RPLP0 | ENSG00000089157 | NCBI 6175

Details for: RPLP0

Gene ID: 6175

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: RPLP0

Ensembl ID: ENSG00000089157

Description: ribosomal protein lateral stalk subunit P0

Cell Significance Landscape

Display Count:

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gene and protein expression by jak-stat signaling after interleukin-12 stimulation
(R-HSA-8950505)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Interleukin-12 family signaling
(R-HSA-447115)
Interleukin-12 signaling
(R-HSA-9020591)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by interleukins
(R-HSA-449147)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic ribonucleoprotein granule
(GO:0036464)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Endoplasmic reticulum
(GO:0005783)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Large ribosomal subunit rrna binding
(GO:0070180)
Membrane
(GO:0016020)
Nucleus
(GO:0005634)
Postsynapse
(GO:0098794)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

hematopoietic stem cell CL0000037

CSI 136.32

rCSI 90.61%

PRS 2.72
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 135

rCSI 90.95%

PRS 2.76
plasmacytoid dendritic cell, human CL0001058

CSI 120.38

rCSI 84.05%

PRS 2.41
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 120.22

rCSI 84.43%

PRS 6.98
class switched memory B cell CL0000972

CSI 118.96

rCSI 88.8%

PRS 3.87
common myeloid progenitor CL0000049

CSI 117.7

rCSI 95.17%

PRS 2.24
group 3 innate lymphoid cell CL0001071

CSI 114.49

rCSI 86.02%

PRS 2.35
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 114.12

rCSI 67.39%

PRS 3.19
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 112.33

rCSI 84.24%

PRS 6.9
epithelial cell of lower respiratory tract CL0002632

CSI 110.94

rCSI 86%

PRS 2.17
keratinocyte CL0000312

CSI 109.61

rCSI 91.88%

PRS 2.75
CD4-positive, alpha-beta memory T cell CL0000897

CSI 109.52

rCSI 78.62%

PRS 3.11
granulocyte monocyte progenitor cell CL0000557

CSI 109.51

rCSI 94.82%

PRS 2.55
T follicular helper cell CL0002038

CSI 109.36

rCSI 81.84%

PRS 3.75
plasmablast CL0000980

CSI 109.26

rCSI 85.95%

PRS 2.71
early lymphoid progenitor CL0000936

CSI 108.8

rCSI 95.56%

PRS 2.55
immature B cell CL0000816

CSI 108.8

rCSI 80.83%

PRS 3.41
CD4-positive helper T cell CL0000492

CSI 106.58

rCSI 80.62%

PRS 3.2
T-helper 17 cell CL0000899

CSI 105.92

rCSI 84.1%

PRS 4.07
mucosal invariant T cell CL0000940

CSI 105.88

rCSI 85.56%

PRS 5.96
mature B cell CL0000785

CSI 104.71

rCSI 91.02%

PRS 2.81
naive T cell CL0000898

CSI 104.35

rCSI 72.62%

PRS 3.33
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 102.92

rCSI 68.59%

PRS 6.49
pro-B cell CL0000826

CSI 101.51

rCSI 84.07%

PRS 2.29
naive B cell CL0000788

CSI 101.51

rCSI 87.06%

PRS 7.33
CD4-positive, alpha-beta thymocyte CL0000810

CSI 101.26

rCSI 81.11%

PRS 4.29
epithelial cell of lung CL0000082

CSI 100.27

rCSI 83.12%

PRS 2.14
bronchus fibroblast of lung CL2000093

CSI 99.01

rCSI 80.45%

PRS 2.4
goblet cell CL0000160

CSI 98.59

rCSI 93.16%

PRS 2.39
unswitched memory B cell CL0000970

CSI 97.93

rCSI 82.39%

PRS 3.85
neural crest cell CL0011012

CSI 95.69

rCSI 75.63%

PRS 1.59
megakaryocyte-erythroid progenitor cell CL0000050

CSI 95.65

rCSI 86.38%

PRS 2.01
precursor B cell CL0000817

CSI 93.79

rCSI 82.16%

PRS 3.08
double-positive, alpha-beta thymocyte CL0000809

CSI 93.45

rCSI 95.25%

PRS 3.32
fallopian tube secretory epithelial cell CL4030006

CSI 92.51

rCSI 89.06%

PRS 2.38
intestine goblet cell CL0019031

CSI 90.85

rCSI 80.65%

PRS 2.29
skin fibroblast CL0002620

CSI 90.45

rCSI 77.97%

PRS 3.82
intestinal epithelial cell CL0002563

CSI 88.12

rCSI 92.1%

PRS 2.46
small pre-B-II cell CL0000954

