RPS16 | ENSG00000105193 | NCBI 6217

Details for: RPS16

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Maturation of ssu-rrna from tricistronic rrna transcript (ssu-rrna, 5.8s rrna, lsu-rrna)
(GO:0000462)
Membrane
(GO:0016020)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Ribosomal small subunit biogenesis
(GO:0042274)
Rna binding
(GO:0003723)
Rrna processing
(GO:0006364)
Small-subunit processome
(GO:0032040)
Small ribosomal subunit
(GO:0015935)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

central memory CD4-positive, alpha-beta T cell CL0000904

CSI 153.38

rCSI 90.58%

PRS 1.2
hematopoietic stem cell CL0000037

CSI 144.76

rCSI 96.22%

PRS 1.02
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 133.6

rCSI 90.01%

PRS 1.04
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 132.74

rCSI 93.23%

PRS 2.63
double negative thymocyte CL0002489

CSI 129.34

rCSI 89.92%

PRS 1.01
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 127.92

rCSI 85.25%

PRS 2.44
CD4-positive, alpha-beta memory T cell CL0000897

CSI 126.6

rCSI 90.88%

PRS 1.17
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 121.87

rCSI 91.39%

PRS 2.6
immature B cell CL0000816

CSI 119.62

rCSI 88.88%

PRS 1.28
T follicular helper cell CL0002038

CSI 119.57

rCSI 89.48%

PRS 1.41
class switched memory B cell CL0000972

CSI 118.27

rCSI 88.29%

PRS 1.46
common myeloid progenitor CL0000049

CSI 117.48

rCSI 94.99%

PRS 0.84
epithelial cell of lower respiratory tract CL0002632

CSI 117.09

rCSI 90.77%

PRS 0.81
keratinocyte CL0000312

CSI 116.3

rCSI 97.48%

PRS 1.04
CD4-positive helper T cell CL0000492

CSI 116.07

rCSI 87.81%

PRS 1.21
T-helper 17 cell CL0000899

CSI 115.91

rCSI 92.04%

PRS 1.53
plasmacytoid dendritic cell, human CL0001058

CSI 115.63

rCSI 80.73%

PRS 0.91
naive T cell CL0000898

CSI 115.62

rCSI 80.47%

PRS 1.26
epithelial cell of lung CL0000082

CSI 115.3

rCSI 95.59%

PRS 0.8
granulocyte monocyte progenitor cell CL0000557

CSI 114.42

rCSI 99.07%

PRS 0.96
CD4-positive, alpha-beta thymocyte CL0000810

CSI 113.77

rCSI 91.13%

PRS 1.62
plasmablast CL0000980

CSI 113.32

rCSI 89.15%

PRS 1.02
group 3 innate lymphoid cell CL0001071

CSI 112.98

rCSI 84.89%

PRS 0.89
unswitched memory B cell CL0000970

CSI 112.27

rCSI 94.46%

PRS 1.45
neural crest cell CL0011012

CSI 109.67

rCSI 86.69%

PRS 0.6
naive B cell CL0000788

CSI 109.57

rCSI 93.98%

PRS 2.8
mature B cell CL0000785

CSI 109.37

rCSI 95.08%

PRS 1.06
effector CD8-positive, alpha-beta T cell CL0001050

CSI 109.25

rCSI 83.1%

PRS 1.14
mucosal invariant T cell CL0000940

CSI 106.2

rCSI 85.81%

PRS 2.26
myeloid leukocyte CL0000766

CSI 105.95

rCSI 97.75%

PRS 0.87
pro-B cell CL0000826

CSI 105.42

rCSI 87.31%

PRS 0.86
megakaryocyte-erythroid progenitor cell CL0000050

CSI 105.22

rCSI 95.02%

PRS 0.76
mature T cell CL0002419

CSI 103.27

rCSI 80.33%

PRS 1.22
skin fibroblast CL0002620

CSI 101.64

rCSI 87.62%

PRS 1.44
fallopian tube secretory epithelial cell CL4030006

CSI 101.42

rCSI 97.63%

PRS 0.9
early lymphoid progenitor CL0000936

CSI 101.25

rCSI 88.92%

PRS 0.96
activated CD4-positive, alpha-beta T cell CL0000896

CSI 101.08

rCSI 93.44%

PRS 1.58
memory B cell CL0000787

CSI 99.84

rCSI 98.6%

PRS 3.82
