Gene RPLP0 - ENSG00000089157 | NCBI Gene ID: 6175

Details for: RPLP0

Gene ID: 6175

Symbol: RPLP0

Ensembl ID: ENSG00000089157

Description: ribosomal protein lateral stalk subunit P0

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gene and protein expression by jak-stat signaling after interleukin-12 stimulation
(R-HSA-8950505)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Interleukin-12 family signaling
(R-HSA-447115)
Interleukin-12 signaling
(R-HSA-9020591)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by interleukins
(R-HSA-449147)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic ribonucleoprotein granule
(GO:0036464)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Endoplasmic reticulum
(GO:0005783)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Large ribosomal subunit rrna binding
(GO:0070180)
Membrane
(GO:0016020)
Nucleus
(GO:0005634)
Postsynapse
(GO:0098794)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Ribonucleoprotein complex
(GO:1990904)
Ribosomal large subunit assembly
(GO:0000027)
Ribosome biogenesis
(GO:0042254)
Rna binding
(GO:0003723)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 7.84
Marker Score: 4419
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 6.07
Marker Score: 4582
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 5.94
Marker Score: 29165
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 5.76
Marker Score: 4512
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.68
Marker Score: 11899
Cell Name: malignant cell (CL0001064)
Fold Change: 5.46
Marker Score: 73383
Cell Name: acinar cell (CL0000622)
Fold Change: 5.3
Marker Score: 3740
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 5.26
Marker Score: 8101
Cell Name: mature T cell (CL0002419)
Fold Change: 5.1
Marker Score: 50499
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 5.03
Marker Score: 8623
Cell Name: radial glial cell (CL0000681)
Fold Change: 4.93
Marker Score: 1816
Cell Name: naive B cell (CL0000788)
Fold Change: 4.84
Marker Score: 4318
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.8
Marker Score: 15140
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.79
Marker Score: 163010
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.73
Marker Score: 249867
Cell Name: theca cell (CL0000503)
Fold Change: 4.73
Marker Score: 3386
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 4.69
Marker Score: 13702.5
Cell Name: naive T cell (CL0000898)
Fold Change: 4.62
Marker Score: 2977
Cell Name: endocardial cell (CL0002350)
Fold Change: 4.6
Marker Score: 2600
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 4.58
Marker Score: 19082
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 4.53
Marker Score: 3856
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.5
Marker Score: 59323
Cell Name: hepatocyte (CL0000182)
Fold Change: 4.43
Marker Score: 3023
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 4.4
Marker Score: 2345.5
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.4
Marker Score: 1050
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 4.32
Marker Score: 3135
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 4.3
Marker Score: 5603.5
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 4.3
Marker Score: 2208.5
Cell Name: blood cell (CL0000081)
Fold Change: 4.29
Marker Score: 49911
Cell Name: elicited macrophage (CL0000861)
Fold Change: 4.28
Marker Score: 26023
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.25
Marker Score: 22338
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 4.23
Marker Score: 3218
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.22
Marker Score: 2570
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 4.21
Marker Score: 31318
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 4.18
Marker Score: 2155
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.16
Marker Score: 11662.5
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.15
Marker Score: 10146
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.15
Marker Score: 232175
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.14
Marker Score: 4004
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.08
Marker Score: 17513
Cell Name: club cell (CL0000158)
Fold Change: 4.07
Marker Score: 4753
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 4.06
Marker Score: 9894
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.04
Marker Score: 9198.5
Cell Name: type I NK T cell (CL0000921)
Fold Change: 4.03
Marker Score: 3165
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 4.01
Marker Score: 4285.5
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.01
Marker Score: 11079
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 4
Marker Score: 2343
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.98
Marker Score: 3540
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.97
Marker Score: 3906
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.95
Marker Score: 3370
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.95
Marker Score: 5820
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.94
Marker Score: 25707
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.9
Marker Score: 2622
Cell Name: chondrocyte (CL0000138)
Fold Change: 3.88
Marker Score: 1748
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 3.87
Marker Score: 4306
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 3.87
Marker Score: 887
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.85
Marker Score: 3380
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.83
Marker Score: 3597
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.81
Marker Score: 3119
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.79
Marker Score: 24206
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.79
Marker Score: 3954.5
Cell Name: supporting cell (CL0000630)
Fold Change: 3.78
Marker Score: 7097
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 3.77
Marker Score: 1210
Cell Name: glial cell (CL0000125)
Fold Change: 3.77
Marker Score: 4143
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 3.76
Marker Score: 1222
Cell Name: endocrine cell (CL0000163)
Fold Change: 3.75
Marker Score: 1942
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.75
Marker Score: 1235
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 3.75
Marker Score: 2840
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.74
Marker Score: 13295
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.73
Marker Score: 1051
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.73
Marker Score: 24233
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 3.72
Marker Score: 1017
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 3.72
Marker Score: 1698
Cell Name: granulocyte (CL0000094)
Fold Change: 3.71
Marker Score: 1664
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.71
Marker Score: 9242
Cell Name: memory B cell (CL0000787)
Fold Change: 3.7
Marker Score: 2802
Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.68
Marker Score: 4074
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.68
Marker Score: 3285
Cell Name: immature B cell (CL0000816)
Fold Change: 3.67
Marker Score: 2433
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.66
Marker Score: 3036.5
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.63
Marker Score: 3197.5
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.62
Marker Score: 2123.5
Cell Name: endothelial cell (CL0000115)
Fold Change: 3.62
Marker Score: 3243
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.61
Marker Score: 28200.5
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.61
Marker Score: 5736
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 3.6
Marker Score: 839
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 3.58
Marker Score: 949
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.58
Marker Score: 9598
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.58
Marker Score: 1020.5
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.58
Marker Score: 5865.5
Cell Name: stromal cell (CL0000499)
Fold Change: 3.57
Marker Score: 4187.5
Cell Name: exhausted T cell (CL0011025)
Fold Change: 3.57
Marker Score: 2054
Cell Name: reticular cell (CL0000432)
Fold Change: 3.57
Marker Score: 1302
Cell Name: paneth cell (CL0000510)
Fold Change: 3.57
Marker Score: 2482
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 3.56
Marker Score: 1479
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.56
Marker Score: 4077
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.56
Marker Score: 2993.5
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 3.54
Marker Score: 4366
Cell Name: late pro-B cell (CL0002048)
Fold Change: 3.54
Marker Score: 4172
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 3.54
Marker Score: 2555

