Details for: RPS29

Gene ID: 6235

Symbol: RPS29

Ensembl ID: ENSG00000213741

Description: ribosomal protein S29

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 668.5073
    Cell Significance Index: -275.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 552.3141
    Cell Significance Index: -260.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 526.4148
    Cell Significance Index: -270.7800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 389.5997
    Cell Significance Index: -261.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 49.7824
    Cell Significance Index: -133.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 15.5362
    Cell Significance Index: 396.9000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 13.7361
    Cell Significance Index: 80.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 12.8954
    Cell Significance Index: 1317.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 11.7759
    Cell Significance Index: 553.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 11.3505
    Cell Significance Index: 303.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 10.0499
    Cell Significance Index: 264.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 9.5693
    Cell Significance Index: 1176.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 9.3411
    Cell Significance Index: 267.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 9.2620
    Cell Significance Index: 1669.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 9.0959
    Cell Significance Index: 643.3000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.9527
    Cell Significance Index: 158.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.9163
    Cell Significance Index: 1224.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 8.8402
    Cell Significance Index: 1142.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.4714
    Cell Significance Index: 177.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 7.8667
    Cell Significance Index: 3478.0600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 7.5266
    Cell Significance Index: 46.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 7.2384
    Cell Significance Index: 539.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 7.1661
    Cell Significance Index: 81.4100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 6.9138
    Cell Significance Index: 59.4100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.6806
    Cell Significance Index: 53.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 6.5147
    Cell Significance Index: 3557.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.4328
    Cell Significance Index: 824.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.0726
    Cell Significance Index: 716.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.3069
    Cell Significance Index: 48.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.7014
    Cell Significance Index: 163.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 4.6472
    Cell Significance Index: 3517.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.5596
    Cell Significance Index: 294.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.3443
    Cell Significance Index: 202.5500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.2497
    Cell Significance Index: 46.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.4564
    Cell Significance Index: 590.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.4283
    Cell Significance Index: 680.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.3099
    Cell Significance Index: 2988.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.1403
    Cell Significance Index: 164.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.0380
    Cell Significance Index: 87.5300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.0261
    Cell Significance Index: 55.9300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.6970
    Cell Significance Index: 34.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5618
    Cell Significance Index: 69.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.9467
    Cell Significance Index: 51.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.5254
    Cell Significance Index: 44.8000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.4963
    Cell Significance Index: 34.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4406
    Cell Significance Index: 142.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2077
    Cell Significance Index: 229.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.9596
    Cell Significance Index: 703.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.3942
    Cell Significance Index: 31.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2708
    Cell Significance Index: 97.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0479
    Cell Significance Index: -9.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0546
    Cell Significance Index: -102.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0758
    Cell Significance Index: -3.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1006
    Cell Significance Index: -74.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1218
    Cell Significance Index: -224.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1489
    Cell Significance Index: -229.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1523
    Cell Significance Index: -95.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2135
    Cell Significance Index: -290.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2183
    Cell Significance Index: -123.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3311
    Cell Significance Index: -210.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3931
    Cell Significance Index: -12.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.4001
    Cell Significance Index: -65.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5164
    Cell Significance Index: -234.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5238
    Cell Significance Index: -110.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6619
    Cell Significance Index: -37.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.7701
    Cell Significance Index: -221.5800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.9229
    Cell Significance Index: -15.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9716
    Cell Significance Index: -110.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.0916
    Cell Significance Index: -125.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -1.3486
    Cell Significance Index: -146.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.3630
    Cell Significance Index: -61.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.5675
    Cell Significance Index: -227.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.5998
    Cell Significance Index: -39.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.6572
    Cell Significance Index: -104.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.7232
    Cell Significance Index: -28.8400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.7492
    Cell Significance Index: -26.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.3883
    Cell Significance Index: -248.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.3945
    Cell Significance Index: -165.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -2.5200
    Cell Significance Index: -88.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.7986
    Cell Significance Index: -60.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -2.9301
    Cell Significance Index: -180.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.0739
    Cell Significance Index: -235.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.4325
    Cell Significance Index: -230.8000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -3.5677
    Cell Significance Index: -9.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.6295
    Cell Significance Index: -222.5200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -3.6807
    Cell Significance Index: -20.0700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -4.1362
    Cell Significance Index: -24.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -4.4666
    Cell Significance Index: -119.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.4706
    Cell Significance Index: -61.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.2366
    Cell Significance Index: -154.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.8312
    Cell Significance Index: -257.9300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -6.0471
    Cell Significance Index: -46.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -6.0633
    Cell Significance Index: -222.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -6.8647
    Cell Significance Index: -133.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -6.9197
    Cell Significance Index: -262.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -7.0626
    Cell Significance Index: -231.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -7.0768
    Cell Significance Index: -84.3600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -7.0808
    Cell Significance Index: -73.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -7.0846
    Cell Significance Index: -121.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -7.1883
    Cell Significance Index: -251.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPS29 is a small, acidic protein (28 kDa) that is highly conserved across species. It is a component of the 40S ribosomal subunit, which is responsible for the initiation of protein synthesis. RPS29 is specifically bound to the 43S pre-initiation complex (PIC) and is involved in the recognition of the start codon and the scanning of the mRNA. This protein is also involved in the regulation of translation initiation and is essential for the proper functioning of the ribosomal machinery. **Pathways and Functions:** RPS29 is involved in multiple cellular pathways, including: 1. **Translation initiation:** RPS29 is essential for the recognition of the start codon and the scanning of the mRNA, which is a critical step in the initiation of protein synthesis. 2. **Stress response:** RPS29 is involved in the regulation of translation in response to stress, including amino acid starvation and viral infection. 3. **Viral infection:** RPS29 is essential for the translation of viral mRNAs and is involved in the regulation of viral replication. 4. **Immune response:** RPS29 is highly expressed in immune cells, including T cells and dendritic cells, and is involved in the regulation of translation in response to antigen presentation. 5. **Cellular responses to stimuli:** RPS29 is involved in the regulation of translation in response to various cellular stimuli, including growth factors and cytokines. **Clinical Significance:** RPS29 has been implicated in various diseases, including: 1. **Influenza infection:** RPS29 is essential for the translation of viral mRNAs and is involved in the regulation of viral replication. 2. **SARS-CoV-2 infection:** RPS29 is involved in the regulation of translation in response to SARS-CoV-2 infection. 3. **Autoimmune diseases:** RPS29 has been implicated in autoimmune diseases, including rheumatoid arthritis and lupus, where it is involved in the regulation of translation and immune response. 4. **Cancer:** RPS29 has been implicated in cancer, where it is involved in the regulation of translation and cell growth. In conclusion, RPS29 is a crucial component of the ribosomal complex and plays a pivotal role in the regulation of translation, stress response, and viral infection. Its dysregulation has been implicated in various diseases, including influenza, SARS-CoV-2, autoimmune diseases, and cancer. Further research is needed to fully understand the mechanisms by which RPS29 regulates translation and immune response, and to explore its potential as a therapeutic target for various diseases. **Signaling Pathways:** RPS29 is involved in multiple signaling pathways, including: 1. **MAPK signaling pathway:** RPS29 is involved in the regulation of translation in response to MAPK signaling. 2. **mTOR signaling pathway:** RPS29 is involved in the regulation of translation in response to mTOR signaling. 3. **PI3K/AKT signaling pathway:** RPS29 is involved in the regulation of translation in response to PI3K/AKT signaling. 4. **NF-κB signaling pathway:** RPS29 is involved in the regulation of translation in response to NF-κB signaling. **Regulation of RPS29 Expression:** RPS29 expression is regulated by various factors, including: 1. **Transcription factors:** RPS29 expression is regulated by transcription factors, including NF-κB and AP-1. 2. **Post-transcriptional regulation:** RPS29 expression is regulated by post-transcriptional mechanisms, including RNA binding proteins and microRNAs. 3. **Cellular stress:** RPS29 expression is regulated by cellular stress, including amino acid starvation and viral infection. In summary, RPS29 is a crucial component of the ribosomal complex and plays a pivotal role in the regulation of translation, stress response, and viral infection. Its dysregulation has been implicated in various diseases, including influenza, SARS-CoV-2, autoimmune diseases, and cancer. Further research is needed to fully understand the mechanisms by which RPS29 regulates translation and immune response, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2574055114