ciliated epithelial cell CL0000067

CSI 96.53

rCSI 84.89%

PRS 0.63
intestine goblet cell CL0019031

CSI 96.07

rCSI 85.27%

PRS 0.86
double-positive, alpha-beta thymocyte CL0000809

CSI 94.04

rCSI 95.84%

PRS 1.25
precursor B cell CL0000817

CSI 93.82

rCSI 82.18%

PRS 1.16
intestinal epithelial cell CL0002563

CSI 92.53

rCSI 96.72%

PRS 0.92
bronchus fibroblast of lung CL2000093

CSI 92.31

rCSI 75.01%

PRS 0.9
elicited macrophage CL0000861

CSI 91.95

rCSI 84.43%

PRS 0.96
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 88.87

rCSI 80.94%

PRS 1.35
small pre-B-II cell CL0000954

CSI 87.03

rCSI 83.69%

PRS 1.88
hematopoietic precursor cell CL0008001

CSI 84.32

rCSI 86.74%

PRS 1.23
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 84.14

rCSI 82.63%

PRS 1.38
CD8-positive, alpha-beta memory T cell CL0000909

CSI 84.04

rCSI 87.77%

PRS 2.78
multi-ciliated epithelial cell CL0005012

CSI 83.88

rCSI 83.71%

PRS 0.72
activated CD8-positive, alpha-beta T cell CL0000906

CSI 82.01

rCSI 80.61%

PRS 2.58
pancreatic D cell CL0000173

CSI 81.12

rCSI 79.79%

PRS 0.95
transit amplifying cell of colon CL0009011

CSI 80.93

rCSI 95.05%

PRS 1.05
respiratory basal cell CL0002633

CSI 80.79

rCSI 83.69%

PRS 1.01
secretory cell CL0000151

CSI 80.23

rCSI 83.72%

PRS 0.88
gamma-delta T cell CL0000798

CSI 79.73

rCSI 93.64%

PRS 8.77
common dendritic progenitor CL0001029

CSI 79.67

rCSI 99.99%

PRS 1.09
extravillous trophoblast CL0008036

CSI 78.53

rCSI 97.14%

PRS 0.76
goblet cell CL0000160

CSI 78

rCSI 73.7%

PRS 0.9
CD1c-positive myeloid dendritic cell CL0002399

CSI 77.55

rCSI 93.66%

PRS 0.99
fraction A pre-pro B cell CL0002045

CSI 77.38

rCSI 88.58%

PRS 1.8
pancreatic A cell CL0000171

CSI 76.52

rCSI 80.16%

PRS 0.93
CD14-low, CD16-positive monocyte CL0002396

CSI 76.44

rCSI 58.89%

PRS 0.78
fibroblast of lung CL0002553

CSI 76.21

rCSI 70.92%

PRS 0.86
IgA plasma cell CL0000987

CSI 75.27

rCSI 77.06%

PRS 1.63
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 75.25

rCSI 94.56%

PRS 4.75
respiratory suprabasal cell CL4033048

CSI 73.02

rCSI 93.66%

PRS 1
mesodermal cell CL0000222

CSI 72.69

rCSI 87.26%

PRS 0.86
B cell CL0000236

CSI 72.01

rCSI 96.35%

PRS 5.3
activated type II NK T cell CL0000931

CSI 71.84

rCSI 80.86%

PRS 1.45
alveolar type 1 fibroblast cell CL4028004

CSI 70.7

rCSI 77.43%

PRS 1
CD14-positive monocyte CL0001054

CSI 70.51

rCSI 87.82%

PRS 1.28
CD4-positive, alpha-beta T cell CL0000624

CSI 69.75

rCSI 89.26%

PRS 18.82
perivascular cell CL4033054

CSI 68.92

rCSI 94.21%

PRS 0.99
nasal mucosa goblet cell CL0002480

CSI 68.31

rCSI 79.23%

PRS 1.29
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 67.94

rCSI 78.46%

PRS 0.81
promyelocyte CL0000836

CSI 67.77

rCSI 97.75%

PRS 1.2
mature NK T cell CL0000814

CSI 67.7

rCSI 86.59%

PRS 4.01
conventional dendritic cell CL0000990

CSI 67.41

rCSI 56.27%

PRS 3.05
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 67.27

rCSI 91.64%

PRS 2.16
mucous neck cell CL0000651

CSI 67.15

rCSI 96.78%

PRS 1.4
peripheral nervous system neuron CL2000032

CSI 66.86

rCSI 91.1%

PRS 0.79
pancreatic acinar cell CL0002064

CSI 66.47

rCSI 88.34%

PRS 0.95
common lymphoid progenitor CL0000051

CSI 66.14

rCSI 88.38%

PRS 1.65