CSI 86.84

rCSI 83.51%

PRS 5
memory B cell CL0000787

CSI 86.27

rCSI 85.2%

PRS 10.15
effector CD8-positive, alpha-beta T cell CL0001050

CSI 83.22

rCSI 63.3%

PRS 3.03
IgA plasma cell CL0000987

CSI 82.14

rCSI 84.09%

PRS 4.33
double negative thymocyte CL0002489

CSI 79.73

rCSI 55.43%

PRS 2.67
colon epithelial cell CL0011108

CSI 78.48

rCSI 82.21%

PRS 2.13
CD8-positive, alpha-beta memory T cell CL0000909

CSI 77.85

rCSI 81.3%

PRS 7.38
fraction A pre-pro B cell CL0002045

CSI 77.06

rCSI 88.21%

PRS 4.77
activated CD4-positive, alpha-beta T cell CL0000896

CSI 76.52

rCSI 70.74%

PRS 4.19
extravillous trophoblast CL0008036

CSI 76.38

rCSI 94.49%

PRS 2.02
activated type II NK T cell CL0000931

CSI 75.33

rCSI 84.78%

PRS 3.85
transit amplifying cell of colon CL0009011

CSI 74.65

rCSI 87.67%

PRS 2.79
secretory cell CL0000151

CSI 74.01

rCSI 77.22%

PRS 2.34
common dendritic progenitor CL0001029

CSI 73.06

rCSI 91.7%

PRS 2.9
mesodermal cell CL0000222

CSI 72.58

rCSI 87.12%

PRS 2.29
myeloid leukocyte CL0000766

CSI 72.44

rCSI 66.83%

PRS 2.31
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 71.77

rCSI 70.48%

PRS 3.65
hematopoietic precursor cell CL0008001

CSI 70.99

rCSI 73.03%

PRS 3.73
fibroblast of lung CL0002553

CSI 70.81

rCSI 65.9%

PRS 2.28
mature T cell CL0002419

CSI 69.92

rCSI 54.38%

PRS 3.29
respiratory basal cell CL0002633

CSI 69.74

rCSI 72.24%

PRS 2.68
ciliated epithelial cell CL0000067

CSI 69.03

rCSI 60.7%

PRS 1.65
promyelocyte CL0000836

CSI 66.54

rCSI 95.97%

PRS 3.17
elicited macrophage CL0000861

CSI 66.23

rCSI 60.8%

PRS 2.6
common lymphoid progenitor CL0000051

CSI 66.13

rCSI 88.37%

PRS 4.38
CD1c-positive myeloid dendritic cell CL0002399

CSI 64.85

rCSI 78.33%

PRS 2.64
nasal mucosa goblet cell CL0002480

CSI 64.74

rCSI 75.09%

PRS 3.42
gamma-delta T cell CL0000798

CSI 64.66

rCSI 75.95%

PRS 23.1
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 64.15

rCSI 58.43%

PRS 3.57
peripheral nervous system neuron CL2000032

CSI 64.13

rCSI 87.39%

PRS 2.08
M cell of gut CL0000682

CSI 63.05

rCSI 67%

PRS 4.14
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 62.6

rCSI 85.27%

PRS 5.74
multi-ciliated epithelial cell CL0005012

CSI 61.13

rCSI 61.01%

PRS 1.93
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 61.11

rCSI 76.8%

PRS 12.61
conventional dendritic cell CL0000990

CSI 60.8

rCSI 50.76%

PRS 7.66
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 60.76

rCSI 70.17%

PRS 2.11
pancreatic acinar cell CL0002064

CSI 60.64

rCSI 80.59%

PRS 2.51
IgG plasma cell CL0000985

CSI 60.34

rCSI 72.28%

PRS 3.97
enteroendocrine cell CL0000164

CSI 59.4

rCSI 81.17%

PRS 2.53
plasma cell CL0000786

CSI 58.25

rCSI 76.34%

PRS 12.5
interstitial cell of Cajal CL0002088

CSI 58.17

rCSI 74.05%

PRS 2.68
epithelial cell CL0000066

CSI 57.76

rCSI 88.75%

PRS 3.33
renal alpha-intercalated cell CL0005011

CSI 57.73

rCSI 77.18%

PRS 3.12
lung ciliated cell CL1000271

CSI 56.73

rCSI 65.6%

PRS 1.66
alveolar type 1 fibroblast cell CL4028004

CSI 56.51

rCSI 61.89%

PRS 2.67
respiratory suprabasal cell CL4033048

CSI 56.51

rCSI 72.48%

PRS 2.64
pancreatic A cell CL0000171

CSI 56.28

rCSI 58.96%

PRS 2.47
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 56.16

rCSI 77.16%

PRS 4.92
perivascular cell CL4033054

CSI 56.11

rCSI 76.7%

PRS 2.62
mucous neck cell CL0000651

CSI 56.04

rCSI 80.77%

PRS 3.72
transit amplifying cell CL0009010

CSI 55.39

rCSI 84.72%

PRS 3.74
pancreatic D cell CL0000173

CSI 55.2

rCSI 54.29%

PRS 2.53
club cell CL0000158

CSI 54.98

rCSI 80.53%

PRS 2.71
placental villous trophoblast CL2000060

CSI 54.9

rCSI 84.83%

PRS 2.16
CD14-low, CD16-positive monocyte CL0002396

CSI 54.56

