Details for: RPL31

Gene ID: 6160

Symbol: RPL31

Ensembl ID: ENSG00000071082

Description: ribosomal protein L31

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 548.2979
    Cell Significance Index: -225.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 466.9973
    Cell Significance Index: -220.4800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 444.2585
    Cell Significance Index: -228.5200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 329.9295
    Cell Significance Index: -221.3900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 27.6799
    Cell Significance Index: 162.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.0450
    Cell Significance Index: -48.3400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 17.4285
    Cell Significance Index: 445.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 16.5592
    Cell Significance Index: 1691.5200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 14.0162
    Cell Significance Index: 247.6900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 11.6354
    Cell Significance Index: 92.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 10.9873
    Cell Significance Index: 288.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 10.5295
    Cell Significance Index: 220.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 10.2413
    Cell Significance Index: 1323.1100
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 10.2347
    Cell Significance Index: 5.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 9.3916
    Cell Significance Index: 699.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 9.2736
    Cell Significance Index: 322.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 9.0548
    Cell Significance Index: 242.2100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 7.5719
    Cell Significance Index: 86.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 7.3672
    Cell Significance Index: 1011.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 7.2097
    Cell Significance Index: 924.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.0203
    Cell Significance Index: 76.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 7.0076
    Cell Significance Index: 861.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 6.8123
    Cell Significance Index: 1228.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 6.7909
    Cell Significance Index: 480.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 5.9273
    Cell Significance Index: 136.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.7786
    Cell Significance Index: 271.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 5.6472
    Cell Significance Index: 2496.7800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 5.4628
    Cell Significance Index: 69.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.2127
    Cell Significance Index: 243.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.0733
    Cell Significance Index: 2770.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.0366
    Cell Significance Index: 593.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.0104
    Cell Significance Index: 109.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.9643
    Cell Significance Index: 208.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 3.5628
    Cell Significance Index: 2696.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.5565
    Cell Significance Index: 229.4500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.8240
    Cell Significance Index: 26.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.7116
    Cell Significance Index: 463.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.6995
    Cell Significance Index: 79.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1063
    Cell Significance Index: 418.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5655
    Cell Significance Index: 41.8000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4278
    Cell Significance Index: 26.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0657
    Cell Significance Index: 202.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7796
    Cell Significance Index: 703.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6121
    Cell Significance Index: 122.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5090
    Cell Significance Index: 50.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4100
    Cell Significance Index: 21.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0939
    Cell Significance Index: 5.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0787
    Cell Significance Index: 28.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0684
    Cell Significance Index: 50.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0232
    Cell Significance Index: -17.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0507
    Cell Significance Index: -95.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0956
    Cell Significance Index: -147.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1027
    Cell Significance Index: -189.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1201
    Cell Significance Index: -74.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1228
    Cell Significance Index: -69.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1483
    Cell Significance Index: -201.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2150
    Cell Significance Index: -136.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4014
    Cell Significance Index: -45.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4090
    Cell Significance Index: -185.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4254
    Cell Significance Index: -89.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4701
    Cell Significance Index: -135.2500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5151
    Cell Significance Index: -8.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.8436
    Cell Significance Index: -137.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8523
    Cell Significance Index: -97.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9098
    Cell Significance Index: -26.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1383
    Cell Significance Index: -19.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.1804
    Cell Significance Index: -171.5900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.3378
    Cell Significance Index: -20.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.3606
    Cell Significance Index: -94.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.3761
    Cell Significance Index: -48.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.4069
