

PRS 3.1%
diffuse bipolar 3b cell CL4033030

CSI -4.2

rCSI -28.0%

PRS 3.3%
erythroid lineage cell CL0000764

CSI -4.0

rCSI -25.6%

PRS 3.4%
diffuse bipolar 3a cell CL4033029

CSI -3.9

rCSI -26.4%

PRS 3.2%
regular ventricular cardiac myocyte CL0002131

CSI -3.7

rCSI -23.1%

PRS 1.1%
kidney granular cell CL0000648

CSI -3.1

rCSI -44.4%

PRS 17.6%
H1 horizontal cell CL0004217

CSI -2.4

rCSI -9.5%

PRS 3.5%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI -2.2

rCSI -5.6%

PRS 1.1%
exhausted T cell CL0011025

CSI -1.7

rCSI -28.1%

PRS 7.0%
kidney collecting duct principal cell CL1001431

CSI -1.5

rCSI -7.7%

PRS 8.5%
Mueller cell CL0000636

CSI -1.5

rCSI -3.4%

PRS 1.2%
lamp5 GABAergic cortical interneuron CL4023011

CSI -1.5

rCSI -2.4%

PRS 0.8%
glycinergic amacrine cell CL4030028

CSI -0.7

rCSI -1.9%

PRS 1.9%
cell of skeletal muscle CL0000188

CSI -0.7

rCSI -7.4%

PRS 8.2%
periportal region hepatocyte CL0019026

CSI -0.7

rCSI -2.6%

PRS 2.1%
hepatic pit cell CL2000054

CSI -0.2

rCSI -3.3%

PRS 16.4%
cardiac muscle cell CL0000746

CSI 0.2

rCSI 0.3%

PRS 1.1%
amacrine cell CL0000561

CSI 0.2

rCSI 0.7%

PRS 1.1%
immature innate lymphoid cell CL0001082

CSI 0.3

rCSI 9.6%

PRS 22.6%
parietal epithelial cell CL1000452

CSI 0.3

rCSI 0.9%

PRS 1.3%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 0.6

rCSI 3.6%

PRS 7.5%
bronchiolar smooth muscle cell CL4033017

CSI 0.7

rCSI 9.7%

PRS 4.1%
group 3 innate lymphoid cell, human CL0001078

CSI 0.7

rCSI 14.4%

PRS 23.4%
tracheobronchial goblet cell CL0019003

CSI 0.8

rCSI 12.9%

PRS 30.8%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.8

rCSI 1.5%

PRS 0.8%
neuroplacodal cell CL0000032

CSI 1.0

rCSI 9.1%

PRS 5.1%
lung resident memory CD4-positive, alpha-beta T cell CL4033038

CSI 1.1

rCSI 11.0%

PRS 16.4%
kidney connecting tubule epithelial cell CL1000768

CSI 1.1

rCSI 2.8%

PRS 1.0%
direct pathway medium spiny neuron CL4023026

CSI 1.2

rCSI 28.0%

PRS 0.7%
endocardial cell CL0002350

CSI 1.3

rCSI 6.4%

PRS 2.2%
lung pericyte CL0009089

CSI 1.4

rCSI 3.6%

PRS 1.4%
macula densa epithelial cell CL1000850

CSI 1.5

rCSI 21.0%

PRS 21.7%
renal principal cell CL0005009

CSI 1.5

rCSI 4.0%

PRS 1.8%
retinal cone cell CL0000573

CSI 1.5

rCSI 2.5%

PRS 1.0%
cone retinal bipolar cell CL0000752

CSI 1.5

rCSI 20.2%

PRS 8.7%
smooth muscle cell of the pulmonary artery CL0002591

CSI 1.6

rCSI 12.3%

PRS 7.3%
enteroglial cell CL4040002

CSI 1.6

rCSI 8.5%

PRS 3.2%
slow muscle cell CL0000189

CSI 1.7

rCSI 22.4%

PRS 18.0%
cytotoxic T cell CL0000910

CSI 1.8

rCSI 10.1%

PRS 2.0%
uterine smooth muscle cell CL0002601

CSI 1.8

rCSI 11.9%

PRS 9.7%
cord blood hematopoietic stem cell CL2000095

CSI 2.0

rCSI 37.4%

PRS 10.0%
retinal pigment epithelial cell CL0002586

CSI 2.0

rCSI 3.9%

PRS 1.4%
fast muscle cell CL0000190

CSI 2.0

rCSI 7.9%

PRS 7.8%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 2.1

rCSI 63.8%

PRS 17.6%
kidney connecting tubule principal cell CL4030018

CSI 2.1

rCSI 15.5%

PRS 19.6%
Purkinje cell CL0000121

CSI 2.1

rCSI 28.1%

PRS 13.5%
metallothionein-positive alveolar macrophage CL4033042

CSI 2.2

rCSI 23.7%

PRS 6.0%
decidual natural killer cell, human CL0002343

CSI 2.3

rCSI 23.1%

PRS 11.6%
retinal ganglion cell CL0000740

CSI 2.3

rCSI 5.0%

PRS 0.9%
enterocyte of epithelium of large intestine CL0002071

CSI 2.3

rCSI 12.1%

PRS 2.6%
collagen secreting cell CL0000667

CSI 2.5

rCSI 14.3%

PRS 7.3%
immature alpha-beta T cell CL0000790

CSI 2.5

rCSI 36.2%

PRS 19.9%
mature astrocyte CL0002627

CSI 2.6

rCSI 10.9%

PRS 3.4%
kidney resident macrophage CL1000698

CSI 2.7

rCSI 54.1%

PRS 32.0%
forebrain neuroblast CL1000042

CSI 2.7

rCSI 29.4%

PRS 19.2%
pluripotent stem cell CL0002248

CSI 2.8

rCSI 83.3%

PRS 3.0%
odontoblast CL0000060

CSI 2.8

rCSI 64.2%

PRS 7.4%
epithelial cell of proximal tubule segment 3 CL4030011

CSI 2.9

rCSI 22.8%

PRS 16.6%
double negative T regulatory cell CL0011024

CSI 3.0

rCSI 56.9%

PRS 11.5%
follicular dendritic cell CL0000442

CSI 3.1

rCSI 49.3%

PRS 7.5%
mesenchymal lymphangioblast CL0005021

CSI 3.1

rCSI 81.6%

PRS 7.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [RPL31](/details-gene/6160) (Ribosomal Protein L31) is a protein-coding gene located on chromosome 2q11.2. It encodes a structural component of the 60S large subunit of the ribosome. As an integral part of the cell's protein synthesis machinery, [RPL31](/details-gene/6160) is fundamentally involved in the process of translation. Its expression pattern reflects this core function, with the **Overall** highest significance observed in highly proliferative and metabolically active cells, including [hematopoietic stem cell](/details-cell/CL0000037)s, various progenitor cell types, and activated lymphocytes. This suggests that the abundance of [RPL31](/details-gene/6160) is a critical factor supporting rapid cell growth, differentiation, and division. ## Cellular Roles and Expression Landscape The expression profile of [RPL31](/details-gene/6160) underscores its essential role in cellular proliferation and protein production. **Overall**, the gene shows the highest significance in cell populations characterized by high rates of division and metabolic activity. This includes key progenitors of the hematopoietic system, such as [hematopoietic stem cell](/details-cell/CL0000037)s (CSI: 