rCSI 42.03%

PRS 2.06
acinar cell CL0000622

CSI 54.32

rCSI 79.66%

PRS 3.03
enteric smooth muscle cell CL0002504

CSI 54.11

rCSI 77.22%

PRS 2.61
radial glial cell CL0000681

CSI 52.64

rCSI 73.13%

PRS 2.42
CD4-positive, alpha-beta T cell CL0000624

CSI 52.34

rCSI 66.98%

PRS 49.08
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 51.99

rCSI 62.07%

PRS 3.98
B cell CL0000236

CSI 51.63

rCSI 69.07%

PRS 14.17
promonocyte CL0000559

CSI 51.09

rCSI 87.52%

PRS 3.05

vascular leptomeningeal cell CL4023051

CSI -51.5

rCSI -90.3%

PRS 1.8%
kidney interstitial alternatively activated macrophage CL1000695

CSI -46.2

rCSI -100.0%

PRS 2.9%
ependymal cell CL0000065

CSI -42.9

rCSI -87.0%

PRS 0.7%
adipocyte CL0000136

CSI -38.5

rCSI -49.4%

PRS 3.1%
VIP GABAergic cortical interneuron CL4023016

CSI -36.3

rCSI -43.4%

PRS 1.5%
inhibitory interneuron CL0000498

CSI -31.8

rCSI -73.3%

PRS 2.3%
mature astrocyte CL0002627

CSI -30.0

rCSI -100.0%

PRS 5.9%
pulmonary capillary endothelial cell CL4028001

CSI -29.4

rCSI -56.1%

PRS 3.7%
retinal bipolar neuron CL0000748

CSI -28.7

rCSI -53.7%

PRS 1.9%
lamp5 GABAergic cortical interneuron CL4023011

CSI -26.1

rCSI -43.8%

PRS 1.5%
sncg GABAergic cortical interneuron CL4023015

CSI -18.7

rCSI -30.1%

PRS 1.7%
pvalb GABAergic cortical interneuron CL4023018

CSI -18.5

rCSI -23.0%

PRS 1.3%
astrocyte of the cerebral cortex CL0002605

CSI -16.9

rCSI -38.0%

PRS 1.5%
rod bipolar cell CL0000751

CSI -16.0

rCSI -28.8%

PRS 2.0%
neural cell CL0002319

CSI -15.8

rCSI -59.5%

PRS 5.4%
cardiac endothelial cell CL0010008

CSI -15.7

rCSI -63.2%

PRS 2.7%
Mueller cell CL0000636

CSI -14.0

rCSI -31.9%

PRS 2.2%
kidney interstitial fibroblast CL1000692

CSI -13.2

rCSI -69.9%

PRS 16.1%
near-projecting glutamatergic cortical neuron CL4023012

CSI -13.1

rCSI -49.6%

PRS 1.6%
OFFx cell CL4033036

CSI -13.0

rCSI -61.0%

PRS 6.2%
GABAergic neuron CL0000617

CSI -12.3

rCSI -41.4%

PRS 2.4%
invaginating midget bipolar cell CL4033034

CSI -11.1

rCSI -65.5%

PRS 5.3%
epicardial adipocyte CL1000309

CSI -9.9

rCSI -32.3%

PRS 4.0%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -9.8

rCSI -23.9%

PRS 1.4%
renal interstitial pericyte CL1001318

CSI -9.3

rCSI -25.6%

PRS 2.7%
diffuse bipolar 6 cell CL4033032

CSI -7.8

rCSI -40.8%

PRS 6.6%
differentiation-committed oligodendrocyte precursor CL4023059

CSI -7.0

rCSI -12.7%

PRS 2.6%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI -6.9

rCSI -24.9%

PRS 1.3%
exhausted T cell CL0011025

CSI -6.5

rCSI -100.0%

PRS 12.8%
regular ventricular cardiac myocyte CL0002131

CSI -6.3

rCSI -39.1%

PRS 1.9%
cerebral cortex endothelial cell CL1001602

CSI -6.2

rCSI -10.8%

PRS 1.8%
Schwann cell CL0002573

CSI -6.1

rCSI -17.4%

PRS 3.2%
glycinergic amacrine cell CL4030028

CSI -5.8

rCSI -15.2%

PRS 3.6%
hepatic stellate cell CL0000632

CSI -5.7

rCSI -21.2%

PRS 2.0%
platelet CL0000233

CSI -5.5

rCSI -22.6%

PRS 7.2%
kidney collecting duct principal cell CL1001431

CSI -5.4

rCSI -27.3%

PRS 15.9%
diffuse bipolar 2 cell CL4033028

CSI -4.9

rCSI -37.9%

PRS 6.0%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -4.4

rCSI -13.6%

PRS 1.7%
diffuse bipolar 3b cell CL4033030

CSI -4.2

rCSI -27.7%

PRS 5.6%
diffuse bipolar 3a cell CL4033029

CSI -3.5

rCSI -23.7%

PRS 5.3%
kidney collecting duct intercalated cell CL1001432

CSI -3.1

rCSI -22.1%

PRS 10.6%
amacrine cell CL0000561

CSI -3.0

rCSI -8.6%

PRS 2.2%
OFF midget ganglion cell CL4033047

CSI -2.4

rCSI -48.0%

PRS 3.0%
cord blood hematopoietic stem cell CL2000095

CSI -2.2

rCSI -42.9%

PRS 20.1%
glutamatergic neuron CL0000679

CSI -2.1

rCSI -4.4%

PRS 2.8%
sst GABAergic cortical interneuron CL4023017

CSI -2.1

rCSI -2.7%

PRS 1.6%
H2 horizontal cell CL0004218

