Details for: RRM2

Gene ID: 6241

Symbol: RRM2

Ensembl ID: ENSG00000171848

Description: ribonucleotide reductase regulatory subunit M2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 44.7873
    Cell Significance Index: -11.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.9565
    Cell Significance Index: -10.5500
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 16.6006
    Cell Significance Index: 7.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.0903
    Cell Significance Index: -9.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2597
    Cell Significance Index: -14.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9257
    Cell Significance Index: -11.5500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.7635
    Cell Significance Index: 17.7900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.7348
    Cell Significance Index: 18.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5256
    Cell Significance Index: 85.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4125
    Cell Significance Index: 139.7300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.4081
    Cell Significance Index: 12.1000
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 1.2971
    Cell Significance Index: 0.9900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.9762
    Cell Significance Index: -2.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9027
    Cell Significance Index: 146.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8074
    Cell Significance Index: 87.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7777
    Cell Significance Index: 91.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.7680
    Cell Significance Index: 22.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7477
    Cell Significance Index: 21.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7219
    Cell Significance Index: 15.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6469
    Cell Significance Index: 75.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6023
    Cell Significance Index: 20.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5987
    Cell Significance Index: 35.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5682
    Cell Significance Index: 18.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5469
    Cell Significance Index: 13.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3863
    Cell Significance Index: 10.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2805
    Cell Significance Index: 7.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2677
    Cell Significance Index: 7.1600
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.2445
    Cell Significance Index: 1.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2125
    Cell Significance Index: 116.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2064
    Cell Significance Index: 186.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1947
    Cell Significance Index: 5.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1726
    Cell Significance Index: 32.8400
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.1529
    Cell Significance Index: 0.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1192
    Cell Significance Index: 8.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1133
    Cell Significance Index: 5.1400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.1045
    Cell Significance Index: 0.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0714
    Cell Significance Index: 1.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0683
    Cell Significance Index: 8.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0655
    Cell Significance Index: 2.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0538
    Cell Significance Index: 23.7700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0514
    Cell Significance Index: 0.5300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0245
    Cell Significance Index: 0.6100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0111
    Cell Significance Index: 0.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0045
    Cell Significance Index: 0.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.5800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0018
    Cell Significance Index: -0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0038
    Cell Significance Index: -7.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0042
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0046
    Cell Significance Index: -2.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0047
    Cell Significance Index: -3.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0055
    Cell Significance Index: -8.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0070
    Cell Significance Index: -3.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0102
    Cell Significance Index: -7.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0104
    Cell Significance Index: -14.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0120
    Cell Significance Index: -8.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0125
    Cell Significance Index: -4.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0147
    Cell Significance Index: -9.3300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0204
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0205
    Cell Significance Index: -4.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0253
    Cell Significance Index: -11.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0299
    Cell Significance Index: -5.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0312
    Cell Significance Index: -5.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0332
    Cell Significance Index: -6.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0340
    Cell Significance Index: -4.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0381
    Cell Significance Index: -3.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0439
    Cell Significance Index: -12.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0499
    Cell Significance Index: -7.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0656
    Cell Significance Index: -8.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0687
    Cell Significance Index: -4.4300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0723
    Cell Significance Index: -1.0900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0773
    Cell Significance Index: -0.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0782
    Cell Significance Index: -4.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0783
    Cell Significance Index: -8.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0875
    Cell Significance Index: -10.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0890
    Cell Significance Index: -11.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0989
    Cell Significance Index: -6.0800
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.1047
    Cell Significance Index: -1.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1072
    Cell Significance Index: -11.1600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1078
    Cell Significance Index: -0.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1212
    Cell Significance Index: -2.6300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1288
    Cell Significance Index: -4.7300
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1417
    Cell Significance Index: -1.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1437
    Cell Significance Index: -2.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1459
    Cell Significance Index: -11.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1573
    Cell Significance Index: -12.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1707
    Cell Significance Index: -11.4800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1824
    Cell Significance Index: -1.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1841
    Cell Significance Index: -13.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1881
    Cell Significance Index: -9.8000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1946
    Cell Significance Index: -3.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1970
    Cell Significance Index: -9.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2009
    Cell Significance Index: -9.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2067
    Cell Significance Index: -12.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2345
    Cell Significance Index: -14.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2720
    Cell Significance Index: -14.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2741
    Cell Significance Index: -12.7800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2787
    Cell Significance Index: -6.7500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2880
    Cell Significance Index: -4.0400
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2889
    Cell Significance Index: -2.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RRM2 is a multifunctional protein with several key characteristics: 1. **Ribonucleotide reductase regulatory subunit**: RRM2 interacts with the ribonucleotide reductase enzyme to modulate its activity, influencing the conversion of ribonucleotides to deoxyribonucleotides. 2. **Cell cycle regulation**: RRM2 is involved in the regulation of the cell cycle, particularly in the G1/S transition, where it interacts with E2F6 to promote DNA synthesis. 3. **Nucleotide metabolism**: RRM2 plays a crucial role in nucleotide metabolism, including the synthesis of deoxyribonucleotides, which are essential for DNA replication and repair. 4. **Protein binding**: RRM2 exhibits protein binding capabilities, interacting with various proteins, including E2F6, thioredoxin, and ribonucleotide reductase. **Pathways and Functions** RRM2 is involved in several pathways and processes, including: 1. **2'-deoxyribonucleotide biosynthetic process**: RRM2 is essential for the synthesis of deoxyribonucleotides, which are required for DNA replication and repair. 2. **Blastocyst development**: RRM2 is involved in the development of blastocysts, highlighting its importance in early embryonic development. 3. **Cell cycle**: RRM2 regulates the cell cycle, particularly in the G1/S transition, where it interacts with E2F6 to promote DNA synthesis. 4. **Gene expression (transcription)**: RRM2 is involved in the regulation of gene expression, particularly in the transcription of genes involved in DNA synthesis and repair. 5. **Metabolism of nucleotides**: RRM2 plays a crucial role in the metabolism of nucleotides, including the synthesis and degradation of nucleotides. **Clinical Significance** Dysregulation of RRM2 has been implicated in various diseases, including: 1. **Cancer**: Alterations in RRM2 expression and function have been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders**: RRM2 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Immunological disorders**: RRM2 is involved in the regulation of immune responses, and alterations in its expression and function have been observed in autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. In conclusion, RRM2 is a critical component of the ribonucleotide reductase complex, playing a pivotal role in cell cycle regulation and nucleotide metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of RRM2 in maintaining cellular homeostasis.