Symbol: RS29_HUMAN

Name: 40S ribosomal protein S29

UniProtKB Accession Codes:

P62273 A8MZ73 P30054

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEBI 5 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 66 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 84 PDBsum 84 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 18 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7772601

Title: Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.

PubMed ID: 7772601

DOI: 10.1016/0167-4781(95)00045-i

PubMed ID: 8781548

Title: The S29 ribosomal protein increases tumor suppressor activity of K rev-1 gene on v-K ras-transformed NIH3T3 cells.

PubMed ID: 8781548

DOI: 10.1016/0167-4889(96)00052-3

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 25957688

Title: Structural snapshots of actively translating human ribosomes.

PubMed ID: 25957688

DOI: 10.1016/j.cell.2015.03.052

PubMed ID: 25901680

Title: Structure of the human 80S ribosome.

PubMed ID: 25901680

DOI: 10.1038/nature14427

PubMed ID: 24829207

Title: Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families.

PubMed ID: 24829207

DOI: 10.1182/blood-2013-11-540278

Sequence Information:

  • Length: 56
  • Mass: 6677
  • Checksum: 41325122B493EFF9
  • Sequence:
    • MGHQQLYWSH PRKFGQGSRS CRVCSNRHGL IRKYGLNMCR QCFRQYAKDI GFIKLD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.