    Cell Significance Index: -111.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.4131
    Cell Significance Index: -45.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.5604
    Cell Significance Index: -95.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.6866
    Cell Significance Index: -48.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.7270
    Cell Significance Index: -108.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.7960
    Cell Significance Index: -44.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -1.9566
    Cell Significance Index: -212.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.0617
    Cell Significance Index: -214.6800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -2.0773
    Cell Significance Index: -17.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.3400
    Cell Significance Index: -179.5700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -2.4367
    Cell Significance Index: -17.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.6432
    Cell Significance Index: -177.7300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -2.7396
    Cell Significance Index: -16.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.9370
    Cell Significance Index: -63.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -3.0212
    Cell Significance Index: -36.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.0229
    Cell Significance Index: -185.3300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -3.2921
    Cell Significance Index: -19.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -3.5193
    Cell Significance Index: -159.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -3.8753
    Cell Significance Index: -103.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -3.8962
    Cell Significance Index: -66.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.9200
    Cell Significance Index: -115.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -4.1381
    Cell Significance Index: -183.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.2606
    Cell Significance Index: -58.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -4.4499
    Cell Significance Index: -86.8500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -4.5628
    Cell Significance Index: -24.8800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -5.0188
    Cell Significance Index: -184.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -5.2024
    Cell Significance Index: -197.0000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -5.4936
    Cell Significance Index: -56.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -5.6955
    Cell Significance Index: -186.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -5.8612
    Cell Significance Index: -205.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural component of the 60S ribosomal subunit:** RPL31 is a conserved protein that forms part of the 60S ribosomal subunit, which is essential for the synthesis of proteins in eukaryotic cells. 2. **Involvement in translation initiation and elongation:** RPL31 regulates the initiation and elongation phases of translation, ensuring the accurate and efficient synthesis of proteins. 3. **Significant expression in various cell types:** RPL31 is expressed in epithelial cells, professional antigen-presenting cells, immune cells, and other cell types, highlighting its importance in cellular homeostasis. 4. **Regulation of translation by L13a-mediated translational silencing:** RPL31 interacts with L13a, a protein that regulates the translation of specific mRNAs, including those involved in the immune response. **Pathways and Functions:** 1. **Eukaryotic translation elongation:** RPL31 plays a crucial role in the elongation phase of translation, where it interacts with other ribosomal proteins to facilitate the synthesis of proteins. 2. **Cap-dependent translation initiation:** RPL31 is involved in the initiation phase of translation, where it regulates the binding of the small ribosomal subunit to the mRNA cap. 3. **Cellular responses to stimuli:** RPL31 is involved in the regulation of cellular responses to various stimuli, including stress, starvation, and infection. 4. **Regulation of protein synthesis:** RPL31 regulates the synthesis of proteins by interacting with other ribosomal proteins and mRNAs. 5. **Regulation of gene expression:** RPL31 regulates the expression of specific genes, including those involved in the immune response and cellular homeostasis. **Clinical Significance:** 1. **Influenza infection:** RPL31 is involved in the regulation of viral RNA transcription and replication, making it a potential target for antiviral therapy. 2. **Immune system disorders:** RPL31 is expressed in immune cells and plays a role in the regulation of immune responses, making it a potential target for the treatment of immune system disorders. 3. **Cancer:** RPL31 is involved in the regulation of protein synthesis and cellular homeostasis, making it a potential target for cancer therapy. 4. **Neurological disorders:** RPL31 is involved in the regulation of protein synthesis and synaptic function, making it a potential target for the treatment of neurological disorders. In conclusion, RPL31 is a multifaceted protein that plays a crucial role in eukaryotic translation elongation and cellular homeostasis. Its involvement in various cellular processes, including translation initiation and elongation, regulation of gene expression, and cellular responses to stimuli, highlights its importance in maintaining cellular homeostasis. Further research is needed to fully elucidate the role of RPL31 in various diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 1685518882

Symbol: RL31_HUMAN

Name: 60S ribosomal protein L31

UniProtKB Accession Codes:

P62899 B7Z4K2 D3DVJ4 P12947 Q53SQ5 Q6IRZ0 Q6LBJ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 71 Ensembl 4 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 86 PDBsum 86 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 13 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2780320

Title: cDNA sequence of human ribosomal protein L31.

PubMed ID: 2780320

DOI: 10.1093/nar/17.17.7105

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2597680

Title: Identification of a human ribosomal protein mRNA with increased expression in colorectal tumours.

PubMed ID: 2597680

DOI: 10.1016/0167-4781(89)90119-x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 125
  • Mass: 14463
  • Checksum: BA9DBE79B9E1C071
  • Sequence:
    • MAPAKKGGEK KKGRSAINEV VTREYTINIH KRIHGVGFKK RAPRALKEIR KFAMKEMGTP 
DVRIDTRLNK AVWAKGIRNV PYRIRVRLSR KRNEDEDSPN KLYTLVTYVP VTTFKNLQTV 
NVDEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.