myofibroblast cell CL0000186

CSI 64.98

rCSI 90%

PRS 1.24
placental villous trophoblast CL2000060

CSI 64.72

rCSI 100%

PRS 0.81
enteroendocrine cell CL0000164

CSI 64.43

rCSI 88.03%

PRS 0.95
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 64.14

rCSI 88.13%

PRS 1.85
myeloid dendritic cell CL0000782

CSI 63.05

rCSI 91.33%

PRS 1.26
endothelial cell of artery CL1000413

CSI 62.77

rCSI 91.97%

PRS 5.32
acinar cell CL0000622

CSI 62.61

rCSI 91.8%

PRS 1.14
colon epithelial cell CL0011108

CSI 62.53

rCSI 65.5%

PRS 0.8
ionocyte CL0005006

CSI 62.51

rCSI 66.99%

PRS 0.79
dendritic cell CL0000451

CSI 62.14

rCSI 76.57%

PRS 2.86
lung ciliated cell CL1000271

CSI 61.64

rCSI 71.28%

PRS 0.62
enteric smooth muscle cell CL0002504

CSI 60.91

rCSI 86.92%

PRS 0.99
melanocyte CL0000148

CSI 60.38

rCSI 44.72%

PRS 0.83
CD8-positive, alpha-beta thymocyte CL0000811

CSI 58.97

rCSI 91.96%

PRS 2.26
plasma cell CL0000786

CSI 58.5

rCSI 76.67%

PRS 4.68

ependymal cell CL0000065

CSI -55.1

rCSI -100.0%

PRS 0.3%
vascular leptomeningeal cell CL4023051

CSI -51.7

rCSI -90.6%

PRS 0.7%
kidney interstitial alternatively activated macrophage CL1000695

CSI -39.1

rCSI -100.0%

PRS 1.1%
inhibitory interneuron CL0000498

CSI -32.8

rCSI -75.6%

PRS 0.9%
pvalb GABAergic cortical interneuron CL4023018

CSI -31.6

rCSI -39.3%

PRS 0.5%
differentiation-committed oligodendrocyte precursor CL4023059

CSI -30.1

rCSI -54.7%

PRS 1.1%
mature astrocyte CL0002627

CSI -28.9

rCSI -100.0%

PRS 2.5%
sncg GABAergic cortical interneuron CL4023015

CSI -27.8

rCSI -44.7%

PRS 0.7%
GABAergic neuron CL0000617

CSI -23.1

rCSI -77.4%

PRS 0.9%
VIP GABAergic cortical interneuron CL4023016

CSI -22.3

rCSI -26.6%

PRS 0.6%
astrocyte of the cerebral cortex CL0002605

CSI -19.9

rCSI -44.5%

PRS 0.6%
retinal bipolar neuron CL0000748

CSI -17.5

rCSI -32.8%

PRS 0.7%
neural cell CL0002319

CSI -17.2

rCSI -64.9%

PRS 2.1%
adipocyte CL0000136

CSI -16.1

rCSI -20.6%

PRS 1.2%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -15.3

rCSI -48.0%

PRS 0.7%
cerebral cortex neuron CL0010012

CSI -15.1

rCSI -61.4%

PRS 1.3%
cardiac endothelial cell CL0010008

CSI -14.7

rCSI -59.1%

PRS 1.1%
kidney collecting duct principal cell CL1001431

CSI -14.5

rCSI -72.8%

PRS 6.1%
rod bipolar cell CL0000751

CSI -14.3

rCSI -25.7%

PRS 0.8%
erythroid lineage cell CL0000764

CSI -13.6

rCSI -87.4%

PRS 2.5%
kidney interstitial fibroblast CL1000692

CSI -13.2

rCSI -70.2%

PRS 8.4%
kidney proximal convoluted tubule epithelial cell CL1000838

CSI -13.2

rCSI -100.0%

PRS 17.6%
glutamatergic neuron CL0000679

CSI -12.8

rCSI -26.4%

PRS 1.1%
epicardial adipocyte CL1000309

CSI -11.7

rCSI -37.9%

PRS 1.7%
renal interstitial pericyte CL1001318

CSI -11.5

rCSI -31.8%

PRS 0.9%
cerebral cortex endothelial cell CL1001602

CSI -11.3

rCSI -19.6%

PRS 0.7%
lamp5 GABAergic cortical interneuron CL4023011

CSI -10.8

rCSI -18.2%

PRS 0.6%
OFFx cell CL4033036

CSI -10.4

rCSI -48.9%

PRS 2.9%
professional antigen presenting cell CL0000145

CSI -10.0

rCSI -34.3%

PRS 3.7%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -9.0

rCSI -21.9%

PRS 0.6%
periportal region hepatocyte CL0019026

CSI -8.4

rCSI -32.6%

PRS 1.5%
invaginating midget bipolar cell CL4033034