135.95), [common myeloid progenitor](/details-cell/CL0000049)s (CSI: 103.40), and [granulocyte monocyte progenitor cell](/details-cell/CL0000557)s (CSI: 100.59). High significance is also noted in various lymphoid populations, including [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907)s (CSI: 102.78) and [mature B cell](/details-cell/CL0000785)s (CSI: 88.24), consistent with the need for rapid protein synthesis during immune cell activation and clonal expansion. Furthermore, its prominence in rapidly renewing tissues is highlighted by its high significance in [keratinocyte](/details-cell/CL0000312)s (CSI: 96.37) and epithelial cells of the lung and intestine. Conversely, [RPL31](/details-gene/6160) is a strong anti-marker for terminally differentiated and relatively quiescent cell types. Its expression is significantly low in various neuronal subtypes, such as [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) (CSI: -27.96) and [cardiac neuron](/details-cell/CL0010022) (CSI: -22.71), as well as in structural cells like [cerebral cortex endothelial cell](/details-cell/CL1001602)s (CSI: -24.24) and glial cells like [astrocyte of the cerebral cortex](/details-cell/CL0002605) (CSI: -19.34). This pattern strongly suggests that [RPL31](/details-gene/6160) expression is tightly correlated with the proliferative state of a cell rather than specialized, static functions. ## Pathways and Molecular Function Functionally, [RPL31](/details-gene/6160) is annotated as a [structural constituent of ribosome](/details-go/GO:0003735), with a primary role in [translation](/details-go/GO:0006412) and [cytoplasmic translation](/details-go/GO:0002181). Its localization to the [cytosolic large ribosomal subunit](/details-go/GO:0022625) places it at the core of protein synthesis. This is extensively supported by its involvement in numerous Reactome pathways related to protein metabolism, including [Eukaryotic translation initiation](/details-pathway/R-HSA-72613), [Peptide chain elongation](/details-pathway/R-HSA-156902), and [Eukaryotic translation termination](/details-pathway/R-HSA-72764). The broad impact of protein synthesis on cellular life is reflected in the diverse high-level pathways associated with [RPL31](/details-gene/6160). These include fundamental processes such as [Metabolism](/details-pathway/R-HSA-1430728), [Developmental biology](/details-pathway/R-HSA-1266738), and [Cellular responses to stress](/details-pathway/R-HSA-2262752), all of which require dynamic regulation of the proteome. Notably, its association with pathways like [Influenza infection](/details-pathway/R-HSA-168255) and [Viral mRNA translation](/details-pathway/R-HSA-192823) highlights the co-opting of the host's ribosomal machinery by pathogens, positioning [RPL31](/details-gene/6160) as a key component in host-pathogen interactions. ## Research Directions Given that ribosomal protein expression is often dysregulated in cancer to meet the high metabolic demands of tumor growth, the role of [RPL31](/details-gene/6160) in pathology warrants further investigation. Early research has already indicated increased expression of its mRNA in colorectal tumors ([Link](https://doi.org/10.1016/0167-4781(89)90119-x)). Based on the available data, several testable hypotheses can be proposed: 1. Targeted knockdown of [RPL31](/details-gene/6160) will selectively impair the proliferation and survival of rapidly dividing cancer cells (e.g., colorectal adenocarcinoma, lung adenocarcinoma) while having a minimal effect on quiescent, terminally differentiated cells. 2. The expression level of [RPL31](/details-gene/6160) in hematopoietic stem and progenitor cells is a critical determinant of their lineage commitment and differentiation capacity, with lower levels favoring quiescence or specific lineage outcomes that require less protein synthesis. 3. Viruses that depend heavily on host translation machinery, such as influenza virus, will exhibit significantly reduced replication efficiency in host cells where [RPL31](/details-gene/6160) expression has been experimentally suppressed. A key experiment to test the first hypothesis would involve using an inducible shRNA or CRISPRi system to suppress [RPL31](/details-gene/6160) expression in a panel of cancer cell lines with high endogenous [RPL31](/details-gene/6160) levels. The impact on cell cycle progression (via flow cytometry), proliferation (via cell counting or metabolic assays like MTS), and apoptosis (via Annexin V staining) would be measured and compared to non-cancerous primary cells, such as differentiated fibroblasts, to assess for a therapeutic window. From a therapeutic standpoint, [RPL31](/details-gene/6160) itself is a challenging direct target due to its essential, ubiquitous role in all cells. Direct inhibition would likely cause unacceptable systemic toxicity. However, its upregulation in proliferative states, including cancer, makes it a valuable biomarker of disease activity. Therapeutic strategies would more likely focus on indirectly targeting the upstream pathways that drive ribosome biogenesis (e.g., MYC signaling) in tumors that are highly dependent on elevated protein synthesis, and [RPL31](/details-gene/6160) levels could serve as a companion diagnostic to identify such patients.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S ribosomal protein L31

