Details for: RPN2

Gene ID: 6185

Symbol: RPN2

Ensembl ID: ENSG00000118705

Description: ribophorin II

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 190.2426
    Cell Significance Index: -78.3700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 175.9077
    Cell Significance Index: -83.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 173.5108
    Cell Significance Index: -70.4900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 158.2083
    Cell Significance Index: -81.3800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 124.1539
    Cell Significance Index: -83.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 74.2765
    Cell Significance Index: -70.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.5716
    Cell Significance Index: -63.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.9399
    Cell Significance Index: -52.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.7232
    Cell Significance Index: -21.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.3864
    Cell Significance Index: 157.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.2397
    Cell Significance Index: 86.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 2.8717
    Cell Significance Index: 293.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1158
    Cell Significance Index: 1155.5100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.8673
    Cell Significance Index: 17.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8447
    Cell Significance Index: 50.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8368
    Cell Significance Index: 364.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7910
    Cell Significance Index: 322.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6745
    Cell Significance Index: 229.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6258
    Cell Significance Index: 199.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5798
    Cell Significance Index: 117.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.3221
    Cell Significance Index: 30.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2861
    Cell Significance Index: 26.9200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.2521
    Cell Significance Index: 7.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1428
    Cell Significance Index: 146.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0599
    Cell Significance Index: 36.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0476
    Cell Significance Index: 135.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0057
    Cell Significance Index: 163.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9886
    Cell Significance Index: 437.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9408
    Cell Significance Index: 48.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9316
    Cell Significance Index: 65.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8715
    Cell Significance Index: 40.9600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8592
    Cell Significance Index: 6.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7934
    Cell Significance Index: 159.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7815
    Cell Significance Index: 20.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6572
    Cell Significance Index: 454.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6152
    Cell Significance Index: 555.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5692
    Cell Significance Index: 36.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5686
    Cell Significance Index: 108.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5620
    Cell Significance Index: 95.9600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5577
    Cell Significance Index: 16.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5245
    Cell Significance Index: 29.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5135
    Cell Significance Index: 14.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4663
    Cell Significance Index: 13.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3538
    Cell Significance Index: 126.9000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.2993
    Cell Significance Index: 2.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2644
    Cell Significance Index: 31.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2530
    Cell Significance Index: 2.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2397
    Cell Significance Index: 23.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2215
    Cell Significance Index: 11.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1931
    Cell Significance Index: 10.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1916
    Cell Significance Index: 20.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1796
    Cell Significance Index: 3.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1787
    Cell Significance Index: 2.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1284
    Cell Significance Index: 97.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0956
    Cell Significance Index: 1.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0331
    Cell Significance Index: 24.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0054
    Cell Significance Index: -10.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0278
    Cell Significance Index: -20.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0339
    Cell Significance Index: -62.5000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0347
    Cell Significance Index: -1.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0400
    Cell Significance Index: -61.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0465
    Cell Significance Index: -29.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0482
    Cell Significance Index: -1.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0496
    Cell Significance Index: -31.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0520
    Cell Significance Index: -70.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0612
    Cell Significance Index: -1.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0942
    Cell Significance Index: -2.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0991
    Cell Significance Index: -55.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1081
    Cell Significance Index: -49.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1378
    Cell Significance Index: -15.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1402
    Cell Significance Index: -29.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2179
    Cell Significance Index: -62.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3018
    Cell Significance Index: -13.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3290
    Cell Significance Index: -47.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3363
    Cell Significance Index: -10.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3494
    Cell Significance Index: -22.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3507
    Cell Significance Index: -26.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4056
    Cell Significance Index: -10.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4718
    Cell Significance Index: -54.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4779
    Cell Significance Index: -12.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4944
    Cell Significance Index: -56.4400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5087
    Cell Significance Index: -6.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5790
    Cell Significance Index: -12.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5849
    Cell Significance Index: -10.8100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5892
    Cell Significance Index: -3.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6252
    Cell Significance Index: -8.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7199
    Cell Significance Index: -74.9600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7436
    Cell Significance Index: -10.9800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7564
    Cell Significance Index: -30.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9252
    Cell Significance Index: -26.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9307
    Cell Significance Index: -73.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9646
    Cell Significance Index: -24.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0039
    Cell Significance Index: -61.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2353
    Cell Significance Index: -54.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4606
    Cell Significance Index: -43.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.4952
    Cell Significance Index: -56.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4986
    Cell Significance Index: -47.7300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.5983
    Cell Significance Index: -55.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.6436
    Cell Significance Index: -53.8100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.6442
    Cell Significance Index: -32.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPN2 is a Golgi membrane protein that is highly expressed in cells involved in immune responses, such as plasmablasts and plasma cells. It is also found in cells of the salivary gland, lung, and placenta. RPN2 is a member of the dolichyl-diphosphooligosaccharide-protein glycotransferase (DOCK) family, which is composed of multiple subunits with distinct functions. The RPN2 subunit is specifically involved in the transfer of dolichol-phosphate-linked sugars to nascent polypeptide chains, a process that is essential for the proper glycosylation of proteins. **Pathways and Functions** RPN2 is involved in several key pathways, including: 1. **Asparagine N-linked Glycosylation**: RPN2 is a key component of the OTC, which is responsible for the transfer of dolichol-phosphate-linked sugars to nascent polypeptide chains. This process is essential for the proper glycosylation of proteins, which affects their stability, function, and interactions with other molecules. 2. **Protein Modification Process**: RPN2 is involved in the modification of proteins through N-linked glycosylation, which is a critical post-translational modification that affects protein function and stability. 3. **Disease Pathways**: Mutations in RPN2 have been associated with various diseases, including infectious diseases caused by SARS-CoV-2. RPN2 is also involved in the maturation of the spike protein, which is essential for viral entry into host cells. **Clinical Significance** RPN2 is a critical component of the oligosaccharyltransferase complex, which plays a key role in the N-linked glycosylation of proteins. Mutations in RPN2 have been associated with various diseases, including: 1. **SARS-CoV-2 Infections**: Mutations in RPN2 have been identified in patients with SARS-CoV-2 infections, suggesting that RPN2 may play a role in the pathogenesis of this disease. 2. **Infectious Diseases**: RPN2 is also involved in the modification of proteins involved in the immune response, suggesting that it may play a role in the pathogenesis of other infectious diseases. 3. **Cancer**: RPN2 has been implicated in the development and progression of certain types of cancer, suggesting that it may play a role in tumorigenesis. In summary, RPN2 is a critical component of the oligosaccharyltransferase complex, which plays a key role in the N-linked glycosylation of proteins. Mutations in RPN2 have been associated with various diseases, including infectious diseases caused by SARS-CoV-2. Further research is needed to fully understand the role of RPN2 in disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 1887059415