CSI -2.0

rCSI -9.7%

PRS 4.4%
kidney granular cell CL0000648

CSI -1.5

rCSI -21.5%

PRS 27.8%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI -1.2

rCSI -2.1%

PRS 1.4%
periportal region hepatocyte CL0019026

CSI -0.9

rCSI -3.5%

PRS 4.0%
GABAergic amacrine cell CL4030027

CSI -0.6

rCSI -2.1%

PRS 3.3%
endocrine cell CL0000163

CSI -0.6

rCSI -3.1%

PRS 11.2%
endocardial cell CL0002350

CSI -0.3

rCSI -1.4%

PRS 4.1%
L6b glutamatergic cortical neuron CL4023038

CSI -0.1

rCSI -0.3%

PRS 1.5%
H1 horizontal cell CL0004217

CSI 0.0

rCSI 0.0%

PRS 6.3%
cell of skeletal muscle CL0000188

CSI 0.2

rCSI 2.5%

PRS 16.9%
endothelial cell of arteriole CL1000412

CSI 0.6

rCSI 3.4%

PRS 12.5%
immature innate lymphoid cell CL0001082

CSI 0.6

rCSI 19.4%

PRS 41.3%
kidney resident macrophage CL1000698

CSI 0.8

rCSI 15.2%

PRS 54.8%
cholangiocyte CL1000488

CSI 0.8

rCSI 5.0%

PRS 5.4%
microglial cell CL0000129

CSI 1.4

rCSI 5.7%

PRS 11.5%
erythroid lineage cell CL0000764

CSI 1.5

rCSI 9.7%

PRS 6.5%
macula densa epithelial cell CL1000850

CSI 1.6

rCSI 22.3%

PRS 33.1%
group 3 innate lymphoid cell, human CL0001078

CSI 1.8

rCSI 37.9%

PRS 44.4%
serous secreting cell CL0000313

CSI 1.8

rCSI 9.1%

PRS 12.1%
hepatic pit cell CL2000054

CSI 1.8

rCSI 25.1%

PRS 27.5%
basal cell of epidermis CL0002187

CSI 1.9

rCSI 3.3%

PRS 3.3%
kidney connecting tubule principal cell CL4030018

CSI 2.0

rCSI 14.4%

PRS 31.9%
slow muscle cell CL0000189

CSI 2.3

rCSI 30.7%

PRS 30.7%
choroid plexus epithelial cell CL0000706

CSI 2.3

rCSI 3.8%

PRS 1.8%
Purkinje cell CL0000121

CSI 2.3

rCSI 30.4%

PRS 22.6%
tracheobronchial goblet cell CL0019003

CSI 2.6

rCSI 41.3%

PRS 53.3%
cytotoxic T cell CL0000910

CSI 2.6

rCSI 15.1%

PRS 3.7%
forebrain neuroblast CL1000042

CSI 2.6

rCSI 28.6%

PRS 33.8%
cone retinal bipolar cell CL0000752

CSI 2.8

rCSI 35.9%

PRS 15.9%
neuroplacodal cell CL0000032

CSI 2.8

rCSI 25.5%

PRS 9.3%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 2.9

rCSI 25.1%

PRS 6.4%
B-1 B cell CL0000819

CSI 2.9

rCSI 75.3%

PRS 14.2%
pluripotent stem cell CL0002248

CSI 3.0

rCSI 88.6%

PRS 5.9%
odontoblast CL0000060

CSI 3.0

rCSI 67.0%

PRS 13.8%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 3.0

rCSI 93.1%

PRS 31.9%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 3.0

rCSI 17.1%

PRS 14.1%
lung microvascular endothelial cell CL2000016

CSI 3.1

rCSI 60.3%

PRS 8.5%
cerebellar granule cell CL0001031

CSI 3.2

rCSI 4.7%

PRS 2.5%
professional antigen presenting cell CL0000145

CSI 3.2

rCSI 11.1%

PRS 10.7%
kidney loop of Henle epithelial cell CL1000909

CSI 3.4

rCSI 70.6%

PRS 21.5%
Bergmann glial cell CL0000644

CSI 3.5

rCSI 4.8%

PRS 2.6%
Merkel cell CL0000242

CSI 3.6

rCSI 83.9%

PRS 17.1%
mesenchymal lymphangioblast CL0005021

CSI 3.7

rCSI 96.5%

PRS 13.3%
epithelial cell of urethra CL1000296

CSI 3.7

rCSI 93.1%

PRS 8.2%
parietal epithelial cell CL1000452

CSI 3.7

rCSI 9.9%

PRS 2.4%
uterine smooth muscle cell CL0002601

CSI 3.8

rCSI 25.0%

PRS 18.4%
retinal ganglion cell CL0000740

CSI 3.9

rCSI 8.6%

PRS 1.7%
double negative T regulatory cell CL0011024

CSI 3.9

rCSI 74.1%

PRS 20.9%
prostate gland microvascular endothelial cell CL2000059

CSI 3.9

rCSI 93.6%

PRS 8.8%
osteoblast CL0000062

CSI 4.0

rCSI 98.1%

PRS 22.8%
renal intercalated cell CL0005010

CSI 4.1

rCSI 36.4%

PRS 22.5%
eye photoreceptor cell CL0000287

CSI 4.1

rCSI 46.3%

PRS 9.3%
bronchiolar smooth muscle cell CL4033017

CSI 4.5

rCSI 67.7%

PRS 7.8%
B-2 B cell CL0000822

CSI 4.5

rCSI 95.9%

PRS 15.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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- High
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- Low