Genular Protein ID: 1685518882

Symbol: RL31_HUMAN

Name: 60S ribosomal protein L31

UniProtKB Accession Codes:

P62899 B7Z4K2 D3DVJ4 P12947 Q53SQ5 Q6IRZ0 Q6LBJ6

Database IDs:

Citations:

PubMed ID: 2780320

Title: cDNA sequence of human ribosomal protein L31.

PubMed ID: 2780320

DOI: 10.1093/nar/17.17.7105

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2597680

Title: Identification of a human ribosomal protein mRNA with increased expression in colorectal tumours.

PubMed ID: 2597680

DOI: 10.1016/0167-4781(89)90119-x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

Length: 125
Mass: 14463
Checksum: BA9DBE79B9E1C071
Sequence:

MAPAKKGGEK KKGRSAINEV VTREYTINIH KRIHGVGFKK RAPRALKEIR KFAMKEMGTP 
DVRIDTRLNK AVWAKGIRNV PYRIRVRLSR KRNEDEDSPN KLYTLVTYVP VTTFKNLQTV 
NVDEN

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Ascending colon UBERON0001156
	\|— Ascending colon Healthy UBERON0001156_PATO0000461
	Atherosclerosis MONDO0005311
	Axilla UBERON0009472
	\|— Axilla Breast cancer UBERON0009472_MONDO0007254
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Breast cancer UBERON0000310_MONDO0007254
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	\|— Caecum Healthy UBERON0001153_PATO0000461
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	\|— Colonic epithelium UBERON0000397
	\|— Colonic epithelium Healthy UBERON0000397_PATO0000461
	Colorectal cancer MONDO0005575
	Colorectum UBERON0012652
	Cornea UBERON0000964
	\|— Cornea Healthy UBERON0000964_PATO0000461
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Entorhinal cortex UBERON0002728
	Fallopian tube UBERON0003889
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileal epithelium UBERON0008345
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Breast cancer UBERON0002107_MONDO0007254
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	\|— Lymph node Healthy UBERON0000029_PATO0000461
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Nonpapillary renal cell carcinoma MONDO0007763
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	\|— Placenta Healthy UBERON0001987_PATO0000461
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Primary motor cortex UBERON0001384
	Prostate gland UBERON0002367
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Right cardiac atrium UBERON0002078
	\|— Right cardiac atrium Healthy UBERON0002078_PATO0000461
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small intestine UBERON0002108
	\|— Small intestine Healthy UBERON0002108_PATO0000461
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	\|— Stomach Healthy UBERON0000945_PATO0000461
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	Trachea UBERON0003126
	Transverse colon UBERON0001157
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952
	Vascular dementia MONDO0004648

Details for: RPL31

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

cDNA sequence of human ribosomal protein L31. PubMed ID: 2780320

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of a human ribosomal protein mRNA with increased expression in colorectal tumours. PubMed ID: 2597680

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. PubMed ID: 32669547