CSI -8.1

rCSI -48.1%

PRS 2.5%
pulmonary capillary endothelial cell CL4028001

CSI -7.9

rCSI -15.0%

PRS 1.4%
starburst amacrine cell CL0004232

CSI -7.7

rCSI -65.0%

PRS 3.0%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -7.5

rCSI -44.3%

PRS 0.7%
cell of skeletal muscle CL0000188

CSI -7.5

rCSI -81.7%

PRS 5.6%
diffuse bipolar 6 cell CL4033032

CSI -7.1

rCSI -37.5%

PRS 3.1%
diffuse bipolar 1 cell CL4033027

CSI -7.0

rCSI -52.9%

PRS 2.6%
flat midget bipolar cell CL4033033

CSI -6.8

rCSI -48.6%

PRS 2.5%
platelet CL0000233

CSI -6.6

rCSI -27.5%

PRS 2.7%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI -6.4

rCSI -23.1%

PRS 0.5%
exhausted T cell CL0011025

CSI -5.5

rCSI -93.0%

PRS 5.2%
near-projecting glutamatergic cortical neuron CL4023012

CSI -5.3

rCSI -20.1%

PRS 0.6%
kidney granular cell CL0000648

CSI -5.3

rCSI -76.2%

PRS 12.9%
diffuse bipolar 4 cell CL4033031

CSI -5.1

rCSI -58.8%

PRS 3.7%
regular ventricular cardiac myocyte CL0002131

CSI -5.0

rCSI -31.4%

PRS 0.8%
diffuse bipolar 2 cell CL4033028

CSI -5.0

rCSI -38.7%

PRS 2.7%
glycinergic amacrine cell CL4030028

CSI -4.6

rCSI -12.0%

PRS 1.4%
kidney collecting duct intercalated cell CL1001432

CSI -3.3

rCSI -23.6%

PRS 4.0%
cord blood hematopoietic stem cell CL2000095

CSI -3.1

rCSI -59.1%

PRS 6.7%
kidney connecting tubule principal cell CL4030018

CSI -2.9

rCSI -21.2%

PRS 14.2%
hepatic stellate cell CL0000632

CSI -2.9

rCSI -10.9%

PRS 0.8%
indirect pathway medium spiny neuron CL4023029

CSI -2.8

rCSI -66.5%

PRS 0.7%
cardiac blood vessel endothelial cell CL0010006

CSI -2.5

rCSI -18.0%

PRS 3.5%
ON midget ganglion cell CL4033046

CSI -2.5

rCSI -50.7%

PRS 1.2%
endocrine cell CL0000163

CSI -2.0

rCSI -10.2%

PRS 3.7%
OFF midget ganglion cell CL4033047

CSI -1.9

rCSI -38.4%

PRS 1.3%
diffuse bipolar 3b cell CL4033030

CSI -1.3

rCSI -8.8%

PRS 2.4%
kidney resident macrophage CL1000698

CSI -1.2

rCSI -24.3%

PRS 23.3%
serous secreting cell CL0000313

CSI -0.9

rCSI -4.5%

PRS 4.5%
sst GABAergic cortical interneuron CL4023017

CSI -0.6

rCSI -0.8%

PRS 0.6%
diffuse bipolar 3a cell CL4033029

CSI -0.6

rCSI -4.0%

PRS 2.3%
L6b glutamatergic cortical neuron CL4023038

CSI -0.4

rCSI -1.1%

PRS 0.6%
GABAergic amacrine cell CL4030027

CSI 0.3

rCSI 1.1%

PRS 1.3%
H2 horizontal cell CL0004218

CSI 0.4

rCSI 1.9%

PRS 1.9%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.6

rCSI 1.1%

PRS 0.5%
endocardial cell CL0002350

CSI 0.7

rCSI 3.3%

PRS 1.6%
immature innate lymphoid cell CL0001082

CSI 0.8

rCSI 26.2%

PRS 16.7%
H1 horizontal cell CL0004217

CSI 1.2

rCSI 4.7%

PRS 2.6%
renal intercalated cell CL0005010

CSI 1.5

rCSI 13.0%

PRS 7.7%
group 3 innate lymphoid cell, human CL0001078

CSI 1.5

rCSI 32.2%

PRS 17.1%
cholangiocyte CL1000488

CSI 1.6

rCSI 9.3%

PRS 2.1%
amacrine cell CL0000561

CSI 1.9

rCSI 5.6%

PRS 0.8%
cardiac muscle cell CL0000746

CSI 1.9

rCSI 2.8%

PRS 0.8%
forebrain neuroblast CL1000042

CSI 2.2

rCSI 23.4%

PRS 14.3%
macula densa epithelial cell CL1000850

CSI 2.2

rCSI 31.1%

PRS 16.7%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 2.6

rCSI 81.3%

PRS 12.6%
fast muscle cell CL0000190

CSI 2.6

rCSI 10.3%

PRS 5.8%
hepatic pit cell CL2000054

CSI 2.7

rCSI 36.4%