Genular Protein ID: 3414086103

Symbol: RIR2_HUMAN

Name: Ribonucleoside-diphosphate reductase subunit M2

UniProtKB Accession Codes:

P31350 B2R9B5 J3KP43 Q5WRU7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CPTC 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 2 EMBL 9 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1627826

Title: Sequence analysis of the large and small subunits of human ribonucleotide reductase.

PubMed ID: 1627826

DOI: 10.3109/10425179209020807

PubMed ID: 11978970

Title: Characterization of the human ribonucleotide reductase M2 subunit gene; genomic structure and promoter analyses.

PubMed ID: 11978970

DOI: 10.1159/000057017

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22632967

Title: Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair.

PubMed ID: 22632967

DOI: 10.1016/j.cell.2012.03.043

Sequence Information:

  • Length: 389
  • Mass: 44878
  • Checksum: 10E6F5F84D34DA94
  • Sequence:
    • MLSLRVPLAP ITDPQQLQLS PLKGLSLVDK ENTPPALSGT RVLASKTARR IFQEPTEPKT 
KAAAPGVEDE PLLRENPRRF VIFPIEYHDI WQMYKKAEAS FWTAEEVDLS KDIQHWESLK 
PEERYFISHV LAFFAASDGI VNENLVERFS QEVQITEARC FYGFQIAMEN IHSEMYSLLI 
DTYIKDPKER EFLFNAIETM PCVKKKADWA LRWIGDKEAT YGERVVAFAA VEGIFFSGSF 
ASIFWLKKRG LMPGLTFSNE LISRDEGLHC DFACLMFKHL VHKPSEERVR EIIINAVRIE 
QEFLTEALPV KLIGMNCTLM KQYIEFVADR LMLELGFSKV FRVENPFDFM ENISLEGKTN 
FFEKRVGEYQ RMGVMSSPTE NSFTLDADF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.