Details for: RPS29

Gene ID: 6235

Symbol: RPS29

Ensembl ID: ENSG00000213741

Description: ribosomal protein S29

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 7.86
    Marker Score: 4428
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 5.91
    Marker Score: 4462
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.9
    Marker Score: 4279
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 5.73
    Marker Score: 28162
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.72
    Marker Score: 2937
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 5.44
    Marker Score: 2810
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.38
    Marker Score: 72248
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.34
    Marker Score: 52844
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.26
    Marker Score: 6852
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 5.25
    Marker Score: 1936
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 5.13
    Marker Score: 8794
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.12
    Marker Score: 14936
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 5.04
    Marker Score: 3558.5
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.93
    Marker Score: 4199
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.92
    Marker Score: 167436
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.91
    Marker Score: 2112
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.9
    Marker Score: 4379
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.88
    Marker Score: 3497
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 4.84
    Marker Score: 3680
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.72
    Marker Score: 24825
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.66
    Marker Score: 19417.5
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.62
    Marker Score: 2975
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.61
    Marker Score: 243890
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.58
    Marker Score: 14467
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.55
    Marker Score: 1479
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.52
    Marker Score: 1079
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.51
    Marker Score: 5007
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 4.5
    Marker Score: 2545
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.36
    Marker Score: 2653
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.32
    Marker Score: 56950
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.31
    Marker Score: 11901
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.3
    Marker Score: 2295.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.26
    Marker Score: 6560
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.26
    Marker Score: 27164
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.24
    Marker Score: 11880
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 4.2
    Marker Score: 25515
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.19
    Marker Score: 10246
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 4.19
    Marker Score: 2860
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.18
    Marker Score: 2448
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.16
    Marker Score: 11160
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.15
    Marker Score: 73644
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.13
    Marker Score: 48047
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.12
    Marker Score: 9383
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.03
    Marker Score: 7576
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.01
    Marker Score: 3873
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.01
    Marker Score: 223989
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4
    Marker Score: 4276
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4
    Marker Score: 8391
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4
    Marker Score: 3937
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 4
    Marker Score: 916
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.96
    Marker Score: 14076
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.95
    Marker Score: 25717
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.93
    Marker Score: 16849
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.93
    Marker Score: 3082
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 3.87
    Marker Score: 900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.85
    Marker Score: 2127
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.83
    Marker Score: 5561
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.81
    Marker Score: 1002
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.8
    Marker Score: 1070
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.8
    Marker Score: 9656
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.8
    Marker Score: 1078
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 3.78
    Marker Score: 763
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.78
    Marker Score: 1378
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.77
    Marker Score: 3216
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.77
    Marker Score: 1563
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.77
    Marker Score: 1688
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.75
    Marker Score: 3341
  • Cell Name: club cell (CL0000158)
    Fold Change: 3.74
    Marker Score: 4368
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.73
    Marker Score: 4375
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.73
    Marker Score: 1228
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.73
    Marker Score: 9287
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.71
    Marker Score: 3274
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.71
    Marker Score: 3501.5
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.71
    Marker Score: 1669.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.71
    Marker Score: 4477.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.71
    Marker Score: 3866
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.71
    Marker Score: 2803.5
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.69
    Marker Score: 2481.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 3.68
    Marker Score: 2119
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 3.67
    Marker Score: 1676
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.67
    Marker Score: 1046
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.67
    Marker Score: 3045
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.66
    Marker Score: 3940
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.66
    Marker Score: 969.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.66
    Marker Score: 8303
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.66
    Marker Score: 4045
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.66
    Marker Score: 5816
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 3.66
    Marker Score: 909
  • Cell Name: glial cell (CL0000125)
    Fold Change: 3.64
    Marker Score: 3998
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 3.63
    Marker Score: 1074
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.63
    Marker Score: 1878
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.63
    Marker Score: 1250
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 3.62
    Marker Score: 2521
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.62
    Marker Score: 3498
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.59
    Marker Score: 3445
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 3.59
    Marker Score: 1079
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.58
    Marker Score: 23318
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 3.58
    Marker Score: 951
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 3.58
    Marker Score: 1010
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.57
    Marker Score: 1849.5

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Other Information

**Key characteristics:** * RS29 is a large protein with a molecular weight of approximately 150 kDa. * It is a member of the RPS29 family of ribosomal proteins. * RS29 is found in both the nucleus and cytosol. * It is involved in the initiation of protein translation. **Pathways and functions:** * RS29 is involved in the initiation of protein translation by binding to the 5' cap of mRNA and promoting the release of the cap-dependent complex. * It is also involved in the elongation of the polypeptide chain by interacting with the ribosome and catalyzing the formation of peptide bonds between amino acids. * RS29 is also involved in the termination of protein translation by binding to the stop codon on mRNA and promoting the release of the completed polypeptide chain. * It is involved in the regulation of gene expression by interacting with the RNA polymerase complex and modulating the transcription of target genes. **Clinical significance:** * Mutations in the RPS29 gene have been linked to several human diseases, including pancreatic cancer, breast cancer, and leukemia. * In pancreatic cancer, mutations in RS29 have been shown to be associated with the development of tumors in exocrine cells of the pancreas. * In breast cancer, mutations in RS29 have been shown to be associated with the development of tumors in luminal cells of the breast. * In leukemia, mutations in RS29 have been shown to be associated with the development of leukemia cells. **Additional points:** * RS29 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is a chaperone protein that helps to fold other ribosomal proteins. * It is a target for anticancer drugs.

Genular Protein ID: 2574055114

Symbol: RS29_HUMAN

Name: 40S ribosomal protein S29

UniProtKB Accession Codes:

P62273 A8MZ73 P30054

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEBI 5 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 43 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 13 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 76 PDBsum 69 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 18 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7772601

Title: Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.

PubMed ID: 7772601

DOI: 10.1016/0167-4781(95)00045-i

PubMed ID: 8781548

Title: The S29 ribosomal protein increases tumor suppressor activity of K rev-1 gene on v-K ras-transformed NIH3T3 cells.

PubMed ID: 8781548

DOI: 10.1016/0167-4889(96)00052-3

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 25957688

Title: Structural snapshots of actively translating human ribosomes.

PubMed ID: 25957688

DOI: 10.1016/j.cell.2015.03.052

PubMed ID: 25901680

Title: Structure of the human 80S ribosome.

PubMed ID: 25901680

DOI: 10.1038/nature14427

PubMed ID: 24829207

Title: Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families.

PubMed ID: 24829207

DOI: 10.1182/blood-2013-11-540278

Sequence Information:

  • Length: 56
  • Mass: 6677
  • Checksum: 41325122B493EFF9
  • Sequence:
    • MGHQQLYWSH PRKFGQGSRS CRVCSNRHGL IRKYGLNMCR QCFRQYAKDI GFIKLD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.