PRS 11.8%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 3.0

rCSI 25.8%

PRS 2.5%
odontoblast CL0000060

CSI 3.1

rCSI 70.8%

PRS 5.3%
midzonal region hepatocyte CL0019028

CSI 3.2

rCSI 7.5%

PRS 1.6%
pluripotent stem cell CL0002248

CSI 3.2

rCSI 96.0%

PRS 2.2%
microglial cell CL0000129

CSI 3.3

rCSI 13.4%

PRS 4.3%
Bergmann glial cell CL0000644

CSI 3.3

rCSI 4.6%

PRS 1.0%
slow muscle cell CL0000189

CSI 3.4

rCSI 44.8%

PRS 13.0%
retinal cone cell CL0000573

CSI 3.4

rCSI 5.5%

PRS 0.7%
collagen secreting cell CL0000667

CSI 3.5

rCSI 20.1%

PRS 5.3%
B-1 B cell CL0000819

CSI 3.6

rCSI 92.5%

PRS 5.4%
Merkel cell CL0000242

CSI 3.6

rCSI 83.5%

PRS 6.1%
mesenchymal lymphangioblast CL0005021

CSI 3.7

rCSI 96.1%

PRS 5.0%
Schwann cell CL0002573

CSI 3.7

rCSI 10.5%

PRS 1.2%
osteoblast CL0000062

CSI 3.7

rCSI 92.8%

PRS 8.5%
retinal ganglion cell CL0000740

CSI 3.8

rCSI 8.5%

PRS 0.7%
neuroplacodal cell CL0000032

CSI 3.9

rCSI 36.0%

PRS 3.8%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 3.9

rCSI 41.2%

PRS 1.5%
parietal epithelial cell CL1000452

CSI 3.9

rCSI 10.4%

PRS 0.9%
epithelial cell of urethra CL1000296

CSI 3.9

rCSI 98.4%

PRS 3.1%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 4.0

rCSI 22.5%

PRS 5.4%
kidney connecting tubule epithelial cell CL1000768

CSI 4.0

rCSI 10.1%

PRS 0.7%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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- High
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- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [RPS16](/details-gene/6217) (Ribosomal Protein S16) is a protein-coding gene located on chromosome 19q13.2. As its name suggests, it encodes a core structural component of the 40S small ribosomal subunit. Its fundamental role in protein synthesis is reflected by its high expression in metabolically active and highly proliferative cell populations. **Overall**, [RPS16](/details-gene/6217) shows the highest significance in hematopoietic and immune cells, including [hematopoietic stem cell](/details-cell/CL0000037), various T cell subsets such as [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904), and B cells. This expression pattern underscores its essential function in supporting the rapid protein turnover, cell growth, and division required for hematopoiesis and immune responses. ## Cellular Roles and Expression Landscape The expression profile of [RPS16](/details-gene/6217) highlights its role as an essential "workhorse" protein in cells with high biosynthetic demands. Its significance is most pronounced across the hematopoietic lineage, indicating a critical function in the development and maintenance of the immune system. **High Significance Contexts:** * **Immune System:** [RPS16](/details-gene/6217) is a top marker in both the adaptive and innate immune systems. It is highly significant in various lymphocyte populations, including [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904), [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907), [immature B cell](/details-cell/CL0000816), and natural killer cells like [CD16-positive, CD56-dim natural killer cell, human](/details-cell/CL0000939). This is consistent with the high rates of protein synthesis