Symbol: RPN2_HUMAN

Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit

UniProtKB Accession Codes:

P04844 Q5JYR6 Q6IBA5 Q96E21 Q9BUQ3 Q9UBE1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 26 EMDB 4 Ensembl 4 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 9 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3034581

Title: Human ribophorins I and II: the primary structure and membrane topology of two highly conserved rough endoplasmic reticulum-specific glycoproteins.

PubMed ID: 3034581

DOI: 10.1002/j.1460-2075.1987.tb04721.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25135935

Title: Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

PubMed ID: 25135935

DOI: 10.1083/jcb.201404083

PubMed ID: 23606741

Title: OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation.

PubMed ID: 23606741

DOI: 10.1242/jcs.115410

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29290612

Title: Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity.

PubMed ID: 29290612

DOI: 10.1016/j.molcel.2017.11.035

PubMed ID: 31831667

Title: Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.

PubMed ID: 31831667

DOI: 10.1126/science.aaz3505

Sequence Information:

  • Length: 631
  • Mass: 69284
  • Checksum: E24D7B3565141676
  • Sequence:
    • MAPPGSSTVF LLALTIIAST WALTPTHYLT KHDVERLKAS LDRPFTNLES AFYSIVGLSS 
LGAQVPDAKK ACTYIRSNLD PSNVDSLFYA AQASQALSGC EISISNETKD LLLAAVSEDS 
SVTQIYHAVA ALSGFGLPLA SQEALSALTA RLSKEETVLA TVQALQTASH LSQQADLRSI 
VEEIEDLVAR LDELGGVYLQ FEEGLETTAL FVAATYKLMD HVGTEPSIKE DQVIQLMNAI 
FSKKNFESLS EAFSVASAAA VLSHNRYHVP VVVVPEGSAS DTHEQAILRL QVTNVLSQPL 
TQATVKLEHA KSVASRATVL QKTSFTPVGD VFELNFMNVK FSSGYYDFLV EVEGDNRYIA 
NTVELRVKIS TEVGITNVDL STVDKDQSIA PKTTRVTYPA KAKGTFIADS HQNFALFFQL 
VDVNTGAELT PHQTFVRLHN QKTGQEVVFV AEPDNKNVYK FELDTSERKI EFDSASGTYT 
LYLIIGDATL KNPILWNVAD VVIKFPEEEA PSTVLSQNLF TPKQEIQHLF REPEKRPPTV 
VSNTFTALIL SPLLLLFALW IRIGANVSNF TFAPSTIIFH LGHAAMLGLM YVYWTQLNMF 
QTLKYLAILG SVTFLAGNRM LAQQAVKRTA H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.