Hover over a box to see details here...

**Key characteristics:** - RPLP0 is a protein of the ribosome large subunit. - It is a highly conserved protein, with a similar sequence in humans, mice, and flies. - It is a key component of the ribosome assembly complex. **Pathways and functions:** - RPLP0 is involved in the assembly and maturation of ribosomes. - It is a component of the E1 and E2 ribosomal subunits. - It is involved in the processing of ribosomal RNA (rRNA). - It is involved in the translation of mRNA. **Clinical significance:** - Mutations in RPLP0 have been linked to several human diseases, including diabetes, cancer, and autoimmune disorders. - RPLP0 is a potential target for therapeutic interventions in these diseases. **Additional notes:** - RPLP0 is a highly conserved protein, with a similar sequence in humans, mice, and flies. - It is a key component of the ribosome assembly complex. - It is involved in the processing of ribosomal RNA (rRNA). - It is involved in the translation of mRNA.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S acidic ribosomal protein P0

Genular Protein ID: 3994815924

Symbol: RLA0_HUMAN

Name: 60S acidic ribosomal protein P0

UniProtKB Accession Codes:

P05388 Q3B7A4 Q9BVK4

Database IDs:

Citations:

PubMed ID: 3323886

Title: Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly.

PubMed ID: 3323886

DOI: 10.1128/mcb.7.11.4065-4074.1987

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 19188445

Title: APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

PubMed ID: 19188445

DOI: 10.1128/mcb.01337-08

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24658146

Title: Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin.

PubMed ID: 24658146

DOI: 10.1371/journal.pone.0091465

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 36638793

Title: An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.

PubMed ID: 36638793

DOI: 10.1016/j.cell.2022.12.025

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

Length: 317
Mass: 34274
Checksum: 255AD25571C51199
Sequence:

MPREDRATWK SNYFLKIIQL LDDYPKCFIV GADNVGSKQM QQIRMSLRGK AVVLMGKNTM 
MRKAIRGHLE NNPALEKLLP HIRGNVGFVF TKEDLTEIRD MLLANKVPAA ARAGAIAPCE 
VTVPAQNTGL GPEKTSFFQA LGITTKISRG TIEILSDVQL IKTGDKVGAS EATLLNMLNI 
SPFSFGLVIQ QVFDNGSIYN PEVLDITEET LHSRFLEGVR NVASVCLQIG YPTVASVPHS 
IINGYKRVLA LSVETDYTFP LAEKVKAFLA DPSAFVAAAP VAAATTAAPA AAAAPAKVEA 
KEESEESDED MGFGLFD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: RPLP0

Associated with

Cells (max top 100)

Other Information

Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly. PubMed ID: 3323886

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Molecular composition of IMP1 ribonucleoprotein granules. PubMed ID: 17289661

APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. PubMed ID: 19188445

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A new system for naming ribosomal proteins. PubMed ID: 24524803

Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin. PubMed ID: 24658146

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. PubMed ID: 36638793

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399