required for immune cell activation, clonal expansion, and effector function (e.g., antibody and cytokine production). * **Hematopoiesis:** High significance in progenitor cells, such as [hematopoietic stem cell](/details-cell/CL0000037) and [common myeloid progenitor](/details-cell/CL0000049), suggests a vital role in the foundational processes of blood cell formation. * **Proliferative Tissues:** Elevated expression in cells like [keratinocyte](/details-cell/CL0000312) and [epithelial cell of lower respiratory tract](/details-cell/CL0002632) further supports its association with tissues undergoing constant renewal and turnover. **Low Significance Contexts (Anti-Markers):** * The gene's significance is notably low in terminally differentiated, post-mitotic cell types, particularly within the central nervous system. These include various neuronal subtypes like [GABAergic neuron](/details-cell/CL0000617) and glial cells such as [mature astrocyte](/details-cell/CL0002627) and [ependymal cell](/details-cell/CL0000065). This pattern strongly suggests that while basal protein synthesis occurs in these cells, the machinery involving [RPS16](/details-gene/6217) is less of a defining or rate-limiting feature compared to highly proliferative cells. ## Pathways and Molecular Function Functionally, [RPS16](/details-gene/6217) is annotated as a [structural constituent of ribosome](/details-cell/GO:0003735) with [RNA binding](/details-cell/GO:0003723) capabilities. Its primary biological process is [translation](/details-cell/GO:0006412), contributing to [ribosomal small subunit biogenesis](/details-cell/GO:0042274) and [rRNA processing](/details-cell/GO:0006364). This core function places [RPS16](/details-gene/6217) at the center of the entire protein synthesis pipeline, as detailed by its involvement in numerous Reactome pathways. It is integral to all major phases of eukaryotic translation, including [Cap-dependent translation initiation](/details-cell/R-HSA-72737), [Peptide chain elongation](/details-cell/R-HSA-156902), and [Eukaryotic translation termination](/details-cell/R-HSA-72764). Beyond this fundamental housekeeping role, the involvement of [RPS16](/details-gene/6217) in pathways like [Cellular responses to stress](/details-cell/R-HSA-2262752) and [Cellular response to starvation](/details-cell/R-HSA-9711097) highlights the ribosome's role as a central hub for integrating environmental cues to regulate cell growth. Furthermore, its annotation in various infectious disease pathways, such as [Influenza infection](/details-cell/R-HSA-168255) and [Sars-cov-2 infection](/details-cell/R-HSA-9694516), underscores the critical reliance of viruses on the host's translational machinery for their replication. The pathway [Sars-cov-2 modulates host translation machinery](/details-cell/R-HSA-9754678) specifically implicates ribosomal components like [RPS16](/details-gene/6217) as key players in the host-pathogen interaction. ## Research Directions Given its ubiquitous and essential nature, research on [RPS16](/details-gene/6217) should focus on its potential specialized or regulatory roles beyond general protein synthesis, particularly in the context of disease. **Proposed Hypotheses:** 1. **Role in Viral Host-Hijacking:** The extensive annotation of [RPS16](/details-gene/6217) in viral infection pathways suggests it may be a key interaction point for viral factors. We hypothesize that specific viral proteins (e.g., from SARS-CoV-2 or Influenza) directly bind to or near [RPS16](/details-gene/6217) to selectively enhance the translation of viral mRNA over host mRNA, effectively commandeering the cell's protein synthesis machinery. 