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- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [RPLP0](/details-gene/6175) (Ribosomal Protein Lateral Stalk Subunit P0) is a protein-coding gene located on chromosome 12q24.23 that encodes a core component of the 60S large ribosomal subunit. As a key structural element of the ribosome, [RPLP0](/details-gene/6175) is fundamental to the process of protein synthesis, specifically cytoplasmic translation ([GO:0002181](https://www.ebi.ac.uk/QuickGO/term/GO:0002181)). Its expression profile reflects this essential function, showing high significance in metabolically active and proliferative cells. **Overall**, it is a defining marker for various hematopoietic lineages, including [hematopoietic stem cells](/details-cell/CL0000037), progenitor cells, and multiple subtypes of activated and memory T and B lymphocytes, suggesting a critical role in supporting the high protein synthesis demands of hematopoiesis and adaptive immunity. The gene has a clinical association documented in OMIM ([180510](https://omim.org/entry/180510)). ## Cellular Roles and Expression Landscape The expression pattern of [RPLP0](/details-gene/6175) underscores its central role in cellular protein production, with its significance being highest in cells characterized by high rates of division, differentiation, or protein secretion. **Overall**, the gene exhibits its highest significance across the hematopoietic system. It is a top marker in progenitor cells such as [hematopoietic stem cell](/details-cell/CL0000037) (CSI: 136.32) and [common myeloid progenitor](/details-cell/CL0000049) (CSI: 117.70), consistent with the high translational activity required for lineage commitment and expansion. This high significance extends to mature immune cells, particularly adaptive lymphocytes like [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) (CSI: 135.00), [naive thymus-derived CD8-positive, alpha-beta T cell](/details-cell/CL0000900) (CSI: 120.22), and [class switched memory B cell](/details-cell/CL0000972) (CSI: 118.96). Its prominence in innate immune cells, such as [plasmacytoid dendritic cell, human](/details-cell/CL0001058) (CSI: 120.38) and [group 3 innate lymphoid cell](/details-cell/CL0001071) (CSI: 114.49), further highlights its indispensable function in facilitating the rapid synthesis of cytokines, antibodies, and other effector molecules during an immune response. Conversely, [RPLP0](/details-gene/6175) shows very low to negative significance in cell types with lower metabolic or proliferative rates. This includes a range of terminally differentiated neural cells, such as [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: -36.32) and [mature astrocyte](/details-cell/CL0002627) (CSI: -30.04), as well as structural cells like [adipocyte](/details-cell/CL0000136) (CSI: -38.51) and [vascular leptomeningeal cell](/details-cell/CL4023051) (CSI: -51.53). This sharp contrast suggests that while [RPLP0](/details-gene/6175) is a ubiquitous and essential component of the translational machinery, its expression levels are tightly regulated and serve as an indicator of a cell's translational demand. ## Pathways and Molecular Function Functionally, [RPLP0](/details-gene/6175) is annotated as a [structural constituent of ribosome](/details-ontology/GO0003735) that participates centrally in [translation](/details-ontology/GO0006412) and binds to both rRNA ([GO:0070180](https://www.ebi.ac.uk/QuickGO/term/GO:0070180)) and other proteins ([GO:0005515](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)). It is a core component of the [cytosolic large ribosomal subunit](/details-ontology/GO0022625), essential for protein synthesis. Its involvement is captured in numerous