2. **Ribosomopathies and Hematopoiesis:** While not directly indicated in the provided data, mutations in ribosomal proteins are linked to diseases known as ribosomopathies (e.g., Diamond-Blackfan anemia), which often manifest as hematopoietic failures. We hypothesize that subtle, undiscovered germline variants in [RPS16](/details-gene/6217) may contribute to mild forms of bone marrow dysfunction or cytopenias by impairing the efficiency of ribosome biogenesis specifically in rapidly dividing hematopoietic progenitors. 3. **Specialized Ribosomes in Neurodevelopment:** The involvement in the [Axon guidance](/details-cell/R-HSA-422475) pathway is paradoxical given the low expression of [RPS16](/details-gene/6217) in mature neurons. This may indicate a transient but critical role during development. We hypothesize that [RPS16](/details-gene/6217) is part of specialized "local translation" ribosomes in the growth cones of developing axons, and its downregulation is a necessary step for synaptic maturation and stabilization. **Key Experimental Proposal:** To test the hypothesis regarding viral hijacking (Hypothesis 1), a protein-protein interaction study could be conducted. The experiment would involve: * Expressing an epitope-tagged version of [RPS16](/details-gene/6217) in a relevant cell line (e.g., human lung epithelial cells). * Infecting these cells with a virus of interest, such as SARS-CoV-2. * Performing co-immunoprecipitation (Co-IP) using an antibody against the epitope tag to pull down [RPS16](/details-gene/6217) and its interacting partners. * Analyzing the co-precipitated proteins by mass spectrometry (MS) to identify specific viral proteins that physically associate with [RPS16](/details-gene/6217). Follow-up structural and functional studies could then map the interaction interface. **Therapeutic Potential:** Directly targeting [RPS16](/details-gene/6217) with an inhibitor is not a viable therapeutic strategy due to its essential housekeeping function, which would lead to profound, non-specific toxicity. However, if specific interactions between [RPS16](/details-gene/6217) and viral or oncogenic proteins are identified, the *interface* of this interaction could become a druggable target. Designing small molecules or peptidomimetics that specifically disrupt the binding of a pathogenic protein to the ribosome, without affecting the ribosome's core function, could offer a highly specific therapeutic window for antiviral or anticancer treatments.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S16
M0R210_HUMAN

Genular Protein ID: 2417051161

Symbol: RS16_HUMAN

Name: 40S ribosomal protein S16

UniProtKB Accession Codes:

P62249 B2RDD5 P17008

Database IDs:

Citations:

PubMed ID: 2016298

Title: Molecular cloning and sequence analysis of the human ribosomal protein S16.

PubMed ID: 2016298

DOI: 10.1016/s0021-9258(20)89575-1

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

Length: 146
Mass: 16445
Checksum: 519BCFB91BB68A15
Sequence:

MPSKGPLQSV QVFGRKKTAT AVAHCKRGNG LIKVNGRPLE MIEPRTLQYK LLEPVLLLGK 
ERFAGVDIRV RVKGGGHVAQ IYAIRQSISK ALVAYYQKYV DEASKKEIKD ILIQYDRTLL 
VADPRRCESK KFGGPGARAR YQKSYR

Genular Protein ID: 3366771388

Symbol: M0R210_HUMAN

Name: N/A

UniProtKB Accession Codes:

M0R210

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

Length: 129
Mass: 14419
Checksum: 46EB78F8F374DEA8
Sequence:

MPSKGPLQSV QVFGRKKTAT AVAHCKRGNG LIKLLEPVLL LGKERFAGVD IRVRVKGGGH 
VAQIYAIRQS ISKALVAYYQ KYVDEASKKE IKDILIQYDR TLLVADPRRC ESKKFGGPGA 
RARYQKSYR

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Ascending colon UBERON0001156
	\|— Ascending colon Healthy UBERON0001156_PATO0000461
	Atherosclerosis MONDO0005311
	Axilla UBERON0009472
	\|— Axilla Breast cancer UBERON0009472_MONDO0007254
	Basal cell carcinoma MONDO0020804
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	\|— Caecum Healthy UBERON0001153_PATO0000461
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	\|— Colonic epithelium UBERON0000397
	\|— Colonic epithelium Healthy UBERON0000397_PATO0000461
	Colorectal cancer MONDO0005575
	Colorectum UBERON0012652
	Cornea UBERON0000964
	\|— Cornea Healthy UBERON0000964_PATO0000461
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fallopian tube UBERON0003889
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileal epithelium UBERON0008345
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	\|— Liver Breast cancer UBERON0002107_MONDO0007254
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	\|— Lymph node Healthy UBERON0000029_PATO0000461
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Nonpapillary renal cell carcinoma MONDO0007763
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	\|— Placenta Healthy UBERON0001987_PATO0000461
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Prostate gland UBERON0002367
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Right cardiac atrium UBERON0002078
	\|— Right cardiac atrium Healthy UBERON0002078_PATO0000461
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small intestine UBERON0002108
	\|— Small intestine Healthy UBERON0002108_PATO0000461
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	\|— Stomach Healthy UBERON0000945_PATO0000461
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	Trachea UBERON0003126
	Transverse colon UBERON0001157
	\|— Transverse colon Healthy UBERON0001157_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952

Details for: RPS16

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Molecular cloning and sequence analysis of the human ribosomal protein S16. PubMed ID: 2016298

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Nucleolar maturation of the human small subunit processome. PubMed ID: 34516797

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The sequence of the human genome. PubMed ID: 11181995

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

PubMed ID: 2016298

PubMed ID: 11875025

PubMed ID: 14702039

PubMed ID: 15489334

PubMed ID: 8706699

PubMed ID: 14654843

PubMed ID: 19608861

PubMed ID: 21269460

PubMed ID: 22814378

PubMed ID: 23186163

PubMed ID: 24524803

PubMed ID: 24275569

PubMed ID: 25944712

PubMed ID: 23636399

PubMed ID: 34516797

PubMed ID: 11237011

PubMed ID: 11181995

PubMed ID: 15057824

PubMed ID: 15496913

PubMed ID: 19608861

PubMed ID: 21269460

PubMed ID: 22814378

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 25944712