fundamental Reactome pathways, including [Eukaryotic translation initiation](/details-pathway/R-HSA-72613), [Eukaryotic translation elongation](/details-pathway/R-HSA-156842), and [Eukaryotic translation termination](/details-pathway/R-HSA-72764). The broad pathway associations reflect its housekeeping role in the [Metabolism of proteins](/details-pathway/R-HSA-392499). Furthermore, its connection to pathways like [Cytokine signaling in immune system](/details-pathway/R-HSA-1280215) and [Signaling by interleukins](/details-pathway/R-HSA-449147) provides a direct molecular link to its high expression in immune cells, where rapid, signal-dependent protein synthesis is critical for function. The gene's participation in [Viral mrna translation](/details-pathway/R-HSA-192823) also suggests it may be a host factor exploited during viral infections, a finding supported by its annotation in [Influenza infection](/details-pathway/R-HSA-168255) pathways. ## Research Directions The ubiquitous yet variably expressed nature of [RPLP0](/details-gene/6175), particularly its high significance in the immune system, points to several avenues for future research. **Proposed Hypotheses:** 1. **Hypothesis 1: Haploinsufficiency or functional impairment of [RPLP0](/details-gene/6175) disproportionately affects hematopoietic stem cell self-renewal and lymphocyte differentiation, leading to specific immunodeficiencies.** Because these cells have exceptionally high demands for protein synthesis during development and activation, they may be more sensitive to perturbations in ribosomal function than less proliferative cell types. 2. **Hypothesis 2: Elevated [RPLP0](/details-gene/6175) expression in hematological malignancies serves as a biomarker of high proliferative capacity and may contribute to tumorigenesis by enabling the massive protein synthesis required for rapid cancer cell growth.** This suggests that the translational machinery itself could be a therapeutic vulnerability in these cancers. **Key Experimental Approach:** To test the role of [RPLP0](/details-gene/6175) in lymphocyte function (Hypothesis 1), a conditional knockout mouse model could be employed using a CD4-Cre or similar lymphocyte-specific driver. Following knockout of *Rplp0* in T cells, a comprehensive immunological challenge (e.g., with LCMV infection) would be performed. The subsequent T cell response would be evaluated by quantifying cell proliferation via BrdU incorporation, effector cytokine production (IFN-gamma, IL-2) using intracellular flow cytometry, and the formation of memory T cell populations. A significant impairment in these functions compared to wild-type controls would confirm the critical, non-redundant role of [RPLP0](/details-gene/6175) in adaptive immunity. **Therapeutic Potential:** As a core ribosomal protein, [RPLP0](/details-gene/6175) is a challenging direct therapeutic target due to the risk of severe on-target toxicity in all cells. Direct inhibition would likely be detrimental. However, its high expression in rapidly proliferating cells, such as those in hematological cancers or autoimmune disorders, makes it a potential indirect target. Therapeutic strategies that disrupt ribosome biogenesis or function are already in development for cancer. Understanding the specific dependencies of malignant cells on components like [RPLP0](/details-gene/6175) could enable more targeted approaches. Therefore, [RPLP0](/details-gene/6175) expression could serve as a valuable prognostic biomarker, and strategies aimed at modulating the translational machinery, rather than inhibiting [RPLP0](/details-gene/6175) itself, may hold therapeutic promise.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S acidic ribosomal protein P0

Genular Protein ID: 3994815924

Symbol: RLA0_HUMAN

Name: 60S acidic ribosomal protein P0

UniProtKB Accession Codes:

P05388 Q3B7A4 Q9BVK4

Database IDs:

Citations:

PubMed ID: 3323886

Title: Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly.

PubMed ID: 3323886

DOI: 10.1128/mcb.7.11.4065-4074.1987

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 19188445

Title: APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

PubMed ID: 19188445

DOI: 10.1128/mcb.01337-08

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24658146

Title: Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin.

PubMed ID: 24658146

DOI: 10.1371/journal.pone.0091465

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 36638793

Title: An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.

PubMed ID: 36638793

DOI: 10.1016/j.cell.2022.12.025

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

Length: 317
Mass: 34274
Checksum: 255AD25571C51199
Sequence:

MPREDRATWK SNYFLKIIQL LDDYPKCFIV GADNVGSKQM QQIRMSLRGK AVVLMGKNTM 
MRKAIRGHLE NNPALEKLLP HIRGNVGFVF TKEDLTEIRD MLLANKVPAA ARAGAIAPCE 
VTVPAQNTGL GPEKTSFFQA LGITTKISRG TIEILSDVQL IKTGDKVGAS EATLLNMLNI 
SPFSFGLVIQ QVFDNGSIYN PEVLDITEET LHSRFLEGVR NVASVCLQIG YPTVASVPHS 
IINGYKRVLA LSVETDYTFP LAEKVKAFLA DPSAFVAAAP VAAATTAAPA AAAAPAKVEA 
KEESEESDED MGFGLFD

Details for: RPLP0

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly. PubMed ID: 3323886

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Molecular composition of IMP1 ribonucleoprotein granules. PubMed ID: 17289661

APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. PubMed ID: 19188445

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A new system for naming ribosomal proteins. PubMed ID: 24524803

Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin. PubMed ID: 24658146

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. PubMed ID: 36638793

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399